What are the cheapest airlines flying from Santo Domingo to Santiago round-trip?

According to our current data, Avianca ($564), and Copa Airlines ($759) offers the cheapest pricing from Santo Domingo to Santiago. Avianca is 7% cheaper than the average price of flights available within the next 90 days to this destination.

What are the cheapest airlines to fly from Santo Domingo to Santiago one-way?

For one-way options, check prices for Avianca. According to our data, you can fly for as low as $310. Users have also found prices from $680 and $2,191 on Delta and Iberia, respectively.

What is the cheapest day to fly from Santo Domingo to Santiago?

Travelers seeking maximum savings on their Santo Domingo to Santiago flight should consider departing on Saturday evenings when fares are most often at their lowest. Friday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in Santiago ranges from 0.0 - 2.8 inches per month. June is typically the wettest month, when rainfall can reach 2.8 in. January is typically the driest time to visit Santiago when rainfall is around 0.0 in.

If weather is an important factor for your trip to Santiago, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 69.8 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 46.4 F).

What is the cheapest day to fly round-trip from Santo Domingo to Santiago?

Leaving on a Sunday is a viable option for saving on travel. Heavily demanded days of the week can typically drive up the prices you see. Booking your travel for a less competitive day can save up to 5% on the overall cost on flights from Santo Domingo to Santiago.

How far in advance should I book a flight from Santo Domingo to Santiago?

Travelers have found it’s best to book a flight 36 days in advance to save up to 35% compared to booking the same week of travel. As your travel date approaches, the cost of this flight route may potentially increase. While opting to book 36 days out may not be an option for all, there are still additional ways to secure a deal in the near future. You might find a flight from Santo Domingo to Santiago 1-2 weeks in advance for as low as $503, or $541 for flights within the next 24 hours.

What is the cheapest month to fly from Santo Domingo to Santiago?

Our data shows that October tends to be the cheapest month to fly to Santiago from Santo Domingo. Users have commonly found prices around $609 for the month, but tickets can be as low as $270. Due to multiple factors, prepare for potentially higher prices in February.

Can I find deals for flights from Santo Domingo to Santiago that include hotel bookings?

Yes. In addition to deals on Santo Domingo to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Santo Domingo to Santiago?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to Santiago.

Can I find deals for business class flights from Santo Domingo to Santiago?

Yes. Cheapflights offers flight deals from Santo Domingo to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$310+ Flights from Santo Domingo to Santiago

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Find cheap flights from Santo Domingo to Santiago with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

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Cheapflights Tip: The best prices from Santo Domingo Las Americas to Santiago Arturo Merino Benitez are usually found in October or August, booked 67 days in advance, depart on a Monday or Tuesday and return on a Monday

Cheap flight deals from Santo Domingo to Santiago

Round-trip from	$458 (Arajet)
One-way from	$310 (Avianca Connect)
Popular in	February
Cheapest in	October
Average price	$539

From Santo Domingo Las Americas to Santiago Arturo Merino Benitez

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One-way flight from Santo Domingo Las Americas to Santiago Arturo Merino Benitez

Search Deals

Highest demand for flights based on searches. 15% potential increase in price ($114 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 4% potential price decrease ($24 potential savings vs. average RT price).

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Average for round-trip flights in July 2025

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Find flight deals from Santo Domingo to Santiago

Cheapest flights from Santo Domingo to Santiago
Explore the most affordable flight options available from Santo Domingo to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 2, 2025.

Tue 11/41:55 pmSDQ - SCL

1 stop12h 40mMultiple Airlines

Wed 11/196:00 amSCL - SDQ

1 stop11h 45mMultiple Airlines

Deal found 7/2

$458

Thu 7/176:10 pmSDQ - SCL

1 stop19h 15mAvianca

Fri 8/12:30 pmSCL - SDQ

1 stop20h 20mAvianca

Deal found 7/2

$564

Wed 8/138:57 amSDQ - SCL

1 stop10h 27mCopa Airlines

Sat 8/162:26 amSCL - SDQ

1 stop20h 00mCopa Airlines

Deal found 7/1

$759

Best flights from Santo Domingo to Santiago
Discover carefully curated flight deals from Santo Domingo to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 2, 2025.

Tue 11/41:55 pmSDQ - SCL

1 stop12h 40mMultiple Airlines

Wed 11/196:00 amSCL - SDQ

1 stop11h 45mMultiple Airlines

Deal found 7/2

$458

Thu 7/176:10 pmSDQ - SCL

1 stop19h 15mAvianca

Fri 8/12:30 pmSCL - SDQ

1 stop20h 20mAvianca

Deal found 7/2

$564

Wed 8/138:57 amSDQ - SCL

1 stop10h 27mCopa Airlines

Sat 8/162:26 amSCL - SDQ

1 stop20h 00mCopa Airlines

Deal found 7/1

$759

Last-minute flights from Santo Domingo to Santiago
Discover last-minute flight deals from Santo Domingo to Santiago. Data last updated July 2, 2025 and is based on user searches.

Tue 7/86:00 amSDQ - SCL

2 stops25h 00mDelta

Tue 7/2211:00 amSCL - SDQ

2 stops26h 12mDelta

Deal found 7/1

$3,098

Tue 7/810:15 amSDQ - SCL

2 stops34h 35mIberia

Tue 7/227:00 pmSCL - SDQ

2 stops47h 20mIberia

Deal found 7/2

$3,366

Thu 7/106:10 pmSDQ - SCL

1 stop19h 15mMultiple Airlines

Tue 7/223:35 amSCL - SDQ

1 stop11h 45mMultiple Airlines

Deal found 7/1

$535

Thu 7/1011:45 amSDQ - SCL

1 stop16h 30mAvianca

Wed 7/2311:55 pmSCL - SDQ

1 stop17h 20mAvianca

Deal found 7/2

$606

Thu 7/1011:54 amSDQ - SCL

1 stop14h 53mCopa Airlines

Tue 7/222:23 amSCL - SDQ

1 stop13h 54mCopa Airlines

Deal found 7/2

$884

Fri 7/1110:15 amSDQ - SCL

2 stops45h 20mBritish Airways

Tue 7/153:00 pmSCL - SDQ

2 stops51h 20mBritish Airways

Deal found 7/1

$3,605

Thu 7/176:10 pmSDQ - SCL

1 stop19h 15mMultiple Airlines

Thu 7/313:35 amSCL - SDQ

1 stop11h 53mMultiple Airlines

Deal found 7/2

$528

Thu 7/176:10 pmSDQ - SCL

1 stop19h 15mAvianca

Fri 8/12:30 pmSCL - SDQ

1 stop20h 20mAvianca

Deal found 7/2

$564

Wed 8/138:57 amSDQ - SCL

1 stop10h 27mCopa Airlines

Sat 8/162:26 amSCL - SDQ

1 stop20h 00mCopa Airlines

Deal found 7/1

$759

One-way flights from Santo Domingo to Santiago
Search for one-way flight options from Santo Domingo to Santiago. Find affordable one-way fares based on user searches. Data last updated July 2, 2025.

Wed 7/166:10 pmSDQ - SCL

1 stop10h 05mAvianca

Deal found 7/2

$310

Thu 7/312:05 pmSDQ - SCL

1 stop12h 30mMultiple Airlines

Deal found 7/1

$350

Sun 9/77:40 pmSDQ - SCL

2 stops33h 20mDelta

Deal found 7/1

$680

Fri 12/196:20 pmSDQ - SCL

2 stops61h 30mIberia

Deal found 7/2

$2,191

Cheapflights Fare Finder

Use the filters below to find and compare flights from Santo Domingo to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Santo DomingoSantiago

SDQ - SCL

SDQSCL

Santo Domingo Las Americas

Tue 11/4

1:55 pm-3:35 am

1 stop12h 40m

Santiago Arturo Merino Benitez

Wed 11/19

6:00 am-4:45 pm

1 stop11h 45m

$458

Santo DomingoSantiago

SDQ - SCL

SDQSCL

Santo Domingo Las Americas

Thu 7/17

6:10 pm-1:25 pm

1 stop19h 15m

Santiago Arturo Merino Benitez

Fri 8/1

2:30 pm-10:50 am

1 stop20h 20m

$564

Santo DomingoSantiago

SDQ - SCL

SDQSCL

Santo Domingo Las Americas

Wed 8/13

8:57 am-7:24 pm

1 stop10h 27m

Santiago Arturo Merino Benitez

Sat 8/16

2:26 am-10:26 pm

1 stop20h 00m

$759

Santo DomingoSantiago

SDQ - SCL

SDQSCL

Santo Domingo Las Americas

Wed 7/16

6:10 pm-4:15 am

1 stop10h 05m

$310

Santo DomingoSantiago

SDQ - SCL

SDQSCL

Santo Domingo Las Americas

Thu 7/31

2:05 pm-2:35 am

1 stop12h 30m

$350

Santo DomingoSantiago

SDQ - SCL

SDQSCL

Santo Domingo Las Americas

Sun 9/7

7:40 pm-6:00 am

2 stops33h 20m

$680

Santo DomingoSantiago

SDQ - SCL

SDQSCL

Santo Domingo Las Americas

Fri 12/19

6:20 pm-8:50 am

2 stops61h 30m

$2,191

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/2

Best time to book a flight from Santo Domingo to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Santo Domingo with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to Santiago

How far ahead should I book a flight from Santo Domingo to Santiago?

The best time to book flights from Santo Domingo to Santiago is 67 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Santo Domingo to Santiago?

Currently, April is the cheapest month in which you can book a flight from Santo Domingo to Santiago (average of $752). Flying from Santo Domingo to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SDQ to SCL?

When flying from Santo Domingo to Santiago, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

How much does it cost to fly round-trip from Santo Domingo to Santiago?

Reviews of airlines servicing Santiago

Get a feel of what it's like to fly with Delta, Copa Airlines, and Iberia from Santo Domingo to Santiago by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,983 reviews

Reviews

1 / 20

2.0

Mediocre

Francis,Aug 2023

DCA - ATL

Horrible experience. Delayed bags, missing items, delayed flights. Complete disaster

Delta

8.0

Very good

7,983 reviews

Delta

8.0

Very good

7,983 reviews

Reviews

1 / 20

2.0

Mediocre

Francis,Aug 2023

DCA - ATL

Horrible experience. Delayed bags, missing items, delayed flights. Complete disaster

Copa Airlines

7.5

Good

1,465 reviews

Delta

8.0

Very good

7,983 reviews

Reviews

1 / 20

2.0

Mediocre

Francis,Aug 2023

DCA - ATL

Horrible experience. Delayed bags, missing items, delayed flights. Complete disaster

Iberia

7.0

Good

2,817 reviews

Delta

8.0

Very good

7,983 reviews

Reviews

1 / 20

2.0

Mediocre

Francis,Aug 2023

DCA - ATL

Horrible experience. Delayed bags, missing items, delayed flights. Complete disaster

Avianca

6.7

Okay

2,363 reviews

Delta

8.0

Very good

7,983 reviews

Reviews

1 / 20

2.0

Mediocre

Francis,Aug 2023

DCA - ATL

Horrible experience. Delayed bags, missing items, delayed flights. Complete disaster

Related info for your journey

What are the cheapest airlines flying from Santo Domingo to Santiago round-trip?
According to our current data, Avianca ($564), and Copa Airlines ($759) offers the cheapest pricing from Santo Domingo to Santiago. Avianca is 7% cheaper than the average price of flights available within the next 90 days to this destination.
What are the cheapest airlines to fly from Santo Domingo to Santiago one-way?
For one-way options, check prices for Avianca. According to our data, you can fly for as low as $310. Users have also found prices from $680 and $2,191 on Delta and Iberia, respectively.
Can I find deals for flights from Santo Domingo to Santiago that include hotel bookings?
Yes. In addition to deals on Santo Domingo to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Santo Domingo to Santiago?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to Santiago.
Can I find deals for business class flights from Santo Domingo to Santiago?
Yes. Cheapflights offers flight deals from Santo Domingo to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Santo Domingo to Santiago?
Currently, April is the cheapest month in which you can book a flight from Santo Domingo to Santiago (average of $752). Flying from Santo Domingo to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Alternative routes for Santo Domingo to Santiago

Punta Cana to Santiago flights

Other flights to Santiago

Top 2 airlines flying from Santo Domingo to Santiago

Airline	Cheapest	Average	Flexibility	On-time
Avianca	Cheapest$439	Average$574	FlexibilityNo cancel fee	On-time71%
Copa Airlines	Cheapest$467	Average$656	FlexibilityNo cancel fee	On-time70%

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$310+ Cheap flights from Santo Domingo (SDQ) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/16. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Santo Domingo to Santiago with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Santo Domingo Las Americas to Santiago Arturo Merino Benitez are usually found in October or August, booked 67 days in advance, depart on a Monday or Tuesday and return on a Monday

Cheap flight deals from Santo Domingo to Santiago

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Santo Domingo to Santiago

Cheapest flights from Santo Domingo to SantiagoExplore the most affordable flight options available from Santo Domingo to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 2, 2025.

Explore the most affordable flight options available from Santo Domingo to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 2, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Santo Domingo to Santiago that are best for you.

Best time to book a flight from Santo Domingo to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Santo Domingo with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to Santiago

How far ahead should I book a flight from Santo Domingo to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from Santo Domingo to Santiago. Price data was last updated on June 27, 2025.

What is the cheapest month to book a flight from Santo Domingo to Santiago?

What is the cheapest time of day to fly from SDQ to SCL?

Find hourly flight availability from Santo Domingo to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 2, 2025.

How much does it cost to fly round-trip from Santo Domingo to Santiago?

Reviews of airlines servicing Santiago

Get a feel of what it's like to fly with Delta, Copa Airlines, and Iberia from Santo Domingo to Santiago by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Santo Domingo to Santiago round-trip?

What are the cheapest airlines to fly from Santo Domingo to Santiago one-way?

Can I find deals for flights from Santo Domingo to Santiago that include hotel bookings?

How can I find direct flights from Santo Domingo to Santiago?

Can I find deals for business class flights from Santo Domingo to Santiago?

What is the cheapest month to book a flight from Santo Domingo to Santiago?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Santo Domingo to Santiago

See prices for flight routes from nearby airports that may be better suited for you.

Top 2 airlines flying from Santo Domingo to Santiago

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Travel Smart

Cheapest flights from Santo Domingo to Santiago
Explore the most affordable flight options available from Santo Domingo to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 2, 2025.