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$273+ Cheap flights from Santa Cruz de la Sierra (VVI) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/19. Fares are subject to change and may not be available on all flights or dates of travel.
VVI — SCL
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheap flight deals from Santa Cruz de la Sierra to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Santa Cruz de la Sierra (VVI) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 17, 2025.

Round-trip from

$419
(Booking.com)

One-way from

$273
(SmartFares)

Popular in

July

Cheapest in

March

Average price

$502
From Santa Cruz de la Sierra Viru Viru Intl to Santiago Arturo Merino Benitez
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One-way flight from Santa Cruz de la Sierra Viru Viru Intl to Santiago Arturo Merino Benitez
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Highest demand for flights based on searches. 3% potential increase in price ($17 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Santa Cruz de la Sierra to Santiago

Cheapest flights from Santa Cruz de la Sierra to Santiago
Explore the most affordable flight options available from Santa Cruz de la Sierra to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This Booking.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/155:25 amVVI - SCL
2 stops16h 56mLATAM Airlines
Sat 1/36:32 amSCL - VVI
1 stop4h 56mLATAM Airlines
Deal found 9/15$419
This CheapOair deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/212:00 amVVI - SCL
1 stop15h 05mMultiple Airlines
Sat 11/291:10 pmSCL - VVI
Nonstop3h 15mMultiple Airlines
Deal found 9/16$464
This Booking.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/210:43 amVVI - SCL
Nonstop3h 02mLATAM Airlines
Fri 11/71:40 pmSCL - VVI
1 stop15h 55mLATAM Airlines
Deal found 9/17$466
This Trip.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/158:00 amVVI - SCL
Nonstop3h 15mBoA
Sat 1/31:10 pmSCL - VVI
Nonstop3h 15mBoA
Deal found 9/15$486
This FlightHub deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/2211:15 amVVI - SCL
Nonstop3h 02mLATAM Airlines
Sat 11/293:00 pmSCL - VVI
1 stop14h 35mLATAM Airlines
Deal found 9/14$490
This CheapOair deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/195:25 amVVI - SCL
1 stop10h 55mLATAM Airlines
Tue 11/254:33 amSCL - VVI
Nonstop3h 07mLATAM Airlines
Deal found 9/17$493
This Priceline deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/215:25 amVVI - SCL
2 stops39h 34mLATAM Airlines
Sun 11/236:00 amSCL - VVI
1 stop4h 56mLATAM Airlines
Deal found 9/14$502

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santa Cruz de la Sierra to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Santa Cruz de la Sierra to Santiago that are best for you.

Fly from

Santa Cruz de la Sierra

Fly to

Santiago

Route

Depart

Return

Price

Santa Cruz de la SierraSantiago

VVI - SCL

VVISCL

Santa Cruz de la Sierra Viru Viru Intl

Mon 12/15

5:25 am-11:21 pm

2 stops16h 56m

Santiago Arturo Merino Benitez

Sat 1/3

6:32 am-10:28 am

1 stop4h 56m

$419

Santa Cruz de la SierraSantiago

VVI - SCL

VVISCL

Santa Cruz de la Sierra Viru Viru Intl

Sun 11/2

10:43 am-2:45 pm

Nonstop3h 02m

Santiago Arturo Merino Benitez

Fri 11/7

1:40 pm-4:35 am

1 stop15h 55m

$466

Santa Cruz de la SierraSantiago

VVI - SCL

VVISCL

Santa Cruz de la Sierra Viru Viru Intl

Wed 3/11

7:26 am-11:28 am

Nonstop3h 02m

Santiago Arturo Merino Benitez

Mon 3/16

1:10 pm-3:25 pm

Nonstop3h 15m

$468

Santa Cruz de la SierraSantiago

VVI - SCL

VVISCL

Santa Cruz de la Sierra Viru Viru Intl

Wed 2/4

7:26 am-11:28 am

Nonstop3h 02m

Santiago Arturo Merino Benitez

Fri 2/13

10:15 am-1:10 am

1 stop15h 55m

$471

Santa Cruz de la SierraSantiago

VVI - SCL

VVISCL

Santa Cruz de la Sierra Viru Viru Intl

Fri 11/21

2:00 am-6:05 pm

1 stop15h 05m

Santiago Arturo Merino Benitez

Sat 11/29

6:32 am-10:28 am

1 stop4h 56m

$472

Santa Cruz de la SierraSantiago

VVI - SCL

VVISCL

Santa Cruz de la Sierra Viru Viru Intl

Fri 11/21

5:25 am-2:05 pm

1 stop7h 40m

Santiago Arturo Merino Benitez

Sun 11/23

6:30 pm-4:35 am

1 stop11h 05m

$490

Santa Cruz de la SierraSantiago

VVI - SCL

VVISCL

Santa Cruz de la Sierra Viru Viru Intl

Wed 11/19

7:26 am-11:28 am

Nonstop3h 02m

$273

Santa Cruz de la SierraSantiago

VVI - SCL

VVISCL

Santa Cruz de la Sierra Viru Viru Intl

Mon 10/6

4:25 pm-12:15 pm

2 stops18h 50m

$307

Santa Cruz de la SierraSantiago

VVI - SCL

VVISCL

Santa Cruz de la Sierra Viru Viru Intl

Mon 10/6

8:00 am-12:15 pm

Nonstop3h 15m

$357

Santa Cruz de la SierraSantiago

VVI - SCL

VVISCL

Santa Cruz de la Sierra Viru Viru Intl

Wed 11/19

12:00 pm-3:00 pm

3 stops26h 00m

$509

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/16

Showing 1-10 of 12 results
1
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Best time to book a flight from Santa Cruz de la Sierra to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Santa Cruz de la Sierra with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santa Cruz de la Sierra to Santiago

How far ahead should I book a flight from Santa Cruz de la Sierra to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from Santa Cruz de la Sierra to Santiago. Price data was last updated on September 12, 2025.

The best time to book flights from Santa Cruz de la Sierra to Santiago is 58 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Santa Cruz de la Sierra to Santiago?

Currently, April is the cheapest month in which you can book a flight from Santa Cruz de la Sierra to Santiago (average of $752). Flying from Santa Cruz de la Sierra to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from VVI to SCL?

Find hourly flight availability from Santa Cruz de la Sierra to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 17, 2025.

Unlike in the morning, when flights are generally more expensive, you can save up to 37% on flights from Santa Cruz de la Sierra to Santiago by exploring options for tickets at noon.

How much does it cost to fly round-trip from Santa Cruz de la Sierra to Santiago?

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated September 17, 2025.
Read through reviews of airlines operating flights from Santa Cruz de la Sierra to Santiago, such as Aerolineas Argentinas and LATAM Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Aerolineas Argentinas
8.1
Very good
932 reviews

Boarding

8.0

Crew

8.3

Overall

8.1

Food

6.5

Entertainment

5.7

Comfort

7.5

Reviews

1 / 5
2.0
Mediocre

Paula,Aug 2025

EZE - MIA

I can not take the flight because Service dogs are not allowed. I m asking the refund of my flight. Please take care of my request # 00447290197500
Aerolineas Argentinas
8.1
Very good
932 reviews
Aerolineas Argentinas
8.1
Very good
932 reviews

Boarding

8.0

Crew

8.3

Overall

8.1

Food

6.5

Entertainment

5.7

Comfort

7.5

Reviews

1 / 5
2.0
Mediocre

Paula,Aug 2025

EZE - MIA

I can not take the flight because Service dogs are not allowed. I m asking the refund of my flight. Please take care of my request # 00447290197500
LATAM Airlines
7.5
Good
1,849 reviews
Aerolineas Argentinas
8.1
Very good
932 reviews

Boarding

8.0

Crew

8.3

Overall

8.1

Food

6.5

Entertainment

5.7

Comfort

7.5

Reviews

1 / 5
2.0
Mediocre

Paula,Aug 2025

EZE - MIA

I can not take the flight because Service dogs are not allowed. I m asking the refund of my flight. Please take care of my request # 00447290197500

Related info for your journey

Find useful and relevant information for your journey from Santa Cruz de la Sierra to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santa Cruz de la Sierra to Santiago?

    LATAM Airlines can get you from Santa Cruz de la Sierra to Santiago in just under 16h 56m. Your travel time can differ by up to . There are 1186 mi between Santa Cruz de la Sierra and Santiago.

  • What are the cheapest airlines flying from Santa Cruz de la Sierra to Santiago round-trip?

    According to our current data, LATAM Airlines ($290), and Aerolineas Argentinas ($366) offers the cheapest pricing from Santa Cruz de la Sierra to Santiago. These flights start at 42% lower than the current average price 3 months from now.

  • Can I find deals for flights from Santa Cruz de la Sierra to Santiago that include hotel bookings?

    Yes. In addition to deals on Santa Cruz de la Sierra to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santa Cruz de la Sierra to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santa Cruz de la Sierra to Santiago.

  • Can I find deals for business class flights from Santa Cruz de la Sierra to Santiago?

    Yes. Cheapflights offers flight deals from Santa Cruz de la Sierra to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santa Cruz de la Sierra to Santiago?

    Currently, April is the cheapest month in which you can book a flight from Santa Cruz de la Sierra to Santiago (average of $752). Flying from Santa Cruz de la Sierra to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Santa Cruz de la Sierra to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
La Paz to Santiago flights

Top 2 airlines flying from Santa Cruz de la Sierra to Santiago

Discover the top 2 airlines that operate flights from Santa Cruz de la Sierra to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
LATAM AirlinesCheapest$290Average$550FlexibilityNo cancel feeOn-time81%
Aerolineas ArgentinasCheapest$366Average$421FlexibilityNo cancel feeOn-time59%

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