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$922+ Cheap flights from Lexington (LEX) to Santiago (SCL)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/7. Fares are subject to change and may not be available on all flights or dates of travel.
LEX — SCL
Apr 22 — Apr 291
Wed 4/22
Wed 4/29
1 adult, Economy
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Cheap flight deals from Lexington to Santiago

Cheapest flights from Lexington to Santiago
Explore the most affordable flight options available from Lexington to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 23, 2026.

This American Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:00 am
LEX
-
SCL
2 stops25h 05m
American Airlines
Wed 5/279:00 pm
SCL
-
LEX
2 stops20h 11m
American Airlines
Deal found 3/23$922
This American Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/82:15 pm
LEX
-
SCL
2 stops16h 50m
American Airlines
Thu 5/289:00 pm
SCL
-
LEX
2 stops19h 05m
American Airlines
Deal found 3/23$971
This eDestinos deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/83:32 pm
LEX
-
SCL
1 stop15h 43m
LATAM Airlines
Thu 5/2811:00 pm
SCL
-
LEX
2 stops20h 33m
LATAM Airlines
Deal found 3/21$1,028
This Delta deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/810:06 am
LEX
-
SCL
2 stops19h 54m
Delta
Thu 5/287:55 pm
SCL
-
LEX
2 stops21h 18m
Delta
Deal found 3/22$1,048
This SmartFares deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:11 pm
LEX
-
SCL
1 stop13h 04m
LATAM Airlines
Fri 5/298:40 pm
SCL
-
LEX
1 stop15h 39m
LATAM Airlines
Deal found 3/22$1,085
This Delta deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/810:06 am
LEX
-
SCL
2 stops19h 54m
Delta
Fri 5/298:40 pm
SCL
-
LEX
1 stop12h 41m
Delta
Deal found 3/22$1,098
This LATAM Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/71:04 pm
LEX
-
SCL
2 stops15h 46m
LATAM Airlines
Wed 5/278:40 pm
SCL
-
LEX
1 stop15h 39m
LATAM Airlines
Deal found 3/23$1,171

Find flight deals from Lexington to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Lexington (LEX) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 23, 2026.

Most accurate provider

Ovago
2 stars

Most trusted provider

Ovago
3 stars

Round-trip from

$922
(American Airlines)
Provider with most accurate pricing for Lexington Blue Grass-Santiago Arturo Merino Benitez flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lexington Blue Grass-Santiago Arturo Merino Benitez flights.
Search Deals
From Lexington Blue Grass to Santiago Arturo Merino Benitez
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Lexington to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 23, 2026.
Use the filters below to find and compare flights from Lexington to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

LexingtonSantiago

LEX - SCL

LEXSCL

Lexington Blue Grass

Fri 5/8

3:32 pm-7:15 am

1 stop15h 43m

Santiago Arturo Merino Benitez

Thu 5/28

11:00 pm-7:33 pm

2 stops20h 33m

$1,028

LexingtonSantiago

LEX - SCL

LEXSCL

Lexington Blue Grass

Fri 5/8

10:06 am-6:00 am

2 stops19h 54m

Santiago Arturo Merino Benitez

Thu 5/28

7:55 pm-5:13 pm

2 stops21h 18m

$1,048

LexingtonSantiago

LEX - SCL

LEXSCL

Lexington Blue Grass

Fri 5/8

10:06 am-6:00 am

2 stops19h 54m

Santiago Arturo Merino Benitez

Fri 5/29

8:40 pm-9:21 am

1 stop12h 41m

$1,098

LexingtonSantiago

LEX - SCL

LEXSCL

Lexington Blue Grass

Thu 5/7

3:32 pm-7:15 am

1 stop15h 43m

Santiago Arturo Merino Benitez

Wed 5/27

8:40 pm-12:19 pm

1 stop15h 39m

$1,171

LexingtonSantiago

LEX - SCL

LEXSCL

Lexington Blue Grass

Fri 7/10

7:45 pm-7:15 am

1 stop11h 30m

Santiago Arturo Merino Benitez

Fri 7/24

10:55 pm-5:10 pm

2 stops18h 15m

$1,200
Quickest round-trip

LexingtonSantiago

LEX - SCL

LEXSCL

Lexington Blue Grass

Wed 4/8

4:14 pm-7:15 am

1 stop15h 01m

Santiago Arturo Merino Benitez

Tue 4/28

8:40 pm-9:35 am

1 stop12h 55m

$1,325

LexingtonSantiago

LEX - SCL

LEXSCL

Lexington Blue Grass

Thu 4/16

4:53 pm-7:15 am

1 stop14h 22m

Santiago Arturo Merino Benitez

Mon 4/20

11:05 pm-7:10 pm

2 stops20h 05m

$1,335

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/21

Sorted by cheapest first
  • Most accurate provider: When it comes to deals on Lexington-Santiago flights, users find the pricing of Ovago to be most consistent on Cheapflights vs. Ovago Users can find the same prices on Lexington-Santiago flight deals on Cheapflights vs. Ovago 90-95% of the time. Price accuracy is based on data collected from Lexington-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Lexington-Santiago flights, Cheapflights users trust Ovago the most. Ovago has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Lexington-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Lexington to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Lexington with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Lexington to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Lexington to Santiago?

    Departing from Lexington to Santiago will take you 15h 43m. Lexington and Santiago are separated by a distance of 5011 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Lexington to Santiago that include hotel bookings?

    Yes. In addition to deals on Lexington to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Lexington to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Lexington to Santiago.

  • Can I find deals for business class flights from Lexington to Santiago?

    Yes. Cheapflights offers flight deals from Lexington to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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