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$178+ Cheap flights from Guayaquil (GYE) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/26. Fares are subject to change and may not be available on all flights or dates of travel.
GYE — SCL
Nov 22 — Nov 291
Sat 11/22
Sat 11/29
1 adult, Economy
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Cheapflights Tip: The best prices from Guayaquil Jose Joaquin de Olmedo to Santiago Arturo Merino Benitez are usually found in November or April, booked 3 days in advance, depart on a Wednesday or Friday and return on a Monday

Find flight deals from Guayaquil to Santiago

Cheapest flights from Guayaquil to Santiago
Explore the most affordable flight options available from Guayaquil to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 23, 2025.

This FlightHub deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/141:00 pmGYE - SCL
1 stop13h 30mLATAM Airlines
Mon 11/2410:15 pmSCL - GYE
1 stop15h 40mLATAM Airlines
Deal found 10/23$359
This Booking.com deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/123:30 amGYE - SCL
1 stop9h 50mMultiple Airlines
Sun 11/165:15 amSCL - GYE
1 stop8h 40mMultiple Airlines
Deal found 10/23$381
This Booking.com deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/131:00 pmGYE - SCL
1 stop14h 50mLATAM Airlines
Sat 11/226:40 amSCL - GYE
1 stop7h 15mLATAM Airlines
Deal found 10/23$393
This Booking.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/71:00 pmGYE - SCL
1 stop15h 25mLATAM Airlines
Wed 12/106:30 pmSCL - GYE
1 stop9h 10mLATAM Airlines
Deal found 10/22$396
This LATAM Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/191:00 pmGYE - SCL
2 stops23h 45mLATAM Airlines
Sat 11/2212:45 amSCL - GYE
Nonstop5h 18mLATAM Airlines
Deal found 10/23$403
This Mytrip deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/71:00 pmGYE - SCL
1 stop13h 30mLATAM Airlines
Sun 12/75:15 amSCL - GYE
1 stop11h 30mLATAM Airlines
Deal found 10/22$405
This Mytrip deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/211:00 pmGYE - SCL
1 stop8h 25mLATAM Airlines
Mon 11/248:15 amSCL - GYE
1 stop8h 00mLATAM Airlines
Deal found 10/23$407
This Booking.com deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/123:30 amGYE - SCL
1 stop9h 50mMultiple Airlines
Sat 11/226:40 amSCL - GYE
1 stop7h 15mMultiple Airlines
Deal found 10/23$411
This LATAM Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/175:37 pmGYE - SCL
2 stops19h 53mLATAM Airlines
Fri 11/214:28 pmSCL - GYE
2 stops21h 27mLATAM Airlines
Deal found 10/23$415
This FlightHub deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/141:00 pmGYE - SCL
1 stop13h 30mLATAM Airlines
Sun 11/2310:15 pmSCL - GYE
1 stop15h 40mLATAM Airlines
Deal found 10/23$419

Cheap flight deals from Guayaquil to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Guayaquil (GYE) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 23, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$359
(FlightHub)

One-way from

$178
(Avianca)

Popular in

February

Cheapest in

November

Average price

$431

Good round-trip deal

$491 or less

Good one-way deal

$260 or less
Provider with most accurate pricing for Guayaquil Jose Joaquin de Olmedo-Santiago Arturo Merino Benitez flight deals.
Search Deals
Provider most trusted by Cheapflights users for Guayaquil Jose Joaquin de Olmedo-Santiago Arturo Merino Benitez flights.
Search Deals
From Guayaquil Jose Joaquin de Olmedo to Santiago Arturo Merino Benitez
Search Deals
One-way flight from Guayaquil Jose Joaquin de Olmedo to Santiago Arturo Merino Benitez
Search Deals
Highest demand for flights based on searches. 3% potential increase in price ($13 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 0% potential price decrease ($4 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals
Price to beat on a round-trip flight from Guayaquil Jose Joaquin de Olmedo to Santiago Arturo Merino Benitez.
Search Deals
Price to beat on a one-way flight from Guayaquil Jose Joaquin de Olmedo to Santiago Arturo Merino Benitez.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Guayaquil to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 23, 2025.
Use the filters below to find and compare flights from Guayaquil to Santiago that are best for you.

Fly from

Guayaquil

Fly to

Santiago

Route

Depart

Return

Price

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

Wed 11/12

3:30 am-3:20 pm

1 stop9h 50m

Santiago Arturo Merino Benitez

Sat 11/22

6:40 am-11:55 am

1 stop7h 15m

$411

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

Thu 11/20

3:30 am-3:20 pm

1 stop9h 50m

Santiago Arturo Merino Benitez

Sun 11/23

4:35 am-2:15 pm

1 stop11h 40m

$440

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

Mon 11/17

1:00 pm-11:25 pm

1 stop8h 25m

Santiago Arturo Merino Benitez

Fri 11/21

6:40 am-11:55 am

1 stop7h 15m

$479

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

Mon 11/17

4:31 am-12:06 am

1 stop17h 35m

Santiago Arturo Merino Benitez

Thu 11/20

3:23 am-11:18 am

1 stop9h 55m

$481

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

Thu 11/13

4:31 am-12:06 am

1 stop17h 35m

Santiago Arturo Merino Benitez

Fri 11/21

5:24 am-8:43 pm

1 stop17h 19m

$481

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

Wed 11/5

4:31 am-12:06 am

1 stop17h 35m

$251

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

Sun 3/15

4:48 pm-11:35 pm

Nonstop4h 47m

$251

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

Tue 11/4

4:31 am-11:41 pm

1 stop17h 10m

$251

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

Sat 11/15

4:31 am-12:06 am

1 stop17h 35m

$251

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

Wed 11/26

1:00 pm-3:51 pm

2 stops24h 51m

$258

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/22

Showing 1-10 of 12 results
1
2

Compare providers for flights from Guayaquil to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Guayaquil to Santiago in October.
ProviderPrice AccuracyTrust Score*
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
Trip.comPrice Accuracy2 starsTrust Score*3 stars
FlightnetworkPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Guayaquil-Santiago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Guayaquil-Santiago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Guayaquil-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Guayaquil-Santiago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Guayaquil-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Guayaquil to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Guayaquil with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Guayaquil to Santiago

How far ahead should I book a flight from Guayaquil to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from Guayaquil to Santiago. Price data was last updated on October 17, 2025.

To ensure you get the cheapest price possible for a flight from Guayaquil to Santiago, you should look to book at least 3 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Guayaquil to Santiago?

Currently, December is the cheapest month in which you can book a flight from Guayaquil to Santiago (average of $180). Flying from Guayaquil to Santiago in February is currently the most expensive (average of $197). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GYE to SCL?

Find hourly flight availability from Guayaquil to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 23, 2025.

Unlike at noon, when flights are generally more expensive, you can save up to 28% on flights from Guayaquil to Santiago by exploring options for tickets in the morning.

What is the cheapest day to fly from Guayaquil to Santiago?

Use this chart to determine the cheapest time to fly round-trip from Guayaquil to Santiago. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Guayaquil to Santiago flight should consider departing on Sunday evenings when fares are most often at their lowest. Sunday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

How much does it cost to fly round-trip from Guayaquil to Santiago?

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated October 23, 2025.
Get a feel of what it's like to fly with Copa Airlines, LATAM Airlines, and Avianca from Guayaquil to Santiago by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,560 reviews

Entertainment

6.8

Crew

8.1

Food

6.8

Boarding

7.8

Comfort

7.4

Overall

7.6

Reviews

1 / 20
6.0
Good

Paul,May 2025

PTY - AUA

Had to use my phone for entertainment? Once we landed people were already out their seats and standing in the isles while the plane was still taxiing to the gate. This is unsafe and flight crew had a responsibility to ensure that people remain seated until the pilots turn off the seatbelt sign.
Copa Airlines
7.6
Good
1,560 reviews
Copa Airlines
7.6
Good
1,560 reviews

Entertainment

6.8

Crew

8.1

Food

6.8

Boarding

7.8

Comfort

7.4

Overall

7.6

Reviews

1 / 20
6.0
Good

Paul,May 2025

PTY - AUA

Had to use my phone for entertainment? Once we landed people were already out their seats and standing in the isles while the plane was still taxiing to the gate. This is unsafe and flight crew had a responsibility to ensure that people remain seated until the pilots turn off the seatbelt sign.
LATAM Airlines
7.5
Good
1,871 reviews
Copa Airlines
7.6
Good
1,560 reviews

Entertainment

6.8

Crew

8.1

Food

6.8

Boarding

7.8

Comfort

7.4

Overall

7.6

Reviews

1 / 20
6.0
Good

Paul,May 2025

PTY - AUA

Had to use my phone for entertainment? Once we landed people were already out their seats and standing in the isles while the plane was still taxiing to the gate. This is unsafe and flight crew had a responsibility to ensure that people remain seated until the pilots turn off the seatbelt sign.
Avianca
6.7
Okay
2,460 reviews
Copa Airlines
7.6
Good
1,560 reviews

Entertainment

6.8

Crew

8.1

Food

6.8

Boarding

7.8

Comfort

7.4

Overall

7.6

Reviews

1 / 20
6.0
Good

Paul,May 2025

PTY - AUA

Had to use my phone for entertainment? Once we landed people were already out their seats and standing in the isles while the plane was still taxiing to the gate. This is unsafe and flight crew had a responsibility to ensure that people remain seated until the pilots turn off the seatbelt sign.

Related info for your journey

Find useful and relevant information for your journey from Guayaquil to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Guayaquil to Santiago flight route?

    Flights from Guayaquil Jose Joaquin de Olmedo to Santiago Arturo Merino Benitez have been viewed 1 times in the past calendar month.

  • How long is the flight from Guayaquil to Santiago?

    A quick flight from Guayaquil to Santiago can take about 14h 50m. LATAM Airlines provides one of the quickest options available for as low as $440. Airlines will cover a distance of 2235 mi.

  • What are the cheapest airlines flying from Guayaquil to Santiago round-trip?

    Avianca, at $162, was found to be the cheapest airline from Guayaquil to Santiago.Alternate airlines to your destination round-trip include Copa Airlines and LATAM Airlines. These flights start at 61% lower than the current average price 3 months from now.

  • What are the cheapest flights from Guayaquil to Santiago?

    Looking at all options, your cheapest flight can be booked for $240. While the most popular route (Guayaquil Jose Joaquin de Olmedo - Santiago Arturo Merino Benitez) can be booked for $393 on average, our data indicates $458 when flying from Guayaquil to Santiago.

  • Can I find deals for flights from Guayaquil to Santiago that include hotel bookings?

    Yes. In addition to deals on Guayaquil to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Guayaquil to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Guayaquil to Santiago.

  • Can I find deals for business class flights from Guayaquil to Santiago?

    Yes. Cheapflights offers flight deals from Guayaquil to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Guayaquil to Santiago?

    Currently, December is the cheapest month in which you can book a flight from Guayaquil to Santiago (average of $180). Flying from Guayaquil to Santiago in February is currently the most expensive (average of $197). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Guayaquil to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
Quito to Santiago flights

Top 3 airlines flying from Guayaquil to Santiago

Discover the top 3 airlines that operate flights from Guayaquil to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 23, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$162Average$334FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$178Average$330FlexibilityNo cancel feeOn-time70%
LATAM AirlinesCheapest$244Average$500FlexibilityNo cancel feeOn-time81%

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