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$184+ Cheap flights from Guayaquil (GYE) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/8. Fares are subject to change and may not be available on all flights or dates of travel.
GYE — SCL
oct. 17 — oct. 241
vie. 10/17
vie. 10/24
1 adult, Economy
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Cheapflights Tip: The best prices from Guayaquil Jose Joaquin de Olmedo to Santiago Arturo Merino Benitez are usually found in November or October, booked 3 days in advance, depart on a Wednesday or Thursday and return on a Monday

Cheap flight deals from Guayaquil to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Guayaquil (GYE) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated septiembre 17, 2025.

Round-trip from

$305
(Gotogate)

One-way from

$184
(SmartFares)

Popular in

February

Cheapest in

November

Average price

$427

Good round-trip deal

$458 or less

Good one-way deal

$249 or less
From Guayaquil Jose Joaquin de Olmedo to Santiago Arturo Merino Benitez
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One-way flight from Guayaquil Jose Joaquin de Olmedo to Santiago Arturo Merino Benitez
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Highest demand for flights based on searches. 3% potential increase in price ($16 potential increase over avg. RT price).
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Cheapest flight prices on average. 0% potential price decrease ($4 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Price to beat on a round-trip flight from Guayaquil Jose Joaquin de Olmedo to Santiago Arturo Merino Benitez.
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Price to beat on a one-way flight from Guayaquil Jose Joaquin de Olmedo to Santiago Arturo Merino Benitez.
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Find flight deals from Guayaquil to Santiago

Cheapest flights from Guayaquil to Santiago
Explore the most affordable flight options available from Guayaquil to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septiembre 17, 2025.

This Avianca deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/1511:05 amGYE - SCL
1 stop10h 25mAvianca
mié. 11/197:25 amSCL - GYE
1 stop12h 20mAvianca
Deal found 9/15$311
This Copa Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 11/1412:21 pmGYE - SCL
1 stop9h 45mCopa Airlines
vie. 11/215:24 amSCL - GYE
1 stop10h 12mCopa Airlines
Deal found 9/17$313
This Avianca deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/139:45 amGYE - SCL
1 stop17h 30mAvianca
lun. 10/207:10 amSCL - GYE
2 stops12h 45mAvianca
Deal found 9/15$331
This Copa Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 11/2612:21 pmGYE - SCL
1 stop9h 45mCopa Airlines
vie. 2/271:16 amSCL - GYE
1 stop14h 18mCopa Airlines
Deal found 9/15$337
This Booking.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/132:45 pmGYE - SCL
Nonstop4h 53mMultiple Airlines
lun. 10/207:10 amSCL - GYE
1 stop12h 10mMultiple Airlines
Deal found 9/15$351
This Copa Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 11/1012:21 pmGYE - SCL
1 stop13h 03mCopa Airlines
mié. 11/195:12 amSCL - GYE
1 stop17h 31mCopa Airlines
Deal found 9/16$361
This LATAM Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/152:45 pmGYE - SCL
Nonstop4h 53mLATAM Airlines
mié. 11/196:40 amSCL - GYE
1 stop7h 15mLATAM Airlines
Deal found 9/15$365
This LATAM Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 11/181:00 pmGYE - SCL
2 stops21h 05mLATAM Airlines
vie. 11/219:13 pmSCL - GYE
2 stops16h 42mLATAM Airlines
Deal found 9/16$368
This Booking.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/202:50 pmGYE - SCL
1 stop12h 25mMultiple Airlines
vie. 10/245:15 amSCL - GYE
1 stop8h 00mMultiple Airlines
Deal found 9/14$369
This Mytrip deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 9/3012:55 pmGYE - SCL
1 stop13h 35mMultiple Airlines
mié. 10/812:55 amSCL - GYE
1 stop18h 25mMultiple Airlines
Deal found 9/15$376

Cheapflights Fare Finder

 
Customize your flight search to find flights from Guayaquil to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 17, 2025.
Use the filters below to find and compare flights from Guayaquil to Santiago that are best for you.

Fly from

Guayaquil

Fly to

Santiago

Route

Depart

Return

Price

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

vie. 11/14

12:21 pm-12:06 am

1 stop9h 45m

Santiago Arturo Merino Benitez

mié. 11/19

5:12 am-1:36 pm

1 stop10h 24m

$313

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

lun. 11/17

6:02 am-3:24 am

1 stop19h 22m

Santiago Arturo Merino Benitez

vie. 11/21

5:24 am-1:36 pm

1 stop10h 12m

$313

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

vie. 11/14

12:21 pm-12:06 am

1 stop9h 45m

Santiago Arturo Merino Benitez

vie. 11/21

5:24 am-1:36 pm

1 stop10h 12m

$313

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

lun. 11/10

12:21 pm-3:43 am

1 stop13h 22m

Santiago Arturo Merino Benitez

mié. 11/19

5:12 am-1:36 pm

1 stop10h 24m

$313

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

mar. 10/14

8:50 am-11:30 pm

1 stop12h 40m

Santiago Arturo Merino Benitez

lun. 10/20

12:55 am-11:25 am

2 stops12h 30m

$331

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

mié. 11/26

12:21 pm-12:06 am

1 stop9h 45m

Santiago Arturo Merino Benitez

vie. 2/27

1:16 am-11:18 am

1 stop12h 02m

$337

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

vie. 11/7

8:30 am-3:24 am

1 stop16h 54m

Santiago Arturo Merino Benitez

mar. 11/11

5:12 am-1:36 pm

1 stop10h 24m

$337

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

mié. 10/15

3:55 pm-5:15 am

2 stops11h 20m

Santiago Arturo Merino Benitez

mié. 11/19

4:25 pm-1:05 am

1 stop10h 40m

$359

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

lun. 11/10

2:35 pm-3:24 am

1 stop10h 49m

Santiago Arturo Merino Benitez

mar. 11/18

5:24 am-8:43 pm

1 stop17h 19m

$361

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

lun. 11/10

6:02 am-3:24 am

1 stop19h 22m

Santiago Arturo Merino Benitez

mar. 11/11

5:24 am-11:55 pm

1 stop20h 31m

$361

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/17

Showing 1-10 of 20 results
1
2

Best time to book a flight from Guayaquil to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Guayaquil with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Guayaquil to Santiago

How far ahead should I book a flight from Guayaquil to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from Guayaquil to Santiago. Price data was last updated on September 12, 2025.

To ensure you get the cheapest price possible for a flight from Guayaquil to Santiago, you should look to book at least 3 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Guayaquil to Santiago?

Currently, April is the cheapest month in which you can book a flight from Guayaquil to Santiago (average of $752). Flying from Guayaquil to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GYE to SCL?

Find hourly flight availability from Guayaquil to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated septiembre 17, 2025.

Unlike at noon, when flights are generally more expensive, you can save up to 28% on flights from Guayaquil to Santiago by exploring options for tickets in the morning.

What is the cheapest day to fly from Guayaquil to Santiago?

Use this chart to determine the cheapest time to fly round-trip from Guayaquil to Santiago. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Guayaquil to Santiago flight should consider departing on Sunday evenings when fares are most often at their lowest. Monday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

How much does it cost to fly round-trip from Guayaquil to Santiago?

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated septiembre 17, 2025.
Get a feel of what it's like to fly with Copa Airlines, LATAM Airlines, and Avianca from Guayaquil to Santiago by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,533 reviews

Entertainment

6.8

Food

6.8

Comfort

7.4

Overall

7.6

Boarding

7.8

Crew

8.1

Reviews

1 / 20
6.0
Good

Paul,May 2025

PTY - AUA

Had to use my phone for entertainment? Once we landed people were already out their seats and standing in the isles while the plane was still taxiing to the gate. This is unsafe and flight crew had a responsibility to ensure that people remain seated until the pilots turn off the seatbelt sign.
Copa Airlines
7.6
Good
1,533 reviews
Copa Airlines
7.6
Good
1,533 reviews

Entertainment

6.8

Food

6.8

Comfort

7.4

Overall

7.6

Boarding

7.8

Crew

8.1

Reviews

1 / 20
6.0
Good

Paul,May 2025

PTY - AUA

Had to use my phone for entertainment? Once we landed people were already out their seats and standing in the isles while the plane was still taxiing to the gate. This is unsafe and flight crew had a responsibility to ensure that people remain seated until the pilots turn off the seatbelt sign.
LATAM Airlines
7.5
Good
1,849 reviews
Copa Airlines
7.6
Good
1,533 reviews

Entertainment

6.8

Food

6.8

Comfort

7.4

Overall

7.6

Boarding

7.8

Crew

8.1

Reviews

1 / 20
6.0
Good

Paul,May 2025

PTY - AUA

Had to use my phone for entertainment? Once we landed people were already out their seats and standing in the isles while the plane was still taxiing to the gate. This is unsafe and flight crew had a responsibility to ensure that people remain seated until the pilots turn off the seatbelt sign.
Avianca
6.7
Okay
2,436 reviews
Copa Airlines
7.6
Good
1,533 reviews

Entertainment

6.8

Food

6.8

Comfort

7.4

Overall

7.6

Boarding

7.8

Crew

8.1

Reviews

1 / 20
6.0
Good

Paul,May 2025

PTY - AUA

Had to use my phone for entertainment? Once we landed people were already out their seats and standing in the isles while the plane was still taxiing to the gate. This is unsafe and flight crew had a responsibility to ensure that people remain seated until the pilots turn off the seatbelt sign.

Related info for your journey

Find useful and relevant information for your journey from Guayaquil to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Guayaquil to Santiago flight route?

    Flights from Guayaquil Jose Joaquin de Olmedo to Santiago Arturo Merino Benitez have been viewed 1 times in the past calendar month.

  • How long is the flight from Guayaquil to Santiago?

    A quick flight from Guayaquil to Santiago can take about 19h 22m. Copa Airlines provides one of the quickest options available for as low as $313. Airlines will cover a distance of 2235 mi.

  • What are the cheapest airlines flying from Guayaquil to Santiago round-trip?

    Avianca, at $162, was found to be the cheapest airline from Guayaquil to Santiago.Alternate airlines to your destination round-trip include Copa Airlines and LATAM Airlines. These flights start at 60% lower than the current average price 3 months from now.

  • What are the cheapest flights from Guayaquil to Santiago?

    Looking at all options, your cheapest flight can be booked for $216. While the most popular route (Guayaquil Jose Joaquin de Olmedo - Santiago Arturo Merino Benitez) can be booked for $335 on average, our data indicates $392 when flying from Guayaquil to Santiago.

  • Can I find deals for flights from Guayaquil to Santiago that include hotel bookings?

    Yes. In addition to deals on Guayaquil to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Guayaquil to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Guayaquil to Santiago.

  • Can I find deals for business class flights from Guayaquil to Santiago?

    Yes. Cheapflights offers flight deals from Guayaquil to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Guayaquil to Santiago?

    Currently, April is the cheapest month in which you can book a flight from Guayaquil to Santiago (average of $752). Flying from Guayaquil to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Guayaquil to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
Quito to Santiago flights

Top 3 airlines flying from Guayaquil to Santiago

Discover the top 3 airlines that operate flights from Guayaquil to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$162Average$329FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$178Average$330FlexibilityNo cancel feeOn-time70%
LATAM AirlinesCheapest$246Average$495FlexibilityNo cancel feeOn-time81%

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