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$235+ Cheap flights from Guayaquil (GYE) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/21. Fares are subject to change and may not be available on all flights or dates of travel.
GYE — SCL
Feb 7 — Feb 141
Sat 2/7
Sat 2/14
1 adult, Economy
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Cheapflights Tip: The best prices from Guayaquil Jose Joaquin de Olmedo to Santiago Arturo Merino Benitez are usually found in April or May, booked 3 days in advance, depart on a Wednesday or Friday and return on a Friday

Cheap flight deals from Guayaquil to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Guayaquil (GYE) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 8, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$441
(Priceline)

One-way from

$235
(Orbitz)

Popular in

February

Cheapest in

April

Average price

$480

Good round-trip deal

$511 or less

Good one-way deal

$264 or less
Provider with most accurate pricing for Guayaquil Jose Joaquin de Olmedo-Santiago Arturo Merino Benitez flight deals.
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Provider most trusted by Cheapflights users for Guayaquil Jose Joaquin de Olmedo-Santiago Arturo Merino Benitez flights.
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From Guayaquil Jose Joaquin de Olmedo to Santiago Arturo Merino Benitez
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One-way flight from Guayaquil Jose Joaquin de Olmedo to Santiago Arturo Merino Benitez
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Highest demand for flights based on searches. 7% potential increase in price ($35 potential increase over avg. RT price).
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Cheapest flight prices on average. 0% potential price decrease ($5 potential savings vs. average RT price).
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Average for round-trip flights in January 2026
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Price to beat on a round-trip flight from Guayaquil Jose Joaquin de Olmedo to Santiago Arturo Merino Benitez.
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Price to beat on a one-way flight from Guayaquil Jose Joaquin de Olmedo to Santiago Arturo Merino Benitez.
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Find flight deals from Guayaquil to Santiago

Cheapest flights from Guayaquil to Santiago
Explore the most affordable flight options available from Guayaquil to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 8, 2026.

This Priceline deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/283:30 amGYE - SCL
1 stop9h 50mAvianca
Tue 4/2811:55 pmSCL - GYE
1 stop11h 00mAvianca
Deal found 1/7$441
This Mytrip deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/296:55 pmGYE - SCL
1 stop18h 25mMultiple Airlines
Tue 4/2812:45 amSCL - GYE
Nonstop5h 18mMultiple Airlines
Deal found 1/7$443
This Mytrip deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/243:30 amGYE - SCL
1 stop9h 50mMultiple Airlines
Fri 4/2412:45 amSCL - GYE
Nonstop5h 18mMultiple Airlines
Deal found 1/7$444
This Travelocity deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/283:30 amGYE - SCL
1 stop9h 50mMultiple Airlines
Mon 4/2712:45 amSCL - GYE
Nonstop5h 18mMultiple Airlines
Deal found 1/7$452
This Booking.com deal was found by Cheapflights users on 1/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/88:45 pmGYE - SCL
1 stop7h 40mLATAM Airlines
Sat 7/182:55 pmSCL - GYE
1 stop11h 45mLATAM Airlines
Deal found 1/8$453
This Avianca deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/213:30 amGYE - SCL
1 stop9h 50mAvianca
Sun 4/1211:55 pmSCL - GYE
1 stop14h 45mAvianca
Deal found 1/6$455
This Kiwi.com deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/95:38 pmGYE - SCL
Nonstop3h 51mLATAM Airlines
Tue 9/297:45 amSCL - GYE
1 stop8h 55mLATAM Airlines
Deal found 1/7$456
This Expedia deal was found by Cheapflights users on 1/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/2310:25 amGYE - SCL
1 stop12h 05mMultiple Airlines
Wed 3/256:30 pmSCL - GYE
1 stop9h 10mMultiple Airlines
Deal found 1/8$457
This Avianca deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/186:30 pmGYE - SCL
1 stop8h 45mAvianca
Fri 5/2211:55 pmSCL - GYE
1 stop14h 45mAvianca
Deal found 1/7$459
This Travelocity deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/255:08 pmGYE - SCL
Nonstop4h 47mLATAM Airlines
Fri 4/2412:45 amSCL - GYE
Nonstop5h 18mLATAM Airlines
Deal found 1/7$463
This Mytrip deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/303:30 amGYE - SCL
1 stop9h 50mMultiple Airlines
Wed 4/297:45 pmSCL - GYE
2 stops12h 08mMultiple Airlines
Deal found 1/7$465

Cheapflights Fare Finder

 
Customize your flight search to find flights from Guayaquil to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 8, 2026.
Use the filters below to find and compare flights from Guayaquil to Santiago that are best for you.

Fly from

Guayaquil

Fly to

Santiago

Route

Depart

Return

Price

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

Mon 5/18

9:45 am-10:30 pm

1 stop11h 45m

Santiago Arturo Merino Benitez

Fri 5/22

11:55 pm-8:35 am

1 stop9h 40m

$452

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

Wed 4/1

8:45 pm-3:05 pm

1 stop16h 20m

Santiago Arturo Merino Benitez

Tue 4/7

7:45 am-2:40 pm

1 stop7h 55m

$453

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

Tue 4/21

6:30 pm-4:15 am

1 stop8h 45m

Santiago Arturo Merino Benitez

Sun 4/26

2:30 pm-10:40 pm

1 stop9h 10m

$455

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

Sat 3/21

3:30 am-3:20 pm

1 stop9h 50m

Santiago Arturo Merino Benitez

Sun 4/12

11:55 pm-1:40 pm

1 stop14h 45m

$455

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

Sun 4/19

3:35 am-1:25 pm

1 stop8h 50m

Santiago Arturo Merino Benitez

Sat 4/25

11:55 pm-8:35 am

1 stop9h 40m

$455

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

Wed 1/28

3:30 am-3:20 pm

1 stop9h 50m

Santiago Arturo Merino Benitez

Tue 4/28

5:53 pm-2:40 pm

2 stops21h 47m

$461

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

Mon 1/26

4:40 am-12:30 am

1 stop17h 50m

Santiago Arturo Merino Benitez

Wed 4/29

6:10 am-5:35 pm

2 stops12h 25m

$461

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

Sun 1/18

9:05 am-4:30 am

1 stop17h 25m

Santiago Arturo Merino Benitez

Wed 3/18

6:30 pm-1:40 am

1 stop9h 10m

$468

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

Mon 1/12

3:30 am-3:20 pm

1 stop9h 50m

$249

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

Sun 1/18

9:05 am-12:30 am

1 stop13h 25m

$257

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/7

Showing 1-10 of 17 results
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Compare providers for flights from Guayaquil to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Guayaquil to Santiago in January.
ProviderPrice AccuracyTrust Score*
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
Trip.comPrice Accuracy2 starsTrust Score*3 stars
SmartFaresPrice Accuracy1 starTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Guayaquil-Santiago flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Guayaquil-Santiago flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Guayaquil-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Guayaquil-Santiago flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Guayaquil-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Guayaquil to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Guayaquil with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Guayaquil to Santiago

How far ahead should I book a flight from Guayaquil to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from Guayaquil to Santiago. Price data was last updated on January 2, 2026.

To ensure you get the cheapest price possible for a flight from Guayaquil to Santiago, you should look to book at least 3 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Guayaquil to Santiago?

Currently, March is the cheapest month in which you can book a flight from Guayaquil to Santiago (average of $183). Flying from Guayaquil to Santiago in January is currently the most expensive (average of $213). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GYE to SCL?

Find hourly flight availability from Guayaquil to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 8, 2026.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Guayaquil to Santiago as you normally would.

How much does it cost to fly round-trip from Guayaquil to Santiago?

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated January 8, 2026.
Get a feel of what it's like to fly with Copa Airlines, LATAM Airlines, and Avianca from Guayaquil to Santiago by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,562 reviews

Entertainment

6.8

Boarding

7.8

Food

6.8

Overall

7.6

Comfort

7.4

Crew

8.1

Reviews

1 / 20
6.0
Good

Maria,Dec 2025

MIA - PTY

The second flight to salta Argentina was terrible..the plain is old no entertainment no good food no nothing
Copa Airlines
7.6
Good
1,562 reviews
Copa Airlines
7.6
Good
1,562 reviews

Entertainment

6.8

Boarding

7.8

Food

6.8

Overall

7.6

Comfort

7.4

Crew

8.1

Reviews

1 / 20
6.0
Good

Maria,Dec 2025

MIA - PTY

The second flight to salta Argentina was terrible..the plain is old no entertainment no good food no nothing
LATAM Airlines
7.5
Good
1,897 reviews
Copa Airlines
7.6
Good
1,562 reviews

Entertainment

6.8

Boarding

7.8

Food

6.8

Overall

7.6

Comfort

7.4

Crew

8.1

Reviews

1 / 20
6.0
Good

Maria,Dec 2025

MIA - PTY

The second flight to salta Argentina was terrible..the plain is old no entertainment no good food no nothing
Avianca
6.6
Okay
2,494 reviews
Copa Airlines
7.6
Good
1,562 reviews

Entertainment

6.8

Boarding

7.8

Food

6.8

Overall

7.6

Comfort

7.4

Crew

8.1

Reviews

1 / 20
6.0
Good

Maria,Dec 2025

MIA - PTY

The second flight to salta Argentina was terrible..the plain is old no entertainment no good food no nothing

Related info for your journey

Find useful and relevant information for your journey from Guayaquil to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Guayaquil to Santiago?

    Santiago Arturo Merino Benitez is the airport most travelers will use when flying to Santiago from Guayaquil Jose Joaquin de Olmedo. Booking flights from Jose Joaquin de Olmedo (GYE) to Arturo Merino Benitez (SCL) should be relatively easy as there is 1 daily flight to Santiago from 3 different airlines. 4h 51m is how long a flight from Guayaquil to Santiago Arturo Merino Benitez will take if you book a nonstop flight.

  • How popular is this Guayaquil to Santiago flight route?

    Flights from Guayaquil Jose Joaquin de Olmedo to Santiago Arturo Merino Benitez have been viewed 2 times in the past calendar month.

  • How long is the flight from Guayaquil to Santiago?

    A quick flight from Guayaquil to Santiago can take about 11h 45m. Avianca provides one of the quickest options available for as low as $452. Airlines will cover a distance of 2235 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Guayaquil to Santiago round-trip?

    Avianca, at $162, was found to be the cheapest airline from Guayaquil to Santiago.Alternate airlines to your destination round-trip include Copa Airlines and LATAM Airlines. These flights start at 63% lower than the current average price 3 months from now.

  • What are the cheapest airlines to fly from Guayaquil to Santiago one-way?

    The cheapest airlines for a one-way flight from Guayaquil to Santiago are Avianca ($171), Copa Airlines ($226), and LATAM Airlines ($239).

  • What are the cheapest flights from Guayaquil to Santiago?

    Looking at all options, your cheapest flight can be booked for $264. While the most popular route (Guayaquil Jose Joaquin de Olmedo - Santiago Arturo Merino Benitez) can be booked for $432 on average, our data indicates $405 when flying from Guayaquil to Santiago.

  • Can I find deals for flights from Guayaquil to Santiago that include hotel bookings?

    Yes. In addition to deals on Guayaquil to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Guayaquil to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Guayaquil to Santiago.

  • Can I find deals for business class flights from Guayaquil to Santiago?

    Yes. Cheapflights offers flight deals from Guayaquil to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Guayaquil to Santiago?

    Currently, March is the cheapest month in which you can book a flight from Guayaquil to Santiago (average of $183). Flying from Guayaquil to Santiago in January is currently the most expensive (average of $213). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Guayaquil to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
Quito to Santiago flights

Top 3 airlines flying from Guayaquil to Santiago

Discover the top 3 airlines that operate flights from Guayaquil to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 8, 2026.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$162Average$334FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$178Average$243FlexibilityNo cancel feeOn-time70%
LATAM AirlinesCheapest$239Average$509FlexibilityNo cancel feeOn-time81%

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