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$239+ Cheap flights from Guayaquil (GYE) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/2. Fares are subject to change and may not be available on all flights or dates of travel.
GYE — SCL
Mar 23 — Mar 301
Mon 3/23
Mon 3/30
1 adult, Economy
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Cheapflights Tip: The best prices from Guayaquil Jose Joaquin de Olmedo to Santiago Arturo Merino Benitez are usually found in April or May, booked 47 days in advance, depart on a Wednesday or Friday and return on a Saturday

Cheap flight deals from Guayaquil to Santiago

Cheapest flights from Guayaquil to Santiago
Explore the most affordable flight options available from Guayaquil to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 21, 2026.

This LATAM Airlines deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/278:45 pm
GYE
-
SCL
1 stop7h 05m
LATAM Airlines
Mon 8/314:10 am
SCL
-
GYE
1 stop11h 30m
LATAM Airlines
Deal found 2/18$456
This Copa Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/812:18 pm
GYE
-
SCL
1 stop13h 38m
Copa Airlines
Sat 10/175:15 am
SCL
-
GYE
1 stop20h 46m
Copa Airlines
Deal found 2/17$458
This Super.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/178:45 pm
GYE
-
SCL
2 stops16h 39m
LATAM Airlines
Mon 5/114:50 pm
SCL
-
GYE
1 stop9h 50m
LATAM Airlines
Deal found 2/19$461
This Kiwi.com deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/79:05 am
GYE
-
SCL
1 stop7h 20m
LATAM Airlines
Tue 4/146:45 pm
SCL
-
GYE
1 stop7h 55m
LATAM Airlines
Deal found 2/21$463
This Kiwi.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/149:05 am
GYE
-
SCL
1 stop6h 20m
LATAM Airlines
Thu 9/2412:45 am
SCL
-
GYE
Nonstop6h 18m
LATAM Airlines
Deal found 2/19$464
This Kiwi.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/269:05 am
GYE
-
SCL
1 stop7h 20m
LATAM Airlines
Sun 5/36:45 pm
SCL
-
GYE
1 stop7h 55m
LATAM Airlines
Deal found 2/19$465
This Kiwi.com deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/105:38 pm
GYE
-
SCL
Nonstop4h 51m
LATAM Airlines
Thu 4/236:45 pm
SCL
-
GYE
1 stop7h 55m
LATAM Airlines
Deal found 2/18$467
This LATAM Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/85:38 pm
GYE
-
SCL
Nonstop4h 51m
LATAM Airlines
Sun 4/126:45 pm
SCL
-
GYE
1 stop7h 55m
LATAM Airlines
Deal found 2/17$472
This Kiwi.com deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/316:29 pm
GYE
-
SCL
1 stop27h 14m
Multiple Airlines
Thu 4/306:40 am
SCL
-
GYE
1 stop8h 55m
Multiple Airlines
Deal found 2/18$475
This LATAM Airlines deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/209:05 am
GYE
-
SCL
1 stop7h 20m
LATAM Airlines
Sat 4/257:45 pm
SCL
-
GYE
2 stops12h 08m
LATAM Airlines
Deal found 2/18$476
This CheapOair deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/189:05 am
GYE
-
SCL
1 stop10h 50m
Multiple Airlines
Thu 5/2112:30 am
SCL
-
GYE
1 stop25h 15m
Multiple Airlines
Deal found 2/20$479

Find flight deals from Guayaquil to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Guayaquil (GYE) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 21, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$451
(Kiwi.com)

One-way from

$236
(SmartFares)

Popular in

February

Cheapest in

April

Average price

$507

Good round-trip deal

$585 or less

Good one-way deal

$300 or less
Provider with most accurate pricing for Guayaquil Jose Joaquin de Olmedo-Santiago Arturo Merino Benitez flight deals.
Search Deals
Provider most trusted by Cheapflights users for Guayaquil Jose Joaquin de Olmedo-Santiago Arturo Merino Benitez flights.
Search Deals
From Guayaquil Jose Joaquin de Olmedo to Santiago Arturo Merino Benitez
Search Deals
One-way flight from Guayaquil Jose Joaquin de Olmedo to Santiago Arturo Merino Benitez
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($42 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals
Price to beat on a round-trip flight from Guayaquil Jose Joaquin de Olmedo to Santiago Arturo Merino Benitez.
Search Deals
Price to beat on a one-way flight from Guayaquil Jose Joaquin de Olmedo to Santiago Arturo Merino Benitez.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Guayaquil to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 21, 2026.
Use the filters below to find and compare flights from Guayaquil to Santiago that are best for you.

Fly from

Guayaquil

Fly to

Santiago

Route

Depart

Return

Price

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

Wed 4/8

8:45 pm-5:25 am

1 stop7h 40m

Santiago Arturo Merino Benitez

Sun 4/12

1:35 pm-1:40 am

1 stop13h 05m

$456

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

Mon 4/20

9:05 am-5:25 pm

1 stop7h 20m

Santiago Arturo Merino Benitez

Sat 4/25

6:45 pm-1:40 am

1 stop7h 55m

$456

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

Mon 5/18

9:05 am-8:55 pm

1 stop10h 50m

Santiago Arturo Merino Benitez

Fri 5/22

6:40 pm-1:40 am

1 stop8h 00m

$456

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

Sun 4/26

9:05 am-5:25 pm

1 stop7h 20m

Santiago Arturo Merino Benitez

Sun 5/3

6:45 pm-1:40 am

1 stop7h 55m

$465

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

Fri 4/10

9:05 am-5:25 pm

1 stop7h 20m

Santiago Arturo Merino Benitez

Fri 4/17

6:45 pm-1:40 am

1 stop7h 55m

$480

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

Thu 4/23

8:45 pm-2:05 pm

1 stop16h 20m

$239

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

Wed 4/1

8:28 am-12:26 am

1 stop13h 58m

$276

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

Thu 3/26

8:32 am-12:34 am

1 stop14h 02m

$276

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

Fri 3/27

8:32 am-3:58 am

1 stop17h 26m

$276

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

Sat 5/9

9:05 am-12:40 pm

2 stops26h 35m

$283

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/18

Showing 1-10 of 11 results
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Compare providers for flights from Guayaquil to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Guayaquil to Santiago in February.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*3 stars
SmartFaresPrice Accuracy1 starTrust Score*1 star
Trip.comPrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Guayaquil-Santiago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Guayaquil-Santiago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Guayaquil-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Guayaquil-Santiago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Guayaquil-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Guayaquil to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Guayaquil with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Guayaquil to Santiago

How far ahead should I book a flight from Guayaquil to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from Guayaquil to Santiago. Price data was last updated on February 20, 2026.

To ensure you get the cheapest price possible for a flight from Guayaquil to Santiago, you should look to book at least 47 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Guayaquil to Santiago?

Currently, March is the cheapest month in which you can book a flight from Guayaquil to Santiago (average of $183). Flying from Guayaquil to Santiago in January is currently the most expensive (average of $204). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GYE to SCL?

Find hourly flight availability from Guayaquil to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 21, 2026.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Guayaquil to Santiago as you normally would.

How much does it cost to fly round-trip from Guayaquil to Santiago?

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated February 21, 2026.
Get a feel of what it's like to fly with LATAM Airlines, Copa Airlines, and Avianca from Guayaquil to Santiago by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
LATAM Airlines
7.5
Good
1,921 reviews

Comfort

7.3

Entertainment

7.0

Food

6.7

Overall

7.5

Crew

8.0

Boarding

7.5

Reviews

1 / 20
8.0
Excellent

LUIS JOSE,Oct 2025

LIM - AEP

Smiles because se upgraded to premiums economy. That was similar to LAN economy years ahí!
LATAM Airlines
7.5
Good
1,921 reviews
LATAM Airlines
7.5
Good
1,921 reviews

Comfort

7.3

Entertainment

7.0

Food

6.7

Overall

7.5

Crew

8.0

Boarding

7.5

Reviews

1 / 20
8.0
Excellent

LUIS JOSE,Oct 2025

LIM - AEP

Smiles because se upgraded to premiums economy. That was similar to LAN economy years ahí!
Copa Airlines
7.5
Good
1,552 reviews
LATAM Airlines
7.5
Good
1,921 reviews

Comfort

7.3

Entertainment

7.0

Food

6.7

Overall

7.5

Crew

8.0

Boarding

7.5

Reviews

1 / 20
8.0
Excellent

LUIS JOSE,Oct 2025

LIM - AEP

Smiles because se upgraded to premiums economy. That was similar to LAN economy years ahí!
Avianca
6.6
Okay
2,496 reviews
LATAM Airlines
7.5
Good
1,921 reviews

Comfort

7.3

Entertainment

7.0

Food

6.7

Overall

7.5

Crew

8.0

Boarding

7.5

Reviews

1 / 20
8.0
Excellent

LUIS JOSE,Oct 2025

LIM - AEP

Smiles because se upgraded to premiums economy. That was similar to LAN economy years ahí!

Related info for your journey

Find useful and relevant information for your journey from Guayaquil to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Guayaquil to Santiago?

    Santiago Arturo Merino Benitez is the airport most travelers will use when flying to Santiago from Guayaquil Jose Joaquin de Olmedo. Booking flights from Jose Joaquin de Olmedo (GYE) to Arturo Merino Benitez (SCL) should be relatively easy as there is 1 daily flight to Santiago from 3 different airlines. 4h 51m is how long a flight from Guayaquil to Santiago Arturo Merino Benitez will take if you book a nonstop flight.

  • How popular is this Guayaquil to Santiago flight route?

    Flights from Guayaquil Jose Joaquin de Olmedo to Santiago Arturo Merino Benitez have been viewed 2 times in the past calendar month.

  • How long is the flight from Guayaquil to Santiago?

    A quick flight from Guayaquil to Santiago can take about 7h 05m. LATAM Airlines provides one of the quickest options available for as low as $451. Airlines will cover a distance of 2235 mi.

  • What are the cheapest airlines flying from Guayaquil to Santiago round-trip?

    Avianca, at $162, was found to be the cheapest airline from Guayaquil to Santiago.Alternate airlines to your destination round-trip include Copa Airlines and LATAM Airlines. These flights start at 63% lower than the current average price 3 months from now.

  • What are the cheapest airlines to fly from Guayaquil to Santiago one-way?

    The cheapest airlines for a one-way flight from Guayaquil to Santiago are Avianca ($171), Copa Airlines ($226), and LATAM Airlines ($239).

  • What are the cheapest flights from Guayaquil to Santiago?

    Looking at all options, your cheapest flight can be booked for $160. While the most popular route (Guayaquil Jose Joaquin de Olmedo - Santiago Arturo Merino Benitez) can be booked for $450 on average, our data indicates $489 when flying from Guayaquil to Santiago.

  • Can I find deals for flights from Guayaquil to Santiago that include hotel bookings?

    Yes. In addition to deals on Guayaquil to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Guayaquil to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Guayaquil to Santiago.

  • Can I find deals for business class flights from Guayaquil to Santiago?

    Yes. Cheapflights offers flight deals from Guayaquil to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Guayaquil to Santiago?

    Currently, March is the cheapest month in which you can book a flight from Guayaquil to Santiago (average of $183). Flying from Guayaquil to Santiago in January is currently the most expensive (average of $204). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Guayaquil to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
Quito to Santiago flights

Top 3 airlines flying from Guayaquil to Santiago

Discover the top 3 airlines that operate flights from Guayaquil to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 21, 2026.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$162Average$310FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$178Average$243FlexibilityNo cancel feeOn-time70%
LATAM AirlinesCheapest$204Average$505FlexibilityNo cancel feeOn-time81%

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