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$238+ Cheap flights from Guayaquil (GYE) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/26. Fares are subject to change and may not be available on all flights or dates of travel.
GYE — SCL
août 12 — août 191
mar. 8/12
mar. 8/19
1 adult, Economy
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Cheapflights Tip: The best prices from Guayaquil Jose Joaquin de Olmedo to Santiago Arturo Merino Benitez are usually found in October or November, booked 3 days in advance, depart on a Thursday or Sunday and return on a Monday

Cheap flight deals from Guayaquil to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Guayaquil (GYE) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated août 7, 2025.

Round-trip from

$431
(Priceline)

One-way from

$238
(Avianca)

Popular in

February

Cheapest in

October

Average price

$386

Good round-trip deal

$459 or less

Good one-way deal

$257 or less
From Guayaquil Jose Joaquin de Olmedo to Santiago Arturo Merino Benitez
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One-way flight from Guayaquil Jose Joaquin de Olmedo to Santiago Arturo Merino Benitez
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Highest demand for flights based on searches. 5% potential increase in price ($25 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($4 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Price to beat on a round-trip flight from Guayaquil Jose Joaquin de Olmedo to Santiago Arturo Merino Benitez.
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Price to beat on a one-way flight from Guayaquil Jose Joaquin de Olmedo to Santiago Arturo Merino Benitez.
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Find flight deals from Guayaquil to Santiago

Cheapest flights from Guayaquil to Santiago
Explore the most affordable flight options available from Guayaquil to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on août 7, 2025.

This Priceline deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sam. 9/133:35 amGYE - SCL
1 stop8h 50mAvianca
dim. 9/217:10 amSCL - GYE
1 stop17h 30mAvianca
Deal found 8/7$431
This Booking.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 9/152:50 pmGYE - SCL
1 stop12h 25mMultiple Airlines
lun. 9/2911:50 pmSCL - GYE
Nonstop5h 23mMultiple Airlines
Deal found 8/6$441
This Mytrip deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jeu. 10/162:45 pmGYE - SCL
Nonstop4h 53mMultiple Airlines
dim. 10/261:35 amSCL - GYE
1 stop18h 10mMultiple Airlines
Deal found 8/6$443
This Booking.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer. 8/203:35 amGYE - SCL
1 stop8h 50mMultiple Airlines
ven. 8/297:58 pmSCL - GYE
2 stops16h 12mMultiple Airlines
Deal found 8/6$449
This Booking.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer. 9/38:40 pmGYE - SCL
1 stop16h 25mLATAM Airlines
mer. 9/1011:50 pmSCL - GYE
Nonstop5h 23mLATAM Airlines
Deal found 8/6$453
This Avianca deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 9/12:50 pmGYE - SCL
1 stop12h 25mAvianca
sam. 9/2012:55 amSCL - GYE
1 stop9h 40mAvianca
Deal found 8/7$455
This Copa Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jeu. 8/214:27 amGYE - SCL
1 stop17h 41mCopa Airlines
jeu. 8/282:26 amSCL - GYE
1 stop12h 20mCopa Airlines
Deal found 8/6$457
This Booking.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sam. 9/138:50 amGYE - SCL
1 stop12h 40mMultiple Airlines
sam. 9/2011:56 pmSCL - GYE
Nonstop5h 23mMultiple Airlines
Deal found 8/6$465
This Gotogate deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sam. 10/412:55 pmGYE - SCL
1 stop7h 00mMultiple Airlines
ven. 10/1012:55 amSCL - GYE
1 stop9h 40mMultiple Airlines
Deal found 8/5$467

Cheapflights Fare Finder

 
Customize your flight search to find flights from Guayaquil to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated août 7, 2025.
Use the filters below to find and compare flights from Guayaquil to Santiago that are best for you.

Fly from

Guayaquil

Fly to

Santiago

Route

Depart

Return

Price

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

sam. 9/13

3:35 am-2:25 pm

1 stop8h 50m

Santiago Arturo Merino Benitez

dim. 9/21

7:10 am-10:40 pm

1 stop17h 30m

$431

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

lun. 9/15

2:50 pm-5:15 am

1 stop12h 25m

Santiago Arturo Merino Benitez

lun. 9/29

11:50 pm-3:13 am

Nonstop5h 23m

$441

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

jeu. 10/16

12:55 pm-10:50 pm

1 stop7h 55m

Santiago Arturo Merino Benitez

dim. 10/26

1:35 am-9:15 am

1 stop9h 40m

$443

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

mer. 8/20

3:35 am-1:25 pm

1 stop8h 50m

Santiago Arturo Merino Benitez

ven. 8/29

7:58 pm-11:10 am

2 stops16h 12m

$449

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

mer. 9/3

8:40 pm-2:05 pm

1 stop16h 25m

Santiago Arturo Merino Benitez

mer. 9/10

11:50 pm-3:13 am

Nonstop5h 23m

$453

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

lun. 9/1

2:50 pm-4:15 am

1 stop12h 25m

Santiago Arturo Merino Benitez

sam. 9/20

12:55 am-8:35 am

1 stop9h 40m

$455

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

jeu. 8/21

4:27 am-11:08 pm

1 stop17h 41m

Santiago Arturo Merino Benitez

jeu. 8/28

2:26 am-1:46 pm

1 stop12h 20m

$457

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

sam. 9/13

8:50 am-11:30 pm

1 stop12h 40m

Santiago Arturo Merino Benitez

sam. 9/20

11:56 pm-3:19 am

Nonstop5h 23m

$465

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

sam. 10/4

12:55 pm-9:55 pm

1 stop7h 00m

Santiago Arturo Merino Benitez

ven. 10/10

12:55 am-8:35 am

1 stop9h 40m

$467

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

mer. 11/26

10:25 am-5:30 am

1 stop17h 05m

$238

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/6

Showing 1-10 of 18 results
1
2

Best time to book a flight from Guayaquil to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Guayaquil with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Guayaquil to Santiago

How far ahead should I book a flight from Guayaquil to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from Guayaquil to Santiago. Price data was last updated on August 1, 2025.

To ensure you get the cheapest price possible for a flight from Guayaquil to Santiago, you should look to book at least 3 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Guayaquil to Santiago?

Currently, April is the cheapest month in which you can book a flight from Guayaquil to Santiago (average of $752). Flying from Guayaquil to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GYE to SCL?

Find hourly flight availability from Guayaquil to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated août 7, 2025.

Unlike in the afternoon, when flights are generally more expensive, you can save up to 32% on flights from Guayaquil to Santiago by exploring options for tickets in the morning.

What is the cheapest day to fly from Guayaquil to Santiago?

Use this chart to determine the cheapest time to fly round-trip from Guayaquil to Santiago. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Guayaquil to Santiago flight should consider departing on Sunday evenings when fares are most often at their lowest. Friday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Guayaquil to Santiago

Explore weekly flight availability from Guayaquil to Santiago. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated août 7, 2025.

The most flights from GYE to SCL are scheduled on a Monday (1 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (1 on average).

How much does it cost to fly round-trip from Guayaquil to Santiago?

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated août 7, 2025.
Get a feel of what it's like to fly with LATAM Airlines, Copa Airlines, and United Airlines from Guayaquil to Santiago by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
LATAM Airlines
7.5
Good
1,834 reviews

Crew

8.0

Entertainment

7.0

Boarding

7.6

Comfort

7.4

Food

6.7

Overall

7.5

Reviews

1 / 20
4.0
Okay

Murilo,Jun 2025

SFO - LAX

I had mixed feelings regarding this flight. Called several times Latam and Delta regarding the purchase of checked baggage and price. I was told 80 dollars, could not buy it ahead of time,, they told me it was not Possible, that I had to buy at the airport. Check in my luggage the attendant says 80 dollars but I was charged 200 . No one could get me a solid answer why. Very disappointing
LATAM Airlines
7.5
Good
1,834 reviews
LATAM Airlines
7.5
Good
1,834 reviews

Crew

8.0

Entertainment

7.0

Boarding

7.6

Comfort

7.4

Food

6.7

Overall

7.5

Reviews

1 / 20
4.0
Okay

Murilo,Jun 2025

SFO - LAX

I had mixed feelings regarding this flight. Called several times Latam and Delta regarding the purchase of checked baggage and price. I was told 80 dollars, could not buy it ahead of time,, they told me it was not Possible, that I had to buy at the airport. Check in my luggage the attendant says 80 dollars but I was charged 200 . No one could get me a solid answer why. Very disappointing
Copa Airlines
7.5
Good
1,500 reviews
LATAM Airlines
7.5
Good
1,834 reviews

Crew

8.0

Entertainment

7.0

Boarding

7.6

Comfort

7.4

Food

6.7

Overall

7.5

Reviews

1 / 20
4.0
Okay

Murilo,Jun 2025

SFO - LAX

I had mixed feelings regarding this flight. Called several times Latam and Delta regarding the purchase of checked baggage and price. I was told 80 dollars, could not buy it ahead of time,, they told me it was not Possible, that I had to buy at the airport. Check in my luggage the attendant says 80 dollars but I was charged 200 . No one could get me a solid answer why. Very disappointing
United Airlines
7.4
Good
8,916 reviews
LATAM Airlines
7.5
Good
1,834 reviews

Crew

8.0

Entertainment

7.0

Boarding

7.6

Comfort

7.4

Food

6.7

Overall

7.5

Reviews

1 / 20
4.0
Okay

Murilo,Jun 2025

SFO - LAX

I had mixed feelings regarding this flight. Called several times Latam and Delta regarding the purchase of checked baggage and price. I was told 80 dollars, could not buy it ahead of time,, they told me it was not Possible, that I had to buy at the airport. Check in my luggage the attendant says 80 dollars but I was charged 200 . No one could get me a solid answer why. Very disappointing
Avianca
6.7
Okay
2,394 reviews
LATAM Airlines
7.5
Good
1,834 reviews

Crew

8.0

Entertainment

7.0

Boarding

7.6

Comfort

7.4

Food

6.7

Overall

7.5

Reviews

1 / 20
4.0
Okay

Murilo,Jun 2025

SFO - LAX

I had mixed feelings regarding this flight. Called several times Latam and Delta regarding the purchase of checked baggage and price. I was told 80 dollars, could not buy it ahead of time,, they told me it was not Possible, that I had to buy at the airport. Check in my luggage the attendant says 80 dollars but I was charged 200 . No one could get me a solid answer why. Very disappointing

Related info for your journey

Find useful and relevant information for your journey from Guayaquil to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Guayaquil to Santiago?

    Santiago Arturo Merino Benitez is the airport most travelers will use when flying to Santiago from Guayaquil Jose Joaquin de Olmedo. Booking flights from Jose Joaquin de Olmedo (GYE) to Arturo Merino Benitez (SCL) should be relatively easy as there is 1 daily flight to Santiago from 3 different airlines. 4h 53m is how long a flight from Guayaquil to Santiago Arturo Merino Benitez will take if you book a nonstop flight.

  • How popular is this Guayaquil to Santiago flight route?

    Flights from Guayaquil Jose Joaquin de Olmedo to Santiago Arturo Merino Benitez have been viewed 1 times in the past calendar month.

  • What is the cheapest airline to fly from Guayaquil to Santiago round-trip?

    Avianca, at $431, was found to be the cheapest airline from Guayaquil to Santiago..

  • What are the cheapest airlines to fly from Guayaquil to Santiago one-way?

    The cheapest airlines for a one-way flight from Guayaquil to Santiago are Avianca ($238), Copa Airlines ($239), and LATAM Airlines ($243).

  • What are the cheapest flights from Guayaquil to Santiago?

    Looking at all options, your cheapest flight can be booked for $244. While the most popular route (Guayaquil Jose Joaquin de Olmedo - Santiago Arturo Merino Benitez) can be booked for $430 on average our data indicates $389 when flying from Guayaquil to Santiago.

  • Can I find deals for flights from Guayaquil to Santiago that include hotel bookings?

    Yes. In addition to deals on Guayaquil to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Guayaquil to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Guayaquil to Santiago.

  • Can I find deals for business class flights from Guayaquil to Santiago?

    Yes. Cheapflights offers flight deals from Guayaquil to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Guayaquil to Santiago?

    Currently, April is the cheapest month in which you can book a flight from Guayaquil to Santiago (average of $752). Flying from Guayaquil to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Guayaquil to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
Quito to Santiago flights

Top 3 airlines flying from Guayaquil to Santiago

Discover the top 3 airlines that operate flights from Guayaquil to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated août 7, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$174Average$270FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$226Average$336FlexibilityNo cancel feeOn-time70%
LATAM AirlinesCheapest$279Average$472FlexibilityNo cancel feeOn-time81%

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