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$239+ Cheap flights from Iowa to Santa Fe (SAF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/5. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SAF
Dec 6 — Dec 131
Sat 12/6
Sat 12/13
1 adult, Economy
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Find flight deals from Iowa to Santa Fe

Cheapest flights from Iowa to Santa Fe
Explore the most affordable flight options available from Iowa to Santa Fe. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 6, 2025.

This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/53:35 pmOMA - SAF
1 stop7h 13mAmerican Airlines
Sun 12/71:16 pmSAF - OMA
1 stop8h 42mAmerican Airlines
Deal found 11/3$244
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/125:00 amDSM - SAF
1 stop5h 28mAmerican Airlines
Mon 12/156:15 amSAF - DSM
1 stop7h 36mAmerican Airlines
Deal found 11/5$244
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/45:00 amOMA - SAF
1 stop5h 28mAmerican Airlines
Sat 12/63:25 pmSAF - OMA
2 stops7h 01mAmerican Airlines
Deal found 11/3$254
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/195:20 pmOMA - SAF
1 stop5h 39mUnited Airlines
Sun 11/237:00 amSAF - OMA
1 stop4h 39mUnited Airlines
Deal found 11/3$274
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/193:39 pmDSM - SAF
1 stop5h 42mAmerican Airlines
Sun 11/239:58 amSAF - DSM
1 stop5h 43mAmerican Airlines
Deal found 11/4$274
This United Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/255:45 amDSM - SAF
1 stop4h 40mUnited Airlines
Mon 12/11:26 pmSAF - DSM
1 stop6h 19mUnited Airlines
Deal found 11/5$289
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1411:30 amDSM - SAF
1 stop5h 57mAmerican Airlines
Mon 11/179:58 amSAF - DSM
1 stop5h 53mAmerican Airlines
Deal found 11/4$334
This United Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/216:00 amOMA - SAF
1 stop4h 25mUnited Airlines
Tue 11/251:26 pmSAF - OMA
1 stop5h 43mUnited Airlines
Deal found 11/6$344
This United Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/215:14 pmDSM - SAF
1 stop5h 45mUnited Airlines
Tue 11/251:26 pmSAF - DSM
1 stop6h 19mUnited Airlines
Deal found 11/6$344
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/195:00 amOMA - SAF
2 stops10h 52mAmerican Airlines
Sun 11/231:12 pmSAF - OMA
1 stop8h 38mAmerican Airlines
Deal found 11/3$365
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/193:43 pmOMA - SAF
1 stop7h 15mAmerican Airlines
Sun 12/213:27 pmSAF - OMA
1 stop7h 05mAmerican Airlines
Deal found 11/5$434
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/15:00 amOMA - SAF
1 stop5h 28mAmerican Airlines
Fri 12/55:10 pmSAF - OMA
1 stop5h 16mAmerican Airlines
Deal found 11/3$447

Cheap flight deals from Iowa to Santa Fe

Keep the following information in mind while searching for Iowa to Santa Fe flight deals. Data was last updated November 6, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$244
(American Airlines)

One-way from

$239
(American Airlines)

Popular in

July

Cheapest in

September

Average price

$483
Provider with most accurate pricing for Des Moines-Santa Fe flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Santa Fe flights.
Search Deals
From Iowa to Santa Fe
Search Deals
One-way flight from Iowa to Santa Fe
Search Deals
Highest demand for flights based on searches. 18% potential increase in price ($105 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($25 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Santa Fe that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
Use the filters below to find and compare flights from Iowa to Santa Fe that are best for you.

Fly from

Iowa

Fly to

Santa Fe

Route

Depart

Return

Price

OmahaSanta Fe

OMA - SAF

OMASAF

Omaha Eppley Airfield

Thu 12/4

3:35 pm-9:54 pm

1 stop7h 19m

Santa Fe

Sat 12/6

1:16 pm-10:58 pm

1 stop8h 42m

$244

OmahaSanta Fe

OMA - SAF

OMASAF

Omaha Eppley Airfield

Fri 12/5

3:35 pm-9:48 pm

1 stop7h 13m

Santa Fe

Sun 12/7

1:16 pm-10:58 pm

1 stop8h 42m

$244

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Fri 12/12

5:00 am-9:28 am

1 stop5h 28m

Santa Fe

Mon 12/15

6:15 am-2:51 pm

1 stop7h 36m

$244

Cedar RapidsSanta Fe

CID - SAF

CIDSAF

Cedar Rapids

Wed 2/4

5:15 am-9:58 am

1 stop5h 43m

Santa Fe

Sun 2/8

3:23 pm-11:53 pm

1 stop7h 30m

$244

OmahaSanta Fe

OMA - SAF

OMASAF

Omaha Eppley Airfield

Wed 11/19

5:20 pm-9:59 pm

1 stop5h 39m

Santa Fe

Sun 11/23

7:00 am-12:39 pm

1 stop4h 39m

$274

OmahaSanta Fe

OMA - SAF

OMASAF

Omaha Eppley Airfield

Thu 11/20

9:34 am-4:26 pm

1 stop7h 52m

Santa Fe

Mon 11/24

1:12 pm-10:50 pm

1 stop8h 38m

$274

Cedar RapidsSanta Fe

CID - SAF

CIDSAF

Cedar Rapids

Wed 2/4

4:33 pm-8:47 pm

1 stop5h 14m

Santa Fe

Sat 2/7

1:16 pm-8:32 pm

1 stop6h 16m

$277

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Wed 11/19

5:00 am-2:52 pm

2 stops10h 52m

Santa Fe

Sun 11/23

4:56 pm-10:53 pm

1 stop4h 57m

$284

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Tue 11/25

5:45 am-9:25 am

1 stop4h 40m

Santa Fe

Mon 12/1

1:26 pm-8:45 pm

1 stop6h 19m

$289

Cedar RapidsSanta Fe

CID - SAF

CIDSAF

Cedar Rapids

Thu 2/5

4:33 pm-8:47 pm

1 stop5h 14m

Santa Fe

Sat 2/7

1:16 pm-8:32 pm

1 stop6h 16m

$304

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/5

Showing 1-10 of 26 results
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Best time to book a flight from Iowa to Santa Fe

Have a flexible travel schedule? Discover the best time to fly to Santa Fe from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Santa Fe

What is the cheapest month to book a flight from Iowa to Santa Fe?

Currently, April is the cheapest month in which you can book a flight from Iowa to Santa Fe (average of $198). Flying from Iowa to Santa Fe in March is currently the most expensive (average of $312). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IA to SAF?

Find hourly flight availability from Iowa to Santa Fe. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 6, 2025.

One of the essential ways to save on airfare from Iowa to Santa Fe is to remain as flexible as possible. Flights that are in the evening tend to be the most expensive. A flight in the morning could potentially save you up to 30% on airfare.

How much does it cost to fly round-trip from Iowa to Santa Fe?

Related info for your journey

Find useful and relevant information for your journey from Iowa to Santa Fe. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santa Fe from Iowa?

    If you book a flight to Santa Fe from Iowa, you will be flying to Santa Fe, which is the city’s only airport. Santa Fe (SAF) is located 9.8 mi from the center of Santa Fe.

  • How long is the flight from Iowa to Santa Fe?

    A quick flight from Iowa to Santa Fe can take about 5h 14m. American Airlines provides one of the quickest options available for as low as $277. The distance between Iowa and Santa Fe is about 885 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Iowa to Santa Fe?

    While some choose either Omaha Eppley Airfield - Santa Fe or Cedar Rapids - Santa Fe, Des Moines - Santa Fe is the most popular route from Iowa to Santa Fe.

  • Can I find deals for flights from Iowa to Santa Fe that include hotel bookings?

    Yes. In addition to deals on Iowa to Santa Fe flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Santa Fe?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Santa Fe.

  • Can I find deals for business class flights from Iowa to Santa Fe?

    Yes. Cheapflights offers flight deals from Iowa to Santa Fe by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Santa Fe?

    Currently, April is the cheapest month in which you can book a flight from Iowa to Santa Fe (average of $198). Flying from Iowa to Santa Fe in March is currently the most expensive (average of $312). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santa Fe?

Book flights to Santa Fe if you plan to visit one of these locations
Santa Rosa

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Alternative routes for Iowa to Santa Fe

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Iowa to Santa Fe

Discover the top 2 airlines that operate flights from Iowa to Santa Fe. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$243Average$441FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$244Average$548FlexibilityNo cancel feeOn-time71%

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