HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Santa Cruz de la Sierra

$393+ Cheap flights from Detroit (DTT) to Santa Cruz de la Sierra (VVI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/23. Fares are subject to change and may not be available on all flights or dates of travel.
DTT — VVI
Dec 6 — Dec 131
Sat 12/6
Sat 12/13
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Detroit to Santa Cruz de la Sierra with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Find flight deals from Detroit to Santa Cruz de la Sierra

Cheapest flights from Detroit to Santa Cruz de la Sierra
Explore the most affordable flight options available from Detroit to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 6, 2025.

This Avianca Connect deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/37:10 amDTW - VVI
2 stops18h 25mMultiple Airlines
Fri 12/53:40 amVVI - DTW
2 stops15h 13mMultiple Airlines
Deal found 11/6$713
This Copa Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/77:40 pmDTW - VVI
2 stops30h 56mCopa Airlines
Sat 12/1311:40 amVVI - DTW
2 stops23h 22mCopa Airlines
Deal found 11/6$995
This Trip.com deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/710:47 amDTW - VVI
2 stops17h 03mMultiple Airlines
Fri 11/148:35 amVVI - DTW
2 stops15h 50mMultiple Airlines
Deal found 11/6$1,014
This Copa Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/89:15 amDTW - VVI
2 stops17h 21mCopa Airlines
Mon 12/1511:40 amVVI - DTW
2 stops23h 22mCopa Airlines
Deal found 11/6$1,047

Cheap flight deals from Detroit to Santa Cruz de la Sierra

Discover tips and strategies to find the most affordable flight options for your journey from Detroit (DTT) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 6, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$713
(Avianca Connect)

One-way from

$393
(Kiwi.com)
Provider with most accurate pricing for Detroit (DTT)-Santa Cruz de la Sierra Viru Viru Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Detroit (DTT)-Santa Cruz de la Sierra Viru Viru Intl flights.
Search Deals
From Detroit (DTT) to Santa Cruz de la Sierra Viru Viru Intl
Search Deals
One-way flight from Detroit (DTT) to Santa Cruz de la Sierra Viru Viru Intl
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Detroit to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
Use the filters below to find and compare flights from Detroit to Santa Cruz de la Sierra that are best for you.

Fly from

Detroit

Fly to

Santa Cruz de la Sierra

Route

Depart

Return

Price

DetroitSanta Cruz de la Sierra

DTW - VVI

DTWVVI

Detroit Metropolitan Wayne County

Wed 12/3

7:10 am-2:35 am

2 stops18h 25m

Santa Cruz de la Sierra Viru Viru Intl

Fri 12/5

3:40 am-5:53 pm

2 stops15h 13m

$713

DetroitSanta Cruz de la Sierra

DTW - VVI

DTWVVI

Detroit Metropolitan Wayne County

Sat 4/4

6:00 am-10:50 pm

2 stops16h 50m

Santa Cruz de la Sierra Viru Viru Intl

Tue 4/7

11:44 am-11:59 pm

2 stops36h 15m

$862

DetroitSanta Cruz de la Sierra

DTW - VVI

DTWVVI

Detroit Metropolitan Wayne County

Fri 3/6

6:00 am-3:35 am

2 stops44h 35m

Santa Cruz de la Sierra Viru Viru Intl

Sat 3/14

3:40 am-11:57 pm

2 stops20h 17m

$882

DetroitSanta Cruz de la Sierra

DTW - VVI

DTWVVI

Detroit Metropolitan Wayne County

Sun 12/7

7:40 pm-3:36 am

2 stops30h 56m

Santa Cruz de la Sierra Viru Viru Intl

Sat 12/13

11:40 am-10:02 am

2 stops23h 22m

$995

DetroitSanta Cruz de la Sierra

DTW - VVI

DTWVVI

Detroit Metropolitan Wayne County

Fri 1/9

6:00 am-4:35 am

2 stops21h 35m

Santa Cruz de la Sierra Viru Viru Intl

Tue 1/13

3:40 am-4:40 am

3 stops26h 00m

$1,027

DetroitSanta Cruz de la Sierra

DTW - VVI

DTWVVI

Detroit Metropolitan Wayne County

Tue 12/23

6:40 pm-10:35 am

3 stops38h 55m

$393

DetroitSanta Cruz de la Sierra

DTW - VVI

DTWVVI

Detroit Metropolitan Wayne County

Mon 12/22

6:06 pm-2:35 am

3 stops31h 29m

$564

DetroitSanta Cruz de la Sierra

DTW - VVI

DTWVVI

Detroit Metropolitan Wayne County

Sun 12/21

11:03 am-2:35 am

3 stops38h 32m

$565

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/5

Compare providers for flights from Detroit to Santa Cruz de la Sierra

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Detroit to Santa Cruz de la Sierra in November.
ProviderPrice AccuracyTrust Score*
eDreamsPrice Accuracy3 starsTrust Score*3 stars
AranGrantPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Detroit-Santa Cruz de la Sierra flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Detroit-Santa Cruz de la Sierra flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Detroit-Santa Cruz de la Sierra flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Detroit-Santa Cruz de la Sierra flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Detroit-Santa Cruz de la Sierra flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Detroit to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Detroit with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Detroit to Santa Cruz de la Sierra
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Detroit to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Detroit to Santa Cruz de la Sierra?

    A quick flight from Detroit to Santa Cruz de la Sierra can take about 16h 50m. United Airlines provides one of the quickest options available for as low as $862. There are 4330 mi between Detroit and Santa Cruz de la Sierra.

  • Can I find deals for flights from Detroit to Santa Cruz de la Sierra that include hotel bookings?

    Yes. In addition to deals on Detroit to Santa Cruz de la Sierra flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Detroit to Santa Cruz de la Sierra?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Detroit to Santa Cruz de la Sierra.

  • Can I find deals for business class flights from Detroit to Santa Cruz de la Sierra?

    Yes. Cheapflights offers flight deals from Detroit to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Detroit to Santa Cruz de la Sierra

See prices for flight routes from nearby airports that may be better suited for you.
O'Hare Intl to Santa Cruz de la Sierra flights
O'Hare Intl to La Paz flights
O'Hare Intl to Cochabamba flights
Detroit to Santa Cruz de la Sierra flights
Detroit to La Paz flights

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.