What are the cheapest airlines flying from Prague to San Francisco round-trip?

Cheapflights users have booked flights from Prague to San Francisco round-trip from $496. Other airlines that can offer you cheap pricing are British Airways, from $497, and American Airlines, from $587. Finnair is 37% cheaper than the average price of flights available within the next 90 days to this destination.

What are the cheapest airlines to fly from Prague to San Francisco one-way?

To fly one-way, consider booking your trip with Iberia, which is currently one of the cheapest options available, starting at $465. Vueling flights start at $477 while deals on Finnair start at $533 one-way.

What is the cheapest day to fly from Prague to San Francisco?

Travelers seeking maximum savings on their Prague to San Francisco flight should consider departing on Monday evenings when fares are most often at their lowest. Thursday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

What are the most popular airlines that fly from Prague to San Francisco?

Before booking your flight from Prague to San Francisco check out the most popular airlines for this route: American Airlines, British Airways or Condor.

What is the cheapest day to fly round-trip from Prague to San Francisco?

Leaving on a Sunday is a viable option for saving on travel. Heavily demanded days of the week can typically drive up the prices you see. Booking your travel for a less competitive day can save up to 12% on the overall cost on flights from Prague to San Francisco.

How far in advance should I book a flight from Prague to San Francisco?

Travelers have found it’s best to book a flight 54 days in advance to save up to 34% compared to booking the same week of travel. As your travel date approaches, the cost of this flight route may potentially increase. While opting to book 54 days out may not be an option for all, there are still additional ways to secure a deal in the near future. You might find a flight from Prague to San Francisco 1-2 weeks in advance for as low as $654, or $843 for flights within the next 24 hours.

What is the cheapest month to fly from Prague to San Francisco?

The best pricing can be found in the month of May. Prices to San Francisco from Prague average $788. You can even find prices in May for less than $788, as users have found deals to San Francisco from as low as $526. The month of August appears to be one of the more expensive times to travel to San Francisco from Prague. Flying in the targeted month can save you up to 12%.

Can I find deals for flights from Prague to San Francisco that include hotel bookings?

Yes. In addition to deals on Prague to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Prague to San Francisco?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Prague to San Francisco.

Can I find deals for business class flights from Prague to San Francisco?

Yes. Cheapflights offers flight deals from Prague to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$450+ Flights from Prague to San Francisco

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Find cheap flights from Prague to San Francisco with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

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Cheapflights Tip: The best prices from Václav Havel Prague to San Francisco are usually found in May or April, booked 54 days in advance, depart on a Monday or Tuesday and return on a Wednesday

Cheap flight deals from Prague to San Francisco

Round-trip from	$496 (Finnair)
One-way from	$450 (Mytrip)
Popular in	August
Cheapest in	May
Average price	$726

From Václav Havel Prague to San Francisco

Search Deals

One-way flight from Václav Havel Prague to San Francisco

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Highest demand for flights based on searches. 7% potential increase in price ($63 potential increase over avg. RT price).

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Cheapest flight prices on average. 1% potential price decrease ($9 potential savings vs. average RT price).

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Average for round-trip flights in June 2025

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Find flight deals from Prague to San Francisco

Cheapest flights from Prague to San Francisco
Explore the most affordable flight options available from Prague to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 13, 2025.

Mon 9/1511:35 amPRG - SFO

2 stops18h 43mFinnair

Tue 9/3010:22 amSFO - PRG

2 stops23h 23mFinnair

Deal found 6/11

$496

Mon 9/155:45 pmPRG - SFO

1 stop29h 05mBritish Airways

Tue 9/308:58 amSFO - PRG

2 stops17h 37mBritish Airways

Deal found 6/11

$497

Mon 6/232:25 pmPRG - SFO

2 stops27h 11mAmerican Airlines

Tue 7/87:20 pmSFO - PRG

1 stop19h 15mAmerican Airlines

Deal found 6/10

$587

Tue 7/12:30 pmPRG - SFO

2 stops27h 58mUnited Airlines

Tue 7/87:00 amSFO - PRG

2 stops21h 40mUnited Airlines

Deal found 6/11

$605

Tue 8/196:00 amPRG - SFO

1 stop14h 45mDelta

Wed 9/310:55 amSFO - PRG

2 stops17h 40mDelta

Deal found 6/13

$609

Mon 6/231:40 pmPRG - SFO

1 stop30h 08mMultiple Airlines

Mon 7/79:05 pmSFO - PRG

1 stop15h 15mMultiple Airlines

Deal found 6/12

$619

Mon 6/231:40 pmPRG - SFO

1 stop17h 13mAir Canada

Mon 7/77:10 amSFO - PRG

2 stops18h 45mAir Canada

Deal found 6/11

$642

Mon 8/188:50 amPRG - SFO

1 stop14h 40mCondor

Tue 9/24:30 pmSFO - PRG

1 stop14h 20mCondor

Deal found 6/13

$645

Mon 8/1811:40 amPRG - SFO

1 stop17h 10mLufthansa

Sat 9/61:20 pmSFO - PRG

1 stop19h 30mLufthansa

Deal found 6/13

$659

Fri 8/229:25 pmPRG - SFO

1 stop23h 20mKLM

Sat 9/61:45 pmSFO - PRG

1 stop23h 50mKLM

Deal found 6/13

$680

Wed 7/237:10 pmPRG - SFO

2 stops34h 44mSWISS

Mon 8/187:40 pmSFO - PRG

2 stops37h 45mSWISS

Deal found 6/12

$710

Wed 8/63:35 pmPRG - SFO

1 stop33h 35mIberia

Sat 9/65:45 pmSFO - PRG

1 stop36h 05mIberia

Deal found 6/12

$868

Best flights from Prague to San Francisco
Discover carefully curated flight deals from Prague to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 13, 2025.

Mon 9/1511:35 amPRG - SFO

2 stops18h 43mFinnair

Tue 9/3010:22 amSFO - PRG

2 stops23h 23mFinnair

Deal found 6/11

$496

Mon 9/155:45 pmPRG - SFO

1 stop29h 05mBritish Airways

Tue 9/308:58 amSFO - PRG

2 stops17h 37mBritish Airways

Deal found 6/11

$497

Mon 6/232:25 pmPRG - SFO

2 stops27h 11mAmerican Airlines

Tue 7/87:20 pmSFO - PRG

1 stop19h 15mAmerican Airlines

Deal found 6/10

$587

Tue 7/12:30 pmPRG - SFO

2 stops27h 58mUnited Airlines

Tue 7/87:00 amSFO - PRG

2 stops21h 40mUnited Airlines

Deal found 6/11

$605

Tue 8/196:00 amPRG - SFO

1 stop14h 45mDelta

Tue 9/99:35 amSFO - PRG

2 stops19h 00mDelta

Deal found 6/13

$609

Mon 6/231:40 pmPRG - SFO

1 stop30h 08mMultiple Airlines

Mon 7/79:05 pmSFO - PRG

1 stop15h 15mMultiple Airlines

Deal found 6/12

$619

Mon 6/231:40 pmPRG - SFO

1 stop17h 13mAir Canada

Mon 7/77:10 amSFO - PRG

2 stops18h 45mAir Canada

Deal found 6/11

$642

Mon 8/188:50 amPRG - SFO

1 stop14h 40mCondor

Tue 9/24:30 pmSFO - PRG

1 stop14h 20mCondor

Deal found 6/13

$645

Mon 8/1811:40 amPRG - SFO

1 stop17h 10mLufthansa

Sat 9/61:20 pmSFO - PRG

1 stop19h 30mLufthansa

Deal found 6/13

$659

Fri 8/229:25 pmPRG - SFO

1 stop23h 20mKLM

Sat 9/61:45 pmSFO - PRG

1 stop23h 50mKLM

Deal found 6/13

$680

Wed 7/237:10 pmPRG - SFO

2 stops34h 44mSWISS

Mon 8/187:40 pmSFO - PRG

2 stops37h 45mSWISS

Deal found 6/12

$710

Wed 8/63:35 pmPRG - SFO

1 stop33h 35mIberia

Sat 9/65:45 pmSFO - PRG

1 stop36h 05mIberia

Deal found 6/12

$868

Last-minute flights from Prague to San Francisco
Discover last-minute flight deals from Prague to San Francisco. Data last updated June 13, 2025 and is based on user searches.

Sat 6/1410:25 amPRG - SFO

1 stop15h 05mScandinavian Airlines

Sat 6/217:40 pmSFO - PRG

1 stop16h 05mScandinavian Airlines

Deal found 6/12

$931

Mon 6/232:25 pmPRG - SFO

2 stops27h 11mAmerican Airlines

Tue 7/87:20 pmSFO - PRG

1 stop19h 15mAmerican Airlines

Deal found 6/10

$587

Mon 6/231:40 pmPRG - SFO

1 stop30h 08mMultiple Airlines

Mon 7/77:30 pmSFO - PRG

1 stop18h 50mMultiple Airlines

Deal found 6/12

$611

Mon 6/231:40 pmPRG - SFO

1 stop17h 13mAir Canada

Mon 7/77:10 amSFO - PRG

2 stops18h 45mAir Canada

Deal found 6/12

$617

Mon 6/231:40 pmPRG - SFO

1 stop30h 08mUnited Airlines

Mon 7/77:25 pmSFO - PRG

1 stop13h 25mUnited Airlines

Deal found 6/11

$630

Mon 6/236:00 amPRG - SFO

1 stop14h 45mDelta

Mon 7/78:25 pmSFO - PRG

1 stop14h 35mDelta

Deal found 6/12

$771

Mon 6/2311:35 amPRG - SFO

2 stops18h 23mFinnair

Mon 7/711:26 amSFO - PRG

2 stops22h 19mFinnair

Deal found 6/11

$893

Mon 6/232:55 pmPRG - SFO

3 stops34h 50mTAP AIR PORTUGAL

Mon 7/74:20 pmSFO - PRG

2 stops20h 00mTAP AIR PORTUGAL

Deal found 6/11

$2,478

Sat 6/2811:10 amPRG - SFO

2 stops16h 50mAustrian Airlines

Wed 7/22:40 pmSFO - PRG

2 stops22h 10mAustrian Airlines

Deal found 6/12

$1,341

Tue 7/12:30 pmPRG - SFO

2 stops27h 58mUnited Airlines

Mon 7/712:20 amSFO - PRG

2 stops24h 20mUnited Airlines

Deal found 6/11

$605

Tue 7/89:10 pmPRG - SFO

2 stops29h 42mBritish Airways

Wed 7/234:30 pmSFO - PRG

1 stop19h 15mBritish Airways

Deal found 6/12

$610

Fri 7/1111:15 amPRG - SFO

2 stops22h 04mDelta

Mon 9/293:05 pmSFO - PRG

1 stop21h 40mDelta

Deal found 6/13

$676

One-way flights from Prague to San Francisco
Search for one-way flight options from Prague to San Francisco. Find affordable one-way fares based on user searches. Data last updated June 13, 2025.

Fri 8/158:35 pmPRG - SFO

3 stops47h 40mMultiple Airlines

Deal found 6/13

$450

Mon 9/158:40 pmPRG - SFO

1 stop30h 30mIberia

Deal found 6/12

$465

Fri 8/299:00 pmPRG - SFO

1 stop30h 10mVueling

Deal found 6/10

$477

Mon 9/2211:35 amPRG - SFO

2 stops18h 43mFinnair

Deal found 6/11

$533

Wed 7/96:40 amPRG - SFO

1 stop16h 10mBritish Airways

Deal found 6/11

$551

Fri 8/158:10 amPRG - SFO

2 stops19h 00mAmerican Airlines

Deal found 6/12

$562

Tue 7/89:50 amPRG - SFO

1 stop15h 45mSWISS

Deal found 6/12

$643

Thu 7/106:20 amPRG - SFO

2 stops22h 20mAir Canada

Deal found 6/11

$654

Thu 7/246:20 amPRG - SFO

1 stop21h 40mLufthansa

Deal found 6/12

$677

Sat 7/261:40 pmPRG - SFO

1 stop28h 27mUnited Airlines

Deal found 6/12

$685

Mon 9/154:40 pmPRG - SFO

3 stops33h 05mTAP AIR PORTUGAL

Deal found 6/11

$765

Sat 7/127:20 pmPRG - SFO

1 stop24h 15mTurkish Airlines

Deal found 6/12

$837

Cheapflights Fare Finder

Use the filters below to find and compare flights from Prague to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

PragueSan Francisco

PRG - SFO

PRGSFO

Václav Havel Prague

Mon 9/15

11:35 am-9:18 pm

2 stops18h 43m

San Francisco

Tue 9/30

10:22 am-6:45 pm

2 stops23h 23m

$496

PragueSan Francisco

PRG - SFO

PRGSFO

Václav Havel Prague

Mon 9/15

5:45 pm-1:50 pm

1 stop29h 05m

San Francisco

Tue 9/30

8:58 am-11:35 am

2 stops17h 37m

$497

PragueSan Francisco

PRG - SFO

PRGSFO

Václav Havel Prague

Mon 6/23

2:25 pm-8:36 am

2 stops27h 11m

San Francisco

Tue 7/8

7:20 pm-11:35 pm

1 stop19h 15m

$587

PragueSan Francisco

PRG - SFO

PRGSFO

Václav Havel Prague

Tue 7/1

2:30 pm-9:28 am

2 stops27h 58m

San Francisco

Mon 7/7

12:20 am-9:40 am

2 stops24h 20m

$605

PragueSan Francisco

PRG - SFO

PRGSFO

Václav Havel Prague

Tue 8/19

6:00 am-11:45 am

1 stop14h 45m

San Francisco

Wed 9/3

10:55 am-1:35 pm

2 stops17h 40m

$609

PragueSan Francisco

PRG - SFO

PRGSFO

Václav Havel Prague

Mon 6/23

1:40 pm-10:48 am

1 stop30h 08m

San Francisco

Mon 7/7

9:05 pm-9:20 pm

1 stop15h 15m

$619

PragueSan Francisco

PRG - SFO

PRGSFO

Václav Havel Prague

Mon 6/23

1:40 pm-9:53 pm

1 stop17h 13m

San Francisco

Mon 7/7

7:10 am-10:55 am

2 stops18h 45m

$642

PragueSan Francisco

PRG - SFO

PRGSFO

Václav Havel Prague

Mon 8/18

8:50 am-2:30 pm

1 stop14h 40m

San Francisco

Tue 9/2

4:30 pm-3:50 pm

1 stop14h 20m

$645

PragueSan Francisco

PRG - SFO

PRGSFO

Václav Havel Prague

Mon 8/18

11:40 am-7:50 pm

1 stop17h 10m

San Francisco

Sat 9/6

1:20 pm-5:50 pm

1 stop19h 30m

$659

PragueSan Francisco

PRG - SFO

PRGSFO

Václav Havel Prague

Fri 8/22

9:25 pm-11:45 am

1 stop23h 20m

San Francisco

Sat 9/6

1:45 pm-10:35 pm

1 stop23h 50m

$680

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/13

Showing 1-10 of 28 results

Best time to book a flight from Prague to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Prague with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Prague to San Francisco

How far ahead should I book a flight from Prague to San Francisco?

The price you pay for your flight from Prague to San Francisco may vary depending on when you book. For the best chance of a lower fare, look to book 53 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Prague to San Francisco?

Currently, January is the cheapest month in which you can book a flight from Prague to San Francisco (average of $276). Flying from Prague to San Francisco in June is currently the most expensive (average of $364). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PRG to SFO?

When flying from Prague to San Francisco, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 35% versus a flight in the afternoon.

Rainfall in San Francisco by month

In terms of precipitation, rainfall in San Francisco ranges from 0.0 - 4.4 inches per month. January is typically the wettest month, when rainfall can reach 4.4 in. July is typically the driest time to visit San Francisco when rainfall is around 0.0 in.

Temperature in San Francisco by month

If weather is an important factor for your trip to San Francisco, use this chart to help with planning. For those seeking warmer temperatures, September is the ideal time of year to visit, when temperatures reach an average of 62.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 51.8 F).

Reviews of airlines servicing San Francisco

Get a feel of what it's like to fly with Delta, KLM and Austrian Airlines from Prague to San Francisco by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,951 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Delta

8.0

Very good

7,951 reviews

Delta

8.0

Very good

7,951 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

KLM

7.8

Good

1,358 reviews

Delta

8.0

Very good

7,951 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Austrian Airlines

7.6

Good

802 reviews

Delta

8.0

Very good

7,951 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Finnair

7.6

Good

1,290 reviews

Delta

8.0

Very good

7,951 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

SWISS

7.5

Good

1,624 reviews

Delta

8.0

Very good

7,951 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

What are the cheapest airlines flying from Prague to San Francisco round-trip?
Cheapflights users have booked flights from Prague to San Francisco round-trip from $496. Other airlines that can offer you cheap pricing are British Airways, from $497, and American Airlines, from $587. Finnair is 37% cheaper than the average price of flights available within the next 90 days to this destination.
What are the cheapest airlines to fly from Prague to San Francisco one-way?
To fly one-way, consider booking your trip with Iberia, which is currently one of the cheapest options available, starting at $465. Vueling flights start at $477 while deals on Finnair start at $533 one-way.
Can I find deals for flights from Prague to San Francisco that include hotel bookings?
Yes. In addition to deals on Prague to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Prague to San Francisco?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Prague to San Francisco.
Can I find deals for business class flights from Prague to San Francisco?
Yes. Cheapflights offers flight deals from Prague to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Prague to San Francisco?
Currently, January is the cheapest month in which you can book a flight from Prague to San Francisco (average of $276). Flying from Prague to San Francisco in June is currently the most expensive (average of $364). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Roseville

Mountain View

South San Francisco

Livermore

Turlock

Santa Cruz

Manteca

Fairfield

Watsonville

Antioch

Hollister

Milpitas

Newark

Hayward

Alameda

Sunnyvale

Daly City

Union City

Campbell

Capitola

Browse thousands of different options on Cheapflights for your next trip

Top 6 airlines flying from Prague to San Francisco

Airline	Cheapest	Average	Flexibility	On-time
Condor	Cheapest$473	Average$620	FlexibilityNo cancel fee	On-time76%
British Airways	Cheapest$530	Average$788	FlexibilityNo cancel fee	On-time70%
American Airlines	Cheapest$546	Average$607	FlexibilityNo cancel fee	On-time71%
United Airlines	Cheapest$610	Average$808	FlexibilityNo cancel fee	On-time69%
SWISS	Cheapest$621	Average$793	FlexibilityNo cancel fee	On-time79%
Lufthansa	Cheapest$702	Average$965	FlexibilityNo cancel fee	On-time76%

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$450+ Cheap flights from Prague (PRG) to San Francisco (SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/15. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Prague to San Francisco with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Václav Havel Prague to San Francisco are usually found in May or April, booked 54 days in advance, depart on a Monday or Tuesday and return on a Wednesday

Cheap flight deals from Prague to San Francisco

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Prague to San Francisco

Cheapest flights from Prague to San FranciscoExplore the most affordable flight options available from Prague to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 13, 2025.

Explore the most affordable flight options available from Prague to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 13, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Prague to San Francisco that are best for you.

Best time to book a flight from Prague to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Prague with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Prague to San Francisco

How far ahead should I book a flight from Prague to San Francisco?

Use this chart to determine the optimal time to book a round-trip flight from Prague to San Francisco. Price data was last updated on June 9, 2025.

What is the cheapest month to book a flight from Prague to San Francisco?

What is the cheapest time of day to fly from PRG to SFO?

Find hourly flight availability from Prague to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 13, 2025.

Rainfall in San Francisco by month

Plan your trip to San Francisco by taking into account the average rainfall totals by month.

Temperature in San Francisco by month

Plan your trip to San Francisco by taking into account the average temperature totals by month.

Reviews of airlines servicing San Francisco

Get a feel of what it's like to fly with Delta, KLM and Austrian Airlines from Prague to San Francisco by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Prague to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Prague to San Francisco round-trip?

What are the cheapest airlines to fly from Prague to San Francisco one-way?

Can I find deals for flights from Prague to San Francisco that include hotel bookings?

How can I find direct flights from Prague to San Francisco?

Can I find deals for business class flights from Prague to San Francisco?

What is the cheapest month to book a flight from Prague to San Francisco?

Traveling to a place near Prague?

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Alternative routes for Prague to San Francisco

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Top 6 airlines flying from Prague to San Francisco

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Cheapest flights from Prague to San Francisco
Explore the most affordable flight options available from Prague to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 13, 2025.