HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
San Francisco

$477+ Cheap flights from Palermo (PMO) to San Francisco (SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/29. Fares are subject to change and may not be available on all flights or dates of travel.
PMO — SFO
Feb 28 — Mar 71
Sat 2/28
Sat 3/7
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Palermo to San Francisco with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Palermo to San Francisco

Cheapest flights from Palermo to San Francisco
Explore the most affordable flight options available from Palermo to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.

This ITA Airways deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure ITA Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/234:10 pm
PMO
-
SFO
1 stop30h 05m
ITA Airways
Sun 4/263:15 pm
SFO
-
PMO
1 stop22h 15m
ITA Airways
Deal found 1/26$613
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/2312:05 pm
PMO
-
SFO
2 stops20h 44m
American Airlines
Sun 4/266:00 am
SFO
-
PMO
2 stops27h 40m
American Airlines
Deal found 1/27$620
This Expedia deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/1412:15 pm
PMO
-
SFO
1 stop16h 55m
Multiple Airlines
Sun 2/227:25 pm
SFO
-
PMO
1 stop14h 00m
Multiple Airlines
Deal found 1/27$640

Find flight deals from Palermo to San Francisco

Discover tips and strategies to find the most affordable flight options for your journey from Palermo (PMO) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$613
(ITA Airways)

One-way from

$477
(American Airlines)
Provider with most accurate pricing for Palermo Punta Raisi-San Francisco flight deals.
Search Deals
Provider most trusted by Cheapflights users for Palermo Punta Raisi-San Francisco flights.
Search Deals
From Palermo Punta Raisi to San Francisco
Search Deals
One-way flight from Palermo Punta Raisi to San Francisco
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Palermo to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Palermo to San Francisco that are best for you.

Fly from

Palermo

Fly to

San Francisco

Route

Depart

Return

Price

PalermoSan Francisco

PMO - SFO

PMOSFO

Palermo Punta Raisi

Thu 4/23

4:10 pm-1:15 pm

1 stop30h 05m

San Francisco

Sun 4/26

3:15 pm-10:30 pm

1 stop22h 15m

$613

PalermoSan Francisco

PMO - SFO

PMOSFO

Palermo Punta Raisi

Thu 4/23

12:05 pm-12:17 am

2 stops21h 12m

San Francisco

Sun 4/26

1:28 pm-6:40 pm

2 stops20h 12m

$617

PalermoSan Francisco

PMO - SFO

PMOSFO

Palermo Punta Raisi

Sat 2/14

12:15 pm-8:10 pm

1 stop16h 55m

San Francisco

Sun 2/22

7:25 pm-6:25 pm

1 stop14h 00m

$640

PalermoSan Francisco

PMO - SFO

PMOSFO

Palermo Punta Raisi

Sun 3/29

1:05 pm-9:43 am

2 stops29h 38m

$477

PalermoSan Francisco

PMO - SFO

PMOSFO

Palermo Punta Raisi

Thu 4/9

1:05 pm-7:30 am

2 stops51h 25m

$480

PalermoSan Francisco

PMO - SFO

PMOSFO

Palermo Punta Raisi

Sun 3/29

4:35 pm-2:35 pm

3 stops55h 00m

$496

PalermoSan Francisco

PMO - SFO

PMOSFO

Palermo Punta Raisi

Thu 4/9

9:25 am-10:50 am

1 stop34h 25m

$629

PalermoSan Francisco

PMO - SFO

PMOSFO

Palermo Punta Raisi

Sun 3/29

9:25 am-10:50 am

1 stop34h 25m

$631

PalermoSan Francisco

PMO - SFO

PMOSFO

Palermo Punta Raisi

Thu 7/2

12:05 pm-10:14 pm

2 stops19h 09m

$2,263

PalermoSan Francisco

PMO - SFO

PMOSFO

Palermo Punta Raisi

Thu 7/2

12:05 pm-11:55 pm

2 stops20h 50m

$2,270

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/28

Showing 1-10 of 11 results
1
2
  • Most accurate provider: When it comes to deals on Palermo-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Palermo-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Palermo-San Francisco flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Palermo-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Palermo-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Palermo to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Palermo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Palermo to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Palermo to San Francisco?

    ITA Airways and American Airlines can get you from Palermo to San Francisco in just under 21h 12m. Your travel time can differ by up to 8h 53m. The distance from Palermo to San Francisco is about 6478 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Palermo to San Francisco one-way?

    The cheapest airlines for a one-way flight from Palermo to San Francisco are ITA Airways ($553), SWISS ($636), and Lufthansa ($664).

  • Can I find deals for flights from Palermo to San Francisco that include hotel bookings?

    Yes. In addition to deals on Palermo to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Palermo to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Palermo to San Francisco.

  • Can I find deals for business class flights from Palermo to San Francisco?

    Yes. Cheapflights offers flight deals from Palermo to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
South San Francisco
Santa Cruz
Roseville
Santa Clara
Livermore
Watsonville
San Bruno
Daly City
Sunnyvale
Turlock
Vacaville
San Carlos
San Ramon
Manteca
Vallejo
San Lorenzo
Davis
Hollister
Redwood City
Union City

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.