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$380+ Cheap flights from Palermo (PMO) to San Francisco (SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/16. Fares are subject to change and may not be available on all flights or dates of travel.
PMO — SFO
Apr 11 — Apr 181
Sat 4/11
Sat 4/18
1 adult, Economy
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Cheap flight deals from Palermo to San Francisco

Cheapest flights from Palermo to San Francisco
Explore the most affordable flight options available from Palermo to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 12, 2026.

This lol.travel deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure lol.travel is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/157:10 pm
PMO
-
SFO
1 stop26h 55m
ITA Airways
Mon 3/234:05 pm
SFO
-
PMO
1 stop33h 15m
ITA Airways
Deal found 3/8$532
This lol.travel deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure lol.travel is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/196:10 am
PMO
-
SFO
1 stop15h 55m
ITA Airways
Mon 3/234:05 pm
SFO
-
PMO
1 stop33h 15m
ITA Airways
Deal found 3/10$546
This lol.travel deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure lol.travel is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/306:10 am
PMO
-
SFO
2 stops21h 46m
ITA Airways
Tue 5/53:15 pm
SFO
-
PMO
1 stop15h 10m
ITA Airways
Deal found 3/10$550
This lol.travel deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure lol.travel is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/256:10 am
PMO
-
SFO
1 stop16h 05m
ITA Airways
Sat 5/25:30 am
SFO
-
PMO
2 stops21h 00m
ITA Airways
Deal found 3/10$552
This lol.travel deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure lol.travel is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/106:10 am
PMO
-
SFO
1 stop16h 05m
ITA Airways
Sat 4/253:15 pm
SFO
-
PMO
1 stop22h 15m
ITA Airways
Deal found 3/8$574
This ITA Airways deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure ITA Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/226:10 am
PMO
-
SFO
1 stop16h 05m
ITA Airways
Sun 4/263:15 pm
SFO
-
PMO
1 stop14h 10m
ITA Airways
Deal found 3/9$576

Find flight deals from Palermo to San Francisco

Discover tips and strategies to find the most affordable flight options for your journey from Palermo (PMO) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 12, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$548
(lol.travel)

One-way from

$380
(Kiwi.com)
Provider with most accurate pricing for Palermo Punta Raisi-San Francisco flight deals.
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Provider most trusted by Cheapflights users for Palermo Punta Raisi-San Francisco flights.
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From Palermo Punta Raisi to San Francisco
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One-way flight from Palermo Punta Raisi to San Francisco
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Palermo to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 12, 2026.
Use the filters below to find and compare flights from Palermo to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

PalermoSan Francisco

PMO - SFO

PMOSFO

Palermo Punta Raisi

Wed 4/22

6:10 am-1:15 pm

1 stop16h 05m

San Francisco

Sun 4/26

8:49 am-11:05 pm

2 stops29h 16m

$576

PalermoSan Francisco

PMO - SFO

PMOSFO

Palermo Punta Raisi

Wed 5/6

7:05 pm-1:15 pm

1 stop27h 10m

San Francisco

Sun 5/10

3:15 pm-7:45 pm

1 stop19h 30m

$578

PalermoSan Francisco

PMO - SFO

PMOSFO

Palermo Punta Raisi

Thu 4/23

12:05 pm-11:51 pm

2 stops20h 46m

San Francisco

Thu 4/30

7:30 pm-11:05 am

1 stop30h 35m

$609
Quickest round-trip

PalermoSan Francisco

PMO - SFO

PMOSFO

Palermo Punta Raisi

Fri 4/10

7:20 am-7:19 pm

2 stops20h 59m

San Francisco

Sat 4/25

3:15 pm-11:05 pm

1 stop22h 50m

$619

PalermoSan Francisco

PMO - SFO

PMOSFO

Palermo Punta Raisi

Fri 4/24

7:50 pm-1:50 pm

1 stop27h 00m

San Francisco

Fri 5/1

7:30 pm-11:15 am

1 stop30h 45m

$635

PalermoSan Francisco

PMO - SFO

PMOSFO

Palermo Punta Raisi

Thu 8/27

12:05 pm-10:39 pm

2 stops19h 34m

San Francisco

Tue 9/1

12:15 pm-11:10 am

2 stops37h 55m

$642
Cheapest one-way

PalermoSan Francisco

PMO - SFO

PMOSFO

Palermo Punta Raisi

Thu 4/16

3:05 pm-5:34 pm

3 stops59h 29m

$380

PalermoSan Francisco

PMO - SFO

PMOSFO

Palermo Punta Raisi

Tue 5/26

11:20 pm-4:35 pm

2 stops50h 15m

$428

PalermoSan Francisco

PMO - SFO

PMOSFO

Palermo Punta Raisi

Wed 4/15

8:30 pm-6:57 pm

2 stops31h 27m

$545

PalermoSan Francisco

PMO - SFO

PMOSFO

Palermo Punta Raisi

Wed 4/15

12:40 pm-11:51 pm

2 stops20h 11m

$551

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/10

Showing 1-10 of 13 resultsSorted by cheapest first
1
2
  • Most accurate provider: When it comes to deals on Palermo-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Palermo-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Palermo-San Francisco flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Palermo-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Palermo-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Palermo to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Palermo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Palermo to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Palermo to San Francisco?

    ITA Airways can get you from Palermo to San Francisco in just under 16h 05m. Your travel time can differ by up to . The distance from Palermo to San Francisco is about 6478 mi.

  • What are the cheapest airlines to fly from Palermo to San Francisco one-way?

    The cheapest airlines for a one-way flight from Palermo to San Francisco are SWISS ($636), ITA Airways ($653), and Lufthansa ($664).

  • Can I find deals for flights from Palermo to San Francisco that include hotel bookings?

    Yes. In addition to deals on Palermo to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Palermo to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Palermo to San Francisco.

  • Can I find deals for business class flights from Palermo to San Francisco?

    Yes. Cheapflights offers flight deals from Palermo to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
South San Francisco
Santa Clara
Santa Cruz
Livermore
Roseville
Watsonville
San Bruno
Sunnyvale
Vacaville
Turlock
San Carlos
San Ramon
Redwood City
Daly City
Rancho Cordova
San Lorenzo
Davis
Hollister
Manteca
Union City

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