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$225+ Cheap flights from Harrisburg to San Francisco (MDT - SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/2. Fares are subject to change and may not be available on all flights or dates of travel.
MDT — SFO
Oct 16 — Oct 231
Thu 10/16
Thu 10/23
1 adult, Economy
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Cheapflights Tip: The best prices from Harrisburg to San Francisco are usually found in September or August, booked 22 days in advance, depart on a Saturday or Tuesday and return on a Wednesday

Cheap flight deals from Harrisburg to San Francisco

Discover tips and strategies to find the most affordable flight options for your journey from Harrisburg (MDT) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 16, 2025.

Round-trip from

$309
(Delta)

One-way from

$225
(Kiwi.com)

Popular in

June

Cheapest in

September

Average price

$370
From Harrisburg to San Francisco
Search Deals
One-way flight from Harrisburg to San Francisco
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Highest demand for flights based on searches. 13% potential increase in price ($75 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($15 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Harrisburg to San Francisco

Cheapest flights from Harrisburg to San Francisco
Explore the most affordable flight options available from Harrisburg to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/316:00 amMDT - SFO
1 stop10h 33mDelta
Tue 11/411:25 amSFO - MDT
1 stop8h 35mDelta
Deal found 9/14$309
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/316:44 amMDT - SFO
2 stops11h 34mAmerican Airlines
Mon 11/311:15 pmSFO - MDT
1 stop8h 57mAmerican Airlines
Deal found 9/14$314
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1212:54 pmMDT - SFO
1 stop10h 36mAmerican Airlines
Sat 11/1512:27 amSFO - MDT
1 stop7h 26mAmerican Airlines
Deal found 9/14$339
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/316:00 amMDT - SFO
1 stop10h 33mDelta
Sat 11/16:00 amSFO - MDT
2 stops14h 00mDelta
Deal found 9/14$371
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/316:00 amMDT - SFO
1 stop10h 33mDelta
Sun 11/25:55 amSFO - MDT
1 stop7h 17mDelta
Deal found 9/14$374
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/125:40 amMDT - SFO
2 stops10h 57mAmerican Airlines
Sat 11/156:00 amSFO - MDT
2 stops9h 37mAmerican Airlines
Deal found 9/14$395
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/712:33 pmMDT - SFO
1 stop8h 18mDelta
Sun 11/166:00 amSFO - MDT
1 stop7h 15mDelta
Deal found 9/15$404
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/314:30 pmMDT - SFO
1 stop8h 14mAmerican Airlines
Fri 10/3112:50 amSFO - MDT
2 stops9h 31mAmerican Airlines
Deal found 9/14$408
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/156:30 amMDT - SFO
1 stop10h 05mUnited Airlines
Tue 10/216:30 amSFO - MDT
1 stop10h 27mUnited Airlines
Deal found 9/16$409
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/246:00 amMDT - SFO
1 stop7h 34mDelta
Sat 10/411:59 amSFO - MDT
1 stop8h 47mDelta
Deal found 9/16$414

Cheapflights Fare Finder

 
Customize your flight search to find flights from Harrisburg to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from Harrisburg to San Francisco that are best for you.

Fly from

Harrisburg

Fly to

San Francisco

Route

Depart

Return

Price

HarrisburgSan Francisco

MDT - SFO

MDTSFO

Harrisburg

Wed 11/12

6:00 am-10:49 am

1 stop7h 49m

San Francisco

Sat 11/15

11:40 am-11:09 pm

1 stop8h 29m

$309

HarrisburgSan Francisco

MDT - SFO

MDTSFO

Harrisburg

Sat 11/8

6:20 am-1:37 pm

1 stop10h 17m

San Francisco

Fri 11/14

12:27 am-11:06 am

1 stop7h 39m

$309

HarrisburgSan Francisco

MDT - SFO

MDTSFO

Harrisburg

Fri 10/31

6:30 am-11:56 am

1 stop8h 26m

San Francisco

Mon 11/3

11:20 pm-9:35 am

1 stop7h 15m

$309

HarrisburgSan Francisco

MDT - SFO

MDTSFO

Harrisburg

Wed 11/12

5:40 am-1:29 pm

2 stops10h 49m

San Francisco

Sat 11/15

1:18 pm-11:36 pm

1 stop7h 18m

$314

HarrisburgSan Francisco

MDT - SFO

MDTSFO

Harrisburg

Fri 11/7

6:25 pm-11:56 pm

1 stop8h 31m

San Francisco

Sat 11/15

11:40 am-11:09 pm

1 stop8h 29m

$339

HarrisburgSan Francisco

MDT - SFO

MDTSFO

Harrisburg

Wed 11/12

6:00 am-2:02 pm

1 stop11h 02m

San Francisco

Sun 11/16

11:18 pm-11:12 am

1 stop8h 54m

$339

HarrisburgSan Francisco

MDT - SFO

MDTSFO

Harrisburg

Sat 10/4

4:45 pm-9:50 pm

1 stop8h 05m

San Francisco

Sat 10/18

11:56 pm-11:00 am

1 stop8h 04m

$339

HarrisburgSan Francisco

MDT - SFO

MDTSFO

Harrisburg

Thu 10/2

8:21 pm-12:16 am

3 stops30h 55m

$225

HarrisburgSan Francisco

MDT - SFO

MDTSFO

Harrisburg

Fri 10/3

11:07 am-12:16 am

2 stops16h 09m

$230

HarrisburgSan Francisco

MDT - SFO

MDTSFO

Harrisburg

Tue 10/21

3:07 pm-8:44 pm

1 stop8h 37m

$295

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 17 results
1
2

Best time to book a flight from Harrisburg to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Harrisburg with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Harrisburg to San Francisco

How far ahead should I book a flight from Harrisburg to San Francisco?

Use this chart to determine the optimal time to book a round-trip flight from Harrisburg to San Francisco. Price data was last updated on September 12, 2025.

The best time to book flights from Harrisburg to San Francisco is 22 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Harrisburg to San Francisco?

Currently, January is the cheapest month in which you can book a flight from Harrisburg to San Francisco (average of $276). Flying from Harrisburg to San Francisco in June is currently the most expensive (average of $357). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MDT to SFO?

Find hourly flight availability from Harrisburg to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 16, 2025.

A simple way to save on the total cost of your ticket is to fly from Harrisburg to San Francisco at noon. If you’re flexible enough to do this you can expect to save up to 23% on your trip compared to booking a flight in the morning.

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated September 16, 2025.
Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Harrisburg to San Francisco by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,957 reviews

Food

7.3

Comfort

7.9

Entertainment

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
8.0
Very good
7,957 reviews
Delta
8.0
Very good
7,957 reviews

Food

7.3

Comfort

7.9

Entertainment

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
United Airlines
7.4
Good
8,924 reviews
Delta
8.0
Very good
7,957 reviews

Food

7.3

Comfort

7.9

Entertainment

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,957 reviews

Food

7.3

Comfort

7.9

Entertainment

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Frontier
5.8
Fair
3,174 reviews
Delta
8.0
Very good
7,957 reviews

Food

7.3

Comfort

7.9

Entertainment

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Harrisburg to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Harrisburg to San Francisco?

    Airlines like Delta, American Airlines, and United Airlines fly from Harrisburg to San Francisco in about 7h 49m. The time it takes to get you to your destination can typically vary by up to 2h 28m. Harrisburg and San Francisco are separated by a distance of 2430 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Harrisburg to San Francisco round-trip?

    Cheapflights users have booked flights from Harrisburg to San Francisco round-trip from $308. Other airlines that can offer you cheap pricing are United Airlines, from $308, and Delta, from $308. You may be able to fly from Harrisburg to San Francisco for 34% less than the average price by searching for these airlines.

  • Can I find deals for flights from Harrisburg to San Francisco that include hotel bookings?

    Yes. In addition to deals on Harrisburg to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Harrisburg to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Harrisburg to San Francisco.

  • Can I find deals for business class flights from Harrisburg to San Francisco?

    Yes. Cheapflights offers flight deals from Harrisburg to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Harrisburg to San Francisco?

    Currently, January is the cheapest month in which you can book a flight from Harrisburg to San Francisco (average of $276). Flying from Harrisburg to San Francisco in June is currently the most expensive (average of $357). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Roseville
Santa Cruz
Livermore
South San Francisco
Turlock
Antioch
Watsonville
Santa Clara
Manteca
Sunnyvale
Hollister
Vacaville
Foster City
Union City
Vallejo
Burlingame
Redwood City
San Mateo
San Leandro
Lathrop

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Harrisburg to San Francisco

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Top 4 airlines flying from Harrisburg to San Francisco

Discover the top 4 airlines that operate flights from Harrisburg to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$308Average$483FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$308Average$531FlexibilityNo cancel feeOn-time69%
DeltaCheapest$308Average$417FlexibilityNo cancel feeOn-timeN/A
FrontierCheapest$350Average$448FlexibilityNo cancel feeOn-time62%

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