$252+ Cheap flights from Grand Cayman to San Francisco (SFO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/26. Fares are subject to change and may not be available on all flights or dates of travel.
GCM — SFO
Mar 14 — Mar 211
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Grand Cayman to San Francisco with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Grand Cayman to San Francisco
Cheapest
Best
Last-minute
One-way
Cheapest flights from Grand Cayman to San FranciscoExplore the most affordable flight options available from Grand Cayman to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 12, 2026.
Explore the most affordable flight options available from Grand Cayman to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 12, 2026.
This Southwest deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/141:05 pm
GCM
- SFO
2 stops13h 15m
Southwest
Mon 5/187:15 pm
SFO
- GCM
2 stops14h 55m
Southwest
Deal found 2/9![Southwest logo]()
$452
This Expedia deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/142:05 pm
GCM
- SFO
1 stop23h 04m
JetBlue
Mon 5/188:00 am
SFO
- GCM
1 stop26h 45m
JetBlue
Deal found 2/9![JetBlue logo]()
$560
This JetBlue deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/242:30 pm
GCM
- SFO
1 stop10h 40m
JetBlue
Fri 10/309:00 pm
SFO
- GCM
1 stop14h 31m
JetBlue
Deal found 2/11![JetBlue logo]()
$578
This Southwest deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/2412:40 pm
GCM
- SFO
2 stops13h 05m
Southwest
Thu 3/267:05 pm
SFO
- GCM
2 stops14h 40m
Southwest
Deal found 2/9![Southwest logo]()
$725
This Delta deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/141:19 pm
GCM
- SFO
1 stop13h 27m
Delta
Mon 5/184:10 pm
SFO
- GCM
2 stops17h 44m
Delta
Deal found 2/9![Delta logo]()
$732
This Orbitz deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/252:40 pm
GCM
- SFO
1 stop21h 38m
Multiple Airlines
Sat 10/3110:20 pm
SFO
- GCM
1 stop15h 40m
Multiple Airlines
Deal found 2/11![Multiple Airlines logo]()
$733
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/132:15 pm
GCM
- SFO
1 stop10h 55m
American Airlines
Thu 3/1912:25 am
SFO
- GCM
1 stop10h 48m
American Airlines
Deal found 2/11![American Airlines logo]()
$741
This Air Canada deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/1312:25 pm
GCM
- SFO
1 stop24h 25m
Air Canada
Wed 6/171:40 pm
SFO
- GCM
1 stop19h 50m
Air Canada
Deal found 2/12![Air Canada logo]()
$745
This Delta deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/2512:55 pm
GCM
- SFO
1 stop11h 56m
Delta
Sun 11/110:30 pm
SFO
- GCM
1 stop11h 10m
Delta
Deal found 2/11![Delta logo]()
$757
Best flights from Grand Cayman to San FranciscoDiscover carefully curated flight deals from Grand Cayman to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 12, 2026.
Discover carefully curated flight deals from Grand Cayman to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 12, 2026.
This Southwest deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/141:05 pm
GCM
- SFO
2 stops13h 15m
Southwest
Mon 5/187:15 pm
SFO
- GCM
2 stops14h 55m
Southwest
Deal found 2/9![Southwest logo]()
$452
This Expedia deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/142:05 pm
GCM
- SFO
1 stop23h 04m
JetBlue
Mon 5/188:00 am
SFO
- GCM
1 stop26h 45m
JetBlue
Deal found 2/9![JetBlue logo]()
$560
This Delta deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/141:19 pm
GCM
- SFO
1 stop13h 27m
Delta
Mon 5/184:10 pm
SFO
- GCM
2 stops17h 44m
Delta
Deal found 2/9![Delta logo]()
$732
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/132:15 pm
GCM
- SFO
1 stop10h 55m
American Airlines
Thu 3/1912:25 am
SFO
- GCM
1 stop10h 48m
American Airlines
Deal found 2/11![American Airlines logo]()
$741
This Air Canada deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/1312:25 pm
GCM
- SFO
1 stop24h 25m
Air Canada
Wed 6/171:40 pm
SFO
- GCM
1 stop19h 50m
Air Canada
Deal found 2/10![Air Canada logo]()
$745
This Southwest deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/2412:40 pm
GCM
- SFO
2 stops13h 05m
Southwest
Thu 3/267:05 pm
SFO
- GCM
2 stops14h 40m
Southwest
Deal found 2/9![Southwest logo]()
$725
Last-minute flights from Grand Cayman to San FranciscoDiscover last-minute flight deals from Grand Cayman to San Francisco. Data last updated February 12, 2026 and is based on user searches.
Discover last-minute flight deals from Grand Cayman to San Francisco. Data last updated February 12, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/218:50 am
GCM
- SFO
2 stops50h 13m
Multiple Airlines
Sat 2/285:20 pm
SFO
- GCM
1 stop19h 40m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$772
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/214:25 pm
GCM
- SFO
1 stop19h 46m
American Airlines
Sat 2/2811:35 pm
SFO
- GCM
1 stop12h 50m
American Airlines
Deal found 2/10![American Airlines logo]()
$991
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/132:15 pm
GCM
- SFO
1 stop10h 55m
American Airlines
Thu 3/1912:25 am
SFO
- GCM
1 stop10h 48m
American Airlines
Deal found 2/11![American Airlines logo]()
$741
This Southwest deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/2412:40 pm
GCM
- SFO
2 stops13h 05m
Southwest
Thu 3/267:05 pm
SFO
- GCM
2 stops14h 40m
Southwest
Deal found 2/9![Southwest logo]()
$725
This Orbitz deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/242:25 pm
GCM
- SFO
1 stop21h 24m
Multiple Airlines
Thu 3/262:30 pm
SFO
- GCM
1 stop18h 55m
Multiple Airlines
Deal found 2/9![Multiple Airlines logo]()
$761
This deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/244:45 pm
GCM
- SFO
1 stop9h 14m
United Airlines
Thu 3/265:00 am
SFO
- GCM
1 stop8h 30m
United Airlines
Deal found 2/10![United Airlines logo]()
$812
One-way flights from Grand Cayman to San FranciscoSearch for one-way flight options from Grand Cayman to San Francisco. Find affordable one-way fares based on user searches. Data last updated February 12, 2026.
Search for one-way flight options from Grand Cayman to San Francisco. Find affordable one-way fares based on user searches. Data last updated February 12, 2026.
This JetBlue deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/263:15 pm
GCM
- SFO
1 stop11h 44m
JetBlue
Deal found 2/8![JetBlue logo]()
$252
This Kiwi.com deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/262:49 pm
GCM
- SFO
2 stops33h 50m
Multiple Airlines
Deal found 2/8![Multiple Airlines logo]()
$269
This Priceline deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/102:15 pm
GCM
- SFO
1 stop21h 14m
JetBlue
Deal found 2/11![JetBlue logo]()
$278
This Trip.com deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/277:00 am
GCM
- SFO
2 stops17h 39m
Multiple Airlines
Deal found 2/8![Multiple Airlines logo]()
$291
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/121:52 pm
GCM
- SFO
3 stops59h 33m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$304
This Kiwi.com deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/1011:30 am
GCM
- SFO
3 stops36h 08m
Multiple Airlines
Deal found 2/11![Multiple Airlines logo]()
$309
This Kiwi.com deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/12:49 pm
GCM
- SFO
2 stops33h 50m
Multiple Airlines
Deal found 2/8![Multiple Airlines logo]()
$310
This Kiwi.com deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/2511:30 am
GCM
- SFO
2 stops37h 09m
Multiple Airlines
Deal found 2/8![Multiple Airlines logo]()
$312
This Southwest deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/2312:45 pm
GCM
- SFO
2 stops14h 05m
Southwest
Deal found 2/10![Southwest logo]()
$339
This Orbitz deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2711:25 am
GCM
- SFO
1 stop29h 55m
Air Canada
Deal found 2/10![Air Canada logo]()
$341
Find flight deals from Grand Cayman to San Francisco
Keep the following information in mind while searching for Grand Cayman to San Francisco flight deals. Data was last updated February 12, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $452 (Southwest) |
One-way from | $252 (JetBlue) |
Cheapflights Fare Finder
Customize your flight search to find flights from Grand Cayman to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 12, 2026.
Use the filters below to find and compare flights from Grand Cayman to San Francisco that are best for you.
Fly from
Grand Cayman
Fly to
San Francisco
Route
Depart
Return
Price
George TownSan Francisco
GCM - SFO
GCMSFO
George Town Owen Roberts Intl
Thu 5/14
1:05 pm-12:20 am
2 stops13h 15m
San Francisco
Mon 5/18
7:15 pm-12:10 pm
2 stops14h 55m
$452
George TownSan Francisco
GCM - SFO
GCMSFO
George Town Owen Roberts Intl
Thu 5/14
2:05 pm-11:09 am
1 stop23h 04m
San Francisco
Mon 5/18
8:00 am-12:45 pm
1 stop26h 45m
$560
George TownSan Francisco
GCM - SFO
GCMSFO
George Town Owen Roberts Intl
Tue 3/24
12:40 pm-11:45 pm
2 stops13h 05m
San Francisco
Thu 3/26
7:05 pm-11:45 am
2 stops14h 40m
$725
George TownSan Francisco
GCM - SFO
GCMSFO
George Town Owen Roberts Intl
Thu 5/14
1:19 pm-12:46 am
1 stop13h 27m
San Francisco
Mon 5/18
4:10 pm-11:54 am
2 stops17h 44m
$732
George TownSan Francisco
GCM - SFO
GCMSFO
George Town Owen Roberts Intl
Fri 3/13
2:15 pm-11:10 pm
1 stop10h 55m
San Francisco
Thu 3/19
12:25 am-1:13 pm
1 stop10h 48m
$741
George TownSan Francisco
GCM - SFO
GCMSFO
George Town Owen Roberts Intl
Sat 6/13
12:25 pm-10:50 am
1 stop24h 25m
San Francisco
Wed 6/17
1:40 pm-11:30 am
1 stop19h 50m
$745
George TownSan Francisco
GCM - SFO
GCMSFO
George Town Owen Roberts Intl
Sat 2/28
2:50 pm-11:59 pm
1 stop12h 09m
$252
George TownSan Francisco
GCM - SFO
GCMSFO
George Town Owen Roberts Intl
Thu 2/26
3:15 pm-11:59 pm
1 stop11h 44m
$252
George TownSan Francisco
GCM - SFO
GCMSFO
George Town Owen Roberts Intl
Thu 2/26
2:49 pm-9:39 pm
2 stops33h 50m
$269
George TownSan Francisco
GCM - SFO
GCMSFO
George Town Owen Roberts Intl
Fri 2/27
7:00 am-9:39 pm
2 stops17h 39m
$291
Showing 1-10 of 16 results
Best time to book a flight from Grand Cayman to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Grand Cayman with our price prediction graph.
GCM-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Grand Cayman to San Francisco
zzLAW-SFO
GCM-SFO
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated February 12, 2026.
Read reviews from past customers who have flown American Airlines from Grand Cayman to San Francisco. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.2
Crew
8.0
Boarding
7.5
Food
6.4
Entertainment
6.9
Overall
7.2
Reviews
1 / 20
2.0
MediocreSusie,Jan 2026
CLT - TPA
Comfort
7.2
Crew
8.0
Boarding
7.5
Food
6.4
Entertainment
6.9
Overall
7.2
Reviews
1 / 20
2.0
MediocreSusie,Jan 2026
CLT - TPA
Related info for your journey
Find useful and relevant information for your journey from Grand Cayman to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSanta Cruz
South San Francisco
Santa Clara
Roseville
Livermore
Watsonville
San Bruno
Daly City
Sunnyvale
Turlock
Vacaville
San Carlos
San Ramon
Redwood City
Rancho Cordova
San Lorenzo
Davis
Hollister
Manteca
Union City
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
San Francisco flight routes
Alternative routes for Grand Cayman to San Francisco
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to San Francisco by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Grand Cayman to San Francisco by cabin class
Find flights from Grand Cayman to San Francisco, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Grand Cayman and San Francisco flights
Browse other Grand Cayman and San Francisco flight options. Last updated on February 12, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to San Francisco
Explore flights to San Francisco departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on February 12, 2026.
Top airline flying from Grand Cayman to San Francisco
Discover the top airline that operate flights from Grand Cayman to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 12, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$709 | Average$1,161 | FlexibilityNo cancel fee | On-time71% |