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$182+ Cheap flights from Irvine, CA to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/12. Fares are subject to change and may not be available on all flights or dates of travel.
LAX — PTY
nov. 29 — dic. 61
sáb. 11/29
sáb. 12/6
1 adult, Economy
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Find flight deals from Irvine to Panama

Cheapest flights from Irvine to Panama
Explore the most affordable flight options available from Irvine to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on octubre 30, 2025.

This Cheapflightsfares deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 11/111:00 pmLAX - PTY
1 stop18h 30mAvianca
dom. 11/167:50 pmPTY - LAX
1 stop18h 45mAvianca
Deal found 10/30$536
This Cheapflightsfares deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/81:00 pmLAX - PTY
1 stop18h 30mAvianca
vie. 11/142:55 amPTY - LAX
2 stops21h 20mAvianca
Deal found 10/30$537
This Cheapflightsfares deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 11/511:20 pmLAX - PTY
1 stop8h 10mAvianca
vie. 11/75:50 pmPTY - LAX
2 stops20h 45mAvianca
Deal found 10/29$540
This Mytrip deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 11/1111:20 pmLAX - PTY
2 stops22h 20mMultiple Airlines
dom. 11/1611:25 amPTY - LAX
3 stops23h 49mMultiple Airlines
Deal found 10/30$545
This Cheapflightsfares deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/81:00 pmLAX - PTY
1 stop18h 30mAvianca
dom. 11/167:50 pmPTY - LAX
1 stop18h 45mAvianca
Deal found 10/30$546
This Cheapflightsfares deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/131:00 pmLAX - PTY
1 stop18h 30mAvianca
jue. 11/209:45 amPTY - LAX
2 stops15h 15mAvianca
Deal found 10/30$547
This Cheapflightsfares deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 11/712:25 pmLAX - PTY
2 stops19h 05mAvianca
lun. 11/103:50 pmPTY - LAX
1 stop9h 10mAvianca
Deal found 10/29$549
This Cheapflightsfares deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/1311:20 pmLAX - PTY
1 stop8h 10mAvianca
lun. 11/173:50 pmPTY - LAX
1 stop9h 10mAvianca
Deal found 10/30$551
This Cheapflightsfares deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 11/712:25 pmLAX - PTY
2 stops19h 05mAvianca
dom. 11/167:50 pmPTY - LAX
1 stop18h 45mAvianca
Deal found 10/30$559
This Cheapflightsfares deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/91:00 pmLAX - PTY
1 stop18h 30mAvianca
vie. 11/142:55 amPTY - LAX
2 stops21h 20mAvianca
Deal found 10/28$561
This FlightHub deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/1511:55 pmLAX - PTY
1 stop16h 00mAvianca
sáb. 11/223:50 pmPTY - LAX
1 stop9h 10mAvianca
Deal found 10/29$564
This Copa Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/1212:47 amLAX - DAV
1 stop13h 37mCopa Airlines
sáb. 12/208:32 amDAV - LAX
1 stop10h 33mCopa Airlines
Deal found 10/29$808

Cheap flight deals from Irvine to Panama

Keep the following information in mind while searching for Irvine to Panama flight deals. Data was last updated octubre 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$498
(Mytrip)

One-way from

$182
(Kiwi.com)

Popular in

December

Cheapest in

August

Average price

$662
Provider with most accurate pricing for Los Angeles-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Los Angeles-Panama City Tocumen Intl flights.
Search Deals
From Irvine to Panama
Search Deals
One-way flight from Irvine to Panama
Search Deals
Highest demand for flights based on searches. 4% potential increase in price ($28 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($8 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Irvine to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 30, 2025.
Use the filters below to find and compare flights from Irvine to Panama that are best for you.

Fly from

Irvine

Fly to

Panama

Route

Depart

Return

Price

Los AngelesPanama City

LAX - PTY

LAXPTY

Los Angeles

jue. 1/29

10:25 pm-10:30 am

1 stop9h 05m

Panama City Tocumen Intl

mar. 2/3

2:55 am-9:15 pm

2 stops21h 20m

$538

Los AngelesPanama City

LAX - PTY

LAXPTY

Los Angeles

jue. 1/29

11:55 pm-4:55 pm

2 stops14h 00m

Panama City Tocumen Intl

mié. 2/4

11:25 am-8:17 am

3 stops23h 52m

$540

Los AngelesPanama City

LAX - PTY

LAXPTY

Los Angeles

jue. 4/16

2:50 pm-10:10 am

3 stops17h 20m

Panama City Tocumen Intl

dom. 4/19

10:05 pm-12:30 pm

2 stops16h 25m

$564

Los AngelesPanama City

LAX - PTY

LAXPTY

Los Angeles

mié. 2/11

9:08 pm-6:37 am

Nonstop6h 29m

Panama City Tocumen Intl

sáb. 2/28

6:24 pm-10:39 pm

Nonstop7h 15m

$598

Los AngelesPanama City

LAX - PTY

LAXPTY

Los Angeles

mié. 1/28

1:11 am-10:25 am

Nonstop6h 14m

Panama City Tocumen Intl

mié. 2/4

6:14 pm-10:29 pm

Nonstop7h 15m

$598

Los AngelesPanama City

LAX - PTY

LAXPTY

Los Angeles

lun. 2/2

9:08 pm-6:37 am

Nonstop6h 29m

Panama City Tocumen Intl

lun. 2/23

6:14 pm-10:29 pm

Nonstop7h 15m

$598

Los AngelesPanama City

LAX - PTY

LAXPTY

Los Angeles

sáb. 4/18

12:11 pm-8:39 pm

Nonstop6h 28m

Panama City Tocumen Intl

sáb. 4/25

7:55 am-1:00 pm

Nonstop7h 05m

$598

Los AngelesPanama City

LAX - PTY

LAXPTY

Los Angeles

jue. 3/19

2:06 am-10:25 am

Nonstop6h 19m

Panama City Tocumen Intl

dom. 3/29

6:24 pm-11:11 pm

Nonstop6h 47m

$598

Los AngelesDavid

LAX - DAV

LAXDAV

Los Angeles

vie. 12/12

12:47 am-5:24 pm

1 stop13h 37m

David Enrique Malek

sáb. 12/20

8:32 am-4:05 pm

1 stop10h 33m

$808

Los AngelesDavid

LAX - DAV

LAXDAV

Los Angeles

sáb. 12/13

11:05 am-7:50 am

1 stop17h 45m

David Enrique Malek

sáb. 12/20

8:32 am-6:10 am

2 stops24h 38m

$1,404

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/30

Showing 1-10 of 26 results
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Best time to book a flight from Irvine to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Irvine with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Irvine to Panama

What is the cheapest month to book a flight from Irvine to Panama?

Currently, August is the cheapest month in which you can book a flight from Irvine to Panama (average of $300). Flying from Irvine to Panama in April is currently the most expensive (average of $466). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IR9 to PA?

Find hourly flight availability from Irvine to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated octubre 30, 2025.

A simple way to save on the total cost of your ticket is to fly from Irvine to Panama in the morning. If you’re flexible enough to do this you can expect to save up to 20% on your trip compared to booking a flight in the evening.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated octubre 30, 2025.
Get a feel of what it's like to fly with Delta, Copa Airlines, and United Airlines from Irvine to Panama by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Overall

7.9

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
7.9
Good
7,998 reviews
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Overall

7.9

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Copa Airlines
7.6
Good
1,561 reviews
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Overall

7.9

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
United Airlines
7.4
Good
8,996 reviews
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Overall

7.9

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
American Airlines
7.2
Good
11,034 reviews
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Overall

7.9

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Avianca
6.6
Okay
2,467 reviews
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Overall

7.9

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from Irvine to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Irvine to Panama flight route?

    The Irvine to Panama flight path was viewed by 141 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Irvine to Panama?

    There are many flights that can get you from Irvine to Panama in 9h 05m. Fly via Avianca, Copa Airlines, or United Airlines to get the fastest option. Airlines will cover a distance of 3009 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Irvine to Panama?

    The most popular flight routes from Irvine to Panama are Los Angeles - Panama City Tocumen Intl, Los Angeles - David Enrique Malek and Los Angeles - Panama City Marcos A. Gelabert Intl.

  • What are the most reliable airlines from Irvine to Panama?

    Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Irvine to Panama on time: EVA Air (95%), Asiana Airlines (95%), United Airlines (95%).

  • What are the cheapest flights from Irvine to Panama?

    Looking for the cheapest flight from Irvine to Panama? While on average our users pay $1,175, our data indicates the cheapest price to be $169. The most popular route (Los Angeles - Panama City Tocumen Intl), is priced around $525.

  • Can I find deals for flights from Irvine to Panama that include hotel bookings?

    Yes. In addition to deals on Irvine to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Irvine to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Irvine to Panama.

  • Can I find deals for business class flights from Irvine to Panama?

    Yes. Cheapflights offers flight deals from Irvine to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Irvine to Panama?

    Currently, August is the cheapest month in which you can book a flight from Irvine to Panama (average of $300). Flying from Irvine to Panama in April is currently the most expensive (average of $466). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Irvine to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from Irvine to Panama

Discover the top 5 airlines that operate flights from Irvine to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$203Average$542FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$299Average$652FlexibilityNo cancel feeOn-time69%
AviancaCheapest$320Average$501FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$504Average$718FlexibilityNo cancel feeOn-time70%
DeltaCheapest$519Average$716FlexibilityNo cancel feeOn-timeN/A

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