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$212+ Cheap flights from Irvine, CA to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/6. Fares are subject to change and may not be available on all flights or dates of travel.
LAX — PTY
Jul 6 — Jul 131
Sun 7/6
Sun 7/13
1 adult, Economy
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Cheap flight deals from Irvine to Panama

Keep the following information in mind while searching for Irvine to Panama flight deals. Data was last updated July 1, 2025.

Round-trip from

$494
(Gotogate)

One-way from

$212
(Kiwi.com)

Popular in

December

Cheapest in

September

Average price

$519
From Irvine to Panama
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One-way flight from Irvine to Panama
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($39 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($11 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from Irvine to Panama

Cheapest flights from Irvine to Panama
Explore the most affordable flight options available from Irvine to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 1, 2025.

This Gotogate deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/142:01 amLAX - PTY
Nonstop6h 34mCopa Airlines
Fri 8/226:14 pmPTY - LAX
Nonstop6h 48mCopa Airlines
Deal found 7/1$494
This Mytrip deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1311:50 pmLAX - PTY
1 stop12h 55mAvianca
Sat 9/203:40 pmPTY - LAX
1 stop8h 50mAvianca
Deal found 6/30$502
This Mytrip deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/147:58 pmLAX - PTY
3 stops23h 12mMultiple Airlines
Mon 8/183:25 amPTY - LAX
3 stops21h 59mMultiple Airlines
Deal found 6/30$511
This Delta deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/319:45 pmLAX - PTY
1 stop19h 46mDelta
Wed 8/62:28 pmPTY - LAX
1 stop20h 05mDelta
Deal found 7/1$512
This United Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/2812:56 amLAX - PTY
1 stop15h 41mUnited Airlines
Wed 8/63:30 pmPTY - LAX
1 stop10h 08mUnited Airlines
Deal found 6/30$519
This American Airlines deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/312:40 amLAX - PTY
2 stops11h 35mAmerican Airlines
Thu 8/73:30 pmPTY - LAX
2 stops18h 39mAmerican Airlines
Deal found 6/29$524
This Copa Airlines deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/612:52 amLAX - DAV
1 stop29h 15mCopa Airlines
Sun 11/99:50 amDAV - LAX
1 stop15h 54mCopa Airlines
Deal found 6/29$765
This United Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1312:56 amLAX - DAV
2 stops30h 03mUnited Airlines
Thu 8/219:44 amDAV - LAX
2 stops38h 11mUnited Airlines
Deal found 6/30$924
This Kiwi.com deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/1310:04 pmLAX - DAV
1 stop8h 56mMultiple Airlines
Sun 8/36:18 pmDAV - LAX
2 stops30h 12mMultiple Airlines
Deal found 7/1$1,410

Cheapflights Fare Finder

Customize your flight search to find flights from Irvine to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 1, 2025.
Use the filters below to find and compare flights from Irvine to Panama that are best for you.

Fly from

Irvine

Fly to

Panama

Route

Depart

Return

Price

Los AngelesPanama City

LAX - PTY

LAXPTY

Los Angeles

Thu 8/14

2:01 am-10:35 am

Nonstop6h 34m

Panama City Tocumen Intl

Fri 8/22

6:14 pm-11:02 pm

Nonstop6h 48m

$494

Los AngelesPanama City

LAX - PTY

LAXPTY

Los Angeles

Sat 9/13

11:50 pm-2:45 pm

1 stop12h 55m

Panama City Tocumen Intl

Sat 9/20

3:40 pm-10:30 pm

1 stop8h 50m

$502

Los AngelesPanama City

LAX - PTY

LAXPTY

Los Angeles

Thu 8/14

7:58 pm-9:10 pm

3 stops23h 12m

Panama City Tocumen Intl

Mon 8/18

3:25 am-11:24 pm

3 stops21h 59m

$511

Los AngelesPanama City

LAX - PTY

LAXPTY

Los Angeles

Thu 7/31

9:45 pm-7:31 pm

1 stop19h 46m

Panama City Tocumen Intl

Wed 8/6

2:28 pm-8:33 am

1 stop20h 05m

$512

Los AngelesPanama City

LAX - PTY

LAXPTY

Los Angeles

Sun 8/3

12:40 am-2:15 pm

2 stops11h 35m

Panama City Tocumen Intl

Thu 8/7

3:30 pm-8:09 am

2 stops18h 39m

$524

Los AngelesPanama City

LAX - PTY

LAXPTY

Los Angeles

Sun 7/27

12:56 am-6:37 pm

1 stop15h 41m

Panama City Tocumen Intl

Mon 8/4

3:30 pm-11:38 pm

1 stop10h 08m

$534

Los AngelesDavid

LAX - DAV

LAXDAV

Los Angeles

Wed 8/13

12:56 am-8:59 am

2 stops30h 03m

David Enrique Malek

Thu 8/21

9:44 am-9:55 pm

2 stops38h 11m

$924

Los AngelesDavid

LAX - DAV

LAXDAV

Los Angeles

Sat 7/12

1:59 am-9:00 am

1 stop29h 01m

David Enrique Malek

Sun 8/3

6:18 pm-4:46 pm

1 stop24h 28m

$1,227

Los AngelesDavid

LAX - DAV

LAXDAV

Los Angeles

Sun 7/13

10:04 pm-9:00 am

1 stop8h 56m

David Enrique Malek

Sun 8/3

6:18 pm-10:30 pm

2 stops30h 12m

$1,410

Los AngelesPanama City

LAX - PTY

LAXPTY

Los Angeles

Sat 9/6

2:31 pm-2:40 pm

3 stops22h 09m

$212

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/30

Showing 1-10 of 18 results
1
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Best time to book a flight from Irvine to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Irvine with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Irvine to Panama

What is the cheapest month to book a flight from Irvine to Panama?

Currently, October is the cheapest month in which you can book a flight from Irvine to Panama (average of $478). Flying from Irvine to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IR9 to PA?

Find hourly flight availability from Irvine to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 1, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Irvine to Panama as you normally would.

What is the cheapest day to fly from Irvine to Panama?

Use this chart to determine the cheapest time to fly round-trip from Irvine to Panama. Price data was last updated on June 30, 2024.

Travelers seeking maximum savings on their Irvine to Panama flight should consider departing on Wednesday mornings when fares are most often at their lowest. Monday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Irvine to Panama

Explore weekly flight availability from Irvine to Panama. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated July 1, 2025.

The most flights from IR9 to PA0 are scheduled on a Tuesday (9 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (8 on average).

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated July 1, 2025.
Get a feel of what it's like to fly with Delta, Copa Airlines, and United Airlines from Irvine to Panama by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,974 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
8.0
Very good
7,974 reviews
Delta
8.0
Very good
7,974 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Copa Airlines
7.5
Good
1,465 reviews
Delta
8.0
Very good
7,974 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
United Airlines
7.4
Good
8,858 reviews
Delta
8.0
Very good
7,974 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,974 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Avianca
6.7
Okay
2,362 reviews
Delta
8.0
Very good
7,974 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from Irvine to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Irvine to Panama flight route?

    The Irvine to Panama flight path was viewed by 162 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines to fly from Irvine to Panama one-way?

    The cheapest airline one-way is Avianca, with whom users have recently found tickets for as low as $218. However, be on the lookout for offers from Copa Airlines and Delta, as they are both options that can get you from Irvine to Panama for a low price.

  • What are the most popular routes from Irvine to Panama?

    The most popular flight routes from Irvine to Panama are Los Angeles - Panama City Tocumen Intl, Los Angeles - David Enrique Malek and Los Angeles - Panama City Marcos A. Gelabert Intl.

  • What are the most reliable airlines from Irvine to Panama?

    Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Irvine to Panama on time: EVA Air (95%), Asiana Airlines (95%), United Airlines (95%).

  • What are the cheapest flights from Irvine to Panama?

    Looking for the cheapest flight from Irvine to Panama? While on average our users pay $1,228, our data indicates the cheapest price to be $174. The most popular route (Los Angeles - Panama City Tocumen Intl), is priced around $495.

  • Can I find deals for flights from Irvine to Panama that include hotel bookings?

    Yes. In addition to deals on Irvine to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Irvine to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Irvine to Panama.

  • Can I find deals for business class flights from Irvine to Panama?

    Yes. Cheapflights offers flight deals from Irvine to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Irvine to Panama?

    Currently, October is the cheapest month in which you can book a flight from Irvine to Panama (average of $478). Flying from Irvine to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Irvine to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from Irvine to Panama

Discover the top 5 airlines that operate flights from Irvine to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$203Average$624FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$299Average$660FlexibilityNo cancel feeOn-time69%
AviancaCheapest$333Average$501FlexibilityNo cancel feeOn-time71%
DeltaCheapest$339Average$715FlexibilityNo cancel feeOn-timeN/A
Copa AirlinesCheapest$493Average$677FlexibilityNo cancel feeOn-time70%

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