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$212+ Cheap flights from Irvine, CA to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/4. Fares are subject to change and may not be available on all flights or dates of travel.
LAX — PTY
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheap flight deals from Irvine to Panama

Keep the following information in mind while searching for Irvine to Panama flight deals. Data was last updated September 15, 2025.

Round-trip from

$489
(Mytrip)

One-way from

$212
(Kiwi.com)

Popular in

December

Cheapest in

September

Average price

$518
From Irvine to Panama
Search Deals
One-way flight from Irvine to Panama
Search Deals
Highest demand for flights based on searches. 4% potential increase in price ($28 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Irvine to Panama

Cheapest flights from Irvine to Panama
Explore the most affordable flight options available from Irvine to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This Cheapflightsfares deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/1511:50 pmLAX - PTY
1 stop8h 35mAvianca
Fri 9/193:40 pmPTY - LAX
1 stop8h 50mAvianca
Deal found 9/15$488
This Mytrip deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/27:50 pmLAX - PTY
3 stops26h 55mMultiple Airlines
Mon 10/63:25 amPTY - LAX
3 stops30h 52mMultiple Airlines
Deal found 9/14$489
This Cheapflightsfares deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/162:50 pmLAX - PTY
3 stops17h 20mAvianca
Mon 9/223:40 pmPTY - LAX
1 stop8h 50mAvianca
Deal found 9/13$490
This Cheapflightsfares deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/132:50 pmLAX - PTY
3 stops17h 20mAvianca
Sat 9/208:10 pmPTY - LAX
2 stops17h 50mAvianca
Deal found 9/13$492
This Cheapflightsfares deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/141:00 amLAX - PTY
1 stop13h 15mAvianca
Mon 9/2910:05 pmPTY - LAX
2 stops16h 25mAvianca
Deal found 9/13$494
This Mytrip deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2912:09 amLAX - PTY
2 stops18h 10mMultiple Airlines
Thu 11/612:03 pmPTY - LAX
1 stop12h 36mMultiple Airlines
Deal found 9/15$497
This Mytrip deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/81:00 pmLAX - PTY
2 stops16h 50mMultiple Airlines
Wed 11/127:50 pmPTY - LAX
1 stop17h 45mMultiple Airlines
Deal found 9/14$518
This KAYAK deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/102:01 amLAX - DAV
1 stop13h 28mCopa Airlines
Tue 10/219:44 amDAV - LAX
1 stop15h 28mCopa Airlines
Deal found 9/13$647
This KAYAK deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/192:01 amLAX - DAV
1 stop13h 28mCopa Airlines
Thu 10/309:52 amDAV - LAX
1 stop15h 20mCopa Airlines
Deal found 9/13$838
This KAYAK deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/212:47 amLAX - DAV
1 stop13h 37mCopa Airlines
Mon 11/109:53 amDAV - LAX
1 stop15h 41mCopa Airlines
Deal found 9/13$869
This oojo deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/111:50 pmLAX - DAV
2 stops25h 39mMultiple Airlines
Tue 10/216:17 pmDAV - LAX
2 stops30h 53mMultiple Airlines
Deal found 9/15$918
This Copa Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/211:46 amLAX - DAV
1 stop13h 43mCopa Airlines
Sun 9/289:42 amDAV - LAX
1 stop9h 04mCopa Airlines
Deal found 9/14$1,009

Cheapflights Fare Finder

 
Customize your flight search to find flights from Irvine to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Irvine to Panama that are best for you.

Fly from

Irvine

Fly to

Panama

Route

Depart

Return

Price

Los AngelesPanama City

LAX - PTY

LAXPTY

Los Angeles

Thu 1/15

10:55 pm-10:20 am

1 stop8h 25m

Panama City Tocumen Intl

Mon 1/19

9:45 am-10:00 pm

2 stops15h 15m

$538

Los AngelesPanama City

LAX - PTY

LAXPTY

Los Angeles

Sun 1/11

10:55 pm-10:20 am

1 stop8h 25m

Panama City Tocumen Intl

Sat 1/17

7:50 pm-10:55 am

2 stops18h 05m

$548

Los AngelesPanama City

LAX - PTY

LAXPTY

Los Angeles

Wed 2/11

9:08 pm-6:37 am

Nonstop6h 29m

Panama City Tocumen Intl

Sat 2/28

7:55 am-12:05 pm

Nonstop7h 10m

$598

Los AngelesPanama City

LAX - PTY

LAXPTY

Los Angeles

Mon 1/19

1:11 am-10:25 am

Nonstop6h 14m

Panama City Tocumen Intl

Sun 1/25

6:24 pm-10:36 pm

Nonstop7h 12m

$598

Los AngelesPanama City

LAX - PTY

LAXPTY

Los Angeles

Tue 11/11

9:04 pm-6:37 am

Nonstop6h 33m

Panama City Tocumen Intl

Wed 11/19

6:14 pm-10:34 pm

Nonstop7h 20m

$608

Los AngelesDavid

LAX - DAV

LAXDAV

Los Angeles

Sat 10/11

12:06 pm-8:58 am

1 stop18h 52m

David Enrique Malek

Tue 10/21

9:44 am-11:12 pm

1 stop15h 28m

$647

Los AngelesDavid

LAX - DAV

LAXDAV

Los Angeles

Mon 10/20

10:05 pm-5:29 pm

1 stop17h 24m

David Enrique Malek

Thu 10/30

8:22 pm-12:45 pm

1 stop18h 23m

$647

Los AngelesDavid

LAX - DAV

LAXDAV

Los Angeles

Sun 11/2

12:47 am-5:24 pm

1 stop13h 37m

David Enrique Malek

Mon 11/10

9:53 am-10:34 pm

1 stop15h 41m

$869

Los AngelesDavid

LAX - DAV

LAXDAV

Los Angeles

Sat 10/11

1:50 pm-5:29 pm

2 stops25h 39m

David Enrique Malek

Tue 10/21

6:17 pm-11:10 pm

2 stops30h 53m

$918

Los AngelesDavid

LAX - DAV

LAXDAV

Los Angeles

Mon 9/22

10:04 pm-8:58 am

1 stop8h 54m

David Enrique Malek

Sun 9/28

8:41 am-11:12 pm

1 stop16h 31m

$1,009

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/13

Showing 1-10 of 29 results
1
2
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Best time to book a flight from Irvine to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Irvine with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Irvine to Panama

What is the cheapest month to book a flight from Irvine to Panama?

Currently, October is the cheapest month in which you can book a flight from Irvine to Panama (average of $478). Flying from Irvine to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IR9 to PA?

Find hourly flight availability from Irvine to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Irvine to Panama as you normally would.

Weekly flight availability from Irvine to Panama

Explore weekly flight availability from Irvine to Panama. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated September 15, 2025.

The most flights from IR9 to PA0 are scheduled on a Monday (9 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (9 on average).

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated September 15, 2025.
Get a feel of what it's like to fly with Delta, Copa Airlines, and United Airlines from Irvine to Panama by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,954 reviews

Food

7.3

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
8.0
Very good
7,954 reviews
Delta
8.0
Very good
7,954 reviews

Food

7.3

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Copa Airlines
7.6
Good
1,531 reviews
Delta
8.0
Very good
7,954 reviews

Food

7.3

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
United Airlines
7.4
Good
8,929 reviews
Delta
8.0
Very good
7,954 reviews

Food

7.3

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,954 reviews

Food

7.3

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Avianca
6.7
Okay
2,435 reviews
Delta
8.0
Very good
7,954 reviews

Food

7.3

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from Irvine to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Irvine to Panama flight route?

    The Irvine to Panama flight path was viewed by 160 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Irvine to Panama?

    There are many flights that can get you from Irvine to Panama in 8h 25m. Fly via Avianca or Copa Airlines to get the fastest option. Airlines will cover a distance of 3009 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Irvine to Panama?

    The most popular flight routes from Irvine to Panama are Los Angeles - Panama City Tocumen Intl, Los Angeles - David Enrique Malek and Los Angeles - Panama City Marcos A. Gelabert Intl.

  • What are the most reliable airlines from Irvine to Panama?

    Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Irvine to Panama on time: EVA Air (88%), Asiana Airlines (88%), United Airlines (88%).

  • What are the cheapest flights from Irvine to Panama?

    Looking for the cheapest flight from Irvine to Panama? While on average our users pay $1,222, our data indicates the cheapest price to be $166. The most popular route (Los Angeles - Panama City Tocumen Intl), is priced around $523.

  • Can I find deals for flights from Irvine to Panama that include hotel bookings?

    Yes. In addition to deals on Irvine to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Irvine to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Irvine to Panama.

  • Can I find deals for business class flights from Irvine to Panama?

    Yes. Cheapflights offers flight deals from Irvine to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Irvine to Panama?

    Currently, October is the cheapest month in which you can book a flight from Irvine to Panama (average of $478). Flying from Irvine to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Irvine to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from Irvine to Panama

Discover the top 5 airlines that operate flights from Irvine to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$203Average$542FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$299Average$653FlexibilityNo cancel feeOn-time69%
AviancaCheapest$341Average$502FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$495Average$702FlexibilityNo cancel feeOn-time70%
DeltaCheapest$519Average$715FlexibilityNo cancel feeOn-timeN/A

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