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$156+ Cheap flights from Irvine, CA to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/24. Fares are subject to change and may not be available on all flights or dates of travel.
LAX — PTY
Mar 2 — Mar 91
Mon 3/2
Mon 3/9
1 adult, Economy
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Cheap flight deals from Irvine to Panama

Cheapest flights from Irvine to Panama
Explore the most affordable flight options available from Irvine to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 31, 2026.

This Gotogate deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/91:00 pm
LAX
-
PTY
2 stops16h 50m
Avianca
Wed 2/112:55 am
PTY
-
LAX
2 stops21h 20m
Avianca
Deal found 1/29$464
This Priceline deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/612:15 am
LAX
-
PTY
1 stop8h 15m
Avianca
Wed 4/155:55 pm
PTY
-
LAX
2 stops20h 30m
Avianca
Deal found 1/28$466
This Gotogate deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/41:00 pm
LAX
-
PTY
2 stops16h 50m
Avianca
Mon 3/97:50 pm
PTY
-
LAX
1 stop18h 45m
Avianca
Deal found 1/29$469
This Mytrip deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/28:20 am
LAX
-
PTY
3 stops29h 35m
Multiple Airlines
Fri 3/69:45 am
PTY
-
LAX
2 stops14h 30m
Multiple Airlines
Deal found 1/29$471
This Gotogate deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/172:50 pm
LAX
-
PTY
3 stops16h 00m
Avianca
Sun 3/225:50 pm
PTY
-
LAX
2 stops30h 25m
Avianca
Deal found 1/29$472
This Super.com deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/2012:25 pm
LAX
-
PTY
2 stops19h 05m
Avianca
Mon 2/237:50 pm
PTY
-
LAX
1 stop29h 10m
Avianca
Deal found 1/29$474
This Priceline deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/611:55 pm
LAX
-
PTY
2 stops22h 05m
Avianca
Sun 3/85:50 pm
PTY
-
LAX
2 stops30h 25m
Avianca
Deal found 1/29$475
This Priceline deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/302:10 pm
LAX
-
PTY
2 stops20h 50m
Avianca
Mon 2/25:50 pm
PTY
-
LAX
2 stops21h 40m
Avianca
Deal found 1/29$476
This Mytrip deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/48:20 am
LAX
-
PTY
3 stops26h 40m
Multiple Airlines
Mon 3/92:55 am
PTY
-
LAX
2 stops22h 05m
Multiple Airlines
Deal found 1/29$478
This United Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/48:15 am
LAX
-
DAV
2 stops22h 53m
United Airlines
Wed 5/69:55 am
DAV
-
LAX
2 stops32h 13m
United Airlines
Deal found 1/30$977
This United Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/275:55 am
LAX
-
DAV
2 stops25h 09m
United Airlines
Fri 4/310:05 am
DAV
-
LAX
2 stops25h 00m
United Airlines
Deal found 1/30$1,114
This FlightHub deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/1211:20 pm
LAX
-
DAV
2 stops15h 11m
Multiple Airlines
Sat 2/219:48 am
DAV
-
LAX
1 stop15h 51m
Multiple Airlines
Deal found 1/30$1,279

Find flight deals from Irvine to Panama

Keep the following information in mind while searching for Irvine to Panama flight deals. Data was last updated January 31, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$466
(Priceline)

One-way from

$156
(Super.com)

Popular in

December

Cheapest in

August

Average price

$675
Provider with most accurate pricing for Los Angeles-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Los Angeles-Panama City Tocumen Intl flights.
Search Deals
From Irvine to Panama
Search Deals
One-way flight from Irvine to Panama
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($60 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($10 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Irvine to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 31, 2026.
Use the filters below to find and compare flights from Irvine to Panama that are best for you.

Fly from

Irvine

Fly to

Panama

Route

Depart

Return

Price

Los AngelesPanama City

LAX - PTY

LAXPTY

Los Angeles

Mon 3/2

11:20 pm-10:30 am

1 stop8h 10m

Panama City Tocumen Intl

Fri 3/6

9:45 am-9:15 pm

2 stops14h 30m

$475

Los AngelesPanama City

LAX - PTY

LAXPTY

Los Angeles

Thu 3/12

12:20 am-10:30 am

1 stop8h 10m

Panama City Tocumen Intl

Sun 3/15

7:50 pm-12:35 pm

1 stop18h 45m

$492

Los AngelesPanama City

LAX - PTY

LAXPTY

Los Angeles

Thu 4/9

2:37 am-10:52 am

Nonstop6h 15m

Panama City Tocumen Intl

Wed 4/15

7:55 am-1:00 pm

Nonstop7h 05m

$545

Los AngelesPanama City

LAX - PTY

LAXPTY

Los Angeles

Thu 4/23

2:09 am-10:24 am

Nonstop6h 15m

Panama City Tocumen Intl

Sun 5/3

7:55 am-1:00 pm

Nonstop7h 05m

$545

Los AngelesPanama City

LAX - PTY

LAXPTY

Los Angeles

Mon 3/30

2:31 am-10:52 am

Nonstop6h 21m

Panama City Tocumen Intl

Mon 4/6

6:10 pm-11:19 pm

Nonstop7h 09m

$545

Los AngelesPanama City

LAX - PTY

LAXPTY

Los Angeles

Sun 4/12

2:37 am-10:52 am

Nonstop6h 15m

Panama City Tocumen Intl

Mon 4/20

6:10 pm-11:19 pm

Nonstop7h 09m

$545

Los AngelesPanama City

LAX - PTY

LAXPTY

Los Angeles

Tue 3/31

2:37 am-10:52 am

Nonstop6h 15m

Panama City Tocumen Intl

Wed 4/8

6:10 pm-11:19 pm

Nonstop7h 09m

$545

Los AngelesPanama City

LAX - PTY

LAXPTY

Los Angeles

Sat 4/4

12:24 pm-8:39 pm

Nonstop6h 15m

Panama City Tocumen Intl

Fri 4/10

6:27 pm-11:36 pm

Nonstop7h 09m

$545

Los AngelesPanama City

LAX - PTY

LAXPTY

Los Angeles

Tue 4/28

2:09 am-10:24 am

Nonstop6h 15m

Panama City Tocumen Intl

Tue 5/12

7:55 am-1:00 pm

Nonstop7h 05m

$545

Los AngelesPanama City

LAX - PTY

LAXPTY

Los Angeles

Fri 4/10

2:09 am-10:24 am

Nonstop6h 15m

Panama City Tocumen Intl

Sat 4/18

7:55 am-1:00 pm

Nonstop7h 05m

$545

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/29

Showing 1-10 of 28 results
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Best time to book a flight from Irvine to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Irvine with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Irvine to Panama

What is the cheapest month to book a flight from Irvine to Panama?

Currently, July is the cheapest month in which you can book a flight from Irvine to Panama (average of $297). Flying from Irvine to Panama in December is currently the most expensive (average of $478). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IR9 to PA?

Find hourly flight availability from Irvine to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 31, 2026.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Irvine to Panama as you normally would.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated January 31, 2026.
Get a feel of what it's like to fly with Copa Airlines, United Airlines, and American Airlines from Irvine to Panama by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,561 reviews

Entertainment

6.8

Overall

7.6

Comfort

7.4

Food

6.8

Boarding

7.8

Crew

8.1

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.
Copa Airlines
7.6
Good
1,561 reviews
Copa Airlines
7.6
Good
1,561 reviews

Entertainment

6.8

Overall

7.6

Comfort

7.4

Food

6.8

Boarding

7.8

Crew

8.1

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.
United Airlines
7.4
Good
9,219 reviews
Copa Airlines
7.6
Good
1,561 reviews

Entertainment

6.8

Overall

7.6

Comfort

7.4

Food

6.8

Boarding

7.8

Crew

8.1

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.
American Airlines
7.2
Good
11,213 reviews
Copa Airlines
7.6
Good
1,561 reviews

Entertainment

6.8

Overall

7.6

Comfort

7.4

Food

6.8

Boarding

7.8

Crew

8.1

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.
Avianca
6.6
Okay
2,493 reviews
Copa Airlines
7.6
Good
1,561 reviews

Entertainment

6.8

Overall

7.6

Comfort

7.4

Food

6.8

Boarding

7.8

Crew

8.1

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.

Related info for your journey

Find useful and relevant information for your journey from Irvine to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Irvine to Panama flight route?

    The Irvine to Panama flight path was viewed by 127 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Irvine to Panama?

    There are many flights that can get you from Irvine to Panama in 6h 15m. Fly via Avianca, Copa Airlines, or United Airlines to get the fastest option. Airlines will cover a distance of 3009 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Irvine to Panama one-way?

    The cheapest airline one-way is Avianca, with whom users have recently found tickets for as low as $179. However, be on the lookout for offers from United Airlines and Copa Airlines, as they are both options that can get you from Irvine to Panama for a low price.

  • What are the most popular routes from Irvine to Panama?

    The most popular flight routes from Irvine to Panama are Los Angeles - Panama City Tocumen Intl, Los Angeles - David Enrique Malek and Los Angeles - Panama City Marcos A. Gelabert Intl.

  • What are the most reliable airlines from Irvine to Panama?

    Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Irvine to Panama on time: Copa Airlines (82%), EVA Air (80%), Asiana Airlines (80%).

  • What are the cheapest flights from Irvine to Panama?

    Looking for the cheapest flight from Irvine to Panama? While on average our users pay $1,249, our data indicates the cheapest price to be $180. The most popular route (Los Angeles - Panama City Tocumen Intl), is priced around $433.

  • Can I find deals for flights from Irvine to Panama that include hotel bookings?

    Yes. In addition to deals on Irvine to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Irvine to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Irvine to Panama.

  • Can I find deals for business class flights from Irvine to Panama?

    Yes. Cheapflights offers flight deals from Irvine to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Irvine to Panama?

    Currently, July is the cheapest month in which you can book a flight from Irvine to Panama (average of $297). Flying from Irvine to Panama in December is currently the most expensive (average of $478). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Irvine to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from Irvine to Panama

Discover the top 5 airlines that operate flights from Irvine to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 31, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$203Average$542FlexibilityNo cancel feeOn-time71%
AviancaCheapest$264Average$537FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$273Average$611FlexibilityNo cancel feeOn-time69%
Copa AirlinesCheapest$474Average$728FlexibilityNo cancel feeOn-time70%
DeltaCheapest$519Average$715FlexibilityNo cancel feeOn-timeN/A

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