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Odessa

$387+ Cheap flights from Missouri to Odessa, TX

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/20. Fares are subject to change and may not be available on all flights or dates of travel.
STL — MAF
Mar 5 — Mar 121
Thu 3/5
Thu 3/12
1 adult, Economy
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Cheap flight deals from Missouri to Odessa

Cheapest flights from Missouri to Odessa
Explore the most affordable flight options available from Missouri to Odessa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 3, 2026.

This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/202:50 pm
STL
-
MAF
1 stop7h 25m
United Airlines
Mon 3/232:48 pm
MAF
-
STL
1 stop7h 28m
United Airlines
Deal found 2/1$387
This Southwest deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/205:45 am
STL
-
MAF
2 stops6h 45m
Southwest
Mon 3/232:25 pm
MAF
-
STL
1 stop4h 20m
Southwest
Deal found 2/1$392
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/195:45 am
STL
-
MAF
1 stop5h 23m
American Airlines
Sun 6/215:23 pm
MAF
-
STL
1 stop4h 11m
American Airlines
Deal found 2/1$412
This United Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/188:41 am
STL
-
MAF
1 stop7h 38m
United Airlines
Sun 2/2211:45 am
MAF
-
STL
1 stop5h 13m
United Airlines
Deal found 2/3$467
This Southwest deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/1810:25 am
STL
-
MAF
2 stops7h 05m
Southwest
Sun 2/227:25 am
MAF
-
STL
2 stops7h 50m
Southwest
Deal found 2/3$489
This Southwest deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/198:15 am
STL
-
MAF
2 stops7h 05m
Southwest
Sun 6/216:35 pm
MAF
-
STL
1 stop5h 35m
Southwest
Deal found 2/1$518
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/186:00 am
STL
-
MAF
1 stop7h 48m
United Airlines
Sat 2/215:31 pm
MAF
-
STL
1 stop4h 43m
United Airlines
Deal found 2/2$537
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/196:00 am
STL
-
MAF
2 stops10h 15m
United Airlines
Sun 6/212:16 pm
MAF
-
STL
2 stops10h 13m
United Airlines
Deal found 2/1$573

Find flight deals from Missouri to Odessa

Keep the following information in mind while searching for Missouri to Odessa flight deals. Data was last updated February 3, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$387
(United Airlines)
Provider with most accurate pricing for Lambert-St Louis-Midland Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Midland Intl flights.
Search Deals
From Missouri to Odessa
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Odessa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
Use the filters below to find and compare flights from Missouri to Odessa that are best for you.

Fly from

Missouri

Fly to

Odessa

Route

Depart

Return

Price

St. LouisMidland

STL - MAF

STLMAF

Lambert-St Louis

Fri 3/20

2:50 pm-10:15 pm

1 stop7h 25m

Midland Intl

Mon 3/23

2:48 pm-10:16 pm

1 stop7h 28m

$387

St. LouisMidland

STL - MAF

STLMAF

Lambert-St Louis

Fri 3/20

5:45 am-12:30 pm

2 stops6h 45m

Midland Intl

Mon 3/23

2:25 pm-6:45 pm

1 stop4h 20m

$392

St. LouisMidland

STL - MAF

STLMAF

Lambert-St Louis

Fri 6/19

5:45 am-11:08 am

1 stop5h 23m

Midland Intl

Sun 6/21

5:23 pm-9:34 pm

1 stop4h 11m

$412

St. LouisMidland

STL - MAF

STLMAF

Lambert-St Louis

Wed 2/18

8:41 am-4:19 pm

1 stop7h 38m

Midland Intl

Sun 2/22

11:45 am-4:58 pm

1 stop5h 13m

$467

St. LouisMidland

STL - MAF

STLMAF

Lambert-St Louis

Wed 2/18

10:25 am-5:30 pm

2 stops7h 05m

Midland Intl

Sun 2/22

7:25 am-3:15 pm

2 stops7h 50m

$489

St. LouisMidland

STL - MAF

STLMAF

Lambert-St Louis

Fri 6/19

8:15 am-3:20 pm

2 stops7h 05m

Midland Intl

Sun 6/21

6:35 pm-12:10 am

1 stop5h 35m

$518

St. LouisMidland

STL - MAF

STLMAF

Lambert-St Louis

Wed 2/18

2:45 pm-10:03 pm

1 stop7h 18m

Midland Intl

Sat 2/21

9:43 am-3:38 pm

1 stop5h 55m

$537

St. LouisMidland

STL - MAF

STLMAF

Lambert-St Louis

Sun 2/8

10:07 am-4:21 pm

1 stop6h 14m

$469

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/2

Best time to book a flight from Missouri to Odessa

Have a flexible travel schedule? Discover the best time to fly to Odessa from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Odessa
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Odessa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Missouri to Odessa?

    United Airlines, Southwest, and American Airlines can get you from Missouri to Odessa in just under 5h 23m. Your travel time can differ by up to 2h 02m. The distance between Missouri and Odessa is about 814 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Missouri to Odessa that include hotel bookings?

    Yes. In addition to deals on Missouri to Odessa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Odessa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Odessa.

  • Can I find deals for business class flights from Missouri to Odessa?

    Yes. Cheapflights offers flight deals from Missouri to Odessa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for Missouri to Odessa

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Missouri to Odessa

Discover the top 3 airlines that operate flights from Missouri to Odessa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$196Average$325FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$233Average$333FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$290Average$367FlexibilityNo cancel feeOn-time63%

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