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$229+ Cheap flights from Santa Fe (SAF) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/18. Fares are subject to change and may not be available on all flights or dates of travel.
SAF — STL
Nov 28 — Dec 51
Fri 11/28
Fri 12/5
1 adult, Economy
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Find flight deals from Santa Fe to Missouri

Cheapest flights from Santa Fe to Missouri
Explore the most affordable flight options available from Santa Fe to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 29, 2025.

This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/49:58 amSAF - STL
1 stop5h 38mAmerican Airlines
Wed 12/105:30 pmSTL - SAF
1 stop5h 18mAmerican Airlines
Deal found 10/27$246
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/264:56 pmSAF - STL
1 stop4h 38mAmerican Airlines
Mon 12/17:00 amSTL - SAF
1 stop8h 52mAmerican Airlines
Deal found 10/28$381
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/185:16 pmSAF - STL
1 stop4h 42mAmerican Airlines
Sat 11/225:17 amSTL - SAF
1 stop5h 11mAmerican Airlines
Deal found 10/28$400
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1310:48 amSAF - STL
1 stop4h 40mUnited Airlines
Mon 11/179:00 amSTL - SAF
1 stop4h 40mUnited Airlines
Deal found 10/28$425
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/183:25 pmSAF - STL
1 stop7h 26mAmerican Airlines
Fri 11/215:17 amSTL - SAF
1 stop5h 11mAmerican Airlines
Deal found 10/28$462
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/197:00 amSAF - STL
2 stops7h 49mUnited Airlines
Sat 11/224:43 pmSTL - SAF
1 stop6h 16mUnited Airlines
Deal found 10/28$486
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/264:56 pmSAF - STL
1 stop4h 38mAmerican Airlines
Sun 11/305:17 amSTL - SAF
1 stop5h 11mAmerican Airlines
Deal found 10/28$503
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/187:00 amSAF - STL
2 stops15h 42mUnited Airlines
Sat 11/224:43 pmSTL - SAF
1 stop6h 16mUnited Airlines
Deal found 10/28$521
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/193:25 pmSAF - STL
1 stop7h 26mAmerican Airlines
Fri 11/215:17 amSTL - SAF
1 stop5h 11mAmerican Airlines
Deal found 10/28$532

Cheap flight deals from Santa Fe to Missouri

Keep the following information in mind while searching for Santa Fe to Missouri flight deals. Data was last updated October 29, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$246
(American Airlines)

One-way from

$229
(American Airlines)

Popular in

June

Cheapest in

September

Average price

$470
Provider with most accurate pricing for Santa Fe-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Santa Fe-Lambert-St Louis flights.
Search Deals
From Santa Fe to Missouri
Search Deals
One-way flight from Santa Fe to Missouri
Search Deals
Highest demand for flights based on searches. 11% potential increase in price ($48 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($16 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santa Fe to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 29, 2025.
Use the filters below to find and compare flights from Santa Fe to Missouri that are best for you.

Fly from

Santa Fe

Fly to

Missouri

Route

Depart

Return

Price

Santa FeSt. Louis

SAF - STL

SAFSTL

Santa Fe

Thu 12/4

4:51 pm-10:25 pm

1 stop4h 34m

Lambert-St Louis

Wed 12/10

7:00 am-2:55 pm

2 stops8h 55m

$308

Santa FeSt. Louis

SAF - STL

SAFSTL

Santa Fe

Sat 2/28

1:23 pm-8:26 pm

1 stop6h 03m

Lambert-St Louis

Tue 3/3

8:41 am-12:48 pm

1 stop5h 07m

$314

Santa FeSt. Louis

SAF - STL

SAFSTL

Santa Fe

Wed 11/26

4:56 pm-10:34 pm

1 stop4h 38m

Lambert-St Louis

Mon 12/1

7:00 am-2:52 pm

1 stop8h 52m

$381

Santa FeSt. Louis

SAF - STL

SAFSTL

Santa Fe

Wed 11/19

6:15 am-12:37 pm

1 stop5h 22m

Lambert-St Louis

Sat 11/22

5:17 am-9:28 am

1 stop5h 11m

$400

Santa FeSt. Louis

SAF - STL

SAFSTL

Santa Fe

Tue 11/18

5:16 pm-10:58 pm

1 stop4h 42m

Lambert-St Louis

Sat 11/22

5:17 am-9:28 am

1 stop5h 11m

$400

Santa FeSt. Louis

SAF - STL

SAFSTL

Santa Fe

Tue 11/18

5:16 pm-10:58 pm

1 stop4h 42m

$229

Santa FeSt. Louis

SAF - STL

SAFSTL

Santa Fe

Tue 11/18

1:25 pm-10:45 pm

2 stops8h 20m

$239

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/28

Best time to book a flight from Santa Fe to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Santa Fe with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santa Fe to Missouri

What is the cheapest month to book a flight from Santa Fe to Missouri?

Currently, July is the cheapest month in which you can book a flight from Santa Fe to Missouri (average of $118). Flying from Santa Fe to Missouri in April is currently the most expensive (average of $286). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated October 29, 2025.
Get a feel of what it's like to fly with United Airlines and American Airlines from Santa Fe to Missouri by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
8,999 reviews

Comfort

7.3

Overall

7.4

Food

6.6

Crew

8.1

Entertainment

7.1

Boarding

7.7

Reviews

1 / 20
2.0
Mediocre

Sebrena,Oct 2025

IAH - RSW

The worst that I have ever experienced in my life so bad if it was free I'm not ever going to use your Airline again I dont believe ..... very disappointed 😞 😔0000000000000
United Airlines
7.4
Good
8,999 reviews
United Airlines
7.4
Good
8,999 reviews

Comfort

7.3

Overall

7.4

Food

6.6

Crew

8.1

Entertainment

7.1

Boarding

7.7

Reviews

1 / 20
2.0
Mediocre

Sebrena,Oct 2025

IAH - RSW

The worst that I have ever experienced in my life so bad if it was free I'm not ever going to use your Airline again I dont believe ..... very disappointed 😞 😔0000000000000
American Airlines
7.2
Good
11,032 reviews
United Airlines
7.4
Good
8,999 reviews

Comfort

7.3

Overall

7.4

Food

6.6

Crew

8.1

Entertainment

7.1

Boarding

7.7

Reviews

1 / 20
2.0
Mediocre

Sebrena,Oct 2025

IAH - RSW

The worst that I have ever experienced in my life so bad if it was free I'm not ever going to use your Airline again I dont believe ..... very disappointed 😞 😔0000000000000

Related info for your journey

Find useful and relevant information for your journey from Santa Fe to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Santa Fe to Missouri?

    Most people fly from Santa Fe (SAF) if they book a flight from Santa Fe to Missouri. Santa Fe is conveniently located just 9.8 mi from Santa Fe’s city center.

  • How long is the flight from Santa Fe to Missouri?

    A quick flight from Santa Fe to Missouri can take about 4h 34m. American Airlines provides one of the quickest options available for as low as $308. The distance between Santa Fe and Missouri is about 890 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Santa Fe to Missouri that include hotel bookings?

    Yes. In addition to deals on Santa Fe to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santa Fe to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santa Fe to Missouri.

  • Can I find deals for business class flights from Santa Fe to Missouri?

    Yes. Cheapflights offers flight deals from Santa Fe to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santa Fe to Missouri?

    Currently, July is the cheapest month in which you can book a flight from Santa Fe to Missouri (average of $118). Flying from Santa Fe to Missouri in April is currently the most expensive (average of $286). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 2 airlines flying from Santa Fe to Missouri

Discover the top 2 airlines that operate flights from Santa Fe to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$194Average$394FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$254Average$369FlexibilityNo cancel feeOn-time69%

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