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$341+ Cheap flights from Madrid, Spain (MAD) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/30. Fares are subject to change and may not be available on all flights or dates of travel.
MAD — STL
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Cheap flight deals from Madrid to Missouri

Keep the following information in mind while searching for Madrid to Missouri flight deals. Data was last updated October 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$764
(United Airlines)

One-way from

$341
(Kiwi.com)

Popular in

December

Cheapest in

May

Average price

$1,180
Provider with most accurate pricing for Madrid Barajas-Lambert-St Louis flight deals.
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Provider most trusted by Cheapflights users for Madrid Barajas-Lambert-St Louis flights.
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From Madrid Barajas to Missouri
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One-way flight from Madrid Barajas to Missouri
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Highest demand for flights based on searches. 5% potential increase in price ($60 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($21 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Madrid to Missouri

Cheapest flights from Madrid to Missouri
Explore the most affordable flight options available from Madrid to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This Mytrip deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1310:10 amMAD - MCI
3 stops33h 18mMultiple Airlines
Mon 11/176:00 amMCI - MAD
3 stops29h 45mMultiple Airlines
Deal found 10/29$780
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/216:00 amMAD - STL
1 stop14h 55mUnited Airlines
Thu 11/277:00 amSTL - MAD
1 stop19h 15mUnited Airlines
Deal found 10/30$815
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/216:00 amMAD - STL
1 stop14h 55mUnited Airlines
Tue 11/258:25 amSTL - MAD
1 stop16h 40mUnited Airlines
Deal found 10/28$816
This Air Canada deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/216:00 amMAD - STL
2 stops40h 29mMultiple Airlines
Thu 11/278:25 amSTL - MAD
2 stops16h 35mMultiple Airlines
Deal found 10/30$822
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/46:00 amMAD - STL
2 stops18h 30mUnited Airlines
Mon 12/810:00 amSTL - MAD
2 stops16h 15mUnited Airlines
Deal found 10/27$824
This Lufthansa deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Lufthansa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/42:00 pmMAD - STL
1 stop30h 55mLufthansa
Mon 12/811:50 amSTL - MAD
1 stop14h 25mLufthansa
Deal found 10/29$840
This KLM deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/161:05 pmMAD - MCI
2 stops17h 42mMultiple Airlines
Mon 1/129:59 amMCI - MAD
2 stops16h 11mMultiple Airlines
Deal found 10/28$850
This Air Canada deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/241:35 pmMAD - MCI
2 stops39h 15mAir Canada
Mon 1/129:05 amMCI - MAD
2 stops15h 55mAir Canada
Deal found 10/29$852
This KLM deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/1611:00 amMAD - MCI
2 stops17h 13mKLM
Mon 1/129:59 amMCI - MAD
1 stop15h 01mKLM
Deal found 10/28$853
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/411:15 amMAD - STL
1 stop16h 47mDelta
Mon 12/85:12 pmSTL - MAD
2 stops15h 08mDelta
Deal found 10/27$856
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/1711:05 amMAD - MCI
1 stop15h 49mUnited Airlines
Sun 1/115:10 pmMCI - MAD
2 stops33h 05mUnited Airlines
Deal found 10/28$866
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/46:00 amMAD - MCI
2 stops20h 54mUnited Airlines
Mon 12/810:00 amMCI - MAD
2 stops16h 15mUnited Airlines
Deal found 10/30$876

Cheapflights Fare Finder

 
Customize your flight search to find flights from Madrid to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Madrid to Missouri that are best for you.

Fly from

Madrid

Fly to

Missouri

Route

Depart

Return

Price

MadridSt. Louis

MAD - STL

MADSTL

Madrid Barajas

Thu 1/22

6:00 am-7:27 pm

2 stops20h 27m

Lambert-St Louis

Mon 1/26

8:45 am-8:00 am

2 stops16h 15m

$764

MadridSt. Louis

MAD - STL

MADSTL

Madrid Barajas

Thu 1/22

11:35 am-6:14 pm

1 stop13h 39m

Lambert-St Louis

Mon 1/26

6:44 pm-4:55 pm

2 stops15h 11m

$767

MadridSt. Louis

MAD - STL

MADSTL

Madrid Barajas

Fri 1/23

6:00 am-1:55 pm

1 stop14h 55m

Lambert-St Louis

Tue 1/27

12:44 pm-8:00 am

2 stops36h 16m

$777

MadridSt. Louis

MAD - STL

MADSTL

Madrid Barajas

Wed 1/21

12:55 am-8:51 am

1 stop14h 56m

Lambert-St Louis

Mon 1/26

6:52 am-5:45 am

1 stop15h 53m

$780

MadridSt. Louis

MAD - STL

MADSTL

Madrid Barajas

Thu 1/22

12:00 pm-6:14 pm

1 stop13h 14m

Lambert-St Louis

Mon 1/26

1:35 pm-8:50 am

1 stop12h 15m

$780

MadridSt. Louis

MAD - STL

MADSTL

Madrid Barajas

Fri 1/23

6:00 am-1:55 pm

1 stop14h 55m

Lambert-St Louis

Tue 1/27

11:22 am-9:15 am

1 stop14h 53m

$783

MadridSt. Louis

MAD - STL

MADSTL

Madrid Barajas

Fri 2/6

6:00 am-3:29 pm

2 stops40h 29m

Lambert-St Louis

Sun 2/22

4:05 pm-8:00 am

2 stops32h 55m

$788

MadridSt. Louis

MAD - STL

MADSTL

Madrid Barajas

Fri 2/6

1:05 pm-11:40 pm

2 stops17h 35m

Lambert-St Louis

Sun 2/22

7:05 pm-9:15 am

1 stop31h 10m

$791

MadridSt. Louis

MAD - STL

MADSTL

Madrid Barajas

Wed 1/21

12:55 am-10:59 pm

1 stop29h 04m

Lambert-St Louis

Mon 1/26

11:55 am-1:55 pm

2 stops19h 00m

$804

MadridSt. Louis

MAD - STL

MADSTL

Madrid Barajas

Fri 2/6

12:00 pm-9:10 pm

1 stop16h 10m

Lambert-St Louis

Sun 2/22

7:00 am-6:15 am

1 stop16h 15m

$813

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/29

Showing 1-10 of 21 results
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Best time to book a flight from Madrid to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Madrid with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Madrid to Missouri

What is the cheapest month to book a flight from Madrid to Missouri?

Currently, December is the cheapest month in which you can book a flight from Madrid to Missouri (average of $466). Flying from Madrid to Missouri in July is currently the most expensive (average of $861). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Madrid to Missouri?

Related info for your journey

Find useful and relevant information for your journey from Madrid to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Madrid to Missouri?

    Located just 8.5 mi from the city center, Madrid Barajas (MAD) is the airport most travelers will use when flying to Missouri from Madrid.

  • How long is the flight from Madrid to Missouri?

    For as low as $767, United Airlines can have you in Missouri from Madrid in 13h 39m. The distance from Madrid to Missouri is about 4414 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Madrid to Missouri that include hotel bookings?

    Yes. In addition to deals on Madrid to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Madrid to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Madrid to Missouri.

  • Can I find deals for business class flights from Madrid to Missouri?

    Yes. Cheapflights offers flight deals from Madrid to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Madrid to Missouri?

    Currently, December is the cheapest month in which you can book a flight from Madrid to Missouri (average of $466). Flying from Madrid to Missouri in July is currently the most expensive (average of $861). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Madrid to Missouri

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