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$535+ Cheap flights from Panama City, FL (ECP) to Mexico City (MEX)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/13. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — MEX
Oct 16 — Oct 231
Thu 10/16
Thu 10/23
1 adult, Economy
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Cheap flight deals from Panama City to Mexico City

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to Mexico City (MEX). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 16, 2025.

Round-trip from

$535
(Aeromexico)

Popular in

October

Cheapest in

May

Average price

$540
From Panama City NW Florida Beaches to Mexico City Benito Juarez
Search Deals
Highest demand for flights based on searches. 15% potential increase in price ($121 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($29 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in September 2025
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Find flight deals from Panama City to Mexico City

Cheapest flights from Panama City to Mexico City
Explore the most affordable flight options available from Panama City to Mexico City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

This Aeromexico deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/136:00 amECP - MEX
2 stops9h 25mAeromexico
Mon 10/207:00 amMEX - ECP
2 stops11h 55mAeromexico
Deal found 9/14$535
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/146:30 amECP - MEX
1 stop12h 20mUnited Airlines
Tue 10/216:30 amMEX - ECP
1 stop8h 46mUnited Airlines
Deal found 9/15$542
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/106:30 amECP - MEX
1 stop5h 45mUnited Airlines
Thu 12/185:45 amMEX - ECP
1 stop16h 09mUnited Airlines
Deal found 9/14$552
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/82:22 pmECP - MEX
1 stop9h 48mUnited Airlines
Tue 11/183:20 pmMEX - ECP
1 stop6h 29mUnited Airlines
Deal found 9/16$562
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/87:15 amECP - MEX
2 stops14h 40mAmerican Airlines
Tue 11/188:00 amMEX - ECP
1 stop11h 16mAmerican Airlines
Deal found 9/16$567
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/156:30 amECP - MEX
1 stop7h 50mUnited Airlines
Sat 11/225:45 pmMEX - ECP
1 stop15h 34mUnited Airlines
Deal found 9/14$582
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/157:02 amECP - MEX
2 stops11h 53mDelta
Sat 11/228:35 amMEX - ECP
2 stops14h 02mDelta
Deal found 9/14$587
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/146:49 amECP - MEX
2 stops14h 26mAmerican Airlines
Tue 10/215:35 amMEX - ECP
2 stops12h 57mAmerican Airlines
Deal found 9/15$592
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/136:30 amECP - MEX
1 stop17h 40mUnited Airlines
Mon 10/204:40 amMEX - ECP
1 stop10h 36mUnited Airlines
Deal found 9/14$625
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/105:55 pmECP - MEX
2 stops17h 25mAmerican Airlines
Thu 12/186:00 amMEX - ECP
2 stops17h 53mAmerican Airlines
Deal found 9/14$632
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/307:10 amECP - MEX
2 stops12h 50mDelta
Thu 11/64:50 pmMEX - ECP
1 stop6h 20mDelta
Deal found 9/15$682

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Mexico City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from Panama City to Mexico City that are best for you.

Fly from

Panama City

Fly to

Mexico City

Route

Depart

Return

Price

Panama CityMexico City

ECP - MEX

ECPMEX

Panama City NW Florida Beaches

Mon 11/10

6:30 am-12:15 pm

1 stop5h 45m

Mexico City Benito Juarez

Thu 12/18

5:45 am-9:54 pm

1 stop16h 09m

$552

Panama CityMexico City

ECP - MEX

ECPMEX

Panama City NW Florida Beaches

Sat 11/8

6:00 am-3:30 pm

2 stops9h 30m

Mexico City Benito Juarez

Tue 11/18

10:30 am-7:00 pm

2 stops8h 30m

$562

Panama CityMexico City

ECP - MEX

ECPMEX

Panama City NW Florida Beaches

Sat 11/1

2:22 pm-11:10 pm

1 stop9h 48m

Mexico City Benito Juarez

Wed 11/5

5:45 am-9:49 pm

1 stop16h 04m

$562

Panama CityMexico City

ECP - MEX

ECPMEX

Panama City NW Florida Beaches

Sat 11/8

2:22 pm-12:10 am

1 stop9h 48m

Mexico City Benito Juarez

Tue 11/18

3:20 pm-9:49 pm

1 stop6h 29m

$562

Panama CityMexico City

ECP - MEX

ECPMEX

Panama City NW Florida Beaches

Sat 11/8

7:15 am-9:55 pm

2 stops14h 40m

Mexico City Benito Juarez

Tue 11/18

8:00 am-7:16 pm

1 stop11h 16m

$567

Panama CityMexico City

ECP - MEX

ECPMEX

Panama City NW Florida Beaches

Sat 11/15

6:00 am-3:30 pm

2 stops9h 30m

Mexico City Benito Juarez

Sat 11/22

8:40 am-7:00 pm

1 stop10h 20m

$582

Panama CityMexico City

ECP - MEX

ECPMEX

Panama City NW Florida Beaches

Sat 11/15

7:02 am-6:55 pm

2 stops11h 53m

Mexico City Benito Juarez

Sat 11/22

8:35 am-10:37 pm

2 stops14h 02m

$587

Panama CityMexico City

ECP - MEX

ECPMEX

Panama City NW Florida Beaches

Tue 10/14

6:49 am-8:15 pm

2 stops14h 26m

Mexico City Benito Juarez

Tue 10/21

5:00 am-7:32 pm

1 stop13h 32m

$592

Panama CityMexico City

ECP - MEX

ECPMEX

Panama City NW Florida Beaches

Mon 10/13

6:30 am-11:10 pm

1 stop17h 40m

Mexico City Benito Juarez

Mon 10/20

4:40 am-4:16 pm

1 stop10h 36m

$625

Panama CityMexico City

ECP - MEX

ECPMEX

Panama City NW Florida Beaches

Mon 11/10

5:55 pm-11:20 am

2 stops17h 25m

Mexico City Benito Juarez

Thu 12/18

6:00 am-11:53 pm

2 stops17h 53m

$632

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Best time to book a flight from Panama City to Mexico City

Have a flexible travel schedule? Discover the best time to fly to Mexico City from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Mexico City

What is the cheapest month to book a flight from Panama City, Florida to Mexico City?

Currently, May is the cheapest month in which you can book a flight from Panama City, Florida to Mexico City (average of $387). Flying from Panama City, Florida to Mexico City in December is currently the most expensive (average of $615). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Mexico City

Get insights into the airlines that provide service to Mexico City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mexico City. Reviews last updated September 16, 2025.
Peruse reviews from past customers who have flown with Delta and United Airlines from Panama City to Mexico City to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,954 reviews

Food

7.3

Boarding

8.2

Crew

8.5

Comfort

7.9

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
8.0
Very good
7,954 reviews
Delta
8.0
Very good
7,954 reviews

Food

7.3

Boarding

8.2

Crew

8.5

Comfort

7.9

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
United Airlines
7.4
Good
8,929 reviews
Delta
8.0
Very good
7,954 reviews

Food

7.3

Boarding

8.2

Crew

8.5

Comfort

7.9

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Mexico City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City, Florida to Mexico City?

    Departing from Panama City, Florida to Mexico City will take you 9h 30m. The distance between Panama City, Florida and Mexico City is about 1121 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Panama City, Florida to Mexico City round-trip?

    Currently priced at $362, Delta will fly you from Panama City, Florida to Mexico City and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on United Airlines for as low as $546. Delta is 44% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Panama City to Mexico City that include hotel bookings?

    Yes. In addition to deals on Panama City to Mexico City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Mexico City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Mexico City.

  • Can I find deals for business class flights from Panama City to Mexico City?

    Yes. Cheapflights offers flight deals from Panama City to Mexico City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to Mexico City?

    Currently, May is the cheapest month in which you can book a flight from Panama City, Florida to Mexico City (average of $387). Flying from Panama City, Florida to Mexico City in December is currently the most expensive (average of $615). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 2 airlines flying from Panama City to Mexico City

Discover the top 2 airlines that operate flights from Panama City to Mexico City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$362Average$577FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$546Average$601FlexibilityNo cancel feeOn-time69%

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