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$550+ Cheap flights from Panama City, FL (ECP) to Mexico City (MEX)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/30. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — MEX
Jan 16 — Jan 231
Fri 1/16
Fri 1/23
1 adult, Economy
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Cheap flight deals from Panama City to Mexico City

Cheapest flights from Panama City to Mexico City
Explore the most affordable flight options available from Panama City to Mexico City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 17, 2025.

This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/175:50 pmECP - MEX
2 stops17h 40mAmerican Airlines
Sun 12/218:00 amMEX - ECP
1 stop13h 24mAmerican Airlines
Deal found 12/15$834
This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/196:46 amECP - MEX
1 stop12h 49mAmerican Airlines
Sun 12/211:45 pmMEX - ECP
1 stop10h 08mAmerican Airlines
Deal found 12/15$904

Find flight deals from Panama City to Mexico City

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to Mexico City (MEX). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 17, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$499
(American Airlines)

Popular in

October

Cheapest in

September

Average price

$609
Provider with most accurate pricing for Panama City NW Florida Beaches-Mexico City Benito Juarez flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City NW Florida Beaches-Mexico City Benito Juarez flights.
Search Deals
From Panama City NW Florida Beaches to Mexico City Benito Juarez
Search Deals
Highest demand for flights based on searches. 10% potential increase in price ($72 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($35 potential savings vs. average RT price).
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Average for round-trip flights in December 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Mexico City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 17, 2025.
Use the filters below to find and compare flights from Panama City to Mexico City that are best for you.

Fly from

Panama City

Fly to

Mexico City

Route

Depart

Return

Price

Panama CityMexico City

ECP - MEX

ECPMEX

Panama City NW Florida Beaches

Fri 1/30

7:02 am-11:20 pm

1 stop16h 18m

Mexico City Benito Juarez

Fri 2/6

12:30 pm-9:19 pm

1 stop8h 49m

$550

Panama CityMexico City

ECP - MEX

ECPMEX

Panama City NW Florida Beaches

Tue 2/10

1:10 pm-12:10 am

1 stop11h 00m

Mexico City Benito Juarez

Tue 3/3

7:50 am-7:51 pm

1 stop12h 01m

$550

Panama CityMexico City

ECP - MEX

ECPMEX

Panama City NW Florida Beaches

Tue 2/10

7:20 am-4:35 pm

2 stops9h 15m

Mexico City Benito Juarez

Tue 3/3

8:35 am-6:52 pm

2 stops10h 17m

$555

Panama CityMexico City

ECP - MEX

ECPMEX

Panama City NW Florida Beaches

Sat 1/31

1:10 pm-8:50 pm

1 stop7h 40m

Mexico City Benito Juarez

Sat 2/7

8:40 am-3:47 pm

1 stop7h 07m

$579

Panama CityMexico City

ECP - MEX

ECPMEX

Panama City NW Florida Beaches

Sun 1/18

7:20 am-8:50 pm

1 stop13h 30m

Mexico City Benito Juarez

Thu 1/22

2:10 pm-10:40 pm

1 stop8h 30m

$590

Panama CityMexico City

ECP - MEX

ECPMEX

Panama City NW Florida Beaches

Tue 1/6

8:24 am-11:20 pm

1 stop14h 56m

Mexico City Benito Juarez

Fri 1/16

8:00 am-9:19 pm

1 stop13h 19m

$595

Panama CityMexico City

ECP - MEX

ECPMEX

Panama City NW Florida Beaches

Tue 1/6

6:03 pm-12:45 pm

1 stop18h 42m

Mexico City Benito Juarez

Sat 1/24

6:00 am-9:19 pm

1 stop15h 19m

$625

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/16

Compare providers for flights from Panama City to Mexico City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Mexico City in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
AranGrantPrice Accuracy2 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City, Florida-Mexico City flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Panama City, Florida-Mexico City flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Panama City, Florida-Mexico City flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City, Florida-Mexico City flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-Mexico City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Mexico City

Have a flexible travel schedule? Discover the best time to fly to Mexico City from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Mexico City

What is the cheapest month to book a flight from Panama City, Florida to Mexico City?

Currently, March is the cheapest month in which you can book a flight from Panama City, Florida to Mexico City (average of $386). Flying from Panama City, Florida to Mexico City in November is currently the most expensive (average of $571). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Mexico City

Get insights into the airlines that provide service to Mexico City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mexico City. Reviews last updated December 17, 2025.
Peruse reviews from past customers who have flown with Delta and United Airlines from Panama City to Mexico City to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,008 reviews

Crew

8.5

Boarding

8.1

Food

7.3

Overall

7.9

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
7.9
Good
8,008 reviews
Delta
7.9
Good
8,008 reviews

Crew

8.5

Boarding

8.1

Food

7.3

Overall

7.9

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
United Airlines
7.4
Good
9,092 reviews
Delta
7.9
Good
8,008 reviews

Crew

8.5

Boarding

8.1

Food

7.3

Overall

7.9

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Mexico City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City, Florida to Mexico City?

    Departing from Panama City, Florida to Mexico City will take you 9h 15m. The distance between Panama City, Florida and Mexico City is about 1121 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Panama City, Florida to Mexico City round-trip?

    Currently priced at $362, Delta will fly you from Panama City, Florida to Mexico City and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on United Airlines for as low as $546. Delta is 42% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Panama City to Mexico City that include hotel bookings?

    Yes. In addition to deals on Panama City to Mexico City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Mexico City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Mexico City.

  • Can I find deals for business class flights from Panama City to Mexico City?

    Yes. Cheapflights offers flight deals from Panama City to Mexico City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to Mexico City?

    Currently, March is the cheapest month in which you can book a flight from Panama City, Florida to Mexico City (average of $386). Flying from Panama City, Florida to Mexico City in November is currently the most expensive (average of $571). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Mexico City?

Book flights to Mexico City if you plan to visit one of these locations
Taxco

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Top 2 airlines flying from Panama City to Mexico City

Discover the top 2 airlines that operate flights from Panama City to Mexico City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$362Average$577FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$546Average$601FlexibilityNo cancel feeOn-time69%

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