In terms of precipitation, rainfall in Mexico City Federal District ranges from 0.0 - 4.7 inches per month. July is typically the wettest month, when rainfall can reach 4.7 in. January is typically the driest time to visit Mexico City Federal District when rainfall is around 0.0 in.

If weather is an important factor for your trip to Mexico City Federal District, use this chart to help with planning. For those seeking warmer temperatures, May is the ideal time of year to visit, when temperatures reach an average of 66.2 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 55.4 F).

What is the cheapest time of day to fly from ECP to DF?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama City, Florida to Mexico City Federal District as you normally would.

What airport do you fly from for flights from Panama City to Mexico City Federal District?

Panama City NW Florida Beaches (ECP), located 16.0 mi from the city center, is the airport you fly out of when you book flights from Panama City to Mexico City Federal District.

How can I find direct flights from Panama City to Mexico City Federal District?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Mexico City Federal District.

Can I find deals for business class flights from Panama City to Mexico City Federal District?

Yes. Cheapflights offers flight deals from Panama City to Mexico City Federal District by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$355+ Flights from Panama City, FL to Mexico City Federal District

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Cheap flight deals from Panama City to Mexico City Federal District

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$543 (Aeromexico)
One-way from	$355 (American Airlines)
Popular in	October
Cheapest in	September
Average price	$807

Provider with most accurate pricing for Panama City NW Florida Beaches-Mexico City Benito Juarez flight deals.

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Provider most trusted by Cheapflights users for Panama City NW Florida Beaches-Mexico City Benito Juarez flights.

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From Panama City NW Florida Beaches to Mexico City Federal District

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One-way flight from Panama City NW Florida Beaches to Mexico City Federal District

Search Deals

Highest demand for flights based on searches. 16% potential increase in price ($129 potential increase over avg. RT price).

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Cheapest flight prices on average. 5% potential price decrease ($33 potential savings vs. average RT price).

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Average for round-trip flights in November 2025

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Find flight deals from Panama City to Mexico City Federal District

Cheapest flights from Panama City to Mexico City Federal District
Explore the most affordable flight options available from Panama City to Mexico City Federal District. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 17, 2025.

Tue 12/304:09 pmECP - MEX

2 stops17h 46mAmerican Airlines

Tue 1/62:55 pmMEX - ECP

2 stops20h 38mAmerican Airlines

Deal found 11/15

$608

Fri 12/264:45 pmECP - MEX

1 stop7h 25mUnited Airlines

Wed 12/315:45 amMEX - ECP

1 stop8h 35mUnited Airlines

Deal found 11/15

$765

Tue 12/304:45 pmECP - MEX

1 stop17h 20mUnited Airlines

Tue 1/65:45 pmMEX - ECP

1 stop22h 27mUnited Airlines

Deal found 11/15

$797

Fri 12/266:46 amECP - MEX

1 stop15h 09mAmerican Airlines

Wed 12/314:55 pmMEX - ECP

2 stops17h 42mAmerican Airlines

Deal found 11/15

$967

Best flights from Panama City to Mexico City Federal District
Discover carefully curated flight deals from Panama City to Mexico City Federal District that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 17, 2025.

Tue 1/277:20 amECP - MEX

1 stop7h 55mAeromexico

Mon 2/24:35 pmMEX - ECP

1 stop6h 05mAeromexico

Deal found 11/16

$543

Tue 1/137:02 amECP - MEX

1 stop8h 58mAmerican Airlines

Tue 1/208:00 amMEX - ECP

1 stop6h 54mAmerican Airlines

Deal found 11/17

$550

Tue 1/136:00 amECP - MEX

1 stop6h 55mDelta

Tue 1/206:40 amMEX - ECP

2 stops11h 34mDelta

Deal found 11/17

$555

Tue 1/277:20 amECP - MEX

1 stop7h 55mAeromexico

Thu 2/512:35 pmMEX - ECP

1 stop7h 15mAeromexico

Deal found 11/16

$543

Tue 1/2712:15 pmECP - MEX

2 stops10h 20mDelta

Tue 2/34:35 pmMEX - ECP

1 stop6h 05mDelta

Deal found 11/16

$555

Wed 1/287:20 amECP - MEX

2 stops9h 15mDelta

Mon 2/28:40 amMEX - ECP

1 stop8h 32mDelta

Deal found 11/16

$555

Thu 1/296:00 amECP - MEX

2 stops10h 35mDelta

Tue 2/37:05 amMEX - ECP

2 stops11h 09mDelta

Deal found 11/16

$555

Tue 1/276:00 amECP - MEX

2 stops10h 35mDelta

Thu 2/512:35 pmMEX - ECP

1 stop7h 15mDelta

Deal found 11/16

$555

Thu 1/297:20 amECP - MEX

2 stops10h 15mDelta

Mon 2/212:35 pmMEX - ECP

1 stop7h 15mDelta

Deal found 11/16

$555

Wed 1/287:20 amECP - MEX

2 stops9h 45mDelta

Tue 2/34:35 pmMEX - ECP

1 stop6h 05mDelta

Deal found 11/16

$555

Last-minute flights from Panama City to Mexico City Federal District
Discover last-minute flight deals from Panama City to Mexico City Federal District. Data last updated November 17, 2025 and is based on user searches.

Fri 12/264:45 pmECP - MEX

1 stop7h 25mUnited Airlines

Wed 12/315:45 amMEX - ECP

1 stop8h 35mUnited Airlines

Deal found 11/15

$765

Fri 12/266:46 amECP - MEX

1 stop15h 09mAmerican Airlines

Wed 12/314:55 pmMEX - ECP

2 stops17h 42mAmerican Airlines

Deal found 11/15

$967

Tue 12/304:09 pmECP - MEX

2 stops17h 46mAmerican Airlines

Tue 1/62:55 pmMEX - ECP

2 stops20h 38mAmerican Airlines

Deal found 11/15

$608

Tue 12/304:45 pmECP - MEX

1 stop17h 20mUnited Airlines

Tue 1/65:45 pmMEX - ECP

1 stop22h 27mUnited Airlines

Deal found 11/15

$797

One-way flights from Panama City to Mexico City Federal District
Search for one-way flight options from Panama City to Mexico City Federal District. Find affordable one-way fares based on user searches. Data last updated November 17, 2025.

Fri 12/512:55 pmECP - MEX

2 stops11h 15mAmerican Airlines

Deal found 11/16

$355

Fri 12/54:26 pmECP - MEX

3 stops37h 19mMultiple Airlines

Deal found 11/16

$870

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to Mexico City Federal District that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CityMexico City

ECP - MEX

ECPMEX

Panama City NW Florida Beaches

Tue 1/27

7:20 am-3:15 pm

1 stop7h 55m

Mexico City Benito Juarez

Mon 2/2

4:35 pm-10:40 pm

1 stop6h 05m

$543

Panama CityMexico City

ECP - MEX

ECPMEX

Panama City NW Florida Beaches

Tue 1/27

7:20 am-3:15 pm

1 stop7h 55m

Mexico City Benito Juarez

Thu 2/5

12:35 pm-7:50 pm

1 stop7h 15m

$543

Panama CityMexico City

ECP - MEX

ECPMEX

Panama City NW Florida Beaches

Tue 1/13

7:02 am-4:00 pm

1 stop8h 58m

Mexico City Benito Juarez

Tue 1/20

8:00 am-2:54 pm

1 stop6h 54m

$550

Panama CityMexico City

ECP - MEX

ECPMEX

Panama City NW Florida Beaches

Tue 1/13

6:00 am-12:55 pm

1 stop6h 55m

Mexico City Benito Juarez

Tue 1/20

6:40 am-6:14 pm

2 stops11h 34m

$555

Panama CityMexico City

ECP - MEX

ECPMEX

Panama City NW Florida Beaches

Tue 1/27

12:15 pm-10:35 pm

2 stops10h 20m

Mexico City Benito Juarez

Tue 2/3

4:35 pm-10:40 pm

1 stop6h 05m

$555

Panama CityMexico City

ECP - MEX

ECPMEX

Panama City NW Florida Beaches

Wed 1/28

7:20 am-4:35 pm

2 stops9h 15m

Mexico City Benito Juarez

Mon 2/2

8:40 am-5:12 pm

1 stop8h 32m

$555

Panama CityMexico City

ECP - MEX

ECPMEX

Panama City NW Florida Beaches

Thu 1/29

6:00 am-4:35 pm

2 stops10h 35m

Mexico City Benito Juarez

Tue 2/3

7:05 am-6:14 pm

2 stops11h 09m

$555

Panama CityMexico City

ECP - MEX

ECPMEX

Panama City NW Florida Beaches

Tue 1/27

6:00 am-4:35 pm

2 stops10h 35m

Mexico City Benito Juarez

Thu 2/5

12:35 pm-7:50 pm

1 stop7h 15m

$555

Panama CityMexico City

ECP - MEX

ECPMEX

Panama City NW Florida Beaches

Thu 1/29

7:20 am-5:35 pm

2 stops10h 15m

Mexico City Benito Juarez

Mon 2/2

12:35 pm-7:50 pm

1 stop7h 15m

$555

Panama CityMexico City

ECP - MEX

ECPMEX

Panama City NW Florida Beaches

Wed 1/28

7:20 am-5:05 pm

2 stops9h 45m

Mexico City Benito Juarez

Tue 2/3

4:35 pm-10:40 pm

1 stop6h 05m

$555

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/16

Showing 1-10 of 12 results

Best time to book a flight from Panama City to Mexico City Federal District

Have a flexible travel schedule? Discover the best time to fly to Mexico City Federal District from Panama City with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Mexico City Federal District

What is the cheapest month to book a flight from Panama City, Florida to Mexico City Federal District?

Currently, November is the cheapest month in which you can book a flight from Panama City, Florida to Mexico City Federal District (average of $276). Flying from Panama City, Florida to Mexico City Federal District in January is currently the most expensive (average of $591). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Mexico City Federal District

Get a feel of what it's like to fly with Delta and United Airlines from Panama City to Mexico City Federal District by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

7.9

Good

8,008 reviews

Reviews

1 / 20

6.0

Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Delta

7.9

Good

8,008 reviews

Delta

7.9

Good

8,008 reviews

Reviews

1 / 20

6.0

Good

pilar,May 2025

RSW - ATL

United Airlines

7.4

Good

9,014 reviews

Delta

7.9

Good

8,008 reviews

Reviews

1 / 20

6.0

Good

pilar,May 2025

RSW - ATL

Related info for your journey

What airport do you fly from for flights from Panama City to Mexico City Federal District?
Panama City NW Florida Beaches (ECP), located 16.0 mi from the city center, is the airport you fly out of when you book flights from Panama City to Mexico City Federal District.
How long is the flight from Panama City, Florida to Mexico City Federal District?
Aeromexico, American Airlines, and Delta can get you from Panama City, Florida to Mexico City Federal District in just under 6h 55m. Your travel time can differ by up to 2h 03m. The distance from Panama City, Florida to Mexico City Federal District is about 1121 mi. This flight may include one or multiple stops.
Can I find deals for flights from Panama City to Mexico City Federal District that include hotel bookings?
Yes. In addition to deals on Panama City to Mexico City Federal District flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Panama City to Mexico City Federal District?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Mexico City Federal District.
Can I find deals for business class flights from Panama City to Mexico City Federal District?
Yes. Cheapflights offers flight deals from Panama City to Mexico City Federal District by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Panama City, Florida to Mexico City Federal District?
Currently, November is the cheapest month in which you can book a flight from Panama City, Florida to Mexico City Federal District (average of $276). Flying from Panama City, Florida to Mexico City Federal District in January is currently the most expensive (average of $591). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top 2 airlines flying from Panama City to Mexico City Federal District

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$362	Average$577	FlexibilityNo cancel fee	On-timeN/A
United Airlines	Cheapest$546	Average$601	FlexibilityNo cancel fee	On-time69%

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$355+ Cheap flights from Panama City, FL (ECP) to Mexico City Federal District

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/5. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Panama City to Mexico City Federal District with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Panama City to Mexico City Federal District

Keep the following information in mind while searching for Panama City to Mexico City Federal District flight deals. Data was last updated November 17, 2025.

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Panama City to Mexico City Federal District

Cheapest flights from Panama City to Mexico City Federal DistrictExplore the most affordable flight options available from Panama City to Mexico City Federal District. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 17, 2025.

Explore the most affordable flight options available from Panama City to Mexico City Federal District. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 17, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to Mexico City Federal District that are best for you.

Best time to book a flight from Panama City to Mexico City Federal District

Have a flexible travel schedule? Discover the best time to fly to Mexico City Federal District from Panama City with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Mexico City Federal District

What is the cheapest month to book a flight from Panama City, Florida to Mexico City Federal District?

Reviews of airlines servicing Mexico City Federal District

Get a feel of what it's like to fly with Delta and United Airlines from Panama City to Mexico City Federal District by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Mexico City Federal District. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly from for flights from Panama City to Mexico City Federal District?

How long is the flight from Panama City, Florida to Mexico City Federal District?

Can I find deals for flights from Panama City to Mexico City Federal District that include hotel bookings?

How can I find direct flights from Panama City to Mexico City Federal District?

Can I find deals for business class flights from Panama City to Mexico City Federal District?

What is the cheapest month to book a flight from Panama City, Florida to Mexico City Federal District?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Panama City to Mexico City Federal District

See prices for flight routes from nearby airports that may be better suited for you.

Top 2 airlines flying from Panama City to Mexico City Federal District

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Book with Flexibility

Travel Smart

Cheapest flights from Panama City to Mexico City Federal District
Explore the most affordable flight options available from Panama City to Mexico City Federal District. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 17, 2025.