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$350+ Cheap flights from Missouri to Madrid, Spain (MAD)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/15. Fares are subject to change and may not be available on all flights or dates of travel.
STL — MAD
Oct 16 — Oct 231
Thu 10/16
Thu 10/23
1 adult, Economy
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Cheap flight deals from Missouri to Madrid

Keep the following information in mind while searching for Missouri to Madrid flight deals. Data was last updated September 16, 2025.

Round-trip from

$417
(Mytrip)

One-way from

$350
(Kiwi.com)

Popular in

May

Cheapest in

September

Average price

$629
From Missouri to Madrid Barajas
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One-way flight from Missouri to Madrid Barajas
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Highest demand for flights based on searches. 25% potential increase in price ($302 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($36 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Missouri to Madrid

Cheapest flights from Missouri to Madrid
Explore the most affordable flight options available from Missouri to Madrid. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

This Mytrip deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/61:30 pmSTL - MAD
1 stop10h 10mAir Canada
Wed 10/2212:45 pmMAD - STL
2 stops33h 33mAir Canada
Deal found 9/15$417
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/121:30 pmSTL - MAD
1 stop10h 10mUnited Airlines
Wed 10/2212:45 pmMAD - STL
2 stops32h 42mUnited Airlines
Deal found 9/16$418
This eDestinos deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/32:48 pmSTL - MAD
1 stop12h 32mIberia
Mon 12/811:35 amMAD - STL
1 stop14h 31mIberia
Deal found 9/15$419
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/16:43 pmSTL - MAD
2 stops31h 17mUnited Airlines
Fri 11/141:35 pmMAD - STL
2 stops33h 11mUnited Airlines
Deal found 9/15$422
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/612:25 pmSTL - MAD
2 stops35h 15mUnited Airlines
Wed 10/2212:45 pmMAD - STL
2 stops33h 59mUnited Airlines
Deal found 9/13$428
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/79:15 amSTL - MAD
1 stop16h 05mUnited Airlines
Wed 10/2211:15 amMAD - STL
2 stops18h 20mUnited Airlines
Deal found 9/13$452
This lastminute.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure lastminute.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/21:37 pmMCI - MAD
1 stop12h 38mVirgin Atlantic
Tue 11/1811:15 amMAD - MCI
1 stop16h 55mVirgin Atlantic
Deal found 9/14$528
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/26:00 amMCI - MAD
2 stops19h 00mUnited Airlines
Wed 12/101:35 pmMAD - MCI
2 stops31h 46mUnited Airlines
Deal found 9/15$534
This Flighttix deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flighttix is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/66:32 pmMCI - MAD
2 stops29h 08mAir Canada
Wed 10/2212:45 pmMAD - MCI
2 stops28h 52mAir Canada
Deal found 9/16$535
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/125:47 pmMCI - MAD
1 stop31h 18mUnited Airlines
Wed 10/2212:45 pmMAD - MCI
2 stops28h 52mUnited Airlines
Deal found 9/15$540
This Air Canada deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/38:00 amMCI - MAD
3 stops17h 00mMultiple Airlines
Wed 12/101:35 pmMAD - MCI
2 stops31h 46mMultiple Airlines
Deal found 9/14$541
This KLM deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/2410:28 amMCI - MAD
1 stop16h 07mKLM
Tue 10/1412:40 pmMAD - MCI
1 stop35h 13mKLM
Deal found 9/15$548

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Madrid that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from Missouri to Madrid that are best for you.

Fly from

Missouri

Fly to

Madrid

Route

Depart

Return

Price

St. LouisMadrid

STL - MAD

STLMAD

Lambert-St Louis

Sun 10/12

1:30 pm-6:40 am

1 stop10h 10m

Madrid Barajas

Wed 10/22

12:45 pm-2:27 pm

2 stops32h 42m

$418

St. LouisMadrid

STL - MAD

STLMAD

Lambert-St Louis

Sun 10/12

1:30 pm-6:40 am

1 stop10h 10m

Madrid Barajas

Wed 10/22

12:30 pm-3:18 pm

1 stop33h 48m

$437

St. LouisMadrid

STL - MAD

STLMAD

Lambert-St Louis

Mon 10/6

9:15 am-8:20 am

1 stop16h 05m

Madrid Barajas

Wed 10/22

12:30 pm-3:18 pm

1 stop33h 48m

$444

St. LouisMadrid

STL - MAD

STLMAD

Lambert-St Louis

Sat 10/11

5:25 pm-9:35 am

1 stop33h 10m

Madrid Barajas

Tue 10/21

6:00 am-5:29 pm

2 stops18h 29m

$476

St. LouisMadrid

STL - MAD

STLMAD

Lambert-St Louis

Sun 11/23

4:05 pm-8:00 am

2 stops56h 55m

Madrid Barajas

Tue 12/2

2:00 pm-1:55 pm

1 stop30h 55m

$482

St. LouisMadrid

STL - MAD

STLMAD

Lambert-St Louis

Wed 12/3

2:48 pm-12:40 pm

2 stops14h 52m

Madrid Barajas

Mon 12/8

11:35 am-7:06 pm

1 stop14h 31m

$486

St. LouisMadrid

STL - MAD

STLMAD

Lambert-St Louis

Tue 10/7

3:59 pm-4:45 pm

2 stops17h 46m

Madrid Barajas

Tue 10/21

1:05 pm-8:05 am

2 stops26h 00m

$490

St. LouisMadrid

STL - MAD

STLMAD

Lambert-St Louis

Tue 10/7

1:30 pm-6:40 am

1 stop10h 10m

Madrid Barajas

Fri 10/17

11:15 am-10:49 am

2 stops30h 34m

$491

St. LouisMadrid

STL - MAD

STLMAD

Lambert-St Louis

Mon 10/6

1:30 pm-6:40 am

1 stop10h 10m

Madrid Barajas

Fri 10/17

11:15 am-10:49 am

2 stops30h 34m

$491

Kansas CityMadrid

MCI - MAD

MCIMAD

Kansas City

Sun 10/12

6:00 am-6:40 am

2 stops17h 40m

Madrid Barajas

Wed 10/22

12:45 pm-10:37 am

2 stops28h 52m

$534

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 35 results
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Best time to book a flight from Missouri to Madrid

Have a flexible travel schedule? Discover the best time to fly to Madrid from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Madrid

What is the cheapest month to book a flight from Missouri to Madrid?

Currently, November is the cheapest month in which you can book a flight from Missouri to Madrid (average of $543). Flying from Missouri to Madrid in June is currently the most expensive (average of $1,054). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to MAD?

Find hourly flight availability from Missouri to Madrid. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 16, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Missouri to Madrid as you normally would.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Madrid. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Madrid from Missouri?

    Most people fly into Madrid Barajas (MAD) if they book a flight to Madrid from Missouri. Barajas is conveniently located just 8.5 mi from Madrid’s city center.

  • How long is the flight from Missouri to Madrid?

    For as low as $418, United Airlines can have you in Madrid from Missouri in 10h 10m. There are 4414 mi between Missouri and Madrid. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Missouri to Madrid one-way?

    The cheapest airlines for a one-way flight from Missouri to Madrid are Scandinavian Airlines ($376), KLM ($382), and Delta ($382).

  • What are the most popular routes from Missouri to Madrid?

    Most travelers choose Lambert-St Louis - Madrid Barajas, Kansas City - Madrid Barajas or Springfield-Branson - Madrid Barajas when deciding on the best route from Missouri to Madrid.

  • Can I find deals for flights from Missouri to Madrid that include hotel bookings?

    Yes. In addition to deals on Missouri to Madrid flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Madrid?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Madrid.

  • Can I find deals for business class flights from Missouri to Madrid?

    Yes. Cheapflights offers flight deals from Missouri to Madrid by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Madrid?

    Currently, November is the cheapest month in which you can book a flight from Missouri to Madrid (average of $543). Flying from Missouri to Madrid in June is currently the most expensive (average of $1,054). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Madrid?

Book flights to Madrid if you plan to visit one of these locations
Fuenlabrada
Getafe

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Alternative routes for Missouri to Madrid

See prices for flight routes from nearby airports that may be better suited for you.
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Top 8 airlines flying from Missouri to Madrid

Discover the top 8 airlines that operate flights from Missouri to Madrid. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
KLMCheapest$492Average$711FlexibilityNo cancel feeOn-time75%
DeltaCheapest$492Average$839FlexibilityNo cancel feeOn-timeN/A
British AirwaysCheapest$546Average$897FlexibilityNo cancel feeOn-time70%
IberiaCheapest$578Average$981FlexibilityNo cancel feeOn-time77%
United AirlinesCheapest$578Average$955FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$584Average$1,015FlexibilityNo cancel feeOn-time71%
LufthansaCheapest$615Average$757FlexibilityNo cancel feeOn-time76%
Air CanadaCheapest$841Average$973FlexibilityNo cancel feeOn-time67%

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