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$312+ Cheap flights from Missouri to Madrid, Spain (MAD)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/16. Fares are subject to change and may not be available on all flights or dates of travel.
STL — MAD
Dec 3 — Dec 101
Wed 12/3
Wed 12/10
1 adult, Economy
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Cheap flight deals from Missouri to Madrid

Keep the following information in mind while searching for Missouri to Madrid flight deals. Data was last updated November 3, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$426
(AirNGo)

One-way from

$312
(Kiwi.com)

Popular in

June

Cheapest in

November

Average price

$624
Provider with most accurate pricing for Lambert-St Louis-Madrid Barajas flight deals.
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Provider most trusted by Cheapflights users for Lambert-St Louis-Madrid Barajas flights.
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From Missouri to Madrid Barajas
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One-way flight from Missouri to Madrid Barajas
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Highest demand for flights based on searches. 18% potential increase in price ($212 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($30 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Find flight deals from Missouri to Madrid

Cheapest flights from Missouri to Madrid
Explore the most affordable flight options available from Missouri to Madrid. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 3, 2025.

This AirNGo deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure AirNGo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/111:39 amSTL - MAD
1 stop14h 36mVirgin Atlantic
Tue 12/1611:15 amMAD - STL
1 stop14h 18mVirgin Atlantic
Deal found 11/2$426
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/19:33 amSTL - MAD
1 stop16h 42mDelta
Tue 12/1610:00 amMAD - STL
2 stops29h 24mDelta
Deal found 11/2$427
This Delta deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/112:18 pmMCI - MAD
1 stop13h 57mDelta
Tue 12/1610:00 amMAD - MCI
2 stops30h 56mDelta
Deal found 11/1$428
This KLM deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/111:39 amSTL - MAD
1 stop14h 36mKLM
Tue 12/1610:00 amMAD - STL
1 stop13h 35mKLM
Deal found 11/3$438
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/32:49 pmMCI - MAD
2 stops17h 31mDelta
Wed 12/1011:15 amMAD - MCI
1 stop18h 09mDelta
Deal found 11/3$457
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/23:27 pmMCI - MAD
1 stop10h 48mDelta
Tue 12/96:00 amMAD - MCI
2 stops24h 10mDelta
Deal found 11/2$462
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/26:00 amSTL - MAD
1 stop20h 15mDelta
Tue 12/96:00 amMAD - STL
2 stops22h 57mDelta
Deal found 11/2$462
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/26:27 pmMCI - MAD
2 stops54h 33mUnited Airlines
Sat 12/131:35 pmMAD - MCI
2 stops39h 23mUnited Airlines
Deal found 11/1$465
This KLM deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/22:13 pmMCI - MAD
2 stops14h 17mMultiple Airlines
Tue 12/96:00 amMAD - MCI
2 stops18h 00mMultiple Airlines
Deal found 11/2$473
This Air France deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/104:32 pmSTL - MAD
1 stop32h 28mMultiple Airlines
Tue 12/2311:15 amMAD - STL
1 stop28h 43mMultiple Airlines
Deal found 11/1$474
This Delta deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/1011:40 amSTL - MAD
2 stops15h 35mDelta
Tue 12/2311:15 amMAD - STL
1 stop28h 43mDelta
Deal found 11/1$475
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/28:05 amMCI - MAD
1 stop18h 10mDelta
Sat 12/1312:35 pmMAD - MCI
2 stops28h 21mDelta
Deal found 11/3$477

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Madrid that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 3, 2025.
Use the filters below to find and compare flights from Missouri to Madrid that are best for you.

Fly from

Missouri

Fly to

Madrid

Route

Depart

Return

Price

St. LouisMadrid

STL - MAD

STLMAD

Lambert-St Louis

Mon 12/1

9:33 am-9:15 am

1 stop16h 42m

Madrid Barajas

Tue 12/16

10:00 am-8:24 am

2 stops29h 24m

$427

Kansas CityMadrid

MCI - MAD

MCIMAD

Kansas City

Mon 12/1

12:18 pm-9:15 am

1 stop13h 57m

Madrid Barajas

Tue 12/16

10:00 am-9:56 am

2 stops30h 56m

$428

St. LouisMadrid

STL - MAD

STLMAD

Lambert-St Louis

Mon 12/1

11:39 am-9:15 am

1 stop14h 36m

Madrid Barajas

Tue 12/16

10:00 am-4:35 pm

1 stop13h 35m

$438

Kansas CityMadrid

MCI - MAD

MCIMAD

Kansas City

Tue 1/13

5:47 pm-3:20 pm

2 stops14h 33m

Madrid Barajas

Tue 1/20

10:00 am-7:19 pm

1 stop16h 19m

$457

Kansas CityMadrid

MCI - MAD

MCIMAD

Kansas City

Wed 12/3

2:49 pm-3:20 pm

2 stops17h 31m

Madrid Barajas

Wed 12/10

11:15 am-10:24 pm

1 stop18h 09m

$457

Kansas CityMadrid

MCI - MAD

MCIMAD

Kansas City

Tue 1/13

10:41 am-11:30 am

2 stops17h 49m

Madrid Barajas

Tue 1/20

10:00 am-9:05 pm

2 stops18h 05m

$461

Kansas CityMadrid

MCI - MAD

MCIMAD

Kansas City

Tue 12/2

5:50 am-9:15 am

1 stop20h 25m

Madrid Barajas

Tue 12/9

6:00 am-10:24 pm

2 stops23h 24m

$462

St. LouisMadrid

STL - MAD

STLMAD

Lambert-St Louis

Tue 12/2

6:00 am-9:15 am

1 stop20h 15m

Madrid Barajas

Tue 12/9

6:00 am-9:57 pm

2 stops22h 57m

$462

Kansas CityMadrid

MCI - MAD

MCIMAD

Kansas City

Mon 1/19

9:57 am-8:00 am

1 stop15h 03m

Madrid Barajas

Mon 2/2

10:00 am-7:19 pm

1 stop16h 19m

$463

St. LouisMadrid

STL - MAD

STLMAD

Lambert-St Louis

Wed 12/3

5:27 pm-8:00 am

2 stops31h 33m

Madrid Barajas

Mon 12/8

1:45 pm-2:25 pm

2 stops31h 40m

$478

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/2

Showing 1-10 of 42 results
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Best time to book a flight from Missouri to Madrid

Have a flexible travel schedule? Discover the best time to fly to Madrid from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Madrid

What is the cheapest month to book a flight from Missouri to Madrid?

Currently, September is the cheapest month in which you can book a flight from Missouri to Madrid (average of $481). Flying from Missouri to Madrid in May is currently the most expensive (average of $841). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to MAD?

Find hourly flight availability from Missouri to Madrid. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 3, 2025.

It’s optimal to fly from Missouri to Madrid in the morning. By choosing this option you can save up to 11% on the cost of your flight, compared to a flight in the evening.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Madrid. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Madrid from Missouri?

    Most people fly into Madrid Barajas (MAD) if they book a flight to Madrid from Missouri. Barajas is conveniently located just 8.5 mi from Madrid’s city center.

  • How long is the flight from Missouri to Madrid?

    For as low as $438, Delta can have you in Madrid from Missouri in 14h 36m. There are 4414 mi between Missouri and Madrid. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Missouri to Madrid one-way?

    The cheapest airlines for a one-way flight from Missouri to Madrid are British Airways ($352), Lufthansa ($404), and United Airlines ($419).

  • What are the most popular routes from Missouri to Madrid?

    Most travelers choose Lambert-St Louis - Madrid Barajas, Kansas City - Madrid Barajas or Springfield-Branson - Madrid Barajas when deciding on the best route from Missouri to Madrid.

  • Can I find deals for flights from Missouri to Madrid that include hotel bookings?

    Yes. In addition to deals on Missouri to Madrid flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Madrid?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Madrid.

  • Can I find deals for business class flights from Missouri to Madrid?

    Yes. Cheapflights offers flight deals from Missouri to Madrid by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Madrid?

    Currently, September is the cheapest month in which you can book a flight from Missouri to Madrid (average of $481). Flying from Missouri to Madrid in May is currently the most expensive (average of $841). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Madrid?

Book flights to Madrid if you plan to visit one of these locations
Fuenlabrada
Getafe

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Alternative routes for Missouri to Madrid

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Top 8 airlines flying from Missouri to Madrid

Discover the top 8 airlines that operate flights from Missouri to Madrid. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 3, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$488Average$824FlexibilityNo cancel feeOn-timeN/A
KLMCheapest$492Average$711FlexibilityNo cancel feeOn-time75%
LufthansaCheapest$524Average$758FlexibilityNo cancel feeOn-time76%
British AirwaysCheapest$546Average$885FlexibilityNo cancel feeOn-time70%
IberiaCheapest$578Average$919FlexibilityNo cancel feeOn-time77%
United AirlinesCheapest$578Average$874FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$586Average$1,044FlexibilityNo cancel feeOn-time71%
Air CanadaCheapest$701Average$947FlexibilityNo cancel feeOn-time67%

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