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$345+ Cheap flights from Missouri to Madrid, Spain (MAD)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/16. Fares are subject to change and may not be available on all flights or dates of travel.
MCI — MAD
Jan 20 — Jan 271
Tue 1/20
Tue 1/27
1 adult, Economy
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Cheap flight deals from Missouri to Madrid

Cheapest flights from Missouri to Madrid
Explore the most affordable flight options available from Missouri to Madrid. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 21, 2025.

This oojo deal was found by Cheapflights users on 12/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/249:08 amSTL - MAD
2 stops27h 57mBritish Airways
Wed 12/3112:00 pmMAD - STL
2 stops36h 10mBritish Airways
Deal found 12/19$910
This KLM deal was found by Cheapflights users on 12/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/237:02 pmSTL - MAD
1 stop31h 13mKLM
Thu 12/251:05 pmMAD - STL
2 stops17h 33mKLM
Deal found 12/19$1,028
This Finnair deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Finnair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/245:05 amSTL - MAD
1 stop17h 45mMultiple Airlines
Fri 12/261:15 pmMAD - STL
1 stop14h 36mMultiple Airlines
Deal found 12/20$1,070
This Expedia deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/216:35 pmSTL - MAD
2 stops22h 15mLufthansa
Sun 12/285:55 amMAD - STL
2 stops17h 32mLufthansa
Deal found 12/20$1,086
This Finnair deal was found by Cheapflights users on 12/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Finnair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/245:05 amSTL - MAD
1 stop17h 45mMultiple Airlines
Wed 12/311:00 pmMAD - STL
1 stop13h 30mMultiple Airlines
Deal found 12/19$1,094
This Finnair deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Finnair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/269:44 amMCI - MAD
1 stop16h 41mMultiple Airlines
Fri 1/21:15 pmMAD - MCI
1 stop15h 28mMultiple Airlines
Deal found 12/20$1,108
This Finnair deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Finnair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/245:00 amMCI - MAD
1 stop17h 50mMultiple Airlines
Fri 12/261:15 pmMAD - MCI
1 stop15h 28mMultiple Airlines
Deal found 12/20$1,124
This oojo deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/278:01 pmSTL - MAD
2 stops37h 54mBritish Airways
Tue 1/62:35 pmMAD - STL
2 stops39h 09mBritish Airways
Deal found 12/20$1,144
This Finnair deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Finnair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/215:16 amSTL - MAD
1 stop21h 09mMultiple Airlines
Sun 12/281:00 pmMAD - STL
1 stop13h 30mMultiple Airlines
Deal found 12/20$1,180
This Iberia deal was found by Cheapflights users on 12/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Iberia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/232:20 pmSGF - MAD
1 stop12h 05mIberia
Thu 12/2512:40 pmMAD - SGF
1 stop15h 24mIberia
Deal found 12/19$1,218
This Expedia deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/2411:41 amSTL - MAD
2 stops19h 34mIberia
Fri 12/265:05 pmMAD - STL
1 stop23h 26mIberia
Deal found 12/20$1,220
This American Airlines deal was found by Cheapflights users on 12/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/238:29 amSGF - MAD
1 stop17h 56mAmerican Airlines
Thu 12/2512:00 pmMAD - SGF
2 stops17h 25mAmerican Airlines
Deal found 12/19$1,283

Find flight deals from Missouri to Madrid

Keep the following information in mind while searching for Missouri to Madrid flight deals. Data was last updated December 21, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$452
(Kiwi.com)

One-way from

$384
(Kiwi.com)

Popular in

June

Cheapest in

November

Average price

$765
Provider with most accurate pricing for Lambert-St Louis-Madrid Barajas flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Madrid Barajas flights.
Search Deals
From Missouri to Madrid Barajas
Search Deals
One-way flight from Missouri to Madrid Barajas
Search Deals
Highest demand for flights based on searches. 22% potential increase in price ($247 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($32 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Madrid that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 21, 2025.
Use the filters below to find and compare flights from Missouri to Madrid that are best for you.

Fly from

Missouri

Fly to

Madrid

Route

Depart

Return

Price

St. LouisMadrid

STL - MAD

STLMAD

Lambert-St Louis

Wed 1/21

3:50 pm-4:00 pm

1 stop17h 10m

Madrid Barajas

Sun 1/25

5:55 am-1:55 pm

1 stop15h 00m

$452

St. LouisMadrid

STL - MAD

STLMAD

Lambert-St Louis

Sun 2/22

7:41 am-12:05 pm

2 stops21h 24m

Madrid Barajas

Mon 3/2

1:35 pm-9:05 pm

2 stops38h 30m

$472

SpringfieldMadrid

SGF - MAD

SGFMAD

Springfield-Branson

Fri 1/30

6:15 am-9:15 am

2 stops20h 00m

Madrid Barajas

Tue 2/3

1:35 pm-2:38 pm

2 stops32h 03m

$473

SpringfieldMadrid

SGF - MAD

SGFMAD

Springfield-Branson

Fri 2/6

7:45 am-9:15 am

2 stops18h 30m

Madrid Barajas

Tue 2/10

1:35 pm-2:38 pm

2 stops32h 03m

$473

ColumbiaMadrid

COU - MAD

COUMAD

Columbia Regional

Fri 1/16

11:17 am-9:15 am

2 stops14h 58m

Madrid Barajas

Tue 2/10

1:35 pm-2:35 pm

2 stops32h 00m

$473

ColumbiaMadrid

COU - MAD

COUMAD

Columbia Regional

Thu 1/15

8:09 am-9:15 am

2 stops18h 06m

Madrid Barajas

Thu 2/5

1:35 pm-10:42 am

2 stops28h 07m

$473

ColumbiaMadrid

COU - MAD

COUMAD

Columbia Regional

Sat 1/17

8:09 am-9:15 am

2 stops18h 06m

Madrid Barajas

Thu 2/5

1:35 pm-10:42 am

2 stops28h 07m

$473

ColumbiaMadrid

COU - MAD

COUMAD

Columbia Regional

Fri 1/16

11:17 am-9:15 am

2 stops14h 58m

Madrid Barajas

Fri 2/6

1:35 pm-10:42 am

2 stops28h 07m

$473

ColumbiaMadrid

COU - MAD

COUMAD

Columbia Regional

Sat 1/17

11:17 am-9:15 am

2 stops14h 58m

Madrid Barajas

Tue 2/10

1:35 pm-9:37 pm

2 stops39h 02m

$473

ColumbiaMadrid

COU - MAD

COUMAD

Columbia Regional

Sat 1/17

8:09 am-9:15 am

2 stops18h 06m

Madrid Barajas

Fri 2/6

1:35 pm-5:19 pm

2 stops34h 44m

$473

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/21

Showing 1-10 of 51 results
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Best time to book a flight from Missouri to Madrid

Have a flexible travel schedule? Discover the best time to fly to Madrid from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Madrid

What is the cheapest month to book a flight from Missouri to Madrid?

Currently, January is the cheapest month in which you can book a flight from Missouri to Madrid (average of $468). Flying from Missouri to Madrid in May is currently the most expensive (average of $841). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to MAD?

Find hourly flight availability from Missouri to Madrid. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 21, 2025.

It’s optimal to fly from Missouri to Madrid in the morning. By choosing this option you can save up to 11% on the cost of your flight, compared to a flight in the evening.

How much does it cost to fly round-trip from Missouri to Madrid?

Related info for your journey

Find useful and relevant information for your journey from Missouri to Madrid. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Madrid from Missouri?

    Most people fly into Madrid Barajas (MAD) if they book a flight to Madrid from Missouri. Barajas is conveniently located just 8.5 mi from Madrid’s city center.

  • How long is the flight from Missouri to Madrid?

    For as low as $452, Lufthansa can have you in Madrid from Missouri in 17h 20m. There are 4414 mi between Missouri and Madrid. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Missouri to Madrid one-way?

    The cheapest airlines for a one-way flight from Missouri to Madrid are American Airlines ($322), United Airlines ($438), and Iberia ($460).

  • What are the most popular routes from Missouri to Madrid?

    Most travelers choose Lambert-St Louis - Madrid Barajas, Kansas City - Madrid Barajas or Columbia Regional - Madrid Barajas when deciding on the best route from Missouri to Madrid.

  • Can I find deals for flights from Missouri to Madrid that include hotel bookings?

    Yes. In addition to deals on Missouri to Madrid flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Madrid?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Madrid.

  • Can I find deals for business class flights from Missouri to Madrid?

    Yes. Cheapflights offers flight deals from Missouri to Madrid by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Madrid?

    Currently, January is the cheapest month in which you can book a flight from Missouri to Madrid (average of $468). Flying from Missouri to Madrid in May is currently the most expensive (average of $841). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Madrid?

Book flights to Madrid if you plan to visit one of these locations
Getafe

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Alternative routes for Missouri to Madrid

See prices for flight routes from nearby airports that may be better suited for you.
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Top 9 airlines flying from Missouri to Madrid

Discover the top 9 airlines that operate flights from Missouri to Madrid. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 21, 2025.
AirlineCheapestAverageFlexibilityOn-time
Virgin AtlanticCheapest$437Average$805FlexibilityNo cancel feeOn-time72%
DeltaCheapest$487Average$814FlexibilityNo cancel feeOn-timeN/A
KLMCheapest$492Average$711FlexibilityNo cancel feeOn-time75%
United AirlinesCheapest$500Average$870FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$513Average$994FlexibilityNo cancel feeOn-time71%
British AirwaysCheapest$516Average$799FlexibilityNo cancel feeOn-time70%
LufthansaCheapest$524Average$762FlexibilityNo cancel feeOn-time76%
IberiaCheapest$578Average$888FlexibilityNo cancel feeOn-time77%
Air CanadaCheapest$701Average$947FlexibilityNo cancel feeOn-time67%

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