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Lisbon

$542+ Cheap flights from Panama to Lisbon (LIS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/25. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — LIS
Jan 15 — Jan 221
Thu 1/15
Thu 1/22
1 adult, Economy
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Cheap flight deals from Panama to Lisbon

Cheapest flights from Panama to Lisbon
Explore the most affordable flight options available from Panama to Lisbon. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 16, 2025.

This KLM deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/256:45 pmPTY - LIS
1 stop34h 50mMultiple Airlines
Sat 1/106:30 pmLIS - PTY
1 stop30h 40mMultiple Airlines
Deal found 12/15$1,207
This Air France deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/306:40 pmPTY - LIS
2 stops17h 50mMultiple Airlines
Tue 1/133:30 pmLIS - PTY
1 stop30h 00mMultiple Airlines
Deal found 12/13$1,220
This Air France deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/256:45 pmPTY - LIS
2 stops17h 45mAir France
Sat 1/106:30 pmLIS - PTY
1 stop30h 40mAir France
Deal found 12/16$1,294

Find flight deals from Panama to Lisbon

Keep the following information in mind while searching for Panama to Lisbon flight deals. Data was last updated December 16, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$765
(Air Europa)

One-way from

$542
(KLM)

Popular in

August

Cheapest in

March

Average price

$1,034
Provider with most accurate pricing for Panama City Tocumen Intl-Lisbon Humberto Delgado flight deals.
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Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Lisbon Humberto Delgado flights.
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From Panama to Lisbon Humberto Delgado
Search Deals
One-way flight from Panama to Lisbon Humberto Delgado
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($86 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($16 potential savings vs. average RT price).
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Average for round-trip flights in December 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to Lisbon that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 16, 2025.
Use the filters below to find and compare flights from Panama to Lisbon that are best for you.

Fly from

Panama

Fly to

Lisbon

Route

Depart

Return

Price

Panama CityLisbon

PTY - LIS

PTYLIS

Panama City Tocumen Intl

Sun 2/15

9:30 pm-7:15 pm

1 stop16h 45m

Lisbon Humberto Delgado

Mon 2/23

7:40 am-7:45 pm

1 stop17h 05m

$831

Panama CityLisbon

PTY - LIS

PTYLIS

Panama City Tocumen Intl

Mon 2/9

9:30 pm-7:15 pm

1 stop16h 45m

Lisbon Humberto Delgado

Sat 2/21

8:05 pm-7:45 pm

1 stop28h 40m

$855

Panama CityLisbon

PTY - LIS

PTYLIS

Panama City Tocumen Intl

Sat 2/14

10:05 pm-6:40 pm

1 stop15h 35m

Lisbon Humberto Delgado

Sun 3/1

5:30 am-8:10 pm

1 stop19h 40m

$895

Panama CityLisbon

PTY - LIS

PTYLIS

Panama City Tocumen Intl

Sat 2/7

6:45 pm-6:40 pm

1 stop18h 55m

Lisbon Humberto Delgado

Sun 2/15

4:10 pm-8:10 pm

1 stop33h 00m

$908

Panama CityLisbon

PTY - LIS

PTYLIS

Panama City Tocumen Intl

Sun 3/15

9:30 pm-3:15 pm

1 stop12h 45m

Lisbon Humberto Delgado

Wed 4/15

7:40 am-6:40 pm

1 stop17h 00m

$913

Panama CityLisbon

PTY - LIS

PTYLIS

Panama City Tocumen Intl

Sat 2/14

9:45 pm-3:05 pm

1 stop36h 20m

Lisbon Humberto Delgado

Sun 3/1

11:35 am-5:05 pm

2 stops34h 30m

$926

Panama CityLisbon

PTY - LIS

PTYLIS

Panama City Tocumen Intl

Sat 2/14

6:45 pm-6:40 pm

1 stop18h 55m

Lisbon Humberto Delgado

Sun 3/1

5:00 am-8:10 pm

2 stops20h 10m

$948

Panama CityLisbon

PTY - LIS

PTYLIS

Panama City Tocumen Intl

Sun 2/15

4:05 pm-5:45 pm

2 stops20h 40m

Lisbon Humberto Delgado

Mon 2/23

6:30 am-4:45 pm

1 stop15h 15m

$950

Panama CityLisbon

PTY - LIS

PTYLIS

Panama City Tocumen Intl

Thu 12/25

6:45 pm-10:35 am

1 stop34h 50m

$542

Panama CityLisbon

PTY - LIS

PTYLIS

Panama City Tocumen Intl

Sat 12/20

2:55 am-9:15 pm

3 stops37h 20m

$639

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/14

Showing 1-10 of 15 results
1
2

Best time to book a flight from Panama to Lisbon

Have a flexible travel schedule? Discover the best time to fly to Lisbon from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to Lisbon

What is the cheapest month to book a flight from Panama to Lisbon?

Currently, May is the cheapest month in which you can book a flight from Panama to Lisbon (average of $636). Flying from Panama to Lisbon in December is currently the most expensive (average of $863). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Lisbon

Get insights into the airlines that provide service to Lisbon. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Lisbon. Reviews last updated December 16, 2025.
Read through reviews of airlines operating flights from Panama to Lisbon, such as Air France and Air Europa. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Air France
7.4
Good
1,506 reviews

Crew

8.2

Entertainment

7.0

Comfort

7.3

Food

7.0

Overall

7.4

Boarding

7.4

Reviews

1 / 20
10.0
Excellent

Alpha Amadu,Dec 2025

CKY - CDG

Super calm and deliberate, staff are exceptionally down to detail
Air France
7.4
Good
1,506 reviews
Air France
7.4
Good
1,506 reviews

Crew

8.2

Entertainment

7.0

Comfort

7.3

Food

7.0

Overall

7.4

Boarding

7.4

Reviews

1 / 20
10.0
Excellent

Alpha Amadu,Dec 2025

CKY - CDG

Super calm and deliberate, staff are exceptionally down to detail
Air Europa
7.0
Good
572 reviews
Air France
7.4
Good
1,506 reviews

Crew

8.2

Entertainment

7.0

Comfort

7.3

Food

7.0

Overall

7.4

Boarding

7.4

Reviews

1 / 20
10.0
Excellent

Alpha Amadu,Dec 2025

CKY - CDG

Super calm and deliberate, staff are exceptionally down to detail

Related info for your journey

Find useful and relevant information for your journey from Panama to Lisbon. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Lisbon from Panama?

    Located just 4.2 mi from the city center, Lisbon Humberto Delgado (LIS) is the airport most travelers will use when flying to Lisbon from Panama.

  • How long is the flight from Panama to Lisbon?

    Departing from Panama to Lisbon will take you 16h 45m. The distance between Panama and Lisbon is about 4762 mi.

  • Can I find deals for flights from Panama to Lisbon that include hotel bookings?

    Yes. In addition to deals on Panama to Lisbon flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to Lisbon?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to Lisbon.

  • Can I find deals for business class flights from Panama to Lisbon?

    Yes. Cheapflights offers flight deals from Panama to Lisbon by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to Lisbon?

    Currently, May is the cheapest month in which you can book a flight from Panama to Lisbon (average of $636). Flying from Panama to Lisbon in December is currently the most expensive (average of $863). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Lisbon?

Book flights to Lisbon if you plan to visit one of these locations
Fátima
Oeiras
Ericeira
Costa da Caparica
Torres Vedras
Beja
Nazaré
Sesimbra
Colares

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Alternative routes for Panama to Lisbon

See prices for flight routes from nearby airports that may be better suited for you.
San José to Lisbon flights
Guatemala City to Lisbon flights
Panama City to Lisbon flights
Panama City to Porto flights
San Salvador to Lisbon flights

Top 2 airlines flying from Panama to Lisbon

Discover the top 2 airlines that operate flights from Panama to Lisbon. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
Air FranceCheapest$697Average$846FlexibilityNo cancel feeOn-time77%
Air EuropaCheapest$783Average$942FlexibilityNo cancel feeOn-time83%

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