HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
La Crosse

Cheap flights from Knoxville to La Crosse (TYS - LSE)

TYS — LSE
Jul 23 — Jul 301
Wed 7/23
Wed 7/30
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to La Crosse with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Best time to book a flight from Knoxville to La Crosse

Have a flexible travel schedule? Discover the best time to fly to La Crosse from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to La Crosse. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • Can I find deals for flights from Knoxville to La Crosse that include hotel bookings?

    Yes. In addition to deals on Knoxville to La Crosse flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to La Crosse?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to La Crosse.

  • Can I find deals for business class flights from Knoxville to La Crosse?

    Yes. Cheapflights offers flight deals from Knoxville to La Crosse by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

Traveling to a place near La Crosse?

Book flights to La Crosse if you plan to visit one of these locations
Decorah

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to La Crosse

See prices for flight routes from nearby airports that may be better suited for you.
Nashville to O'Hare Intl flights
Memphis to O'Hare Intl flights
Knoxville to O'Hare Intl flights
Nashville to Minneapolis flights
Chattanooga to O'Hare Intl flights
Knoxville to Minneapolis flights
Nashville to Milwaukee flights
Memphis to Minneapolis flights
Nashville to Madison flights
Memphis to Milwaukee flights
Chattanooga to Minneapolis flights
Chattanooga to Madison flights
Knoxville to Appleton flights
Knoxville to Milwaukee flights
Blountville to O'Hare Intl flights
Knoxville to Green Bay flights
Knoxville to Madison flights
Memphis to Madison flights
Nashville to Green Bay flights
Nashville to Rhinelander flights
Memphis to Green Bay flights
Chattanooga to Milwaukee flights
Nashville to Duluth flights
Blountville to Milwaukee flights
Nashville to Appleton flights
Nashville to Wausau flights
Chattanooga to Duluth flights
Nashville to La Crosse flights
Blountville to Madison flights
Nashville to Escanaba flights
Blountville to Minneapolis flights
Knoxville to Wausau flights
Blountville to Duluth flights
Nashville to Dubuque flights
Chattanooga to La Crosse flights

Top airline flying from Knoxville to La Crosse

Discover the top airline that operate flights from Knoxville to La Crosse. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$400Average$445FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.