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$399+ Cheap flights from Panama City, FL (ECP) to Italy

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/8. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — NAP
dic. 26 — ene. 21
vie. 12/26
vie. 1/2
1 adult, Economy
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Cheap flight deals from Panama City to Italy

Keep the following information in mind while searching for Panama City to Italy flight deals. Data was last updated noviembre 26, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$476
(Delta)

One-way from

$399
(United Airlines)

Popular in

May

Cheapest in

January

Average price

$797
Provider with most accurate pricing for Panama City NW Florida Beaches-Rome (ROM) flight deals.
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Provider most trusted by Cheapflights users for Panama City NW Florida Beaches-Rome (ROM) flights.
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From Panama City NW Florida Beaches to Italy
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One-way flight from Panama City NW Florida Beaches to Italy
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Highest demand for flights based on searches. 28% potential increase in price ($445 potential increase over avg. RT price).
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Cheapest flight prices on average. 7% potential price decrease ($80 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Find flight deals from Panama City to Italy

Cheapest flights from Panama City to Italy
Explore the most affordable flight options available from Panama City to Italy. Find the lowest fares from popular airlines and budget airlines, with prices last updated on noviembre 26, 2025.

This United Airlines deal was found by Cheapflights users on 11/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/176:30 amECP - FCO
2 stops18h 15mUnited Airlines
mié. 12/247:05 amFCO - ECP
2 stops37h 22mUnited Airlines
Deal found 11/23$1,197
This KLM deal was found by Cheapflights users on 11/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/171:32 pmECP - FCO
1 stop13h 58mKLM
mié. 12/2410:05 amFCO - ECP
1 stop19h 57mKLM
Deal found 11/23$1,480
This Delta deal was found by Cheapflights users on 11/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/177:30 amECP - FCO
1 stop17h 25mDelta
mié. 12/2410:05 amFCO - ECP
2 stops19h 57mDelta
Deal found 11/23$1,484
This United Airlines deal was found by Cheapflights users on 11/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/224:45 pmECP - FCO
2 stops56h 45mUnited Airlines
lun. 12/2910:55 amFCO - ECP
2 stops57h 32mUnited Airlines
Deal found 11/23$1,660
This KLM deal was found by Cheapflights users on 11/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/227:02 pmECP - FCO
1 stop29h 53mKLM
lun. 12/2912:40 pmFCO - ECP
1 stop14h 16mKLM
Deal found 11/23$1,877
This Delta deal was found by Cheapflights users on 11/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/229:22 amECP - FCO
2 stops16h 48mDelta
lun. 12/2912:40 pmFCO - ECP
1 stop14h 16mDelta
Deal found 11/23$2,524

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Italy that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated noviembre 26, 2025.
Use the filters below to find and compare flights from Panama City to Italy that are best for you.

Fly from

Panama City

Fly to

Italy

Route

Depart

Return

Price

Panama CityVenice

ECP - VCE

ECPVCE

Panama City NW Florida Beaches

mié. 1/28

12:15 pm-11:20 am

2 stops16h 05m

Venice Marco Polo

dom. 2/1

12:20 pm-11:08 am

2 stops29h 48m

$476

Panama CityRome

ECP - FCO

ECPFCO

Panama City NW Florida Beaches

mié. 1/21

9:24 am-10:30 am

1 stop18h 06m

Rome Fiumicino

dom. 1/25

12:45 pm-10:40 pm

2 stops16h 55m

$481

Panama CityRome

ECP - FCO

ECPFCO

Panama City NW Florida Beaches

mié. 1/21

6:30 am-7:55 am

2 stops18h 25m

Rome Fiumicino

dom. 1/25

12:45 pm-12:02 pm

2 stops30h 17m

$494

Panama CityRome

ECP - FCO

ECPFCO

Panama City NW Florida Beaches

mié. 1/21

6:00 am-10:30 am

1 stop21h 30m

Rome Fiumicino

dom. 1/25

12:45 pm-10:40 pm

2 stops16h 55m

$506

Panama CityRome

ECP - FCO

ECPFCO

Panama City NW Florida Beaches

mar. 2/10

6:30 am-7:55 am

2 stops18h 25m

Rome Fiumicino

lun. 3/2

7:05 am-9:56 pm

2 stops21h 51m

$529

Panama CityRome

ECP - FCO

ECPFCO

Panama City NW Florida Beaches

dom. 2/8

6:30 am-7:55 am

2 stops18h 25m

$399

Panama CityRome

ECP - FCO

ECPFCO

Panama City NW Florida Beaches

dom. 2/8

7:20 am-10:30 am

1 stop20h 10m

$419

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/24

Best time to book a flight from Panama City to Italy

Have a flexible travel schedule? Discover the best time to fly to Italy from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Italy

What is the cheapest month to book a flight from Panama City, Florida to Italy?

Currently, October is the cheapest month in which you can book a flight from Panama City, Florida to Italy (average of $544). Flying from Panama City, Florida to Italy in June is currently the most expensive (average of $1,245). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ECP to IT?

Find hourly flight availability from Panama City to Italy. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated noviembre 26, 2025.

It’s optimal to fly from Panama City, Florida to Italy in the afternoon. By choosing this option you can save up to 29% on the cost of your flight, compared to a flight at noon.

What is the cheapest day to fly from Panama City, Florida to Italy?

Use this chart to determine the cheapest time to fly round-trip from Panama City to Italy. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Panama City, Florida to Italy flight should consider departing on Tuesday afternoons when fares are most often at their lowest. Saturday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Italy

Get insights into the airlines that provide service to Italy. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Italy. Reviews last updated noviembre 26, 2025.
Read through reviews of airlines operating flights from Panama City to Italy, such as Delta, KLM, and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Crew

8.5

Overall

7.9

Food

7.3

Entertainment

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
7.9
Good
7,998 reviews
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Crew

8.5

Overall

7.9

Food

7.3

Entertainment

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
KLM
7.7
Good
1,423 reviews
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Crew

8.5

Overall

7.9

Food

7.3

Entertainment

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
United Airlines
7.4
Good
9,046 reviews
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Crew

8.5

Overall

7.9

Food

7.3

Entertainment

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
11,038 reviews
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Crew

8.5

Overall

7.9

Food

7.3

Entertainment

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Italy. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to Italy?

    Panama City NW Florida Beaches (ECP), located 16.0 mi from the city center, is the airport you fly out of when you book flights from Panama City to Italy.

  • How long is the flight from Panama City, Florida to Italy?

    Departing from Panama City, Florida to Italy will take you 16h 05m. Airlines will cover a distance of 5112 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Panama City to Italy that include hotel bookings?

    Yes. In addition to deals on Panama City to Italy flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Italy?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Italy.

  • Can I find deals for business class flights from Panama City to Italy?

    Yes. Cheapflights offers flight deals from Panama City to Italy by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to Italy?

    Currently, October is the cheapest month in which you can book a flight from Panama City, Florida to Italy (average of $544). Flying from Panama City, Florida to Italy in June is currently the most expensive (average of $1,245). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 2 airlines flying from Panama City to Italy

Discover the top 2 airlines that operate flights from Panama City to Italy. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated noviembre 26, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$729Average$1,300FlexibilityNo cancel feeOn-timeN/A
KLMCheapest$783Average$928FlexibilityNo cancel feeOn-time75%

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