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$457+ Cheap flights from Panama City, FL (ECP) to Italy

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/18. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — NAP
Feb 15 — Feb 221
Sun 2/15
Sun 2/22
1 adult, Economy
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Cheap flight deals from Panama City to Italy

Keep the following information in mind while searching for Panama City to Italy flight deals. Data was last updated January 16, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$457
(Delta)

Popular in

May

Cheapest in

February

Average price

$700
Provider with most accurate pricing for Panama City NW Florida Beaches-Rome (ROM) flight deals.
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Provider most trusted by Cheapflights users for Panama City NW Florida Beaches-Rome (ROM) flights.
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From Panama City NW Florida Beaches to Italy
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Highest demand for flights based on searches. 31% potential increase in price ($483 potential increase over avg. RT price).
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Cheapest flight prices on average. 8% potential price decrease ($81 potential savings vs. average RT price).
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Average for round-trip flights in January 2026
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Find flight deals from Panama City to Italy

Cheapest flights from Panama City to Italy
Explore the most affordable flight options available from Panama City to Italy. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 16, 2026.

This Delta deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/189:26 am
ECP
-
FCO
1 stop18h 04m
Delta
Wed 2/2512:40 pm
FCO
-
ECP
1 stop16h 59m
Delta
Deal found 1/14$457
This KLM deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/182:05 pm
ECP
-
FCO
1 stop13h 25m
KLM
Wed 2/2512:40 pm
FCO
-
ECP
1 stop16h 59m
KLM
Deal found 1/14$458
This KLM deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/104:45 pm
ECP
-
FCO
2 stops16h 40m
Multiple Airlines
Tue 2/246:00 am
FCO
-
ECP
2 stops23h 39m
Multiple Airlines
Deal found 1/14$511
This United Airlines deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/285:00 pm
ECP
-
VCE
2 stops36h 45m
United Airlines
Sat 3/73:05 pm
VCE
-
ECP
2 stops48h 38m
United Airlines
Deal found 1/14$511
This United Airlines deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/16:30 am
ECP
-
FCO
2 stops33h 30m
United Airlines
Sun 3/87:05 am
FCO
-
ECP
2 stops32h 38m
United Airlines
Deal found 1/15$514
This United Airlines deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/185:00 pm
ECP
-
FCO
2 stops31h 45m
United Airlines
Wed 2/2511:15 am
FCO
-
ECP
2 stops41h 41m
United Airlines
Deal found 1/14$516
This United Airlines deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/16:30 am
ECP
-
FCO
2 stops33h 30m
United Airlines
Sun 3/1512:15 pm
FCO
-
ECP
3 stops54h 59m
United Airlines
Deal found 1/14$529
This United Airlines deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/159:00 am
ECP
-
FCO
2 stops41h 15m
United Airlines
Sun 8/2312:45 pm
FCO
-
ECP
2 stops31h 24m
United Airlines
Deal found 1/14$567
This United Airlines deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/106:30 am
ECP
-
FCO
2 stops18h 25m
United Airlines
Tue 2/247:05 am
FCO
-
ECP
3 stops19h 46m
United Airlines
Deal found 1/14$570
This American Airlines deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/2811:11 am
ECP
-
VCE
2 stops19h 34m
American Airlines
Sat 3/710:50 am
VCE
-
ECP
3 stops19h 59m
American Airlines
Deal found 1/14$762
This Ovago deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/104:55 pm
ECP
-
VCE
2 stops32h 00m
Lufthansa
Thu 9/179:55 am
VCE
-
ECP
2 stops17h 11m
Lufthansa
Deal found 1/14$979
This Delta deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/114:10 pm
ECP
-
VCE
2 stops14h 10m
Delta
Sun 6/283:25 pm
VCE
-
ECP
1 stop14h 21m
Delta
Deal found 1/15$1,222

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Italy that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 16, 2026.
Use the filters below to find and compare flights from Panama City to Italy that are best for you.

Fly from

Panama City

Fly to

Italy

Route

Depart

Return

Price

Panama CityRome

ECP - FCO

ECPFCO

Panama City NW Florida Beaches

Wed 2/18

9:26 am-10:30 am

1 stop18h 04m

Rome Fiumicino

Wed 2/25

12:40 pm-10:39 pm

1 stop16h 59m

$457

Panama CityRome

ECP - FCO

ECPFCO

Panama City NW Florida Beaches

Wed 2/18

2:05 pm-10:30 am

1 stop13h 25m

Rome Fiumicino

Wed 2/25

12:40 pm-10:39 pm

1 stop16h 59m

$458

Panama CityVenice

ECP - VCE

ECPVCE

Panama City NW Florida Beaches

Sat 2/28

5:00 pm-12:45 pm

2 stops36h 45m

Venice Marco Polo

Sat 3/7

3:05 pm-8:43 am

2 stops48h 38m

$511

Panama CityRome

ECP - FCO

ECPFCO

Panama City NW Florida Beaches

Sun 3/1

6:30 am-11:00 pm

2 stops33h 30m

Rome Fiumicino

Sun 3/8

7:05 am-8:43 am

2 stops32h 38m

$514

Panama CityRome

ECP - FCO

ECPFCO

Panama City NW Florida Beaches

Wed 2/18

5:00 pm-7:45 am

2 stops31h 45m

Rome Fiumicino

Wed 2/25

11:15 am-9:56 pm

2 stops41h 41m

$516

Panama CityRome

ECP - FCO

ECPFCO

Panama City NW Florida Beaches

Sun 3/1

6:30 am-11:00 pm

2 stops33h 30m

Rome Fiumicino

Sun 3/15

12:15 pm-1:14 pm

3 stops54h 59m

$529

Panama CityRome

ECP - FCO

ECPFCO

Panama City NW Florida Beaches

Tue 2/10

6:30 am-7:55 am

2 stops18h 25m

Rome Fiumicino

Tue 2/24

7:05 am-7:51 pm

3 stops19h 46m

$570

Panama CityRome

ECP - FCO

ECPFCO

Panama City NW Florida Beaches

Tue 2/10

4:45 pm-4:25 pm

2 stops16h 40m

Rome Fiumicino

Tue 2/24

6:00 am-10:39 pm

2 stops23h 39m

$594

Panama CityRome

ECP - FCO

ECPFCO

Panama City NW Florida Beaches

Tue 2/10

4:45 pm-4:25 pm

2 stops16h 40m

Rome Fiumicino

Tue 2/24

12:40 pm-10:39 pm

1 stop16h 59m

$595

Panama CityVenice

ECP - VCE

ECPVCE

Panama City NW Florida Beaches

Sat 2/28

11:11 am-1:45 pm

2 stops19h 34m

Venice Marco Polo

Sat 3/7

10:50 am-11:49 pm

3 stops19h 59m

$762

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/14

Showing 1-10 of 22 results
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2
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Best time to book a flight from Panama City to Italy

Have a flexible travel schedule? Discover the best time to fly to Italy from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Italy

What is the cheapest month to book a flight from Panama City, Florida to Italy?

Currently, January is the cheapest month in which you can book a flight from Panama City, Florida to Italy (average of $447). Flying from Panama City, Florida to Italy in June is currently the most expensive (average of $1,232). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Italy

Get insights into the airlines that provide service to Italy. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Italy. Reviews last updated January 16, 2026.
Read through reviews of airlines operating flights from Panama City to Italy, such as Delta, KLM, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,050 reviews

Food

7.2

Boarding

8.1

Comfort

7.9

Entertainment

7.8

Overall

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
7.9
Good
8,050 reviews
Delta
7.9
Good
8,050 reviews

Food

7.2

Boarding

8.1

Comfort

7.9

Entertainment

7.8

Overall

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
KLM
7.7
Good
1,440 reviews
Delta
7.9
Good
8,050 reviews

Food

7.2

Boarding

8.1

Comfort

7.9

Entertainment

7.8

Overall

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
11,135 reviews
Delta
7.9
Good
8,050 reviews

Food

7.2

Boarding

8.1

Comfort

7.9

Entertainment

7.8

Overall

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Italy. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to Italy?

    Panama City NW Florida Beaches (ECP), located 16.0 mi from the city center, is the airport you fly out of when you book flights from Panama City to Italy.

  • How long is the flight from Panama City, Florida to Italy?

    Departing from Panama City, Florida to Italy will take you 13h 25m. Airlines will cover a distance of 5228 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Panama City to Italy that include hotel bookings?

    Yes. In addition to deals on Panama City to Italy flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Italy?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Italy.

  • Can I find deals for business class flights from Panama City to Italy?

    Yes. Cheapflights offers flight deals from Panama City to Italy by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to Italy?

    Currently, January is the cheapest month in which you can book a flight from Panama City, Florida to Italy (average of $447). Flying from Panama City, Florida to Italy in June is currently the most expensive (average of $1,232). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Panama City to Italy

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Panama City to Italy

Discover the top 2 airlines that operate flights from Panama City to Italy. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 16, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$729Average$985FlexibilityNo cancel feeOn-timeN/A
KLMCheapest$783Average$928FlexibilityNo cancel feeOn-time75%

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