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$647+ Cheap flights from Panama to Istanbul

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/14. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — IST
May 27 — Jun 31
Wed 5/27
Wed 6/3
1 adult, Economy
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Cheap flight deals from Panama to Istanbul

Cheapest flights from Panama to Istanbul
Explore the most affordable flight options available from Panama to Istanbul. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 27, 2026.

This Booking.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/59:30 pm
PTY
-
IST
1 stop33h 25m
Air Europa
Thu 11/194:35 pm
IST
-
PTY
1 stop35h 10m
Air Europa
Deal found 4/23$1,097
This FlightHub deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/308:25 pm
PTY
-
IST
1 stop33h 30m
Air Europa
Wed 10/143:45 pm
IST
-
PTY
1 stop34h 55m
Air Europa
Deal found 4/26$1,120
This Justfly.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/302:55 am
PTY
-
IST
2 stops35h 50m
Multiple Airlines
Fri 12/116:30 am
IST
-
PTY
2 stops34h 20m
Multiple Airlines
Deal found 4/27$1,121
This FlightHub deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/16:31 pm
PTY
-
IST
2 stops20h 14m
Lufthansa
Fri 12/116:30 am
IST
-
PTY
2 stops32h 08m
Lufthansa
Deal found 4/23$1,125
This Booking.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/158:25 pm
PTY
-
IST
1 stop33h 30m
Air Europa
Sun 10/254:35 pm
IST
-
PTY
1 stop35h 10m
Air Europa
Deal found 4/23$1,134
This KLM deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:50 pm
PTY
-
IST
1 stop22h 30m
KLM
Sat 5/235:20 pm
IST
-
PTY
1 stop31h 30m
KLM
Deal found 4/26$1,140
This Kiwi.com deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/610:20 pm
PTY
-
IST
Nonstop12h 45m
Multiple Airlines
Wed 5/2011:15 pm
IST
-
PTY
2 stops51h 25m
Multiple Airlines
Deal found 4/24$1,146
This Trip.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/312:55 am
PTY
-
IST
2 stops28h 00m
Multiple Airlines
Fri 11/64:35 pm
IST
-
PTY
2 stops32h 20m
Multiple Airlines
Deal found 4/22$1,149
This Air Europa deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/78:25 pm
PTY
-
IST
1 stop33h 30m
Air Europa
Wed 10/213:45 pm
IST
-
PTY
1 stop34h 55m
Air Europa
Deal found 4/25$1,158
This United Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/79:13 am
PTY
-
IST
2 stops22h 57m
United Airlines
Sun 10/1810:10 am
IST
-
PTY
2 stops28h 03m
United Airlines
Deal found 4/25$1,159
This KLM deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:50 pm
PTY
-
IST
1 stop22h 30m
KLM
Wed 10/144:25 am
IST
-
PTY
2 stops20h 25m
KLM
Deal found 4/27$1,160

Find flight deals from Panama to Istanbul

Keep the following information in mind while searching for Panama to Istanbul flight deals. Data was last updated April 27, 2026.

Round-trip from

$1,120
(FlightHub)

One-way from

$647
(United Airlines)

Popular in

April

Cheapest in

March

Average price

$1,401
From Panama to Istanbul
Search Deals
One-way flight from Panama to Istanbul
Search Deals
High demand for flights, 1% potential price rise
Search Deals
Cheapest flight prices on average. 0% potential price decrease ($10 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to Istanbul that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 27, 2026.
Use the filters below to find and compare flights from Panama to Istanbul that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityIstanbul

PTY - IST

PTYIST

Panama City Tocumen Intl

Wed 10/21

8:10 am-6:55 pm

2 stops26h 45m

Istanbul

Mon 11/2

7:55 am-6:13 am

2 stops30h 18m

$1,163

Panama CityIstanbul

PTY - IST

PTYIST

Panama City Tocumen Intl

Wed 9/30

9:13 am-6:55 pm

2 stops25h 42m

Istanbul

Wed 10/14

10:10 am-6:13 am

2 stops28h 03m

$1,163
Quickest round-trip

Panama CityIstanbul

PTY - IST

PTYIST

Panama City Tocumen Intl

Mon 5/25

9:13 am-5:15 pm

2 stops24h 02m

Istanbul

Tue 6/2

10:10 am-6:13 am

2 stops28h 03m

$1,170

Panama CityIstanbul

PTY - IST

PTYIST

Panama City Tocumen Intl

Mon 6/15

9:13 am-12:15 am

2 stops31h 02m

Istanbul

Tue 6/23

10:10 am-6:13 am

2 stops28h 03m

$1,174

Panama CityIstanbul

PTY - IST

PTYIST

Panama City Tocumen Intl

Thu 10/1

9:13 am-4:10 pm

2 stops22h 57m

Istanbul

Wed 10/28

6:30 am-6:13 am

2 stops31h 43m

$1,179

Panama CityIstanbul

PTY - IST

PTYIST

Panama City Tocumen Intl

Sat 10/3

9:45 am-5:15 pm

2 stops23h 30m

Istanbul

Sun 11/8

10:35 am-8:02 pm

2 stops41h 27m

$1,183

Panama CityIstanbul

PTY - IST

PTYIST

Panama City Tocumen Intl

Mon 6/22

10:00 am-5:15 pm

2 stops23h 15m

Istanbul

Sun 7/5

5:50 am-6:37 pm

2 stops44h 47m

$1,185

Panama CityIstanbul

PTY - IST

PTYIST

Panama City Tocumen Intl

Thu 6/4

9:13 am-12:15 am

2 stops31h 02m

Istanbul

Thu 6/25

5:40 am-8:35 pm

2 stops22h 55m

$1,189
Cheapest one-way

Panama CityIstanbul

PTY - IST

PTYIST

Panama City Tocumen Intl

Tue 6/2

9:45 am-6:55 pm

2 stops25h 10m

$648

Panama CityIstanbul

PTY - IST

PTYIST

Panama City Tocumen Intl

Tue 5/5

5:55 pm-6:55 pm

2 stops41h 00m

$649

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/24

Showing 1-10 of 16 resultsSorted by cheapest first
1
2

Best time to book a flight from Panama to Istanbul

Have a flexible travel schedule? Discover the best time to fly to Istanbul from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to Istanbul

How far ahead should I book a flight from Panama to Istanbul?

The best time to book flights from Panama to Istanbul is 65 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Panama to Istanbul?

Currently, July is the cheapest month in which you can book a flight from Panama to Istanbul (average of $522). Flying from Panama to Istanbul in September is currently the most expensive (average of $992). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PA to IST?

Find hourly flight availability from Panama to Istanbul. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 27, 2026.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama to Istanbul as you normally would.

How often are flights from Panama to Istanbul delayed?

About 24% of weekly flights between Panama and Istanbul have experienced delays in the past year, with the average delay time being 154 minutes.

What is the most punctual flight time for Panama to Istanbul flights?

Historically, flights departing at night are less likely to be delayed, whereas flights leaving in the evening tend to experience delays more often.

What day of the week experiences the fewest flight delays on this route?

Wednesday tends to have the lowest number of delays on this route, whereas Tuesday has historically faced a higher average of delays compared to other days of the week.

Which airline has the best punctuality record on Panama to Istanbul flights?

Over the last year, Turkish Airlines have had the lowest number of delays on this route, with just 24% of flights being delayed.

Reviews of airlines servicing Istanbul

Get insights into the airlines that provide service to Istanbul. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Istanbul. Reviews last updated April 27, 2026.
See what other customers who have flown with KLM,Turkish Airlines, andAir Europa from Panama to Istanbul have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
KLM
7.8
Good
1,508 reviews

Boarding

7.8

Overall

7.8

Comfort

7.7

Crew

8.4

Food

7.3

Entertainment

7.1

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2026

EZE - SCL

It was a short trip The aeroplane was delay I arrived in Chile late and I lost my fly with Qantas
KLM
7.8
Good
1,508 reviews
KLM
7.8
Good
1,508 reviews

Boarding

7.8

Overall

7.8

Comfort

7.7

Crew

8.4

Food

7.3

Entertainment

7.1

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2026

EZE - SCL

It was a short trip The aeroplane was delay I arrived in Chile late and I lost my fly with Qantas
Turkish Airlines
7.4
Good
4,337 reviews
KLM
7.8
Good
1,508 reviews

Boarding

7.8

Overall

7.8

Comfort

7.7

Crew

8.4

Food

7.3

Entertainment

7.1

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2026

EZE - SCL

It was a short trip The aeroplane was delay I arrived in Chile late and I lost my fly with Qantas
Air Europa
6.9
Okay
603 reviews
KLM
7.8
Good
1,508 reviews

Boarding

7.8

Overall

7.8

Comfort

7.7

Crew

8.4

Food

7.3

Entertainment

7.1

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2026

EZE - SCL

It was a short trip The aeroplane was delay I arrived in Chile late and I lost my fly with Qantas

Related info for your journey

Find useful and relevant information for your journey from Panama to Istanbul. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama to Istanbul?

    A quick flight from Panama to Istanbul can take about 26h 45m. United Airlines provides one of the quickest options available for as low as $1,163. The distance from Panama to Istanbul is about 6717 mi.

  • What are the cheapest flights from Panama to Istanbul?

    While on average a flight from Panama to Istanbul is generally $1,397, our data shows the cheapest flight currently is $627. When looking at the most popular route, (Panama City Tocumen Intl - Istanbul), you can expect to pay $1,067 for that flight.

  • Can I find deals for flights from Panama to Istanbul that include hotel bookings?

    Yes. In addition to deals on Panama to Istanbul flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to Istanbul?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to Istanbul.

  • Can I find deals for business class flights from Panama to Istanbul?

    Yes. Cheapflights offers flight deals from Panama to Istanbul by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to Istanbul?

    Currently, July is the cheapest month in which you can book a flight from Panama to Istanbul (average of $522). Flying from Panama to Istanbul in September is currently the most expensive (average of $992). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top 3 airlines flying from Panama to Istanbul

Discover the top 3 airlines that operate flights from Panama to Istanbul. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 27, 2026.
AirlineCheapestAverageFlexibilityOn-time
Air EuropaCheapest$853Average$1,048FlexibilityNo cancel feeOn-time83%
KLMCheapest$1,142Average$1,977FlexibilityNo cancel feeOn-time75%
Turkish AirlinesCheapest$1,190Average$1,354FlexibilityNo cancel feeOn-time77%

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