For US-bound flights, expect two security checks at PTY, with the second right at the gate. Allow extra time for this process.

Round-trip from | $366 (Kiwi.com) |
|---|---|
One-way from | $273 (Mytrip) |
Popular in | January |
Cheapest in | June |
Average price | $915 |
Fly from
Fly to
Route
Depart
Return
Price
Panama CityHouston
PTY - IAH
PTYIAH
Panama City Tocumen Intl
Mon 3/30
3:25 am-11:49 pm
2 stops20h 24m
Houston George Bush Intcntl
Mon 4/6
7:30 am-2:45 pm
1 stop7h 15m
Panama CityHouston
PTY - IAH
PTYIAH
Panama City Tocumen Intl
Sat 1/10
7:50 pm-11:34 pm
3 stops28h 44m
Houston George Bush Intcntl
Sat 1/17
5:46 am-10:30 am
3 stops27h 44m
Panama CityHouston
PTY - IAH
PTYIAH
Panama City Tocumen Intl
Mon 1/12
11:25 am-11:05 am
2 stops24h 40m
Houston George Bush Intcntl
Mon 1/19
4:35 pm-4:55 pm
2 stops23h 20m
Panama CityHouston
PTY - IAH
PTYIAH
Panama City Tocumen Intl
Tue 2/3
11:25 am-11:05 am
2 stops24h 40m
Houston George Bush Intcntl
Thu 2/26
1:00 pm-2:00 pm
2 stops24h 00m
Panama CityHouston
PTY - IAH
PTYIAH
Panama City Tocumen Intl
Mon 5/4
7:55 am-12:19 pm
Nonstop4h 24m
Houston George Bush Intcntl
Tue 6/9
9:59 am-2:14 pm
Nonstop4h 15m
Panama CityHouston
PTY - IAH
PTYIAH
Panama City Tocumen Intl
Tue 2/3
3:20 pm-11:56 pm
1 stop9h 36m
Houston George Bush Intcntl
Thu 2/26
5:30 am-1:55 pm
1 stop7h 25m
Panama CityHouston
PTY - IAH
PTYIAH
Panama City Tocumen Intl
Tue 2/3
3:20 pm-11:56 pm
1 stop9h 36m
Houston George Bush Intcntl
Mon 2/16
5:30 am-1:55 pm
1 stop7h 25m
Panama CityHouston
PTY - IAH
PTYIAH
Panama City Tocumen Intl
Mon 5/4
2:20 pm-11:57 pm
1 stop9h 37m
Houston George Bush Intcntl
Tue 6/9
5:55 am-1:05 pm
1 stop7h 10m
Panama CityHouston
PTY - IAH
PTYIAH
Panama City Tocumen Intl
Tue 5/5
2:20 pm-11:57 pm
1 stop9h 37m
Houston George Bush Intcntl
Tue 6/2
5:55 am-12:55 pm
1 stop7h 00m
Panama CityHouston
PTY - HOU
PTYHOU
Panama City Tocumen Intl
Tue 5/5
1:55 pm-1:32 pm
2 stops23h 37m
Houston Hobby
Tue 6/2
6:37 pm-12:25 pm
2 stops17h 48m
Currently, April is the cheapest month in which you can book a flight from Panama City to Houston (average of $424). Flying from Panama City to Houston in September is currently the most expensive (average of $787). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
A simple way to save on the total cost of your ticket is to fly from Panama City to Houston at noon. If you’re flexible enough to do this you can expect to save up to 41% on your trip compared to booking a flight in the afternoon.
About 8% of weekly flights between Panama City and Houston have experienced delays in the past year, with the average delay time being 180 minutes.
Historically, flights departing in the morning are less likely to be delayed, whereas flights leaving in the early afternoon tend to experience delays more often.
Monday tends to have the lowest number of delays on this route, whereas Saturday has historically faced a higher average of delays compared to other days of the week.
Over the last year, United Airlines have had the lowest number of delays on this route, with just 8% of flights being delayed.
Entertainment
Crew
Boarding
Overall
Food
Comfort
Reviews
Anonymous,Dec 2025
AMS - EWR
Entertainment
Crew
Boarding
Overall
Food
Comfort
Reviews
Anonymous,Dec 2025
AMS - EWR
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$781 | Average$979 | FlexibilityNo cancel fee | On-time69% |