HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Guayaquil

$151+ Cheap flights from Santiago (SCL) to Guayaquil (GYE)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/17. Fares are subject to change and may not be available on all flights or dates of travel.
SCL — GYE
ago. 4 — ago. 111
lun. 8/4
lun. 8/11
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Santiago to Guayaquil with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo are usually found in November or October, booked 57 days in advance, depart on a Monday or Wednesday and return on a Thursday

Cheap flight deals from Santiago to Guayaquil

Discover tips and strategies to find the most affordable flight options for your journey from Santiago (SCL) to Guayaquil (GYE). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated julio 30, 2025.

Round-trip from

$310
(FlightHub)

One-way from

$151
(FlightHub)

Popular in

January

Cheapest in

November

Average price

$408

Good round-trip deal

$197 or less

Good one-way deal

$216 or less
From Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo
Search Deals
One-way flight from Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo
Search Deals
Highest demand for flights based on searches. 10% potential increase in price ($50 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2025
Search Deals
Price to beat on a round-trip flight from Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo.
Search Deals
Price to beat on a one-way flight from Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo.
Search Deals

Find flight deals from Santiago to Guayaquil

Cheapest flights from Santiago to Guayaquil
Explore the most affordable flight options available from Santiago to Guayaquil. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 30, 2025.

This FlightHub deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 11/512:45 amSCL - GYE
Nonstop5h 18mLATAM Airlines
mar. 11/111:00 pmGYE - SCL
1 stop6h 55mLATAM Airlines
Deal found 7/30$310
This Copa Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 8/2812:13 amSCL - GYE
1 stop14h 33mCopa Airlines
mié. 9/34:27 amGYE - SCL
1 stop17h 37mCopa Airlines
Deal found 7/29$319
This Avianca deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 11/51:35 amSCL - GYE
1 stop18h 10mAvianca
lun. 11/104:40 amGYE - SCL
1 stop17h 50mAvianca
Deal found 7/30$398
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 9/412:24 amSCL - GYE
1 stop14h 22mMultiple Airlines
mié. 9/102:45 pmGYE - SCL
Nonstop4h 53mMultiple Airlines
Deal found 7/30$428

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santiago to Guayaquil that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated julio 30, 2025.
Use the filters below to find and compare flights from Santiago to Guayaquil that are best for you.

Fly from

Santiago

Fly to

Guayaquil

Route

Depart

Return

Price

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

mié. 11/5

4:35 am-11:55 am

1 stop9h 20m

Guayaquil Jose Joaquin de Olmedo

mar. 11/11

1:00 pm-11:25 pm

1 stop8h 25m

$310

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

jue. 8/28

12:13 am-11:15 am

1 stop12h 02m

Guayaquil Jose Joaquin de Olmedo

mar. 9/2

12:17 pm-10:40 pm

1 stop9h 23m

$319

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

mié. 11/5

1:35 am-2:30 pm

1 stop14h 55m

Guayaquil Jose Joaquin de Olmedo

lun. 11/10

3:30 am-3:20 pm

1 stop9h 50m

$398

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

jue. 9/4

12:24 am-1:46 pm

1 stop14h 22m

Guayaquil Jose Joaquin de Olmedo

mar. 9/9

2:45 pm-9:38 pm

Nonstop4h 53m

$428

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

dom. 8/17

9:40 pm-11:10 am

1 stop14h 30m

$151

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

mié. 8/13

11:29 am-11:55 pm

1 stop13h 26m

$153

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

dom. 8/17

11:55 pm-1:40 pm

1 stop14h 45m

$188

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

mié. 8/20

12:40 am-2:10 pm

2 stops14h 30m

$340

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/30

Best time to book a flight from Santiago to Guayaquil

Have a flexible travel schedule? Discover the best time to fly to Guayaquil from Santiago with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santiago to Guayaquil

How far ahead should I book a flight from Santiago to Guayaquil?

Use this chart to determine the optimal time to book a round-trip flight from Santiago to Guayaquil. Price data was last updated on July 25, 2025.

The best time to book flights from Santiago to Guayaquil is 57 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Santiago to Guayaquil?

Currently, April is the cheapest month in which you can book a flight from Santiago to Guayaquil (average of $440). Flying from Santiago to Guayaquil in December is currently the most expensive (average of $722). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SCL to GYE?

Find hourly flight availability from Santiago to Guayaquil. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated julio 30, 2025.

It’s typically best to fly out from Santiago to Guayaquil in the morning. Doing so could potentially save you 11% on the flight price compared to flying at noon, which is usually more expensive.

How much does it cost to fly round-trip from Santiago to Guayaquil?

Reviews of airlines servicing Guayaquil

Get insights into the airlines that provide service to Guayaquil. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Guayaquil. Reviews last updated julio 30, 2025.
Read reviews from past customers who have flown LATAM Airlines, Copa Airlines, and Avianca from Santiago to Guayaquil. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
LATAM Airlines
7.5
Good
1,822 reviews

Boarding

7.6

Comfort

7.4

Crew

8.1

Overall

7.5

Food

6.7

Entertainment

7.0

Reviews

1 / 20
4.0
Okay

Murilo,Jun 2025

SFO - LAX

I had mixed feelings regarding this flight. Called several times Latam and Delta regarding the purchase of checked baggage and price. I was told 80 dollars, could not buy it ahead of time,, they told me it was not Possible, that I had to buy at the airport. Check in my luggage the attendant says 80 dollars but I was charged 200 . No one could get me a solid answer why. Very disappointing
LATAM Airlines
7.5
Good
1,822 reviews
LATAM Airlines
7.5
Good
1,822 reviews

Boarding

7.6

Comfort

7.4

Crew

8.1

Overall

7.5

Food

6.7

Entertainment

7.0

Reviews

1 / 20
4.0
Okay

Murilo,Jun 2025

SFO - LAX

I had mixed feelings regarding this flight. Called several times Latam and Delta regarding the purchase of checked baggage and price. I was told 80 dollars, could not buy it ahead of time,, they told me it was not Possible, that I had to buy at the airport. Check in my luggage the attendant says 80 dollars but I was charged 200 . No one could get me a solid answer why. Very disappointing
Copa Airlines
7.5
Good
1,493 reviews
LATAM Airlines
7.5
Good
1,822 reviews

Boarding

7.6

Comfort

7.4

Crew

8.1

Overall

7.5

Food

6.7

Entertainment

7.0

Reviews

1 / 20
4.0
Okay

Murilo,Jun 2025

SFO - LAX

I had mixed feelings regarding this flight. Called several times Latam and Delta regarding the purchase of checked baggage and price. I was told 80 dollars, could not buy it ahead of time,, they told me it was not Possible, that I had to buy at the airport. Check in my luggage the attendant says 80 dollars but I was charged 200 . No one could get me a solid answer why. Very disappointing
Avianca
6.7
Okay
2,387 reviews
LATAM Airlines
7.5
Good
1,822 reviews

Boarding

7.6

Comfort

7.4

Crew

8.1

Overall

7.5

Food

6.7

Entertainment

7.0

Reviews

1 / 20
4.0
Okay

Murilo,Jun 2025

SFO - LAX

I had mixed feelings regarding this flight. Called several times Latam and Delta regarding the purchase of checked baggage and price. I was told 80 dollars, could not buy it ahead of time,, they told me it was not Possible, that I had to buy at the airport. Check in my luggage the attendant says 80 dollars but I was charged 200 . No one could get me a solid answer why. Very disappointing

Related info for your journey

Find useful and relevant information for your journey from Santiago to Guayaquil. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Santiago to Guayaquil flight route?

    The Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo flight path was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines flying from Santiago to Guayaquil round-trip?

    Our cheapest airline available from Santiago to Guayaquil is LATAM Airlines. Our recent data shows that you can find tickets from as low as $310 on this airline. Additional options worth looking into are Copa Airlines and Avianca, starting at $319 and $398 round-trip. LATAM Airlines is currently priced 24% below the average price you’ll pay for this route.

  • What are the cheapest airlines to fly from Santiago to Guayaquil one-way?

    One-way options have recently been found by users for as low as $151 on LATAM Airlines. Other airlines that offer cheap prices include Copa Airlines from $153 and Avianca from $193 one-way.

  • What are the cheapest flights from Santiago to Guayaquil?

    Looking at all options, your cheapest flight can be booked for $197. While the most popular route (Santiago Arturo Merino Benitez - Guayaquil Jose Joaquin de Olmedo) can be booked for $318 on average our data indicates $217 when flying from Santiago to Guayaquil.

  • Can I find deals for flights from Santiago to Guayaquil that include hotel bookings?

    Yes. In addition to deals on Santiago to Guayaquil flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santiago to Guayaquil?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santiago to Guayaquil.

  • Can I find deals for business class flights from Santiago to Guayaquil?

    Yes. Cheapflights offers flight deals from Santiago to Guayaquil by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santiago to Guayaquil?

    Currently, April is the cheapest month in which you can book a flight from Santiago to Guayaquil (average of $440). Flying from Santiago to Guayaquil in December is currently the most expensive (average of $722). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Santiago to Guayaquil

See prices for flight routes from nearby airports that may be better suited for you.
Santiago to Quito flights

Top airline flying from Santiago to Guayaquil

Discover the top airline that operate flights from Santiago to Guayaquil. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated julio 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
LATAM AirlinesCheapest$313Average$470FlexibilityNo cancel feeOn-time81%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.