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Guayaquil

$159+ Cheap flights from Santiago (SCL) to Guayaquil (GYE)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/27. Fares are subject to change and may not be available on all flights or dates of travel.
SCL — GYE
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheapflights Tip: The best prices from Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo are usually found in November or October, booked 57 days in advance, depart on a Monday or Wednesday and return on a Wednesday

Cheap flight deals from Santiago to Guayaquil

Discover tips and strategies to find the most affordable flight options for your journey from Santiago (SCL) to Guayaquil (GYE). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$327
(Priceline)

One-way from

$159
(FlightHub)

Popular in

January

Cheapest in

November

Average price

$398

Good round-trip deal

$197 or less

Good one-way deal

$205 or less
From Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo
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One-way flight from Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo
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Highest demand for flights based on searches. 10% potential increase in price ($47 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Price to beat on a round-trip flight from Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo.
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Price to beat on a one-way flight from Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo.
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Find flight deals from Santiago to Guayaquil

Cheapest flights from Santiago to Guayaquil
Explore the most affordable flight options available from Santiago to Guayaquil. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This Priceline deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/287:10 amSCL - GYE
1 stop18h 10mAvianca
Tue 10/76:25 pmGYE - SCL
1 stop8h 50mAvianca
Deal found 9/10$327
This FlightHub deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/610:15 pmSCL - GYE
1 stop15h 40mLATAM Airlines
Tue 11/114:48 pmGYE - SCL
Nonstop4h 47mLATAM Airlines
Deal found 9/10$337
This LATAM Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/2810:40 pmSCL - GYE
1 stop17h 30mLATAM Airlines
Tue 10/712:50 pmGYE - SCL
2 stops24h 18mLATAM Airlines
Deal found 9/10$339
This Copa Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/125:24 amSCL - GYE
1 stop10h 10mCopa Airlines
Thu 11/2012:21 pmGYE - SCL
1 stop13h 22mCopa Airlines
Deal found 9/11$340
This Booking.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/1512:55 amSCL - GYE
1 stop9h 40mMultiple Airlines
Sun 10/192:45 pmGYE - SCL
Nonstop4h 53mMultiple Airlines
Deal found 9/10$351
This Copa Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/3012:20 pmSCL - GYE
1 stop13h 33mCopa Airlines
Sun 11/98:30 amGYE - SCL
1 stop17h 13mCopa Airlines
Deal found 9/11$360
This Booking.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1112:45 amSCL - GYE
Nonstop5h 18mMultiple Airlines
Wed 11/193:30 amGYE - SCL
1 stop9h 50mMultiple Airlines
Deal found 9/11$369
This Copa Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3112:20 pmSCL - GYE
1 stop13h 33mCopa Airlines
Fri 11/72:35 pmGYE - SCL
1 stop10h 49mCopa Airlines
Deal found 9/11$380
This Orbitz deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/1512:55 amSCL - GYE
1 stop9h 40mAvianca
Sun 10/196:25 pmGYE - SCL
1 stop27h 05mAvianca
Deal found 9/10$381

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santiago to Guayaquil that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Santiago to Guayaquil that are best for you.

Fly from

Santiago

Fly to

Guayaquil

Route

Depart

Return

Price

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Wed 11/12

5:24 am-1:34 pm

1 stop10h 10m

Guayaquil Jose Joaquin de Olmedo

Thu 11/20

12:21 pm-3:43 am

1 stop13h 22m

$340

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Fri 11/28

5:12 am-11:55 pm

1 stop20h 43m

Guayaquil Jose Joaquin de Olmedo

Fri 1/9

12:20 pm-12:32 am

1 stop10h 12m

$340

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Thu 11/6

10:15 pm-4:34 pm

2 stops20h 19m

Guayaquil Jose Joaquin de Olmedo

Tue 11/11

1:00 pm-12:05 pm

2 stops21h 05m

$359

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Mon 11/17

3:23 am-1:34 pm

1 stop12h 11m

Guayaquil Jose Joaquin de Olmedo

Tue 11/25

12:21 pm-3:43 am

1 stop13h 22m

$403

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Wed 10/15

12:55 am-8:35 am

1 stop9h 40m

Guayaquil Jose Joaquin de Olmedo

Sat 10/18

3:35 am-2:25 pm

1 stop8h 50m

$407

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Sat 11/8

12:45 am-4:03 am

Nonstop5h 18m

Guayaquil Jose Joaquin de Olmedo

Thu 11/13

8:40 pm-3:30 pm

1 stop16h 50m

$419

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Thu 11/27

12:20 pm-8:43 pm

1 stop10h 23m

Guayaquil Jose Joaquin de Olmedo

Mon 12/1

6:34 pm-6:01 am

1 stop9h 27m

$432

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Fri 11/28

5:12 am-11:55 pm

1 stop20h 43m

Guayaquil Jose Joaquin de Olmedo

Fri 1/9

4:33 am-12:32 am

1 stop17h 59m

$437

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Mon 12/15

8:25 am-1:40 am

2 stops19h 15m

$163

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Sun 10/19

11:50 pm-3:13 am

Nonstop5h 23m

$178

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Showing 1-10 of 18 results
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2

Best time to book a flight from Santiago to Guayaquil

Have a flexible travel schedule? Discover the best time to fly to Guayaquil from Santiago with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santiago to Guayaquil

How far ahead should I book a flight from Santiago to Guayaquil?

Use this chart to determine the optimal time to book a round-trip flight from Santiago to Guayaquil. Price data was last updated on August 29, 2025.

The best time to book flights from Santiago to Guayaquil is 57 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Santiago to Guayaquil?

Currently, April is the cheapest month in which you can book a flight from Santiago to Guayaquil (average of $440). Flying from Santiago to Guayaquil in December is currently the most expensive (average of $722). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SCL to GYE?

Find hourly flight availability from Santiago to Guayaquil. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

It’s typically best to fly out from Santiago to Guayaquil in the morning. Doing so could potentially save you 10% on the flight price compared to flying at noon, which is usually more expensive.

Reviews of airlines servicing Guayaquil

Get insights into the airlines that provide service to Guayaquil. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Guayaquil. Reviews last updated September 11, 2025.
Read reviews from past customers who have flown LATAM Airlines from Santiago to Guayaquil. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
LATAM Airlines
7.5
Good
1,847 reviews

Boarding

7.6

Overall

7.5

Entertainment

7.0

Food

6.7

Crew

8.0

Comfort

7.4

Reviews

1 / 20
4.0
Okay

Murilo,Jun 2025

SFO - LAX

I had mixed feelings regarding this flight. Called several times Latam and Delta regarding the purchase of checked baggage and price. I was told 80 dollars, could not buy it ahead of time,, they told me it was not Possible, that I had to buy at the airport. Check in my luggage the attendant says 80 dollars but I was charged 200 . No one could get me a solid answer why. Very disappointing
LATAM Airlines
7.5
Good
1,847 reviews
LATAM Airlines
7.5
Good
1,847 reviews

Boarding

7.6

Overall

7.5

Entertainment

7.0

Food

6.7

Crew

8.0

Comfort

7.4

Reviews

1 / 20
4.0
Okay

Murilo,Jun 2025

SFO - LAX

I had mixed feelings regarding this flight. Called several times Latam and Delta regarding the purchase of checked baggage and price. I was told 80 dollars, could not buy it ahead of time,, they told me it was not Possible, that I had to buy at the airport. Check in my luggage the attendant says 80 dollars but I was charged 200 . No one could get me a solid answer why. Very disappointing

Related info for your journey

Find useful and relevant information for your journey from Santiago to Guayaquil. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Santiago to Guayaquil flight route?

    The Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo flight path was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Santiago to Guayaquil?

    Airlines like Copa Airlines and LATAM Airlines fly from Santiago to Guayaquil in about 10h 10m. The time it takes to get you to your destination can typically vary by up to 10h 09m. The distance between Santiago and Guayaquil is about 2235 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What is the cheapest airline to fly from Santiago to Guayaquil round-trip?

    Our cheapest airline available from Santiago to Guayaquil is LATAM Airlines. Our recent data shows that you can find tickets from as low as $316 on this airline. LATAM Airlines is currently priced 23% below the average price you’ll pay for this route.

  • What are the cheapest flights from Santiago to Guayaquil?

    Looking at all options, your cheapest flight can be booked for $197. While the most popular route (Santiago Arturo Merino Benitez - Guayaquil Jose Joaquin de Olmedo) can be booked for $410 on average, our data indicates $354 when flying from Santiago to Guayaquil.

  • Can I find deals for flights from Santiago to Guayaquil that include hotel bookings?

    Yes. In addition to deals on Santiago to Guayaquil flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santiago to Guayaquil?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santiago to Guayaquil.

  • Can I find deals for business class flights from Santiago to Guayaquil?

    Yes. Cheapflights offers flight deals from Santiago to Guayaquil by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santiago to Guayaquil?

    Currently, April is the cheapest month in which you can book a flight from Santiago to Guayaquil (average of $440). Flying from Santiago to Guayaquil in December is currently the most expensive (average of $722). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Santiago to Guayaquil

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Top airline flying from Santiago to Guayaquil

Discover the top airline that operate flights from Santiago to Guayaquil. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
LATAM AirlinesCheapest$316Average$473FlexibilityNo cancel feeOn-time81%

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