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Guayaquil

$226+ Cheap flights from Santiago (SCL) to Guayaquil (GYE)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/31. Fares are subject to change and may not be available on all flights or dates of travel.
SCL — GYE
Jan 14 — Jan 211
Wed 1/14
Wed 1/21
1 adult, Economy
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Cheapflights Tip: The best prices from Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo are usually found in July or April, booked 72 days in advance, depart on a Friday or Wednesday and return on a Wednesday

Cheap flight deals from Santiago to Guayaquil

Cheapest flights from Santiago to Guayaquil
Explore the most affordable flight options available from Santiago to Guayaquil. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 15, 2025.

This Copa Airlines deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/295:12 amSCL - GYE
1 stop10h 22mCopa Airlines
Fri 1/22:35 pmGYE - SCL
1 stop10h 42mCopa Airlines
Deal found 12/13$510
This Copa Airlines deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/145:12 amSCL - GYE
1 stop10h 22mCopa Airlines
Sat 12/2012:20 pmGYE - SCL
1 stop15h 41mCopa Airlines
Deal found 12/13$513
This Copa Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/245:12 amSCL - GYE
1 stop10h 22mCopa Airlines
Sat 1/34:33 amGYE - SCL
1 stop17h 59mCopa Airlines
Deal found 12/15$514
This Copa Airlines deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/175:12 amSCL - GYE
1 stop10h 22mCopa Airlines
Fri 12/2612:20 pmGYE - SCL
1 stop13h 23mCopa Airlines
Deal found 12/13$530
This Copa Airlines deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/293:23 amSCL - GYE
1 stop12h 11mCopa Airlines
Sat 1/108:34 amGYE - SCL
1 stop13h 58mCopa Airlines
Deal found 12/13$531
This Copa Airlines deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/203:23 amSCL - GYE
1 stop9h 55mCopa Airlines
Fri 1/98:34 amGYE - SCL
1 stop13h 58mCopa Airlines
Deal found 12/13$534
This Copa Airlines deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/255:12 amSCL - GYE
1 stop10h 22mCopa Airlines
Thu 1/112:20 pmGYE - SCL
1 stop15h 40mCopa Airlines
Deal found 12/14$541
This Copa Airlines deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/265:44 amSCL - GYE
1 stop9h 50mCopa Airlines
Sat 1/108:34 amGYE - SCL
1 stop13h 58mCopa Airlines
Deal found 12/13$550
This Copa Airlines deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/143:23 amSCL - GYE
1 stop12h 11mCopa Airlines
Mon 12/228:30 amGYE - SCL
1 stop9h 51mCopa Airlines
Deal found 12/14$556
This Copa Airlines deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/183:23 amSCL - GYE
1 stop9h 55mCopa Airlines
Sat 1/34:33 amGYE - SCL
1 stop17h 59mCopa Airlines
Deal found 12/14$557
This FlightHub deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/246:30 pmSCL - GYE
1 stop9h 10mLATAM Airlines
Wed 2/49:05 amGYE - SCL
1 stop10h 50mLATAM Airlines
Deal found 12/14$578

Find flight deals from Santiago to Guayaquil

Discover tips and strategies to find the most affordable flight options for your journey from Santiago (SCL) to Guayaquil (GYE). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 15, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$415
(Priceline)

One-way from

$226
(Copa Airlines)

Popular in

January

Cheapest in

July

Average price

$494
Provider with most accurate pricing for Santiago Arturo Merino Benitez-Guayaquil Jose Joaquin de Olmedo flight deals.
Search Deals
Provider most trusted by Cheapflights users for Santiago Arturo Merino Benitez-Guayaquil Jose Joaquin de Olmedo flights.
Search Deals
From Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo
Search Deals
One-way flight from Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo
Search Deals
Highest demand for flights based on searches. 11% potential increase in price ($57 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santiago to Guayaquil that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 15, 2025.
Use the filters below to find and compare flights from Santiago to Guayaquil that are best for you.

Fly from

Santiago

Fly to

Guayaquil

Route

Depart

Return

Price

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Thu 4/9

11:55 pm-11:25 am

2 stops12h 30m

Guayaquil Jose Joaquin de Olmedo

Sun 4/12

9:45 am-10:30 pm

1 stop11h 45m

$415

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Thu 4/9

4:10 am-2:40 pm

1 stop11h 30m

Guayaquil Jose Joaquin de Olmedo

Sun 4/12

8:45 pm-5:45 am

1 stop8h 00m

$415

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Fri 5/29

4:09 am-1:33 pm

1 stop10h 24m

Guayaquil Jose Joaquin de Olmedo

Wed 6/17

12:21 pm-3:00 am

1 stop13h 39m

$422

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Mon 12/29

5:12 am-1:34 pm

1 stop10h 22m

Guayaquil Jose Joaquin de Olmedo

Fri 1/2

12:20 pm-4:14 am

1 stop13h 54m

$510

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Fri 12/26

3:23 am-11:18 am

1 stop9h 55m

Guayaquil Jose Joaquin de Olmedo

Tue 1/6

12:20 pm-12:32 am

1 stop10h 12m

$514

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Mon 12/29

3:23 am-1:34 pm

1 stop12h 11m

Guayaquil Jose Joaquin de Olmedo

Sat 1/10

8:34 am-12:32 am

1 stop13h 58m

$531

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Thu 12/25

5:12 am-1:34 pm

1 stop10h 22m

Guayaquil Jose Joaquin de Olmedo

Thu 1/1

12:20 pm-6:00 am

1 stop15h 40m

$541

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Fri 12/26

5:44 am-1:34 pm

1 stop9h 50m

Guayaquil Jose Joaquin de Olmedo

Sat 1/10

8:34 am-12:32 am

1 stop13h 58m

$550

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Sat 2/21

8:15 am-2:45 pm

1 stop8h 30m

Guayaquil Jose Joaquin de Olmedo

Sat 2/28

5:08 pm-11:55 pm

Nonstop4h 47m

$557

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Wed 12/31

5:44 am-1:34 pm

1 stop9h 50m

$226

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/13

Showing 1-10 of 15 results
1
2

Compare providers for flights from Santiago to Guayaquil

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santiago to Guayaquil in December.
ProviderPrice AccuracyTrust Score*
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Santiago-Guayaquil flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Santiago-Guayaquil flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Santiago-Guayaquil flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santiago-Guayaquil flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santiago-Guayaquil flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santiago to Guayaquil

Have a flexible travel schedule? Discover the best time to fly to Guayaquil from Santiago with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santiago to Guayaquil

How far ahead should I book a flight from Santiago to Guayaquil?

Use this chart to determine the optimal time to book a round-trip flight from Santiago to Guayaquil. Price data was last updated on December 12, 2025.

The best time to book flights from Santiago to Guayaquil is 72 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Santiago to Guayaquil?

Currently, May is the cheapest month in which you can book a flight from Santiago to Guayaquil (average of $224). Flying from Santiago to Guayaquil in January is currently the most expensive (average of $402). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SCL to GYE?

Find hourly flight availability from Santiago to Guayaquil. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 15, 2025.

When flying from Santiago to Guayaquil, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Guayaquil

Get insights into the airlines that provide service to Guayaquil. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Guayaquil. Reviews last updated December 15, 2025.
Read reviews from past customers who have flown LATAM Airlines from Santiago to Guayaquil. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
LATAM Airlines
7.5
Good
1,892 reviews

Overall

7.5

Entertainment

7.0

Crew

8.1

Comfort

7.4

Food

6.7

Boarding

7.6

Reviews

1 / 20
8.0
Excellent

LUIS JOSE,Oct 2025

LIM - AEP

Smiles because se upgraded to premiums economy. That was similar to LAN economy years ahí!
LATAM Airlines
7.5
Good
1,892 reviews
LATAM Airlines
7.5
Good
1,892 reviews

Overall

7.5

Entertainment

7.0

Crew

8.1

Comfort

7.4

Food

6.7

Boarding

7.6

Reviews

1 / 20
8.0
Excellent

LUIS JOSE,Oct 2025

LIM - AEP

Smiles because se upgraded to premiums economy. That was similar to LAN economy years ahí!

Related info for your journey

Find useful and relevant information for your journey from Santiago to Guayaquil. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Santiago to Guayaquil?

    To fly from Santiago to Guayaquil, you need to book a flight from Arturo Merino Benitez (SCL) to Jose Joaquin de Olmedo (GYE). Nonstop flights to Guayaquil Jose Joaquin de Olmedo from Santiago Arturo Merino Benitez take 8h 25m on average. When it comes time to book airfare, you have a few options: there is 1 outbound flight from Arturo Merino Benitez to Jose Joaquin de Olmedo offered by 1 airline.

  • How popular is this Santiago to Guayaquil flight route?

    The Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo flight path was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Santiago to Guayaquil?

    Airlines like Avianca, LATAM Airlines, and Copa Airlines fly from Santiago to Guayaquil in about 10h 24m. The time it takes to get you to your destination can typically vary by up to 2h 06m. The distance between Santiago and Guayaquil is about 2235 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What is the cheapest airline to fly from Santiago to Guayaquil round-trip?

    Our cheapest airline available from Santiago to Guayaquil is LATAM Airlines. Our recent data shows that you can find tickets from as low as $320 on this airline. LATAM Airlines is currently priced 27% below the average price you’ll pay for this route.

  • Can I find deals for flights from Santiago to Guayaquil that include hotel bookings?

    Yes. In addition to deals on Santiago to Guayaquil flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santiago to Guayaquil?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santiago to Guayaquil.

  • Can I find deals for business class flights from Santiago to Guayaquil?

    Yes. Cheapflights offers flight deals from Santiago to Guayaquil by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santiago to Guayaquil?

    Currently, May is the cheapest month in which you can book a flight from Santiago to Guayaquil (average of $224). Flying from Santiago to Guayaquil in January is currently the most expensive (average of $402). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Santiago to Guayaquil

See prices for flight routes from nearby airports that may be better suited for you.
Santiago to Quito flights

Top airline flying from Santiago to Guayaquil

Discover the top airline that operate flights from Santiago to Guayaquil. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
LATAM AirlinesCheapest$320Average$477FlexibilityNo cancel feeOn-time81%

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