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Guayaquil

$203+ Cheap flights from Santiago (SCL) to Guayaquil (GYE)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/25. Fares are subject to change and may not be available on all flights or dates of travel.
SCL — GYE
Feb 28 — Mar 71
Sat 2/28
Sat 3/7
1 adult, Economy
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Cheapflights Tip: The best prices from Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo are usually found in April or August, booked 72 days in advance, depart on a Friday or Monday and return on a Wednesday

Cheap flight deals from Santiago to Guayaquil

Cheapest flights from Santiago to Guayaquil
Explore the most affordable flight options available from Santiago to Guayaquil. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.

This Mytrip deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/512:45 am
SCL
-
GYE
Nonstop5h 18m
Multiple Airlines
Tue 5/263:35 am
GYE
-
SCL
1 stop8h 50m
Multiple Airlines
Deal found 1/27$392
This Priceline deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/66:10 am
SCL
-
GYE
2 stops12h 25m
Avianca
Tue 5/263:35 am
GYE
-
SCL
1 stop8h 50m
Avianca
Deal found 1/27$401
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/116:30 pm
SCL
-
GYE
1 stop9h 10m
LATAM Airlines
Wed 4/19:05 am
GYE
-
SCL
1 stop7h 20m
LATAM Airlines
Deal found 1/27$403
This Expedia deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/114:25 pm
SCL
-
GYE
1 stop24h 05m
Multiple Airlines
Wed 4/19:05 am
GYE
-
SCL
1 stop11h 50m
Multiple Airlines
Deal found 1/27$411
This Avianca deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:10 am
SCL
-
GYE
1 stop12h 10m
Avianca
Sun 5/1711:05 am
GYE
-
SCL
1 stop10h 25m
Avianca
Deal found 1/27$419
This Travelocity deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/512:45 am
SCL
-
GYE
Nonstop5h 18m
LATAM Airlines
Wed 5/275:38 pm
GYE
-
SCL
Nonstop4h 51m
LATAM Airlines
Deal found 1/27$426
This Mytrip deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/136:30 pm
SCL
-
GYE
1 stop9h 10m
Multiple Airlines
Fri 3/203:35 pm
GYE
-
SCL
1 stop21h 45m
Multiple Airlines
Deal found 1/27$428
This CheapOair deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/612:45 am
SCL
-
GYE
Nonstop5h 18m
Multiple Airlines
Sun 5/174:05 am
GYE
-
SCL
1 stop23h 40m
Multiple Airlines
Deal found 1/28$430
This CheapOair deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/712:45 am
SCL
-
GYE
Nonstop5h 18m
Multiple Airlines
Sun 5/179:45 am
GYE
-
SCL
1 stop26h 40m
Multiple Airlines
Deal found 1/27$433
This FlightHub deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/612:45 am
SCL
-
GYE
Nonstop5h 18m
LATAM Airlines
Tue 5/195:38 pm
GYE
-
SCL
Nonstop4h 51m
LATAM Airlines
Deal found 1/27$440

Find flight deals from Santiago to Guayaquil

Discover tips and strategies to find the most affordable flight options for your journey from Santiago (SCL) to Guayaquil (GYE). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$392
(Mytrip)

One-way from

$203
(Super.com)

Popular in

January

Cheapest in

April

Average price

$557

Good round-trip deal

$508 or less
Provider with most accurate pricing for Santiago Arturo Merino Benitez-Guayaquil Jose Joaquin de Olmedo flight deals.
Search Deals
Provider most trusted by Cheapflights users for Santiago Arturo Merino Benitez-Guayaquil Jose Joaquin de Olmedo flights.
Search Deals
From Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo
Search Deals
One-way flight from Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo
Search Deals
Highest demand for flights based on searches. 13% potential increase in price ($68 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals
Price to beat on a round-trip flight from Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santiago to Guayaquil that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Santiago to Guayaquil that are best for you.

Fly from

Santiago

Fly to

Guayaquil

Route

Depart

Return

Price

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Tue 5/5

12:45 am-5:03 am

Nonstop5h 18m

Guayaquil Jose Joaquin de Olmedo

Tue 5/26

3:35 am-1:25 pm

1 stop8h 50m

$392

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Wed 3/11

6:30 pm-1:40 am

1 stop9h 10m

Guayaquil Jose Joaquin de Olmedo

Wed 4/1

9:05 am-6:25 pm

1 stop7h 20m

$403

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Wed 3/11

4:25 pm-2:30 pm

1 stop24h 05m

Guayaquil Jose Joaquin de Olmedo

Wed 4/1

9:05 am-10:55 pm

1 stop11h 50m

$411

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Thu 5/7

3:20 pm-12:45 am

1 stop10h 25m

Guayaquil Jose Joaquin de Olmedo

Tue 5/19

9:10 am-11:20 pm

1 stop13h 10m

$419

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Fri 5/8

6:40 am-2:35 pm

1 stop8h 55m

Guayaquil Jose Joaquin de Olmedo

Sat 5/16

3:30 am-2:15 pm

1 stop9h 45m

$419

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Thu 5/7

6:10 am-5:20 pm

1 stop12h 10m

Guayaquil Jose Joaquin de Olmedo

Sun 5/17

11:05 am-10:30 pm

1 stop10h 25m

$419

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Thu 5/7

2:30 pm-11:20 pm

1 stop9h 50m

Guayaquil Jose Joaquin de Olmedo

Tue 5/19

5:38 pm-11:29 pm

Nonstop4h 51m

$428

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Wed 5/6

12:45 am-5:03 am

Nonstop5h 18m

Guayaquil Jose Joaquin de Olmedo

Sun 5/17

4:05 am-4:45 am

1 stop23h 40m

$430

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Wed 2/25

6:30 pm-1:40 am

1 stop9h 10m

$203

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Wed 2/11

12:45 am-4:03 am

Nonstop5h 18m

$214

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/27

Showing 1-10 of 13 results
1
2
  • Most accurate provider: When it comes to deals on Santiago-Guayaquil flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santiago-Guayaquil flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santiago-Guayaquil flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santiago-Guayaquil flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santiago-Guayaquil flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santiago to Guayaquil

Have a flexible travel schedule? Discover the best time to fly to Guayaquil from Santiago with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santiago to Guayaquil

How far ahead should I book a flight from Santiago to Guayaquil?

Use this chart to determine the optimal time to book a round-trip flight from Santiago to Guayaquil. Price data was last updated on January 23, 2026.

The best time to book flights from Santiago to Guayaquil is 72 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Santiago to Guayaquil?

Currently, October is the cheapest month in which you can book a flight from Santiago to Guayaquil (average of $210). Flying from Santiago to Guayaquil in January is currently the most expensive (average of $431). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SCL to GYE?

Find hourly flight availability from Santiago to Guayaquil. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 29, 2026.

When flying from Santiago to Guayaquil, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

How much does it cost to fly round-trip from Santiago to Guayaquil?

Reviews of airlines servicing Guayaquil

Get insights into the airlines that provide service to Guayaquil. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Guayaquil. Reviews last updated January 29, 2026.
Read reviews from past customers who have flown LATAM Airlines from Santiago to Guayaquil. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
LATAM Airlines
7.5
Good
1,917 reviews

Entertainment

7.0

Crew

8.0

Comfort

7.3

Overall

7.5

Boarding

7.5

Food

6.7

Reviews

1 / 20
2.0
Mediocre

JC,Jan 2026

FLN - GRU

Plane was late in FLN and missed connection in GRU. No alternative was given to me until 6 hours later and I was delayed by over 12 hours total.
LATAM Airlines
7.5
Good
1,917 reviews
LATAM Airlines
7.5
Good
1,917 reviews

Entertainment

7.0

Crew

8.0

Comfort

7.3

Overall

7.5

Boarding

7.5

Food

6.7

Reviews

1 / 20
2.0
Mediocre

JC,Jan 2026

FLN - GRU

Plane was late in FLN and missed connection in GRU. No alternative was given to me until 6 hours later and I was delayed by over 12 hours total.

Related info for your journey

Find useful and relevant information for your journey from Santiago to Guayaquil. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Santiago to Guayaquil?

    To fly from Santiago to Guayaquil, you need to book a flight from Arturo Merino Benitez (SCL) to Jose Joaquin de Olmedo (GYE). Nonstop flights to Guayaquil Jose Joaquin de Olmedo from Santiago Arturo Merino Benitez take 5h 18m on average. When it comes time to book airfare, you have a few options: there is 1 outbound flight from Arturo Merino Benitez to Jose Joaquin de Olmedo offered by 1 airline.

  • How popular is this Santiago to Guayaquil flight route?

    The Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo flight path was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Santiago to Guayaquil?

    Airlines like LATAM Airlines and Avianca fly from Santiago to Guayaquil in about 9h 10m. The time it takes to get you to your destination can typically vary by up to 40m. The distance between Santiago and Guayaquil is about 2235 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What is the cheapest airline to fly from Santiago to Guayaquil round-trip?

    Our cheapest airline available from Santiago to Guayaquil is LATAM Airlines. Our recent data shows that you can find tickets from as low as $316 on this airline. LATAM Airlines is currently priced 29% below the average price you’ll pay for this route.

  • What are the cheapest flights from Santiago to Guayaquil?

    Looking at all options, your cheapest flight can be booked for $221. While the most popular route (Santiago Arturo Merino Benitez - Guayaquil Jose Joaquin de Olmedo) can be booked for $392 on average, our data indicates $565 when flying from Santiago to Guayaquil.

  • Can I find deals for flights from Santiago to Guayaquil that include hotel bookings?

    Yes. In addition to deals on Santiago to Guayaquil flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santiago to Guayaquil?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santiago to Guayaquil.

  • Can I find deals for business class flights from Santiago to Guayaquil?

    Yes. Cheapflights offers flight deals from Santiago to Guayaquil by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santiago to Guayaquil?

    Currently, October is the cheapest month in which you can book a flight from Santiago to Guayaquil (average of $210). Flying from Santiago to Guayaquil in January is currently the most expensive (average of $431). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Santiago to Guayaquil

See prices for flight routes from nearby airports that may be better suited for you.
Santiago to Quito flights

Top airline flying from Santiago to Guayaquil

Discover the top airline that operate flights from Santiago to Guayaquil. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
LATAM AirlinesCheapest$316Average$490FlexibilityNo cancel feeOn-time81%

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