HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Guayaquil

$155+ Cheap flights from Key Largo, FL to Guayaquil (GYE)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/10. Fares are subject to change and may not be available on all flights or dates of travel.
MIA — GYE
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Key Largo to Guayaquil with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Key Largo to Guayaquil Jose Joaquin de Olmedo are usually found in January or September, booked 63 days in advance, depart on a Friday or Sunday and return on a Sunday

Cheap flight deals from Key Largo to Guayaquil

Keep the following information in mind while searching for Key Largo to Guayaquil flight deals. Data was last updated September 15, 2025.

Round-trip from

$322
(Copa Airlines)

One-way from

$155
(Kiwi.com)

Popular in

December

Cheapest in

January

Average price

$422
From Key Largo to Guayaquil Jose Joaquin de Olmedo
Search Deals
One-way flight from Key Largo to Guayaquil Jose Joaquin de Olmedo
Search Deals
Highest demand for flights based on searches. 7% potential increase in price ($39 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($21 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in September 2025
Search Deals

Find flight deals from Key Largo to Guayaquil

Cheapest flights from Key Largo to Guayaquil
Explore the most affordable flight options available from Key Largo to Guayaquil. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This Copa Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/16:09 amMIA - GYE
1 stop6h 06mCopa Airlines
Sat 10/46:33 pmGYE - MIA
1 stop16h 47mCopa Airlines
Deal found 9/13$322
This Avianca deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/87:00 amMIA - GYE
1 stop7h 30mAvianca
Fri 11/216:50 pmGYE - MIA
Nonstop4h 25mAvianca
Deal found 9/14$325
This Avianca deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/23:25 pmMIA - GYE
2 stops11h 40mAvianca
Fri 11/216:50 pmGYE - MIA
Nonstop4h 25mAvianca
Deal found 9/13$326
This Copa Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/141:28 pmMIA - GYE
1 stop10h 27mCopa Airlines
Tue 11/256:35 pmGYE - MIA
1 stop16h 37mCopa Airlines
Deal found 9/14$329
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/176:09 amMIA - GYE
1 stop8h 37mCopa Airlines
Sun 10/266:05 amGYE - MIA
1 stop9h 39mCopa Airlines
Deal found 9/13$332
This Avianca deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2112:45 amMIA - GYE
Nonstop4h 35mAvianca
Sun 12/76:50 pmGYE - MIA
Nonstop4h 25mAvianca
Deal found 9/14$335
This Avianca deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/251:00 amMIA - GYE
Nonstop4h 35mAvianca
Sun 11/306:55 pmGYE - MIA
1 stop8h 15mAvianca
Deal found 9/13$339
This Avianca deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/312:45 amMIA - GYE
Nonstop4h 35mAvianca
Mon 11/106:50 pmGYE - MIA
Nonstop4h 25mAvianca
Deal found 9/13$342
This Avianca deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/232:05 amMIA - GYE
1 stop7h 10mAvianca
Thu 12/47:05 pmGYE - MIA
Nonstop4h 25mAvianca
Deal found 9/13$345
This Avianca deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/301:00 amMIA - GYE
Nonstop4h 35mAvianca
Tue 1/1310:25 amGYE - MIA
1 stop12h 05mAvianca
Deal found 9/14$355
This Gotogate deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/31:00 pmMIA - GYE
1 stop12h 05mAvianca
Mon 11/106:50 pmGYE - MIA
Nonstop4h 25mAvianca
Deal found 9/13$356
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/302:00 amMIA - GYE
Nonstop4h 35mMultiple Airlines
Sat 11/83:30 amGYE - MIA
3 stops37h 56mMultiple Airlines
Deal found 9/13$362

Cheapflights Fare Finder

 
Customize your flight search to find flights from Key Largo to Guayaquil that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Key Largo to Guayaquil that are best for you.

Fly from

Key Largo

Fly to

Guayaquil

Route

Depart

Return

Price

MiamiGuayaquil

MIA - GYE

MIAGYE

Miami

Thu 10/30

5:12 pm-11:53 pm

1 stop7h 41m

Guayaquil Jose Joaquin de Olmedo

Mon 11/3

8:30 am-9:45 pm

1 stop13h 15m

$322

MiamiGuayaquil

MIA - GYE

MIAGYE

Miami

Fri 11/14

12:45 am-5:20 am

Nonstop4h 35m

Guayaquil Jose Joaquin de Olmedo

Sat 11/29

10:25 am-10:30 pm

1 stop12h 05m

$329

MiamiGuayaquil

MIA - GYE

MIAGYE

Miami

Thu 10/30

2:00 am-5:35 am

Nonstop4h 35m

Guayaquil Jose Joaquin de Olmedo

Sun 11/2

3:30 am-11:30 am

1 stop8h 00m

$329

MiamiGuayaquil

MIA - GYE

MIAGYE

Miami

Fri 11/14

1:28 pm-11:55 pm

1 stop10h 27m

Guayaquil Jose Joaquin de Olmedo

Tue 11/25

6:35 pm-11:12 am

1 stop16h 37m

$329

MiamiGuayaquil

MIA - GYE

MIAGYE

Miami

Sat 11/22

7:00 am-2:30 pm

1 stop7h 30m

Guayaquil Jose Joaquin de Olmedo

Sun 12/7

6:50 pm-11:15 pm

Nonstop4h 25m

$335

MiamiGuayaquil

MIA - GYE

MIAGYE

Miami

Fri 10/31

2:37 pm-11:37 pm

1 stop10h 00m

Guayaquil Jose Joaquin de Olmedo

Mon 11/3

6:35 pm-12:45 am

1 stop6h 10m

$339

MiamiGuayaquil

MIA - GYE

MIAGYE

Miami

Tue 11/4

1:00 am-5:35 am

Nonstop4h 35m

Guayaquil Jose Joaquin de Olmedo

Thu 11/13

7:05 pm-11:30 pm

Nonstop4h 25m

$342

MiamiGuayaquil

MIA - GYE

MIAGYE

Miami

Tue 11/25

4:59 am-11:18 am

1 stop6h 19m

Guayaquil Jose Joaquin de Olmedo

Sun 11/30

12:21 pm-9:45 pm

1 stop9h 24m

$368

MiamiGuayaquil

MIA - GYE

MIAGYE

Miami

Wed 11/19

4:59 am-11:18 am

1 stop6h 19m

Guayaquil Jose Joaquin de Olmedo

Tue 1/13

4:33 am-9:43 pm

1 stop17h 10m

$368

MiamiGuayaquil

MIA - GYE

MIAGYE

Miami

Thu 11/27

4:10 pm-11:55 pm

1 stop7h 45m

Guayaquil Jose Joaquin de Olmedo

Sun 11/30

2:35 pm-12:45 am

1 stop10h 10m

$368

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/12

Showing 1-10 of 18 results
1
2

Best time to book a flight from Key Largo to Guayaquil

Have a flexible travel schedule? Discover the best time to fly to Guayaquil from Key Largo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key Largo to Guayaquil

How far ahead should I book a flight from Key Largo to Guayaquil?

Use this chart to determine the optimal time to book a round-trip flight from Key Largo to Guayaquil. Price data was last updated on September 12, 2025.

To ensure you get the cheapest price possible for a flight from Key Largo to Guayaquil, you should look to book at least 63 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Key Largo to Guayaquil?

Currently, April is the cheapest month in which you can book a flight from Key Largo to Guayaquil (average of $440). Flying from Key Largo to Guayaquil in December is currently the most expensive (average of $722). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from KE9 to GYE?

Find hourly flight availability from Key Largo to Guayaquil. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

When flying from Key Largo to Guayaquil, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

What is the cheapest day to fly from Key Largo to Guayaquil?

Use this chart to determine the cheapest time to fly round-trip from Key Largo to Guayaquil. Price data was last updated on September 14, 2025.

Travelers seeking maximum savings on their Key Largo to Guayaquil flight should consider departing on Monday at noon when fares are most often at their lowest. Monday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

How much does it cost to fly round-trip from Key Largo to Guayaquil?

Reviews of airlines servicing Guayaquil

Get insights into the airlines that provide service to Guayaquil. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Guayaquil. Reviews last updated September 15, 2025.
Get a feel of what it's like to fly with Copa Airlines, LATAM Airlines, and American Airlines from Key Largo to Guayaquil by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,531 reviews

Crew

8.1

Overall

7.6

Food

6.8

Entertainment

6.8

Comfort

7.4

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Copa Airlines
7.6
Good
1,531 reviews
Copa Airlines
7.6
Good
1,531 reviews

Crew

8.1

Overall

7.6

Food

6.8

Entertainment

6.8

Comfort

7.4

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
LATAM Airlines
7.5
Good
1,847 reviews
Copa Airlines
7.6
Good
1,531 reviews

Crew

8.1

Overall

7.6

Food

6.8

Entertainment

6.8

Comfort

7.4

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
American Airlines
7.2
Good
10,000 reviews
Copa Airlines
7.6
Good
1,531 reviews

Crew

8.1

Overall

7.6

Food

6.8

Entertainment

6.8

Comfort

7.4

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Avianca
6.7
Okay
2,435 reviews
Copa Airlines
7.6
Good
1,531 reviews

Crew

8.1

Overall

7.6

Food

6.8

Entertainment

6.8

Comfort

7.4

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Spirit Airlines
6.3
Okay
8,015 reviews
Copa Airlines
7.6
Good
1,531 reviews

Crew

8.1

Overall

7.6

Food

6.8

Entertainment

6.8

Comfort

7.4

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Related info for your journey

Find useful and relevant information for your journey from Key Largo to Guayaquil. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Guayaquil from Key Largo?

    For a flight from Key Largo to Guayaquil, you will be flying into Jose Joaquin de Olmedo. Guayaquil Jose Joaquin de Olmedo (GYE) is just 2.5 mi from the center of the city. Jose Joaquin de Olmedo is the only Guayaquil airport and it handles 0 inbound flights from Key Largo per day. 6 airlines have flights to Guayaquil Jose Joaquin de Olmedo from Key Largo on a regular basis.

  • How long is the flight from Key Largo to Guayaquil?

    Copa Airlines and Avianca can get you from Key Largo to Guayaquil in just under 4h 35m. Your travel time can differ by up to 3h 06m. Key Largo and Guayaquil are separated by a distance of 1930 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest flights from Key Largo to Guayaquil?

    Looking at all options, your cheapest flight can be booked for $230. While the most popular route (Miami - Guayaquil Jose Joaquin de Olmedo) can be booked for $249 on average, our data indicates $613 when flying from Key Largo to Guayaquil.

  • Can I find deals for flights from Key Largo to Guayaquil that include hotel bookings?

    Yes. In addition to deals on Key Largo to Guayaquil flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key Largo to Guayaquil?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key Largo to Guayaquil.

  • Can I find deals for business class flights from Key Largo to Guayaquil?

    Yes. Cheapflights offers flight deals from Key Largo to Guayaquil by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key Largo to Guayaquil?

    Currently, April is the cheapest month in which you can book a flight from Key Largo to Guayaquil (average of $440). Flying from Key Largo to Guayaquil in December is currently the most expensive (average of $722). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Key Largo to Guayaquil

See prices for flight routes from nearby airports that may be better suited for you.
Miami to Quito flights
Miami to Guayaquil flights
Fort Lauderdale to Guayaquil flights
Orlando to Quito flights
Fort Lauderdale to Quito flights
Orlando to Guayaquil flights
Tampa to Quito flights
Tampa to Guayaquil flights
Jacksonville to Quito flights
Miami to Cuenca flights
Gainesville to Quito flights
West Palm Beach to Quito flights
Orlando to Manta flights
Jacksonville to Guayaquil flights
Miami to San Cristobal flights
Orlando to Cuenca flights
West Palm Beach to Guayaquil flights
Miami to Baltra flights
Valparaiso to Quito flights
Tallahassee to Guayaquil flights
Panama City to Guayaquil flights
Fort Lauderdale to Cuenca flights
Fort Lauderdale to Baltra flights
Orlando to Baltra flights
Fort Lauderdale to San Cristobal flights
Tallahassee to Quito flights
Sarasota to Quito flights
Daytona Beach to Quito flights
Tampa to Baltra flights
Tampa to Cuenca flights
Fort Myers to Quito flights
Pensacola to Guayaquil flights
Melbourne to Quito flights
Orlando to San Cristobal flights
Miami to Puerto Francisco de Orellana flights
Tampa to San Cristobal flights
Orlando to Loja flights

Top 6 airlines flying from Key Largo to Guayaquil

Discover the top 6 airlines that operate flights from Key Largo to Guayaquil. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$123Average$308FlexibilityNo cancel feeOn-time65%
Copa AirlinesCheapest$177Average$452FlexibilityNo cancel feeOn-time70%
AviancaCheapest$260Average$415FlexibilityNo cancel feeOn-time71%
JetBlueCheapest$261Average$383FlexibilityNo cancel feeOn-time62%
American AirlinesCheapest$361Average$571FlexibilityNo cancel feeOn-time71%
LATAM AirlinesCheapest$436Average$628FlexibilityNo cancel feeOn-time81%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.