$337+ Cheap flights from St. Louis (STL) to Grand Cayman
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/21. Fares are subject to change and may not be available on all flights or dates of travel.
STL — GCM
Apr 11 — Apr 181
Round-trip
1 adult, Economy
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Find cheap flights from St. Louis to Grand Cayman with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from St. Louis to Grand Cayman
Cheapest
Best
Last-minute
Cheapest flights from St. Louis to Grand CaymanExplore the most affordable flight options available from St. Louis to Grand Cayman. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 12, 2026.
Explore the most affordable flight options available from St. Louis to Grand Cayman. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 12, 2026.
This Delta deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:00 am
STL
- GCM
1 stop6h 00m
Delta
Tue 4/281:25 pm
GCM
- STL
1 stop7h 54m
Delta
Deal found 3/7![Delta logo]()
$337
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/176:54 pm
STL
- GCM
2 stops16h 06m
American Airlines
Fri 5/2212:33 pm
GCM
- STL
1 stop6h 27m
American Airlines
Deal found 3/9![American Airlines logo]()
$342
This American Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/186:53 pm
STL
- GCM
1 stop16h 38m
American Airlines
Sat 5/24:03 pm
GCM
- STL
1 stop16h 27m
American Airlines
Deal found 3/8![American Airlines logo]()
$362
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/105:24 am
STL
- GCM
1 stop5h 36m
American Airlines
Thu 5/1412:00 pm
GCM
- STL
2 stops20h 30m
American Airlines
Deal found 3/9![American Airlines logo]()
$442
This United Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/106:00 am
STL
- GCM
1 stop6h 30m
United Airlines
Thu 5/141:35 pm
GCM
- STL
1 stop8h 55m
United Airlines
Deal found 3/9![United Airlines logo]()
$447
This Delta deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:00 am
STL
- GCM
1 stop5h 54m
Delta
Tue 6/21:19 pm
GCM
- STL
1 stop10h 40m
Delta
Deal found 3/11![Delta logo]()
$468
This United Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/176:00 am
STL
- GCM
1 stop6h 30m
United Airlines
Fri 5/221:35 pm
GCM
- STL
2 stops19h 06m
United Airlines
Deal found 3/9![United Airlines logo]()
$472
This American Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/106:55 pm
STL
- GCM
1 stop16h 36m
American Airlines
Fri 4/172:10 pm
GCM
- STL
1 stop8h 14m
American Airlines
Deal found 3/10![American Airlines logo]()
$492
Best flights from St. Louis to Grand CaymanDiscover carefully curated flight deals from St. Louis to Grand Cayman that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 12, 2026.
Discover carefully curated flight deals from St. Louis to Grand Cayman that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 12, 2026.
This Delta deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:00 am
STL
- GCM
1 stop6h 00m
Delta
Tue 4/281:25 pm
GCM
- STL
1 stop7h 54m
Delta
Deal found 3/7![Delta logo]()
$337
This American Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/215:53 pm
STL
- GCM
2 stops17h 07m
American Airlines
Tue 4/2812:00 pm
GCM
- STL
1 stop10h 24m
American Airlines
Deal found 3/7![American Airlines logo]()
$342
This United Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/106:00 am
STL
- GCM
1 stop6h 30m
United Airlines
Thu 5/141:35 pm
GCM
- STL
1 stop8h 55m
United Airlines
Deal found 3/9![United Airlines logo]()
$447
This American Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/186:11 pm
STL
- GCM
2 stops17h 20m
American Airlines
Sat 5/22:10 pm
GCM
- STL
2 stops18h 20m
American Airlines
Deal found 3/8![American Airlines logo]()
$367
This United Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/226:30 am
STL
- GCM
1 stop6h 15m
United Airlines
Fri 4/241:35 pm
GCM
- STL
1 stop8h 52m
United Airlines
Deal found 3/9![United Airlines logo]()
$467
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/105:21 pm
STL
- GCM
2 stops18h 10m
American Airlines
Thu 5/142:10 pm
GCM
- STL
2 stops18h 20m
American Airlines
Deal found 3/9![American Airlines logo]()
$442
This Delta deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/176:00 am
STL
- GCM
1 stop5h 54m
Delta
Fri 5/221:19 pm
GCM
- STL
1 stop10h 40m
Delta
Deal found 3/10![Delta logo]()
$506
This United Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/176:00 am
STL
- GCM
1 stop6h 30m
United Airlines
Fri 5/221:35 pm
GCM
- STL
2 stops19h 06m
United Airlines
Deal found 3/9![United Airlines logo]()
$472
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/176:54 pm
STL
- GCM
1 stop16h 37m
American Airlines
Fri 5/2212:33 pm
GCM
- STL
1 stop11h 11m
American Airlines
Deal found 3/9![American Airlines logo]()
$467
This United Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:00 am
STL
- GCM
1 stop6h 30m
United Airlines
Tue 4/281:35 pm
GCM
- STL
2 stops18h 50m
United Airlines
Deal found 3/11![United Airlines logo]()
$472
Last-minute flights from St. Louis to Grand CaymanDiscover last-minute flight deals from St. Louis to Grand Cayman. Data last updated March 12, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to Grand Cayman. Data last updated March 12, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/106:55 pm
STL
- GCM
1 stop16h 36m
American Airlines
Fri 4/172:10 pm
GCM
- STL
1 stop8h 14m
American Airlines
Deal found 3/10![American Airlines logo]()
$492
This American Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/186:53 pm
STL
- GCM
1 stop16h 38m
American Airlines
Sat 5/24:03 pm
GCM
- STL
1 stop16h 27m
American Airlines
Deal found 3/8![American Airlines logo]()
$362
This Delta deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:00 am
STL
- GCM
1 stop6h 00m
Delta
Tue 4/281:25 pm
GCM
- STL
1 stop7h 54m
Delta
Deal found 3/7![Delta logo]()
$337
This American Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/215:53 pm
STL
- GCM
2 stops17h 07m
American Airlines
Tue 4/2812:00 pm
GCM
- STL
1 stop10h 24m
American Airlines
Deal found 3/7![American Airlines logo]()
$342
This United Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:00 am
STL
- GCM
1 stop6h 30m
United Airlines
Tue 4/281:35 pm
GCM
- STL
2 stops18h 50m
United Airlines
Deal found 3/11![United Airlines logo]()
$472
This United Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/226:30 am
STL
- GCM
1 stop6h 15m
United Airlines
Fri 4/241:35 pm
GCM
- STL
1 stop8h 52m
United Airlines
Deal found 3/9![United Airlines logo]()
$467
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/226:55 pm
STL
- GCM
1 stop16h 36m
American Airlines
Fri 4/2412:35 pm
GCM
- STL
2 stops19h 52m
American Airlines
Deal found 3/9![American Airlines logo]()
$502
This Southwest deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/245:00 am
STL
- GCM
1 stop7h 10m
Southwest
Fri 5/11:05 pm
GCM
- STL
1 stop10h 35m
Southwest
Deal found 3/10![Southwest logo]()
$503
This American Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/257:00 am
STL
- GCM
1 stop8h 03m
American Airlines
Sat 5/23:13 pm
GCM
- STL
1 stop7h 44m
American Airlines
Deal found 3/11![American Airlines logo]()
$531
Find flight deals from St. Louis to Grand Cayman
Keep the following information in mind while searching for St. Louis to Grand Cayman flight deals. Data was last updated March 12, 2026.
Round-trip from | $337 (Delta) |
|---|---|
Popular in | December |
Cheapest in | September |
Average price | $638 |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Grand Cayman that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 12, 2026.
Use the filters below to find and compare flights from St. Louis to Grand Cayman that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Tue 4/21
6:00 am-12:00 pm
1 stop6h 00m
George Town Owen Roberts Intl
Tue 4/28
1:25 pm-9:19 pm
1 stop7h 54m
$337
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Tue 4/21
5:53 pm-11:00 am
2 stops17h 07m
George Town Owen Roberts Intl
Tue 4/28
12:00 pm-10:24 pm
1 stop10h 24m
$342
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Sat 4/18
6:11 pm-11:31 am
2 stops17h 20m
George Town Owen Roberts Intl
Sat 5/2
2:10 pm-8:30 am
2 stops18h 20m
$367
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Sun 5/10
5:21 pm-11:31 am
2 stops18h 10m
George Town Owen Roberts Intl
Thu 5/14
2:10 pm-8:30 am
2 stops18h 20m
$442
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Sun 5/10
6:00 am-12:30 pm
1 stop6h 30m
George Town Owen Roberts Intl
Thu 5/14
1:35 pm-10:30 pm
1 stop8h 55m
$447
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Wed 4/22
6:30 am-12:45 pm
1 stop6h 15m
George Town Owen Roberts Intl
Fri 4/24
1:35 pm-10:27 pm
1 stop8h 52m
$467
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Sun 5/17
6:54 pm-11:31 am
1 stop16h 37m
George Town Owen Roberts Intl
Fri 5/22
12:33 pm-11:44 pm
1 stop11h 11m
$467
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Sun 5/17
6:00 am-12:30 pm
1 stop6h 30m
George Town Owen Roberts Intl
Fri 5/22
1:35 pm-8:41 am
2 stops19h 06m
$472
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Tue 4/21
6:00 am-12:30 pm
1 stop6h 30m
George Town Owen Roberts Intl
Tue 4/28
1:35 pm-8:25 am
2 stops18h 50m
$472
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Sun 5/17
6:00 am-11:54 am
1 stop5h 54m
George Town Owen Roberts Intl
Fri 5/22
1:19 pm-11:59 pm
1 stop10h 40m
$506
Sorted by cheapest first
Best time to book a flight from St. Louis to Grand Cayman
Have a flexible travel schedule? Discover the best time to fly to Grand Cayman from St. Louis with our price prediction graph.
STL-GCM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to Grand Cayman
STL-zzLAW
STL-GCM
What is the cheapest month to book a flight from St. Louis to Grand Cayman?
Currently, August is the cheapest month in which you can book a flight from St. Louis to Grand Cayman (average of $248). Flying from St. Louis to Grand Cayman in June is currently the most expensive (average of $540). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Grand Cayman
Get insights into the airlines that provide service to Grand Cayman. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Grand Cayman. Reviews last updated March 12, 2026.
See what other customers who have flown with Southwest,Delta, andUnited Airlines from St. Louis to Grand Cayman have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Comfort
8.0
Overall
8.0
Crew
8.6
Boarding
8.1
Food
7.0
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Entertainment
7.5
Comfort
8.0
Overall
8.0
Crew
8.6
Boarding
8.1
Food
7.0
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Entertainment
7.5
Comfort
8.0
Overall
8.0
Crew
8.6
Boarding
8.1
Food
7.0
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Entertainment
7.5
Comfort
8.0
Overall
8.0
Crew
8.6
Boarding
8.1
Food
7.0
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Entertainment
7.5
Comfort
8.0
Overall
8.0
Crew
8.6
Boarding
8.1
Food
7.0
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Grand Cayman. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
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St. Louis and Grand Cayman flights
Browse other St. Louis and Grand Cayman flight options. Last updated on March 12, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 4 airlines flying from St. Louis to Grand Cayman
Discover the top 4 airlines that operate flights from St. Louis to Grand Cayman. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 12, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$190 | Average$597 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$364 | Average$625 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$429 | Average$585 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$446 | Average$610 | FlexibilityNo cancel fee | On-time71% |