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Grand Cayman

$260+ Cheap flights from Missouri to Grand Cayman

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/13. Fares are subject to change and may not be available on all flights or dates of travel.
STL — GCM
Oct 26 — Nov 21
Sun 10/26
Sun 11/2
1 adult, Economy
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Cheap flight deals from Missouri to Grand Cayman

Keep the following information in mind while searching for Missouri to Grand Cayman flight deals. Data was last updated September 26, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$410
(American Airlines)

One-way from

$260
(Delta)

Popular in

August

Cheapest in

July

Average price

$527
Provider with most accurate pricing for Kansas City-George Town Owen Roberts Intl flight deals.
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Provider most trusted by Cheapflights users for Kansas City-George Town Owen Roberts Intl flights.
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From Missouri to Grand Cayman
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One-way flight from Missouri to Grand Cayman
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High demand for flights, 4% potential price rise
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Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Missouri to Grand Cayman

Cheapest flights from Missouri to Grand Cayman
Explore the most affordable flight options available from Missouri to Grand Cayman. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 26, 2025.

This American Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/35:15 amSTL - GCM
1 stop6h 05mAmerican Airlines
Thu 11/63:10 pmGCM - STL
1 stop9h 55mAmerican Airlines
Deal found 9/25$410
This American Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/195:04 amMCI - GCM
1 stop14h 24mAmerican Airlines
Wed 12/171:25 pmGCM - MCI
1 stop12h 00mAmerican Airlines
Deal found 9/24$446
This Delta deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/96:00 amSTL - GCM
1 stop5h 35mDelta
Wed 11/121:50 pmGCM - STL
1 stop9h 08mDelta
Deal found 9/24$446
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/96:43 pmSTL - GCM
2 stops20h 47mUnited Airlines
Wed 11/125:45 pmGCM - STL
2 stops19h 43mUnited Airlines
Deal found 9/23$450
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/82:08 pmSTL - GCM
1 stop20h 49mAmerican Airlines
Wed 11/121:05 pmGCM - STL
1 stop11h 02mAmerican Airlines
Deal found 9/23$454
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/75:06 pmSTL - GCM
1 stop17h 28mAmerican Airlines
Wed 11/123:36 pmGCM - STL
1 stop7h 51mAmerican Airlines
Deal found 9/23$460
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/78:20 amSTL - GCM
1 stop7h 10mUnited Airlines
Wed 11/125:45 pmGCM - STL
2 stops21h 40mUnited Airlines
Deal found 9/23$464
This American Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/82:08 pmSTL - GCM
1 stop20h 49mAmerican Airlines
Sat 11/154:01 pmGCM - STL
1 stop17h 08mAmerican Airlines
Deal found 9/24$468
This American Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/16:36 pmMCI - GCM
1 stop16h 21mAmerican Airlines
Mon 12/223:45 pmGCM - MCI
1 stop10h 09mAmerican Airlines
Deal found 9/24$491
This American Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/36:00 amSTL - GCM
2 stops13h 28mAmerican Airlines
Fri 11/712:55 pmGCM - STL
2 stops21h 00mAmerican Airlines
Deal found 9/25$500
This American Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/66:36 pmMCI - GCM
1 stop16h 20mAmerican Airlines
Mon 11/101:20 pmGCM - MCI
1 stop11h 39mAmerican Airlines
Deal found 9/24$536
This American Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2212:40 pmMCI - GCM
1 stop22h 45mAmerican Airlines
Sat 10/253:15 pmGCM - MCI
2 stops17h 46mAmerican Airlines
Deal found 9/25$551

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Grand Cayman that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 26, 2025.
Use the filters below to find and compare flights from Missouri to Grand Cayman that are best for you.

Fly from

Missouri

Fly to

Grand Cayman

Route

Depart

Return

Price

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

Mon 11/3

5:15 am-12:20 pm

1 stop6h 05m

George Town Owen Roberts Intl

Thu 11/6

3:10 pm-12:05 am

1 stop9h 55m

$410

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

Sun 11/9

6:00 am-12:35 pm

1 stop5h 35m

George Town Owen Roberts Intl

Wed 11/12

1:50 pm-9:58 pm

1 stop9h 08m

$446

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

Sun 11/9

6:43 pm-4:30 pm

2 stops20h 47m

George Town Owen Roberts Intl

Wed 11/12

5:45 pm-12:28 pm

2 stops19h 43m

$450

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

Sat 11/8

2:08 pm-11:57 am

1 stop20h 49m

George Town Owen Roberts Intl

Wed 11/12

1:05 pm-11:07 pm

1 stop11h 02m

$454

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

Fri 11/7

5:06 pm-11:34 am

1 stop17h 28m

George Town Owen Roberts Intl

Wed 11/12

3:36 pm-10:27 pm

1 stop7h 51m

$460

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

Fri 11/7

8:20 am-4:30 pm

1 stop7h 10m

George Town Owen Roberts Intl

Wed 11/12

5:45 pm-2:25 pm

2 stops21h 40m

$464

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

Sat 11/8

2:08 pm-11:57 am

1 stop20h 49m

George Town Owen Roberts Intl

Sat 11/15

1:20 pm-12:05 am

2 stops11h 45m

$473

Kansas CityGeorge Town

MCI - GCM

MCIGCM

Kansas City

Sat 1/31

6:08 pm-11:00 am

1 stop15h 52m

George Town Owen Roberts Intl

Sat 2/7

11:55 am-5:03 pm

1 stop6h 08m

$476

Kansas CityGeorge Town

MCI - GCM

MCIGCM

Kansas City

Sun 11/9

6:15 am-4:30 pm

1 stop9h 15m

George Town Owen Roberts Intl

Sun 11/16

5:45 pm-9:29 am

1 stop16h 44m

$491

Kansas CityGeorge Town

MCI - GCM

MCIGCM

Kansas City

Sat 1/31

6:09 pm-11:41 am

2 stops16h 32m

George Town Owen Roberts Intl

Sat 2/7

8:30 am-4:16 pm

1 stop8h 46m

$495

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/24

Showing 1-10 of 19 results
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Best time to book a flight from Missouri to Grand Cayman

Have a flexible travel schedule? Discover the best time to fly to Grand Cayman from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Grand Cayman

What is the cheapest month to book a flight from Missouri to Grand Cayman?

Currently, January is the cheapest month in which you can book a flight from Missouri to Grand Cayman (average of $467). Flying from Missouri to Grand Cayman in March is currently the most expensive (average of $594). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to LAW?

Find hourly flight availability from Missouri to Grand Cayman. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 26, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Missouri to Grand Cayman as you normally would.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Grand Cayman. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Missouri to Grand Cayman?

    Departing from Missouri to Grand Cayman will take you 5h 35m. There are 1448 mi between Missouri and Grand Cayman. This flight may include one or multiple stops.

  • Can I find deals for flights from Missouri to Grand Cayman that include hotel bookings?

    Yes. In addition to deals on Missouri to Grand Cayman flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Grand Cayman?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Grand Cayman.

  • Can I find deals for business class flights from Missouri to Grand Cayman?

    Yes. Cheapflights offers flight deals from Missouri to Grand Cayman by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Grand Cayman?

    Currently, January is the cheapest month in which you can book a flight from Missouri to Grand Cayman (average of $467). Flying from Missouri to Grand Cayman in March is currently the most expensive (average of $594). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Missouri to Grand Cayman

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Missouri to Grand Cayman

Discover the top 4 airlines that operate flights from Missouri to Grand Cayman. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 26, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$216Average$587FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$238Average$629FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$429Average$638FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$439Average$630FlexibilityNo cancel feeOn-time71%

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