$326+ Cheap flights from Missouri to Grand Cayman
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/17. Fares are subject to change and may not be available on all flights or dates of travel.
STL — GCM
Apr 12 — Apr 191
Round-trip
1 adult, Economy
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Cheapest flights from Missouri to Grand CaymanExplore the most affordable flight options available from Missouri to Grand Cayman. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 13, 2026.
Explore the most affordable flight options available from Missouri to Grand Cayman. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 13, 2026.
This American Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/176:28 pm
MCI
- GCM
2 stops16h 32m
American Airlines
Fri 5/225:12 pm
GCM
- MCI
2 stops18h 13m
American Airlines
Deal found 3/8![American Airlines logo]()
$326
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/176:54 pm
STL
- GCM
2 stops16h 06m
American Airlines
Fri 5/2212:33 pm
GCM
- STL
1 stop6h 27m
American Airlines
Deal found 3/9![American Airlines logo]()
$342
This Delta deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:00 am
STL
- GCM
1 stop6h 00m
Delta
Tue 4/281:25 pm
GCM
- STL
1 stop7h 54m
Delta
Deal found 3/11![Delta logo]()
$357
This Delta deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/65:40 am
MCI
- GCM
1 stop6h 20m
Delta
Sat 5/91:19 pm
GCM
- MCI
1 stop7h 28m
Delta
Deal found 3/10![Delta logo]()
$364
This Delta deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/75:39 am
MCI
- GCM
1 stop6h 15m
Delta
Sun 5/101:19 pm
GCM
- MCI
1 stop9h 11m
Delta
Deal found 3/8![Delta logo]()
$367
This American Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/96:28 pm
MCI
- GCM
1 stop17h 03m
American Airlines
Thu 4/1612:35 pm
GCM
- MCI
1 stop10h 43m
American Airlines
Deal found 3/12![American Airlines logo]()
$374
This American Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:28 pm
MCI
- GCM
2 stops16h 32m
American Airlines
Sun 5/102:10 pm
GCM
- MCI
2 stops20h 05m
American Airlines
Deal found 3/8![American Airlines logo]()
$377
This Expedia deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/61:00 pm
STL
- GCM
2 stops46h 25m
Air Canada
Sat 6/1310:55 am
GCM
- STL
1 stop25h 11m
Air Canada
Deal found 3/12![Air Canada logo]()
$419
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/105:24 am
STL
- GCM
1 stop5h 36m
American Airlines
Thu 5/1412:00 pm
GCM
- STL
2 stops20h 30m
American Airlines
Deal found 3/9![American Airlines logo]()
$442
This United Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/106:00 am
STL
- GCM
1 stop6h 30m
United Airlines
Thu 5/141:35 pm
GCM
- STL
1 stop8h 55m
United Airlines
Deal found 3/9![United Airlines logo]()
$447
This Delta deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:00 am
STL
- GCM
1 stop5h 54m
Delta
Tue 6/21:19 pm
GCM
- STL
1 stop10h 40m
Delta
Deal found 3/11![Delta logo]()
$468
This United Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/178:30 pm
STL
- GCM
2 stops16h 00m
United Airlines
Fri 5/221:35 pm
GCM
- STL
2 stops19h 06m
United Airlines
Deal found 3/9![United Airlines logo]()
$472
Best flights from Missouri to Grand CaymanDiscover carefully curated flight deals from Missouri to Grand Cayman that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 13, 2026.
Discover carefully curated flight deals from Missouri to Grand Cayman that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 13, 2026.
This Delta deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:00 am
STL
- GCM
1 stop6h 00m
Delta
Tue 4/281:25 pm
GCM
- STL
1 stop7h 54m
Delta
Deal found 3/11![Delta logo]()
$357
This American Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:28 pm
MCI
- GCM
2 stops16h 32m
American Airlines
Sun 5/102:10 pm
GCM
- MCI
2 stops20h 05m
American Airlines
Deal found 3/8![American Airlines logo]()
$377
This Expedia deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/61:00 pm
STL
- GCM
2 stops46h 25m
Air Canada
Sat 6/1310:55 am
GCM
- STL
1 stop25h 11m
Air Canada
Deal found 3/12![Air Canada logo]()
$419
This United Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/106:00 am
STL
- GCM
1 stop6h 30m
United Airlines
Thu 5/141:35 pm
GCM
- STL
1 stop8h 55m
United Airlines
Deal found 3/9![United Airlines logo]()
$447
This Kiwi.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/2812:24 pm
MCI
- GCM
1 stop24h 33m
Multiple Airlines
Wed 4/111:30 am
GCM
- MCI
2 stops32h 31m
Multiple Airlines
Deal found 3/9![Multiple Airlines logo]()
$607
This Delta deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/75:39 am
MCI
- GCM
1 stop6h 15m
Delta
Sun 5/101:19 pm
GCM
- MCI
1 stop9h 11m
Delta
Deal found 3/8![Delta logo]()
$367
This Delta deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/15:40 am
MCI
- GCM
1 stop6h 20m
Delta
Tue 5/51:25 pm
GCM
- MCI
1 stop6h 45m
Delta
Deal found 3/10![Delta logo]()
$374
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/105:21 pm
STL
- GCM
2 stops18h 10m
American Airlines
Thu 5/142:10 pm
GCM
- STL
2 stops18h 20m
American Airlines
Deal found 3/9![American Airlines logo]()
$442
This United Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/226:30 am
STL
- GCM
1 stop6h 15m
United Airlines
Fri 4/241:35 pm
GCM
- STL
1 stop8h 52m
United Airlines
Deal found 3/9![United Airlines logo]()
$467
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/176:54 pm
STL
- GCM
1 stop16h 37m
American Airlines
Fri 5/2212:33 pm
GCM
- STL
1 stop11h 11m
American Airlines
Deal found 3/9![American Airlines logo]()
$467
This United Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/176:00 am
STL
- GCM
1 stop6h 30m
United Airlines
Fri 5/221:35 pm
GCM
- STL
2 stops19h 06m
United Airlines
Deal found 3/9![United Airlines logo]()
$472
This Delta deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/45:40 am
MCI
- GCM
1 stop5h 46m
Delta
Tue 8/1812:56 pm
GCM
- MCI
1 stop10h 56m
Delta
Deal found 3/8![Delta logo]()
$447
This United Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:00 am
STL
- GCM
1 stop6h 30m
United Airlines
Tue 4/281:35 pm
GCM
- STL
2 stops18h 50m
United Airlines
Deal found 3/11![United Airlines logo]()
$472
This American Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/106:28 pm
MCI
- GCM
2 stops16h 27m
American Airlines
Mon 4/132:10 pm
GCM
- MCI
2 stops20h 05m
American Airlines
Deal found 3/11![American Airlines logo]()
$498
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/97:49 pm
MCI
- GCM
2 stops15h 21m
American Airlines
Wed 9/161:20 pm
GCM
- MCI
2 stops19h 26m
American Airlines
Deal found 3/9![American Airlines logo]()
$502
This Delta deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/176:00 am
STL
- GCM
1 stop5h 54m
Delta
Fri 5/221:19 pm
GCM
- STL
1 stop10h 40m
Delta
Deal found 3/10![Delta logo]()
$506
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/226:15 am
MCI
- GCM
1 stop6h 30m
United Airlines
Wed 4/2912:55 pm
GCM
- MCI
1 stop9h 35m
United Airlines
Deal found 3/8![United Airlines logo]()
$557
This American Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/256:12 pm
STL
- GCM
2 stops16h 49m
American Airlines
Mon 6/112:01 pm
GCM
- STL
2 stops11h 53m
American Airlines
Deal found 3/12![American Airlines logo]()
$528
This American Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/185:16 pm
MCI
- GCM
2 stops17h 45m
American Airlines
Tue 6/235:12 pm
GCM
- MCI
2 stops15h 23m
American Airlines
Deal found 3/8![American Airlines logo]()
$564
Last-minute flights from Missouri to Grand CaymanDiscover last-minute flight deals from Missouri to Grand Cayman. Data last updated March 13, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to Grand Cayman. Data last updated March 13, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/96:28 pm
MCI
- GCM
1 stop17h 03m
American Airlines
Thu 4/1612:35 pm
GCM
- MCI
1 stop10h 43m
American Airlines
Deal found 3/12![American Airlines logo]()
$374
This American Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/106:55 pm
STL
- GCM
1 stop16h 36m
American Airlines
Fri 4/172:10 pm
GCM
- STL
1 stop8h 14m
American Airlines
Deal found 3/10![American Airlines logo]()
$492
This American Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/106:28 pm
MCI
- GCM
2 stops16h 27m
American Airlines
Mon 4/132:10 pm
GCM
- MCI
2 stops20h 05m
American Airlines
Deal found 3/11![American Airlines logo]()
$498
This Delta deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/105:54 am
MCI
- GCM
1 stop5h 53m
Delta
Mon 4/131:25 pm
GCM
- MCI
1 stop8h 46m
Delta
Deal found 3/11![Delta logo]()
$536
This Delta deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:00 am
STL
- GCM
1 stop6h 00m
Delta
Tue 4/281:25 pm
GCM
- STL
1 stop7h 54m
Delta
Deal found 3/11![Delta logo]()
$357
This United Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:00 am
STL
- GCM
1 stop6h 30m
United Airlines
Tue 4/281:35 pm
GCM
- STL
2 stops18h 50m
United Airlines
Deal found 3/11![United Airlines logo]()
$472
This United Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/226:30 am
STL
- GCM
1 stop6h 15m
United Airlines
Fri 4/241:35 pm
GCM
- STL
1 stop8h 52m
United Airlines
Deal found 3/9![United Airlines logo]()
$467
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/226:55 pm
STL
- GCM
1 stop16h 36m
American Airlines
Fri 4/2412:35 pm
GCM
- STL
2 stops19h 52m
American Airlines
Deal found 3/9![American Airlines logo]()
$502
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/226:15 am
MCI
- GCM
1 stop6h 30m
United Airlines
Wed 4/2912:55 pm
GCM
- MCI
1 stop9h 35m
United Airlines
Deal found 3/8![United Airlines logo]()
$557
This American Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/246:28 pm
MCI
- GCM
2 stops16h 27m
American Airlines
Fri 5/112:00 pm
GCM
- MCI
2 stops11h 18m
American Airlines
Deal found 3/10![American Airlines logo]()
$497
This Southwest deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/245:00 am
STL
- GCM
1 stop7h 10m
Southwest
Fri 5/11:05 pm
GCM
- STL
1 stop10h 35m
Southwest
Deal found 3/10![Southwest logo]()
$503
This American Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/257:00 am
STL
- GCM
1 stop8h 03m
American Airlines
Sat 5/23:13 pm
GCM
- STL
1 stop7h 44m
American Airlines
Deal found 3/11![American Airlines logo]()
$531
Find flight deals from Missouri to Grand Cayman
Keep the following information in mind while searching for Missouri to Grand Cayman flight deals. Data was last updated March 13, 2026.
Round-trip from | $326 (American Airlines) |
|---|---|
Popular in | December |
Cheapest in | September |
Average price | $638 |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to Grand Cayman that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 13, 2026.
Use the filters below to find and compare flights from Missouri to Grand Cayman that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Tue 4/21
6:00 am-12:00 pm
1 stop6h 00m
George Town Owen Roberts Intl
Tue 4/28
1:25 pm-9:19 pm
1 stop7h 54m
$357
Kansas CityGeorge Town
MCI - GCM
MCIGCM
Kansas City
Thu 5/7
5:39 am-11:54 am
1 stop6h 15m
George Town Owen Roberts Intl
Sun 5/10
1:19 pm-10:30 pm
1 stop9h 11m
$367
Quickest round-trip
Kansas CityGeorge Town
MCI - GCM
MCIGCM
Kansas City
Fri 5/1
5:40 am-12:00 pm
1 stop6h 20m
George Town Owen Roberts Intl
Tue 5/5
1:25 pm-8:10 pm
1 stop6h 45m
$374
Kansas CityGeorge Town
MCI - GCM
MCIGCM
Kansas City
Thu 5/7
6:28 pm-11:00 am
2 stops16h 32m
George Town Owen Roberts Intl
Sun 5/10
2:10 pm-10:15 am
2 stops20h 05m
$377
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Sat 6/6
1:00 pm-11:25 am
2 stops46h 25m
George Town Owen Roberts Intl
Sat 6/13
10:55 am-12:06 pm
1 stop25h 11m
$419
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Sun 5/10
5:21 pm-11:31 am
2 stops18h 10m
George Town Owen Roberts Intl
Thu 5/14
2:10 pm-8:30 am
2 stops18h 20m
$442
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Sun 5/10
6:00 am-12:30 pm
1 stop6h 30m
George Town Owen Roberts Intl
Thu 5/14
1:35 pm-10:30 pm
1 stop8h 55m
$447
Kansas CityGeorge Town
MCI - GCM
MCIGCM
Kansas City
Tue 8/4
5:40 am-11:26 am
1 stop5h 46m
George Town Owen Roberts Intl
Tue 8/18
12:56 pm-11:52 pm
1 stop10h 56m
$447
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Wed 4/22
6:30 am-12:45 pm
1 stop6h 15m
George Town Owen Roberts Intl
Fri 4/24
1:35 pm-10:27 pm
1 stop8h 52m
$467
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Sun 5/17
6:54 pm-11:31 am
1 stop16h 37m
George Town Owen Roberts Intl
Fri 5/22
12:33 pm-11:44 pm
1 stop11h 11m
$467
Showing 1-10 of 19 resultsSorted by cheapest first
Best time to book a flight from Missouri to Grand Cayman
Have a flexible travel schedule? Discover the best time to fly to Grand Cayman from Missouri with our price prediction graph.
STL-GCM
MCI-GCM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to Grand Cayman
USMO-zzLAW
STL-GCM
MCI-GCM
What is the cheapest month to book a flight from Missouri to Grand Cayman?
Currently, February is the cheapest month in which you can book a flight from Missouri to Grand Cayman (average of $108). Flying from Missouri to Grand Cayman in December is currently the most expensive (average of $488). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Related info for your journey
Find useful and relevant information for your journey from Missouri to Grand Cayman. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Missouri to Grand Cayman
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Grand Cayman by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Missouri to Grand Cayman by cabin class
Find flights from Missouri to Grand Cayman, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Missouri and Grand Cayman flights
Browse other Missouri and Grand Cayman flight options. Last updated on March 13, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 4 airlines flying from Missouri to Grand Cayman
Discover the top 4 airlines that operate flights from Missouri to Grand Cayman. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 13, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$190 | Average$566 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$238 | Average$585 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$418 | Average$581 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$429 | Average$585 | FlexibilityNo cancel fee | On-time63% |