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Grand Cayman

$106+ Cheap flights from Missouri to Grand Cayman

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/23. Fares are subject to change and may not be available on all flights or dates of travel.
STL — GCM
Feb 18 — Feb 251
Wed 2/18
Wed 2/25
1 adult, Economy
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Cheap flight deals from Missouri to Grand Cayman

Keep the following information in mind while searching for Missouri to Grand Cayman flight deals. Data was last updated January 19, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

Expedia
3 stars

Round-trip from

$317
(American Airlines)

One-way from

$106
(American Airlines)

Popular in

March

Cheapest in

September

Average price

$571
Provider with most accurate pricing for Lambert-St Louis-George Town Owen Roberts Intl flight deals.
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Provider most trusted by Cheapflights users for Lambert-St Louis-George Town Owen Roberts Intl flights.
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From Missouri to Grand Cayman
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One-way flight from Missouri to Grand Cayman
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Highest demand for flights based on searches. 7% potential increase in price ($52 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($15 potential savings vs. average RT price).
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Average for round-trip flights in January 2026
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Find flight deals from Missouri to Grand Cayman

Cheapest flights from Missouri to Grand Cayman
Explore the most affordable flight options available from Missouri to Grand Cayman. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 19, 2026.

This American Airlines deal was found by Cheapflights users on 1/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/17:05 am
MCI
-
GCM
1 stop6h 40m
American Airlines
Tue 3/107:45 am
GCM
-
MCI
1 stop10h 47m
American Airlines
Deal found 1/17$317
This Delta deal was found by Cheapflights users on 1/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/236:00 am
STL
-
GCM
1 stop5h 29m
Delta
Tue 3/31:54 pm
GCM
-
STL
1 stop10h 42m
Delta
Deal found 1/18$317
This Delta deal was found by Cheapflights users on 1/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/205:50 am
MCI
-
GCM
1 stop5h 34m
Delta
Thu 4/3012:45 pm
GCM
-
MCI
1 stop7h 22m
Delta
Deal found 1/18$321
This American Airlines deal was found by Cheapflights users on 1/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/16:13 am
STL
-
GCM
2 stops13h 02m
American Airlines
Thu 3/54:25 pm
GCM
-
STL
1 stop17h 30m
American Airlines
Deal found 1/17$322
This Delta deal was found by Cheapflights users on 1/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/226:56 pm
STL
-
GCM
1 stop16h 33m
Delta
Thu 3/51:54 pm
GCM
-
STL
1 stop7h 47m
Delta
Deal found 1/18$352
This Delta deal was found by Cheapflights users on 1/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/225:35 am
MCI
-
GCM
1 stop5h 54m
Delta
Wed 2/251:54 pm
GCM
-
MCI
1 stop10h 46m
Delta
Deal found 1/18$354
This Delta deal was found by Cheapflights users on 1/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/205:35 pm
STL
-
GCM
1 stop18h 26m
Delta
Tue 3/31:54 pm
GCM
-
STL
1 stop10h 42m
Delta
Deal found 1/18$377
This Delta deal was found by Cheapflights users on 1/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/95:50 am
MCI
-
GCM
1 stop5h 50m
Delta
Sat 2/213:56 pm
GCM
-
MCI
1 stop8h 04m
Delta
Deal found 1/16$379
This American Airlines deal was found by Cheapflights users on 1/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/96:28 pm
MCI
-
GCM
2 stops18h 43m
American Airlines
Sat 5/164:03 pm
GCM
-
MCI
1 stop7h 15m
American Airlines
Deal found 1/17$382
This American Airlines deal was found by Cheapflights users on 1/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/2311:22 am
STL
-
GCM
1 stop7h 53m
American Airlines
Tue 3/38:45 am
GCM
-
STL
2 stops16h 03m
American Airlines
Deal found 1/18$382
This Air Canada deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/184:05 pm
STL
-
GCM
1 stop19h 05m
Air Canada
Sat 5/212:25 pm
GCM
-
STL
1 stop7h 39m
Air Canada
Deal found 1/19$384
This American Airlines deal was found by Cheapflights users on 1/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/216:36 pm
STL
-
GCM
1 stop18h 59m
American Airlines
Tue 3/38:45 am
GCM
-
STL
2 stops13h 52m
American Airlines
Deal found 1/18$388

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Grand Cayman that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 19, 2026.
Use the filters below to find and compare flights from Missouri to Grand Cayman that are best for you.

Fly from

Missouri

Fly to

Grand Cayman

Route

Depart

Return

Price

Kansas CityGeorge Town

MCI - GCM

MCIGCM

Kansas City

Wed 3/4

5:00 am-2:45 pm

1 stop8h 45m

George Town Owen Roberts Intl

Wed 3/11

3:30 pm-12:12 am

1 stop8h 42m

$317

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

Wed 3/4

6:00 am-12:29 pm

1 stop5h 29m

George Town Owen Roberts Intl

Wed 3/11

1:12 pm-9:06 pm

1 stop7h 54m

$317

Kansas CityGeorge Town

MCI - GCM

MCIGCM

Kansas City

Sun 3/1

7:05 am-2:45 pm

1 stop6h 40m

George Town Owen Roberts Intl

Tue 3/10

7:45 am-6:32 pm

1 stop10h 47m

$317

Kansas CityGeorge Town

MCI - GCM

MCIGCM

Kansas City

Mon 4/20

5:50 am-11:24 am

1 stop5h 34m

George Town Owen Roberts Intl

Thu 4/30

12:45 pm-8:07 pm

1 stop7h 22m

$321

Kansas CityGeorge Town

MCI - GCM

MCIGCM

Kansas City

Mon 4/20

6:28 pm-1:11 pm

2 stops18h 43m

George Town Owen Roberts Intl

Thu 4/30

2:10 pm-8:52 am

2 stops18h 42m

$322

Kansas CityGeorge Town

MCI - GCM

MCIGCM

Kansas City

Sun 2/22

5:35 am-12:29 pm

1 stop5h 54m

George Town Owen Roberts Intl

Wed 2/25

1:54 pm-11:40 pm

1 stop10h 46m

$354

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

Thu 2/26

6:00 am-12:29 pm

1 stop5h 29m

George Town Owen Roberts Intl

Wed 3/4

1:54 pm-7:39 pm

1 stop6h 45m

$377

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

Fri 2/20

6:10 am-2:40 pm

1 stop7h 30m

George Town Owen Roberts Intl

Fri 2/27

1:54 pm-8:41 pm

1 stop7h 47m

$377

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

Tue 2/10

6:00 am-12:40 pm

1 stop5h 40m

George Town Owen Roberts Intl

Sat 2/14

1:54 pm-11:36 pm

1 stop10h 42m

$377

Kansas CityGeorge Town

MCI - GCM

MCIGCM

Kansas City

Mon 2/9

5:50 am-12:40 pm

1 stop5h 50m

George Town Owen Roberts Intl

Sat 2/21

3:56 pm-11:00 pm

1 stop8h 04m

$379

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/17

Showing 1-10 of 26 results
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Best time to book a flight from Missouri to Grand Cayman

Have a flexible travel schedule? Discover the best time to fly to Grand Cayman from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Grand Cayman

What is the cheapest month to book a flight from Missouri to Grand Cayman?

Currently, May is the cheapest month in which you can book a flight from Missouri to Grand Cayman (average of $239). Flying from Missouri to Grand Cayman in March is currently the most expensive (average of $500). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Grand Cayman. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Missouri to Grand Cayman?

    Departing from Missouri to Grand Cayman will take you 5h 29m. There are 1448 mi between Missouri and Grand Cayman. This flight may include one or multiple stops.

  • Can I find deals for flights from Missouri to Grand Cayman that include hotel bookings?

    Yes. In addition to deals on Missouri to Grand Cayman flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Grand Cayman?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Grand Cayman.

  • Can I find deals for business class flights from Missouri to Grand Cayman?

    Yes. Cheapflights offers flight deals from Missouri to Grand Cayman by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Grand Cayman?

    Currently, May is the cheapest month in which you can book a flight from Missouri to Grand Cayman (average of $239). Flying from Missouri to Grand Cayman in March is currently the most expensive (average of $500). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Missouri to Grand Cayman

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Missouri to Grand Cayman

Discover the top 4 airlines that operate flights from Missouri to Grand Cayman. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 19, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$198Average$584FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$238Average$618FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$421Average$578FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$429Average$585FlexibilityNo cancel feeOn-time63%

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