$191+ Cheap flights from La Crosse (LSE) to Florida Keys
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/12. Fares are subject to change and may not be available on all flights or dates of travel.
LSE — EYW
Sep 22 — Sep 291
Round-trip
1 adult, Economy
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Best
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One-way
Cheapest flights from La Crosse to Florida KeysExplore the most affordable flight options available from La Crosse to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 23, 2026.
Explore the most affordable flight options available from La Crosse to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 23, 2026.
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/612:23 pm -
1 stop5h 25m
Tue 10/135:15 am -
1 stop7h 38m
Deal found 8/22![American Airlines logo]()
$381
This American Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/275:22 pm -
1 stop14h 52m
Sat 10/38:22 am -
1 stop16h 58m
Deal found 8/19![American Airlines logo]()
$398
This Kiwi.com deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/2810:15 am -
1 stop27h 28m
Wed 12/21:22 pm -
2 stops20h 38m
Deal found 8/21![Multiple Airlines logo]()
$402
This American Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2412:23 pm -
1 stop7h 24m
Fri 10/306:56 pm -
1 stop6h 03m
Deal found 8/21![American Airlines logo]()
$405
This American Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/53:14 pm -
1 stop6h 03m
Wed 9/96:54 pm -
1 stop6h 26m
Deal found 8/20![American Airlines logo]()
$413
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/16:00 am -
1 stop5h 50m
Sat 9/58:28 am -
1 stop7h 14m
Deal found 8/18![American Airlines logo]()
$446
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/66:02 am -
2 stops9h 09m
Thu 9/102:15 pm -
2 stops11h 05m
Deal found 8/22![American Airlines logo]()
$481
This American Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals ”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/286:01 am -
2 stops12h 26m
Wed 12/26:25 pm -
1 stop6h 53m
Deal found 8/21![American Airlines logo]()
$561
This American Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:01 am -
2 stops11h 00m
Sun 11/157:18 pm -
2 stops17h 34m
Deal found 8/20![American Airlines logo]()
$635
This American Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/45:20 pm -
1 stop21h 59m
Tue 9/87:03 pm -
2 stops17h 19m
Deal found 8/20![American Airlines logo]()
$672
This American Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/176:00 am -
2 stops10h 30m
Mon 12/215:16 pm -
1 stop8h 14m
Deal found 8/19![American Airlines logo]()
$673
Best flights from La Crosse to Florida KeysDiscover carefully curated flight deals from La Crosse to Florida Keys that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 23, 2026.
Discover carefully curated flight deals from La Crosse to Florida Keys that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 23, 2026.
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/1912:23 pm -
1 stop8h 20m
Wed 1/271:02 pm -
1 stop6h 18m
Deal found 8/22![American Airlines logo]()
$380
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2412:23 pm -
1 stop8h 21m
Fri 10/306:56 pm -
1 stop6h 03m
Deal found 8/18![American Airlines logo]()
$438
This American Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/612:23 pm -
1 stop5h 25m
Sat 2/131:02 pm -
1 stop6h 18m
Deal found 8/21![American Airlines logo]()
$470
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/66:02 am -
2 stops9h 09m
Thu 9/102:15 pm -
2 stops11h 05m
Deal found 8/22![American Airlines logo]()
$481
This American Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/275:22 pm -
1 stop15h 55m
Sat 10/38:52 am -
2 stops9h 00m
Deal found 8/20![American Airlines logo]()
$490
This American Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/286:01 am -
2 stops12h 26m
Wed 12/21:52 pm -
2 stops11h 26m
Deal found 8/21![American Airlines logo]()
$566
This American Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/45:20 pm -
1 stop21h 59m
Tue 9/87:03 pm -
2 stops17h 19m
Deal found 8/20![American Airlines logo]()
$672
This American Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/176:00 am -
2 stops10h 30m
Mon 12/215:16 pm -
1 stop8h 14m
Deal found 8/19![American Airlines logo]()
$673
Last-minute flights from La Crosse to Florida KeysDiscover last-minute flight deals from La Crosse to Florida Keys. Data last updated August 23, 2026 and is based on user searches.
Discover last-minute flight deals from La Crosse to Florida Keys. Data last updated August 23, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/16:00 am -
1 stop5h 50m
Sat 9/58:28 am -
1 stop7h 14m
Deal found 8/18![American Airlines logo]()
$446
This American Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/45:20 pm -
1 stop21h 59m
Tue 9/87:03 pm -
2 stops17h 19m
Deal found 8/20![American Airlines logo]()
$672
This American Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/53:14 pm -
1 stop6h 03m
Wed 9/96:54 pm -
1 stop6h 26m
Deal found 8/20![American Airlines logo]()
$413
This American Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/611:53 am -
1 stop7h 35m
Thu 9/104:52 pm -
1 stop8h 28m
Deal found 8/21![American Airlines logo]()
$470
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/66:02 am -
2 stops9h 09m
Thu 9/102:15 pm -
2 stops11h 05m
Deal found 8/22![American Airlines logo]()
$481
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1112:02 pm -
1 stop8h 43m
Sun 9/133:31 pm -
2 stops9h 49m
Deal found 8/18![American Airlines logo]()
$507
This American Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/275:22 pm -
1 stop14h 52m
Sat 10/38:22 am -
1 stop16h 58m
Deal found 8/19![American Airlines logo]()
$398
One-way flights from La Crosse to Florida KeysSearch for one-way flight options from La Crosse to Florida Keys. Find affordable one-way fares based on user searches. Data last updated August 23, 2026.
Search for one-way flight options from La Crosse to Florida Keys. Find affordable one-way fares based on user searches. Data last updated August 23, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1210:21 am -
3 stops34h 28m
Deal found 8/20![Multiple Airlines logo]()
$191
This Kiwi.com deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/1511:21 am -
3 stops55h 30m
Deal found 8/20![Multiple Airlines logo]()
$244
This American Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:01 am -
1 stop15h 23m
Deal found 8/20![American Airlines logo]()
$319
This American Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/96:49 pm -
1 stop25h 16m
Deal found 8/20![American Airlines logo]()
$399
This American Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1012:22 pm -
2 stops9h 02m
Deal found 8/20![American Airlines logo]()
$471
Find flight deals from La Crosse to Florida Keys
Keep the following information in mind while searching for La Crosse to Florida Keys flight deals. Data was last updated August 23, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $380 (American Airlines) |
One-way from | $191 (Kiwi.com) |
Popular in | June |
Cheapest in | October |
Average price | $446 |
Cheapflights Fare Finder
Customize your flight search to find flights from La Crosse to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 23, 2026.
Use the filters below to find and compare flights from La Crosse to Florida Keys that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
La CrosseMiami
LSE La Crosse - MIA Miami
LSEMIA
La Crosse
Tue 1/19
12:23 pm-9:43 pm
1 stop8h 20m
Miami
Wed 1/27
1:02 pm-6:20 pm
1 stop6h 18m
$380
La CrosseMiami
LSE La Crosse - MIA Miami
LSEMIA
La Crosse
Sat 10/24
12:23 pm-9:44 pm
1 stop8h 21m
Miami
Fri 10/30
6:56 pm-11:59 pm
1 stop6h 03m
$438
Quickest round-trip
La CrosseMiami
LSE La Crosse - MIA Miami
LSEMIA
La Crosse
Sat 2/6
12:23 pm-6:48 pm
1 stop5h 25m
Miami
Sat 2/13
1:02 pm-6:20 pm
1 stop6h 18m
$470
La CrosseKey West
LSE La Crosse - EYW Key West
LSEEYW
La Crosse
Sun 9/6
6:02 am-4:11 pm
2 stops9h 09m
Key West
Thu 9/10
2:15 pm-12:20 am
2 stops11h 05m
$481
La CrosseMiami
LSE La Crosse - MIA Miami
LSEMIA
La Crosse
Sun 9/27
5:22 pm-10:17 am
1 stop15h 55m
Miami
Sat 10/3
8:52 am-4:52 pm
2 stops9h 00m
$490
La CrosseKey West
LSE La Crosse - EYW Key West
LSEEYW
La Crosse
Sat 11/28
6:01 am-7:27 pm
2 stops12h 26m
Key West
Wed 12/2
1:52 pm-12:18 am
2 stops11h 26m
$566
La CrosseKey West
LSE La Crosse - EYW Key West
LSEEYW
La Crosse
Fri 9/4
5:20 pm-4:19 pm
1 stop21h 59m
Key West
Tue 9/8
7:03 pm-11:22 am
2 stops17h 19m
$672
La CrosseKey West
LSE La Crosse - EYW Key West
LSEEYW
La Crosse
Thu 12/17
6:00 am-5:30 pm
2 stops10h 30m
Key West
Mon 12/21
5:16 pm-12:30 am
1 stop8h 14m
$673
Cheapest one-way
La CrosseMiami
LSE La Crosse - MIA Miami
LSEMIA
La Crosse
Sun 11/15
11:21 am-7:51 pm
3 stops55h 30m
$244
Quickest one-way
La CrosseMiami
LSE La Crosse - MIA Miami
LSEMIA
La Crosse
Tue 11/10
12:22 pm-11:59 pm
1 stop10h 37m
$399
Showing 1-10 of 13 resultsSorted by cheapest first
Best time to book a flight from La Crosse to Florida Keys
Have a flexible travel schedule? Discover the best time to fly to Florida Keys from La Crosse with our price prediction graph.
LSE-MIA
LSE-EYW
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from La Crosse to Florida Keys
LSE-zzEOA
LSE-MIA
LSE-EYW
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing Florida Keys
Get insights into the airlines that provide service to Florida Keys. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florida Keys. Reviews last updated August 23, 2026.
See what other customers who have flown with American Airlines from La Crosse to Florida Keys have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
7.5
Overall
7.1
Crew
7.9
Food
6.4
Comfort
7.2
Entertainment
6.8
Reviews
1 / 20
4.0
OkayElizabeth,Mar 2026
ORD - MIA
Boarding
7.5
Overall
7.1
Crew
7.9
Food
6.4
Comfort
7.2
Entertainment
6.8
Reviews
1 / 20
4.0
OkayElizabeth,Mar 2026
ORD - MIA
Related info for your journey
Find useful and relevant information for your journey from La Crosse to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for La Crosse to Florida Keys
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Complete your trip
Complete your trip to Florida Keys by adding a car rental and/or hotel reservation to your travel itinerary.
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La Crosse and Florida Keys flights
Browse other La Crosse and Florida Keys flight options. Last updated on August 23, 2026.
Popular flight searches
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La Crosse to Florida Keys flights
Consider these flights traveling from La Crosse to Florida Keys.
Top airline flying from La Crosse to Florida Keys
Discover the top airline that operate flights from La Crosse to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 23, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$481 | Average$585 | FlexibilityNo cancel fee | On-time71% |