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$148+ Cheap flights from Santo Domingo (SDQ) to Charleston (CHS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/16. Fares are subject to change and may not be available on all flights or dates of travel.
SDQ — CHS
Feb 27 — Mar 61
Fri 2/27
Fri 3/6
1 adult, Economy
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Cheap flight deals from Santo Domingo to Charleston

Cheapest flights from Santo Domingo to Charleston
Explore the most affordable flight options available from Santo Domingo to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 28, 2026.

This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/263:32 pm
SDQ
-
CHS
1 stop27h 08m
Spirit Airlines
Thu 3/56:35 pm
CHS
-
SDQ
1 stop18h 45m
Spirit Airlines
Deal found 1/27$321
This American Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/135:07 pm
SDQ
-
CHS
2 stops16h 26m
American Airlines
Wed 2/1810:58 am
CHS
-
SDQ
2 stops11h 55m
American Airlines
Deal found 1/28$333
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/303:37 pm
SDQ
-
CHS
1 stop7h 04m
Multiple Airlines
Tue 5/53:35 pm
CHS
-
SDQ
1 stop13h 54m
Multiple Airlines
Deal found 1/27$347
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/306:29 pm
SDQ
-
CHS
1 stop6h 29m
American Airlines
Tue 2/39:27 am
CHS
-
SDQ
1 stop6h 56m
American Airlines
Deal found 1/27$350
This American Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/15:55 pm
SDQ
-
CHS
1 stop18h 52m
American Airlines
Mon 5/48:09 pm
CHS
-
SDQ
1 stop13h 11m
American Airlines
Deal found 1/28$352
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/14:00 pm
SDQ
-
CHS
1 stop18h 24m
American Airlines
Tue 5/511:04 am
CHS
-
SDQ
1 stop5h 51m
American Airlines
Deal found 1/27$353
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/302:25 pm
SDQ
-
CHS
2 stops18h 06m
American Airlines
Tue 5/57:39 pm
CHS
-
SDQ
2 stops13h 41m
American Airlines
Deal found 1/27$358
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/263:32 pm
SDQ
-
CHS
2 stops20h 20m
Multiple Airlines
Thu 3/56:35 pm
CHS
-
SDQ
1 stop18h 45m
Multiple Airlines
Deal found 1/27$361
This Faresmojo deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Faresmojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/166:35 am
SDQ
-
CHS
1 stop14h 49m
JetBlue
Thu 3/197:35 am
CHS
-
SDQ
1 stop5h 35m
JetBlue
Deal found 1/26$431
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/16:29 pm
SDQ
-
CHS
2 stops16h 19m
American Airlines
Mon 3/236:00 am
CHS
-
SDQ
1 stop7h 00m
American Airlines
Deal found 1/26$449

Find flight deals from Santo Domingo to Charleston

Discover tips and strategies to find the most affordable flight options for your journey from Santo Domingo (SDQ) to Charleston (CHS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 28, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$321
(Kiwi.com)

One-way from

$148
(Cheapflightsfares)

Popular in

November

Cheapest in

September
Provider with most accurate pricing for Santo Domingo Las Americas-Charleston flight deals.
Search Deals
Provider most trusted by Cheapflights users for Santo Domingo Las Americas-Charleston flights.
Search Deals
From Santo Domingo Las Americas to Charleston
Search Deals
One-way flight from Santo Domingo Las Americas to Charleston
Search Deals
Highest demand for flights based on searches. 4% potential increase in price ($26 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($8 potential savings vs. average RT price).
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santo Domingo to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 28, 2026.
Use the filters below to find and compare flights from Santo Domingo to Charleston that are best for you.

Fly from

Santo Domingo

Fly to

Charleston

Route

Depart

Return

Price

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Thu 2/26

3:32 pm-5:40 pm

1 stop27h 08m

Charleston

Thu 3/5

6:35 pm-2:20 pm

1 stop18h 45m

$321

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Fri 2/13

5:07 pm-8:33 am

2 stops16h 26m

Charleston

Wed 2/18

10:58 am-11:53 pm

2 stops11h 55m

$333

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Thu 4/30

3:37 pm-10:41 pm

1 stop7h 04m

Charleston

Tue 5/5

3:35 pm-5:29 am

1 stop13h 54m

$347

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Fri 5/1

5:55 pm-12:47 pm

1 stop18h 52m

Charleston

Mon 5/4

11:04 am-10:52 pm

1 stop11h 48m

$352

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Fri 5/1

4:00 pm-10:24 am

1 stop18h 24m

Charleston

Tue 5/5

11:04 am-4:55 pm

1 stop5h 51m

$353

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Thu 4/30

2:25 pm-8:31 am

2 stops18h 06m

Charleston

Tue 5/5

7:39 pm-9:20 am

2 stops13h 41m

$358

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Thu 2/26

3:32 pm-10:52 am

2 stops20h 20m

Charleston

Thu 3/5

6:35 pm-2:20 pm

1 stop18h 45m

$361

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Wed 5/27

3:37 pm-10:41 pm

1 stop7h 04m

$166

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Sun 6/7

1:40 am-2:40 pm

1 stop13h 00m

$169

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Wed 2/18

3:32 pm-5:40 pm

1 stop27h 08m

$169

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/27

Showing 1-10 of 16 results
1
2
  • Most accurate provider: When it comes to deals on Santo Domingo-Charleston flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santo Domingo-Charleston flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santo Domingo-Charleston flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santo Domingo-Charleston flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santo Domingo-Charleston flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santo Domingo to Charleston

Have a flexible travel schedule? Discover the best time to fly to Charleston from Santo Domingo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to Charleston. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santo Domingo to Charleston?

    A quick flight from Santo Domingo to Charleston can take about 16h 26m. Spirit Airlines provides one of the quickest options available for as low as $333. Santo Domingo and Charleston are separated by a distance of 1187 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Santo Domingo to Charleston that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to Charleston flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to Charleston?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to Charleston.

  • Can I find deals for business class flights from Santo Domingo to Charleston?

    Yes. Cheapflights offers flight deals from Santo Domingo to Charleston by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Charleston?

Book flights to Charleston if you plan to visit one of these locations
North Charleston
Santee
Summerville
Walterboro
Isle of Palms
Mount Pleasant
Edisto Beach

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