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$101+ Cheap flights from Mesa, AZ to Charleston (CHS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/12. Fares are subject to change and may not be available on all flights or dates of travel.
PHX — CHS
Apr 28 — May 51
Tue 4/28
Tue 5/5
1 adult, Economy
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Cheapflights Tip: The best prices from Mesa to Charleston are usually found in February or October, booked 87 days in advance, depart on a Tuesday or Monday and return on a Monday

Cheap flight deals from Mesa to Charleston

Cheapest flights from Mesa to Charleston
Explore the most affordable flight options available from Mesa to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 29, 2026.

This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/261:15 am
PHX
-
CHS
1 stop7h 16m
American Airlines
Tue 6/97:19 pm
CHS
-
PHX
1 stop6h 54m
American Airlines
Deal found 3/24$221
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/261:15 am
PHX
-
CHS
1 stop7h 16m
American Airlines
Wed 6/37:19 pm
CHS
-
PHX
1 stop6h 54m
American Airlines
Deal found 3/24$234
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/110:17 pm
PHX
-
CHS
1 stop7h 15m
American Airlines
Tue 5/57:39 pm
CHS
-
PHX
1 stop6h 23m
American Airlines
Deal found 3/24$239
This Southwest deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/55:05 am
PHX
-
CHS
2 stops8h 00m
Southwest
Sat 6/66:30 am
CHS
-
PHX
2 stops8h 50m
Southwest
Deal found 3/24$268
This American Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/185:00 am
PHX
-
CHS
1 stop7h 30m
American Airlines
Wed 4/228:21 pm
CHS
-
PHX
1 stop6h 38m
American Airlines
Deal found 3/27$271
This United Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/1411:47 pm
PHX
-
CHS
1 stop7h 26m
United Airlines
Sat 5/236:30 pm
CHS
-
PHX
1 stop7h 52m
United Airlines
Deal found 3/26$274
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/135:10 am
PHX
-
CHS
1 stop6h 05m
Southwest
Tue 4/211:15 pm
CHS
-
PHX
1 stop7h 10m
Southwest
Deal found 3/26$276
This United Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/156:05 am
PHX
-
CHS
1 stop7h 06m
United Airlines
Sat 4/182:53 pm
CHS
-
PHX
1 stop7h 56m
United Airlines
Deal found 3/26$277
This Delta deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/1412:59 am
PHX
-
CHS
1 stop6h 49m
Delta
Sat 5/236:15 am
CHS
-
PHX
1 stop7h 50m
Delta
Deal found 3/26$280
This Southwest deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/288:10 am
PHX
-
CHS
1 stop7h 25m
Southwest
Fri 5/14:45 pm
CHS
-
PHX
2 stops8h 20m
Southwest
Deal found 3/27$288

Find flight deals from Mesa to Charleston

Keep the following information in mind while searching for Mesa to Charleston flight deals. Data was last updated March 29, 2026.

Round-trip from

$221
(American Airlines)

One-way from

$101
(American Airlines)

Popular in

March

Cheapest in

February

Average price

$420
From Mesa to Charleston
Search Deals
One-way flight from Mesa to Charleston
Search Deals
High demand for flights, 2% potential price rise
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($5 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mesa to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 29, 2026.
Use the filters below to find and compare flights from Mesa to Charleston that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

PhoenixCharleston

PHX - CHS

PHXCHS

Phoenix Sky Harbor Intl

Sat 5/16

6:00 am-4:11 pm

1 stop7h 11m

Charleston

Sat 5/23

6:30 pm-11:22 pm

1 stop7h 52m

$287

PhoenixCharleston

PHX - CHS

PHXCHS

Phoenix Sky Harbor Intl

Wed 5/6

8:55 am-8:00 pm

2 stops8h 05m

Charleston

Mon 5/11

5:45 pm-11:10 pm

2 stops8h 25m

$297

PhoenixCharleston

PHX - CHS

PHXCHS

Phoenix Sky Harbor Intl

Fri 5/29

5:10 am-2:15 pm

1 stop6h 05m

Charleston

Wed 6/3

6:40 am-1:00 pm

2 stops9h 20m

$308

PhoenixCharleston

PHX - CHS

PHXCHS

Phoenix Sky Harbor Intl

Thu 5/28

12:15 pm-10:56 pm

1 stop7h 41m

Charleston

Mon 6/1

5:55 pm-11:44 pm

1 stop8h 49m

$309
Quickest round-trip

PhoenixCharleston

PHX - CHS

PHXCHS

Phoenix Sky Harbor Intl

Tue 5/19

12:59 am-10:48 am

1 stop6h 49m

Charleston

Sun 5/24

6:03 pm-10:36 pm

1 stop7h 33m

$313

PhoenixCharleston

PHX - CHS

PHXCHS

Phoenix Sky Harbor Intl

Tue 4/28

8:55 am-8:00 pm

2 stops8h 05m

Charleston

Thu 4/30

6:00 am-12:40 pm

2 stops9h 40m

$336

PhoenixCharleston

PHX - CHS

PHXCHS

Phoenix Sky Harbor Intl

Sat 5/9

11:30 pm-12:17 pm

1 stop9h 47m

Charleston

Tue 5/12

5:07 pm-9:05 pm

1 stop6h 58m

$338

PhoenixCharleston

PHX - CHS

PHXCHS

Phoenix Sky Harbor Intl

Sat 4/18

7:00 am-11:59 pm

2 stops13h 59m

Charleston

Wed 4/22

5:12 pm-9:41 pm

1 stop7h 29m

$343

PhoenixCharleston

PHX - CHS

PHXCHS

Phoenix Sky Harbor Intl

Tue 6/16

5:05 am-3:35 pm

1 stop7h 30m

Charleston

Wed 6/24

4:15 pm-8:45 pm

2 stops7h 30m

$346
Cheapest one-way

PhoenixCharleston

PHX - CHS

PHXCHS

Phoenix Sky Harbor Intl

Mon 5/4

11:47 pm-10:13 am

1 stop7h 26m

$120

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/26

Showing 1-10 of 19 resultsSorted by cheapest first
1
2

Best time to book a flight from Mesa to Charleston

Have a flexible travel schedule? Discover the best time to fly to Charleston from Mesa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mesa to Charleston

How far ahead should I book a flight from Mesa to Charleston?

Use this chart to determine the optimal time to book a round-trip flight from Mesa to Charleston. Price data was last updated on March 13, 2026.

Booking 86 days in advance of your planned departure date is, on average, the best time to get cheap flights from Mesa to Charleston. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Mesa to Charleston?

Currently, October is the cheapest month in which you can book a flight from Mesa to Charleston (average of $192). Flying from Mesa to Charleston in November is currently the most expensive (average of $273). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Mesa to Charleston?

Reviews of airlines servicing Charleston

Get insights into the airlines that provide service to Charleston. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Charleston. Reviews last updated March 29, 2026.
Read through reviews of airlines operating flights from Mesa to Charleston, such as Southwest,Delta, andUnited Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,331 reviews

Food

7.0

Boarding

8.1

Comfort

8.0

Entertainment

7.5

Overall

8.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
Southwest
8.0
Very good
4,331 reviews
Southwest
8.0
Very good
4,331 reviews

Food

7.0

Boarding

8.1

Comfort

8.0

Entertainment

7.5

Overall

8.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
Delta
7.9
Good
8,359 reviews
Southwest
8.0
Very good
4,331 reviews

Food

7.0

Boarding

8.1

Comfort

8.0

Entertainment

7.5

Overall

8.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
United Airlines
7.4
Good
9,509 reviews
Southwest
8.0
Very good
4,331 reviews

Food

7.0

Boarding

8.1

Comfort

8.0

Entertainment

7.5

Overall

8.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
American Airlines
7.1
Good
11,521 reviews
Southwest
8.0
Very good
4,331 reviews

Food

7.0

Boarding

8.1

Comfort

8.0

Entertainment

7.5

Overall

8.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Related info for your journey

Find useful and relevant information for your journey from Mesa to Charleston. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Charleston from Mesa?

    Charleston (CHS), located 10.2 mi from the city center, is the airport you fly into when you book flights from Mesa to Charleston. 4 airlines have flights to Charleston from Mesa on a regular basis. Booking flights from Mesa to Charleston should not be difficult; the airport handles an average of 0 inbound flights from Mesa per day.

  • How long is the flight from Mesa to Charleston?

    For as low as $287, United Airlines can have you in Charleston from Mesa in 7h 11m. The distance between Mesa and Charleston is about 1840 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Mesa to Charleston one-way?

    To fly one-way, consider booking your trip with United Airlines, which is currently one of the cheapest options available, starting at $121. Delta flights start at $121 while deals on American Airlines start at $125 one-way.

  • Can I find deals for flights from Mesa to Charleston that include hotel bookings?

    Yes. In addition to deals on Mesa to Charleston flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mesa to Charleston?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mesa to Charleston.

  • Can I find deals for business class flights from Mesa to Charleston?

    Yes. Cheapflights offers flight deals from Mesa to Charleston by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mesa to Charleston?

    Currently, October is the cheapest month in which you can book a flight from Mesa to Charleston (average of $192). Flying from Mesa to Charleston in November is currently the most expensive (average of $273). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Charleston?

Book flights to Charleston if you plan to visit one of these locations
North Charleston
Santee
Walterboro
Summerville
Isle of Palms
Mount Pleasant
Goose Creek
Edisto Beach

Browse thousands of different options on Cheapflights for your next trip

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Top 4 airlines flying from Mesa to Charleston

Discover the top 4 airlines that operate flights from Mesa to Charleston. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$198Average$344FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$242Average$417FlexibilityNo cancel feeOn-time63%
DeltaCheapest$242Average$368FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$258Average$310FlexibilityNo cancel feeOn-time69%

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