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Cayman Islands

$144+ Cheap flights from South Carolina to the Cayman Islands

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/13. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — GCM
Oct 16 — Oct 231
Thu 10/16
Thu 10/23
1 adult, Economy
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Cheap flight deals from South Carolina to Cayman Islands

Keep the following information in mind while searching for South Carolina to Cayman Islands flight deals. Data was last updated September 16, 2025.

Round-trip from

$290
(American Airlines)

One-way from

$144
(Priceline)
From South Carolina to Cayman Islands
Search Deals
One-way flight from South Carolina to Cayman Islands
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Find flight deals from South Carolina to Cayman Islands

Cheapest flights from South Carolina to Cayman Islands
Explore the most affordable flight options available from South Carolina to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/66:00 amCHS - GCM
1 stop8h 42mAmerican Airlines
Sat 12/131:25 pmGCM - CHS
1 stop11h 21mAmerican Airlines
Deal found 9/14$290
This Mytrip deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/311:40 amCHS - GCM
2 stops23h 20mSpirit Airlines
Sun 12/711:55 amGCM - CHS
2 stops20h 39mSpirit Airlines
Deal found 9/14$402
This Priceline deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/299:30 amCLT - GCM
1 stop26h 55mMultiple Airlines
Sun 12/711:55 amGCM - CLT
1 stop13h 04mMultiple Airlines
Deal found 9/16$403
This Mytrip deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/261:50 pmCLT - GCM
1 stop8h 25mMultiple Airlines
Mon 9/2912:50 pmGCM - CLT
1 stop24h 42mMultiple Airlines
Deal found 9/15$415
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/2110:20 pmCLT - GCM
1 stop14h 15mMultiple Airlines
Thu 9/254:45 pmGCM - CLT
1 stop14h 26mMultiple Airlines
Deal found 9/15$441
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2210:20 pmCLT - GCM
1 stop18h 45mMultiple Airlines
Thu 9/257:00 amGCM - CLT
1 stop24h 11mMultiple Airlines
Deal found 9/15$448
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2510:25 pmCLT - GCM
1 stop13h 45mAmerican Airlines
Wed 10/2912:25 pmGCM - CLT
Nonstop3h 00mAmerican Airlines
Deal found 9/14$458
This Expedia deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/32:43 pmCHS - GCM
2 stops24h 12mJetBlue
Sun 12/73:40 pmGCM - CHS
1 stop27h 59mJetBlue
Deal found 9/14$468
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/510:20 pmCLT - GCM
1 stop14h 15mMultiple Airlines
Sat 10/118:50 amGCM - CLT
1 stop26h 49mMultiple Airlines
Deal found 9/15$473
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/136:45 amCLT - GCM
1 stop9h 45mUnited Airlines
Mon 11/175:45 pmGCM - CLT
1 stop17h 06mUnited Airlines
Deal found 9/14$476
This Mytrip deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/253:09 pmCLT - GCM
2 stops23h 51mMultiple Airlines
Fri 10/3112:30 pmGCM - CLT
2 stops21h 17mMultiple Airlines
Deal found 9/15$477
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/157:53 pmCHS - GCM
1 stop16h 04mAmerican Airlines
Sat 11/221:20 pmGCM - CHS
1 stop10h 43mAmerican Airlines
Deal found 9/14$497

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Cayman Islands that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from South Carolina to the Cayman Islands that are best for you.

Fly from

South Carolina

Fly to

Cayman Islands

Route

Depart

Return

Price

CharlestonGeorge Town

CHS - GCM

CHSGCM

Charleston

Sat 12/6

6:00 am-2:42 pm

1 stop8h 42m

George Town Owen Roberts Intl

Sat 12/13

1:25 pm-12:46 am

1 stop11h 21m

$290

CharlestonGeorge Town

CHS - GCM

CHSGCM

Charleston

Fri 1/9

7:30 am-11:41 am

1 stop4h 11m

George Town Owen Roberts Intl

Mon 1/12

8:30 am-12:05 am

2 stops15h 35m

$294

CharlotteGeorge Town

CLT - GCM

CLTGCM

Charlotte Douglas

Sat 1/24

5:45 am-11:00 am

1 stop5h 15m

George Town Owen Roberts Intl

Thu 1/29

11:55 am-8:41 pm

1 stop8h 46m

$391

CharlestonGeorge Town

CHS - GCM

CHSGCM

Charleston

Wed 12/3

11:40 am-11:00 am

2 stops23h 20m

George Town Owen Roberts Intl

Sun 12/7

11:55 am-8:34 am

2 stops20h 39m

$402

CharlotteGeorge Town

CLT - GCM

CLTGCM

Charlotte Douglas

Fri 9/26

9:10 am-9:15 pm

2 stops13h 05m

George Town Owen Roberts Intl

Mon 9/29

12:50 pm-2:32 pm

1 stop24h 42m

$456

CharlotteGeorge Town

CLT - GCM

CLTGCM

Charlotte Douglas

Sat 1/17

5:45 am-11:00 am

1 stop5h 15m

George Town Owen Roberts Intl

Sat 1/24

11:55 am-12:59 am

1 stop13h 04m

$456

CharlotteGeorge Town

CLT - GCM

CLTGCM

Charlotte Douglas

Sat 10/25

10:25 pm-11:10 am

1 stop13h 45m

George Town Owen Roberts Intl

Wed 10/29

12:25 pm-4:25 pm

Nonstop3h 00m

$458

CharlestonGeorge Town

CHS - GCM

CHSGCM

Charleston

Wed 12/3

2:43 pm-2:55 pm

2 stops24h 12m

George Town Owen Roberts Intl

Sun 12/7

3:40 pm-7:39 pm

1 stop27h 59m

$468

CharlestonGeorge Town

CHS - GCM

CHSGCM

Charleston

Tue 3/10

5:30 am-11:35 am

1 stop7h 05m

George Town Owen Roberts Intl

Wed 3/11

1:00 pm-10:03 pm

1 stop8h 03m

$472

CharlotteGeorge Town

CLT - GCM

CLTGCM

Charlotte Douglas

Wed 10/29

6:45 am-3:30 pm

1 stop9h 45m

George Town Owen Roberts Intl

Wed 11/5

5:45 pm-9:36 pm

1 stop27h 51m

$482

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/13

Showing 1-10 of 39 results
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Best time to book a flight from South Carolina to Cayman Islands

Have a flexible travel schedule? Discover the best time to fly to Cayman Islands from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to the Cayman Islands

What is the cheapest month to book a flight from South Carolina to Cayman Islands?

Currently, January is the cheapest month in which you can book a flight from South Carolina to Cayman Islands (average of $467). Flying from South Carolina to Cayman Islands in March is currently the most expensive (average of $594). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Cayman Islands. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from South Carolina to Cayman Islands?

    Departing from South Carolina to Cayman Islands will take you 4h 50m. Airlines will cover a distance of 1079 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from South Carolina to Cayman Islands that include hotel bookings?

    Yes. In addition to deals on South Carolina to Cayman Islands flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Cayman Islands?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Cayman Islands.

  • Can I find deals for business class flights from South Carolina to Cayman Islands?

    Yes. Cheapflights offers flight deals from South Carolina to Cayman Islands by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Cayman Islands?

    Currently, January is the cheapest month in which you can book a flight from South Carolina to Cayman Islands (average of $467). Flying from South Carolina to Cayman Islands in March is currently the most expensive (average of $594). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for South Carolina to Cayman Islands

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from South Carolina to Cayman Islands

Discover the top 2 airlines that operate flights from South Carolina to Cayman Islands. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$428Average$605FlexibilityNo cancel feeOn-time71%
DeltaCheapest$504Average$672FlexibilityNo cancel feeOn-timeN/A

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