$143+ Cheap flights from South Carolina to the Cayman Islands
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/29. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — GCM
Jul 2 — Jul 91
Round-trip
1 adult, Economy
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Find cheap flights from South Carolina to Cayman Islands with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from South Carolina to Cayman Islands
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Cheapest flights from South Carolina to Cayman IslandsExplore the most affordable flight options available from South Carolina to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 2, 2026.
Explore the most affordable flight options available from South Carolina to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 2, 2026.
This Orbitz deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/39:15 am
CLT
- GCM
1 stop27h 10m
Air Canada
Mon 6/812:25 pm
GCM
- CLT
1 stop25h 32m
Air Canada
Deal found 5/28![Air Canada logo]()
$385
This Air Canada deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/39:15 am
CLT
- GCM
1 stop27h 10m
Air Canada
Sat 6/610:55 am
GCM
- CLT
1 stop9h 02m
Air Canada
Deal found 5/28![Air Canada logo]()
$387
This Air Canada deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/63:40 pm
CLT
- GCM
1 stop20h 45m
Air Canada
Sat 9/1212:25 pm
GCM
- CLT
1 stop25h 32m
Air Canada
Deal found 6/1![Air Canada logo]()
$407
This Air Canada deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/285:00 pm
CLT
- GCM
1 stop19h 00m
Air Canada
Sun 11/11:10 pm
GCM
- CLT
1 stop7h 49m
Air Canada
Deal found 6/2![Air Canada logo]()
$432
This Kiwi.com deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/226:48 pm
CLT
- GCM
1 stop27h 27m
Multiple Airlines
Tue 7/2811:30 am
GCM
- CLT
1 stop28h 42m
Multiple Airlines
Deal found 5/29![Multiple Airlines logo]()
$433
This Air Canada deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/39:15 am
CLT
- GCM
1 stop27h 10m
Air Canada
Thu 6/1112:25 pm
GCM
- CLT
1 stop25h 32m
Air Canada
Deal found 5/28![Air Canada logo]()
$436
This American Airlines deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/166:51 am
CHS
- GCM
1 stop5h 39m
American Airlines
Fri 6/195:12 pm
GCM
- CHS
1 stop5h 47m
American Airlines
Deal found 6/1![American Airlines logo]()
$439
This American Airlines deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/157:50 pm
CHS
- GCM
1 stop16h 40m
American Airlines
Thu 6/185:12 pm
GCM
- CHS
1 stop5h 47m
American Airlines
Deal found 5/31![American Airlines logo]()
$446
This American Airlines deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/226:00 am
CHS
- GCM
1 stop5h 55m
American Airlines
Thu 8/2712:30 pm
GCM
- CHS
1 stop8h 21m
American Airlines
Deal found 5/28![American Airlines logo]()
$449
This Orbitz deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/213:40 pm
CLT
- GCM
1 stop19h 05m
Air Canada
Mon 8/2412:25 pm
GCM
- CLT
1 stop25h 37m
Air Canada
Deal found 6/1![Air Canada logo]()
$449
This American Airlines deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/36:00 am
CHS
- GCM
1 stop14h 20m
American Airlines
Sun 11/83:14 pm
GCM
- CHS
1 stop17h 27m
American Airlines
Deal found 5/31![American Airlines logo]()
$455
This Kiwi.com deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/66:48 pm
CLT
- GCM
1 stop17h 47m
Multiple Airlines
Tue 8/1111:30 am
GCM
- CLT
1 stop28h 42m
Multiple Airlines
Deal found 5/28![Multiple Airlines logo]()
$455
Best flights from South Carolina to Cayman IslandsDiscover carefully curated flight deals from South Carolina to Cayman Islands that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 2, 2026.
Discover carefully curated flight deals from South Carolina to Cayman Islands that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 2, 2026.
This American Airlines deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/136:00 am
CHS
- GCM
1 stop11h 10m
American Airlines
Thu 7/165:10 pm
GCM
- CHS
1 stop5h 49m
American Airlines
Deal found 5/31![American Airlines logo]()
$439
This Kiwi.com deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/226:48 pm
CLT
- GCM
1 stop17h 47m
Multiple Airlines
Tue 7/2811:30 am
GCM
- CLT
2 stops29h 33m
Multiple Airlines
Deal found 5/29![Multiple Airlines logo]()
$531
This Delta deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/16:43 am
SAV
- GCM
1 stop5h 51m
Delta
Tue 7/712:56 pm
GCM
- SAV
1 stop7h 21m
Delta
Deal found 6/1![Delta logo]()
$631
This Booking.com deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/143:40 pm
CLT
- GCM
1 stop20h 50m
Air Canada
Mon 10/1912:25 pm
GCM
- CLT
2 stops32h 10m
Air Canada
Deal found 6/1![Air Canada logo]()
$737
This American Airlines deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/255:00 am
CHS
- GCM
1 stop11h 03m
American Airlines
Fri 7/315:10 pm
GCM
- CHS
1 stop5h 49m
American Airlines
Deal found 6/2![American Airlines logo]()
$439
This American Airlines deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/166:51 am
CHS
- GCM
1 stop5h 39m
American Airlines
Fri 6/195:12 pm
GCM
- CHS
1 stop5h 47m
American Airlines
Deal found 6/1![American Airlines logo]()
$439
This American Airlines deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/1611:04 am
CHS
- GCM
1 stop6h 06m
American Airlines
Thu 7/235:10 pm
GCM
- CHS
2 stops18h 09m
American Airlines
Deal found 5/31![American Airlines logo]()
$444
This American Airlines deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/226:00 am
CHS
- GCM
1 stop5h 55m
American Airlines
Thu 8/2712:30 pm
GCM
- CHS
1 stop8h 21m
American Airlines
Deal found 5/28![American Airlines logo]()
$449
This Delta deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/95:30 am
CLT
- GCM
1 stop6h 55m
Delta
Fri 11/131:50 pm
GCM
- CLT
1 stop6h 28m
Delta
Deal found 5/31![Delta logo]()
$641
This American Airlines deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/36:00 am
CHS
- GCM
1 stop14h 20m
American Airlines
Sun 11/83:14 pm
GCM
- CHS
1 stop17h 27m
American Airlines
Deal found 5/31![American Airlines logo]()
$455
This Delta deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/85:30 am
CLT
- GCM
1 stop7h 10m
Delta
Mon 10/1212:55 pm
GCM
- CLT
1 stop7h 38m
Delta
Deal found 5/29![Delta logo]()
$701
This American Airlines deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/19:27 am
CHS
- GCM
1 stop10h 53m
American Airlines
Fri 11/63:14 pm
GCM
- CHS
1 stop9h 09m
American Airlines
Deal found 5/29![American Airlines logo]()
$490
This Delta deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/126:59 am
CLT
- GCM
1 stop5h 32m
Delta
Wed 7/1512:56 pm
GCM
- CLT
1 stop10h 02m
Delta
Deal found 5/28![Delta logo]()
$731
This Delta deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/155:35 am
CAE
- GCM
1 stop6h 56m
Delta
Mon 7/2012:56 pm
GCM
- CAE
1 stop9h 47m
Delta
Deal found 6/1![Delta logo]()
$731
This Delta deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/156:43 am
SAV
- GCM
1 stop5h 51m
Delta
Fri 6/1912:59 pm
GCM
- SAV
1 stop7h 08m
Delta
Deal found 5/28![Delta logo]()
$751
This American Airlines deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/65:18 am
GSP
- GCM
1 stop7h 12m
American Airlines
Tue 8/112:10 pm
GCM
- GSP
2 stops7h 40m
American Airlines
Deal found 5/28![American Airlines logo]()
$666
This American Airlines deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/186:00 pm
GSP
- GCM
2 stops18h 00m
American Airlines
Wed 7/225:10 pm
GCM
- GSP
2 stops18h 04m
American Airlines
Deal found 5/29![American Airlines logo]()
$666
This American Airlines deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/207:30 pm
GSP
- GCM
2 stops16h 30m
American Airlines
Thu 7/235:10 pm
GCM
- GSP
2 stops18h 04m
American Airlines
Deal found 5/30![American Airlines logo]()
$667
This American Airlines deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/155:00 am
CAE
- GCM
1 stop7h 25m
American Airlines
Mon 7/205:10 pm
GCM
- CAE
2 stops16h 34m
American Airlines
Deal found 6/1![American Airlines logo]()
$671
This American Airlines deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/196:00 am
SAV
- GCM
1 stop6h 00m
American Airlines
Sun 8/2312:30 pm
GCM
- SAV
1 stop8h 51m
American Airlines
Deal found 5/31![American Airlines logo]()
$671
This American Airlines deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/229:25 am
CLT
- GCM
Nonstop3h 00m
American Airlines
Tue 7/2812:33 pm
GCM
- CLT
Nonstop3h 12m
American Airlines
Deal found 5/29![American Airlines logo]()
$682
This American Airlines deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/810:12 am
GSP
- GCM
1 stop5h 48m
American Airlines
Sat 8/1511:55 am
GCM
- GSP
1 stop10h 03m
American Airlines
Deal found 6/1![American Airlines logo]()
$691
This United Airlines deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/157:45 pm
CAE
- GCM
3 stops17h 45m
United Airlines
Mon 7/201:35 pm
GCM
- CAE
3 stops19h 21m
United Airlines
Deal found 5/30![United Airlines logo]()
$4,593
This American Airlines deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/255:00 am
SAV
- GCM
1 stop11h 03m
American Airlines
Mon 7/272:41 pm
GCM
- SAV
1 stop7h 43m
American Airlines
Deal found 5/30![American Airlines logo]()
$691
This American Airlines deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/117:00 am
SAV
- GCM
1 stop9h 03m
American Airlines
Sat 7/1812:30 pm
GCM
- SAV
1 stop10h 27m
American Airlines
Deal found 5/31![American Airlines logo]()
$691
This American Airlines deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/67:30 pm
GSP
- GCM
2 stops16h 30m
American Airlines
Thu 7/912:33 pm
GCM
- GSP
1 stop7h 57m
American Airlines
Deal found 5/29![American Airlines logo]()
$703
This American Airlines deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/89:00 am
CLT
- GCM
Nonstop3h 00m
American Airlines
Mon 10/1212:40 pm
GCM
- CLT
Nonstop3h 05m
American Airlines
Deal found 5/31![American Airlines logo]()
$707
This American Airlines deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/159:00 am
CLT
- GCM
Nonstop3h 00m
American Airlines
Mon 10/1912:40 pm
GCM
- CLT
Nonstop3h 05m
American Airlines
Deal found 6/1![American Airlines logo]()
$707
This American Airlines deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/37:07 am
CLT
- GCM
1 stop4h 48m
American Airlines
Mon 10/121:25 pm
GCM
- CLT
1 stop7h 45m
American Airlines
Deal found 6/2![American Airlines logo]()
$721
This American Airlines deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/67:30 pm
GSP
- GCM
2 stops16h 30m
American Airlines
Fri 7/105:10 pm
GCM
- GSP
1 stop5h 46m
American Airlines
Deal found 5/29![American Airlines logo]()
$728
Last-minute flights from South Carolina to Cayman IslandsDiscover last-minute flight deals from South Carolina to Cayman Islands. Data last updated June 2, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Cayman Islands. Data last updated June 2, 2026 and is based on user searches.
This Orbitz deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/39:15 am
CLT
- GCM
1 stop27h 10m
Air Canada
Mon 6/812:25 pm
GCM
- CLT
1 stop25h 32m
Air Canada
Deal found 5/28![Air Canada logo]()
$385
This Air Canada deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/39:15 am
CLT
- GCM
1 stop27h 10m
Air Canada
Sat 6/610:55 am
GCM
- CLT
1 stop9h 02m
Air Canada
Deal found 5/28![Air Canada logo]()
$387
This Air Canada deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/39:15 am
CLT
- GCM
1 stop27h 10m
Air Canada
Thu 6/1112:25 pm
GCM
- CLT
1 stop25h 32m
Air Canada
Deal found 5/28![Air Canada logo]()
$436
This American Airlines deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/147:50 pm
CHS
- GCM
2 stops16h 11m
American Airlines
Wed 6/1712:33 pm
GCM
- CHS
1 stop6h 17m
American Airlines
Deal found 5/31![American Airlines logo]()
$535
This American Airlines deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/157:50 pm
CHS
- GCM
1 stop16h 40m
American Airlines
Thu 6/185:12 pm
GCM
- CHS
1 stop5h 47m
American Airlines
Deal found 5/31![American Airlines logo]()
$446
This American Airlines deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/166:51 am
CHS
- GCM
1 stop5h 39m
American Airlines
Fri 6/195:12 pm
GCM
- CHS
1 stop5h 47m
American Airlines
Deal found 6/1![American Airlines logo]()
$439
This Kiwi.com deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/86:48 pm
CLT
- GCM
1 stop17h 47m
Multiple Airlines
Sat 7/188:50 am
GCM
- CLT
1 stop7h 22m
Multiple Airlines
Deal found 5/28![Multiple Airlines logo]()
$543
This Kiwi.com deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/116:48 pm
CLT
- GCM
1 stop17h 47m
Multiple Airlines
Sat 7/188:50 am
GCM
- CLT
1 stop7h 22m
Multiple Airlines
Deal found 5/30![Multiple Airlines logo]()
$575
This Kiwi.com deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/136:48 pm
CLT
- GCM
1 stop22h 17m
Multiple Airlines
Fri 7/177:00 am
GCM
- CLT
1 stop9h 12m
Multiple Airlines
Deal found 5/30![Multiple Airlines logo]()
$531
This Kiwi.com deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/166:48 pm
CLT
- GCM
1 stop17h 47m
Multiple Airlines
Thu 7/237:00 am
GCM
- CLT
1 stop9h 12m
Multiple Airlines
Deal found 6/1![Multiple Airlines logo]()
$519
This Kiwi.com deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/226:48 pm
CLT
- GCM
1 stop27h 27m
Multiple Airlines
Tue 7/2811:30 am
GCM
- CLT
1 stop28h 42m
Multiple Airlines
Deal found 5/29![Multiple Airlines logo]()
$433
This Kiwi.com deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/226:48 pm
CLT
- GCM
1 stop17h 47m
Multiple Airlines
Mon 7/274:45 pm
GCM
- CLT
1 stop23h 27m
Multiple Airlines
Deal found 6/1![Multiple Airlines logo]()
$478
One-way flights from South Carolina to Cayman IslandsSearch for one-way flight options from South Carolina to Cayman Islands. Find affordable one-way fares based on user searches. Data last updated June 2, 2026.
Search for one-way flight options from South Carolina to Cayman Islands. Find affordable one-way fares based on user searches. Data last updated June 2, 2026.
This Trip.com deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/296:48 pm
CLT
- GCM
1 stop17h 47m
Multiple Airlines
Deal found 6/2![Multiple Airlines logo]()
$143
This Air Canada deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/249:20 am
CLT
- GCM
1 stop27h 05m
Air Canada
Deal found 5/29![Air Canada logo]()
$144
This Trip.com deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/294:56 pm
CLT
- GCM
1 stop19h 39m
Multiple Airlines
Deal found 6/2![Multiple Airlines logo]()
$148
This Trip.com deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/286:48 pm
CLT
- GCM
1 stop22h 17m
Multiple Airlines
Deal found 5/31![Multiple Airlines logo]()
$150
This Air Canada deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/269:20 am
CLT
- GCM
1 stop27h 05m
Air Canada
Deal found 5/29![Air Canada logo]()
$158
This Kiwi.com deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/306:48 pm
CLT
- GCM
1 stop27h 27m
Multiple Airlines
Deal found 6/2![Multiple Airlines logo]()
$160
This Kiwi.com deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/14:56 pm
CLT
- GCM
1 stop24h 09m
Multiple Airlines
Deal found 6/2![Multiple Airlines logo]()
$165
This Kiwi.com deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/254:56 pm
CLT
- GCM
1 stop24h 09m
Multiple Airlines
Deal found 5/30![Multiple Airlines logo]()
$167
This Kiwi.com deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/226:48 pm
CLT
- GCM
1 stop17h 47m
Multiple Airlines
Deal found 5/29![Multiple Airlines logo]()
$173
Find flight deals from South Carolina to Cayman Islands
Keep the following information in mind while searching for South Carolina to Cayman Islands flight deals. Data was last updated June 2, 2026.
Round-trip from | $385 (Orbitz) |
|---|---|
One-way from | $143 (Air Canada) |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Cayman Islands that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 2, 2026.
Use the filters below to find and compare flights from South Carolina to the Cayman Islands that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlestonGeorge Town
CHS - GCM
CHSGCM
Charleston
Mon 7/13
6:00 am-4:10 pm
1 stop11h 10m
George Town Owen Roberts Intl
Thu 7/16
5:10 pm-11:59 pm
1 stop5h 49m
$439
CharlestonGeorge Town
CHS - GCM
CHSGCM
Charleston
Sat 7/25
5:00 am-3:03 pm
1 stop11h 03m
George Town Owen Roberts Intl
Fri 7/31
5:10 pm-11:59 pm
1 stop5h 49m
$439
CharlestonGeorge Town
CHS - GCM
CHSGCM
Charleston
Tue 6/16
6:51 am-11:30 am
1 stop5h 39m
George Town Owen Roberts Intl
Fri 6/19
5:12 pm-11:59 pm
1 stop5h 47m
$439
CharlestonGeorge Town
CHS - GCM
CHSGCM
Charleston
Thu 7/16
11:04 am-4:10 pm
1 stop6h 06m
George Town Owen Roberts Intl
Thu 7/23
5:10 pm-12:19 pm
2 stops18h 09m
$444
CharlestonGeorge Town
CHS - GCM
CHSGCM
Charleston
Sat 8/22
6:00 am-10:55 am
1 stop5h 55m
George Town Owen Roberts Intl
Thu 8/27
12:30 pm-9:51 pm
1 stop8h 21m
$449
CharlestonGeorge Town
CHS - GCM
CHSGCM
Charleston
Tue 11/3
6:00 am-8:20 pm
1 stop14h 20m
George Town Owen Roberts Intl
Sun 11/8
3:14 pm-8:41 am
1 stop17h 27m
$455
CharlestonGeorge Town
CHS - GCM
CHSGCM
Charleston
Sun 11/1
9:27 am-8:20 pm
1 stop10h 53m
George Town Owen Roberts Intl
Fri 11/6
3:14 pm-12:23 am
1 stop9h 09m
$490
CharlotteGeorge Town
CLT - GCM
CLTGCM
Charlotte Douglas
Wed 7/22
6:48 pm-11:35 am
1 stop17h 47m
George Town Owen Roberts Intl
Tue 7/28
11:30 am-6:03 pm
2 stops29h 33m
$531
SavannahGeorge Town
SAV - GCM
SAVGCM
Savannah/Hilton Head
Wed 7/1
6:43 am-11:34 am
1 stop5h 51m
George Town Owen Roberts Intl
Tue 7/7
12:56 pm-9:17 pm
1 stop7h 21m
$631
CharlotteGeorge Town
CLT - GCM
CLTGCM
Charlotte Douglas
Mon 11/9
5:30 am-12:25 pm
1 stop6h 55m
George Town Owen Roberts Intl
Fri 11/13
1:50 pm-8:18 pm
1 stop6h 28m
$641
Showing 1-10 of 38 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Cayman Islands
Have a flexible travel schedule? Discover the best time to fly to Cayman Islands from South Carolina with our price prediction graph.
CLT-GCM
CHS-GCM
SAV-GCM
CAE-GCM
GSP-GCM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to the Cayman Islands
USSC-KY0
CLT-GCM
CHS-GCM
SAV-GCM
CAE-GCM
What is the cheapest month to book a flight from South Carolina to Cayman Islands?
Currently, November is the cheapest month in which you can book a flight from South Carolina to Cayman Islands (average of $286). Flying from South Carolina to Cayman Islands in July is currently the most expensive (average of $673). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Cayman Islands. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Complete your trip
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Alternative routes for South Carolina to Cayman Islands
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Cayman Islands by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Cayman Islands by cabin class
Find flights from South Carolina to Cayman Islands, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Cayman Islands flights
Browse other South Carolina and Cayman Islands flight options. Last updated on June 2, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Fly to Cayman Islands regions
Consider these flights traveling to Cayman Islands regions.
Top 2 airlines flying from South Carolina to Cayman Islands
Discover the top 2 airlines that operate flights from South Carolina to Cayman Islands. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 2, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$287 | Average$455 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$289 | Average$675 | FlexibilityNo cancel fee | On-time71% |