$328+ Cheap flights from South Carolina to the Cayman Islands
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/5. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — GCM
Nov 19 — Nov 261
Round-trip
1 adult, Economy
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Find cheap flights from South Carolina to Cayman Islands with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider ’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from South Carolina to Cayman Islands
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Cheapest flights from South Carolina to Cayman IslandsExplore the most affordable flight options available from South Carolina to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 20, 2026.
Explore the most affordable flight options available from South Carolina to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 20, 2026.
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/35:04 am -
1 stop6h 22m
Thu 12/103:45 pm -
1 stop8h 56m
Deal found 10/19![American Airlines logo]()
$626
This American Airlines deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/17:00 am -
1 stop5h 05m
Tue 12/88:15 am -
1 stop13h 41m
Deal found 10/17![American Airlines logo]()
$650
This Kiwi.com deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/288:24 pm -
1 stop21h 56m
Sat 10/3111:25 am -
1 stop22h 07m
Deal found 10/15![Multiple Airlines logo]()
$664
This United Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/226:30 am -
1 stop7h 15m
Mon 12/282:55 pm -
1 stop18h 38m
Deal found 10/15![United Airlines logo]()
$680
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/106:20 am -
1 stop5h 03m
Tue 11/1712:18 pm -
1 stop10h 41m
Deal found 10/19![American Airlines logo]()
$697
This Kiwi.com deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/288:24 pm -
1 stop21h 56m
Sun 11/112:40 pm -
2 stops19h 33m
Deal found 10/15![Multiple Airlines logo]()
$713
This Kiwi.com deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/288:24 pm -
1 stop21h 56m
Mon 11/212:40 pm -
1 stop7h 32m
Deal found 10/15![Multiple Airlines logo]()
$714
This United Airlines deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/56:30 am -
1 stop10h 00m
Tue 11/105:45 pm -
1 stop22h 34m
Deal found 10/17![United Airlines logo]()
$718
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/117:41 pm -
1 stop15h 42m
Mon 11/168:23 am -
1 stop15h 29m
Deal found 10/15![American Airlines logo]()
$724
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/15:05 am -
1 stop6h 18m
Fri 11/612:54 pm -
1 stop11h 05m
Deal found 10/20![American Airlines logo]()
$736
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/27:41 pm -
1 stop15h 42m
Thu 11/512:18 pm -
1 stop8h 41m
Deal found 10/16![American Airlines logo]()
$746
This Kiwi.com deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/178:24 pm -
1 stop21h 56m
Mon 10/2612:40 pm -
1 stop6h 32m
Deal found 10/15![Multiple Airlines logo]()
$763
Best flights from South Carolina to Cayman IslandsDiscover carefully curated flight deals from South Carolina to Cayman Islands that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 20, 2026.
Discover carefully curated flight deals from South Carolina to Cayman Islands that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 20, 2026.
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/2410:37 am -
2 stops9h 11m
Wed 3/312:49 pm -
2 stops8h 42m
Deal found 10/19![American Airlines logo]()
$605
This United Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/96:00 am -
1 stop7h 15m
Mon 2/155:45 pm -
1 stop22h 27m
Deal found 10/19![United Airlines logo]()
$608
This Kiwi.com deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/1410:12 am -
1 stop7h 08m
Mon 1/1812:40 pm -
1 stop7h 37m
Deal found 10/15![Multiple Airlines logo]()
$655
This United Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/136:05 am -
1 stop7h 40m
Mon 4/191:35 pm -
1 stop7h 19m
Deal found 10/19![United Airlines logo]()
$634
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/138:16 pm -
2 stops15h 44m
Mon 4/1912:00 pm -
1 stop6h 05m
Deal found 10/19![American Airlines logo]()
$693
This United Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/226:30 am -
1 stop7h 15m
Mon 12/282:55 pm -
1 stop18h 38m
Deal found 10/15![United Airlines logo]()
$680
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/106:20 am -
1 stop5h 03m
Tue 11/1712:18 pm -
1 stop10h 41m
Deal found 10/19![American Airlines logo]()
$697
This United Airlines deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/56:30 am -
1 stop10h 00m
Tue 11/105:45 pm -
1 stop22h 34m
Deal found 10/17![United Airlines logo]()
$718
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/117:41 pm -
1 stop15h 42m
Mon 11/168:23 am -
1 stop15h 29m
Deal found 10/15![American Airlines logo]()
$724
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/1510:53 am -
1 stop4h 22m
Tue 1/1912:48 pm -
1 stop6h 51m
Deal found 10/19![American Airlines logo]()
$726
This United Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/236:15 am -
1 stop7h 30m
Sat 12/265:15 pm -
1 stop16h 46m
Deal found 10/16![United Airlines logo]()
$776
This American Airlines deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/15:05 am -
1 stop6h 18m
Fri 11/612:18 pm -
1 stop7h 24m
Deal found 10/17![American Airlines logo]()
$736
This United Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/146:30 am -
1 stop7h 15m
Mon 1/182:55 pm -
1 stop19h 06m
Deal found 10/16![United Airlines logo]()
$807
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/86:27 am -
1 stop4h 56m
Sat 11/1412:10 pm -
1 stop10h 49m
Deal found 10/19![American Airlines logo]()
$736
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/27:41 pm -
1 stop15h 42m
Thu 11/512:18 pm -
1 stop8h 41m
Deal found 10/16![American Airlines logo]()
$746
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/237:00 am -
1 stop7h 50m
Sat 12/2612:59 pm -
2 stops10h 58m
Deal found 10/16![American Airlines logo]()
$1,065
This United Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/107:54 pm -
2 stops20h 36m
Tue 11/175:45 pm -
3 stops23h 15m
Deal found 10/19![United Airlines logo]()
$5,024
Last-minute flights from South Carolina to Cayman IslandsDiscover last-minute flight deals from South Carolina to Cayman Islands. Data last updated October 20, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Cayman Islands. Data last updated October 20, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/276:49 am -
1 stop9h 41m
Sat 10/311:25 pm -
1 stop8h 35m
Deal found 10/15![United Airlines logo]()
$885
This Kiwi.com deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/288:24 pm -
1 stop21h 56m
Sat 10/3111:25 am -
1 stop22h 07m
Deal found 10/15![Multiple Airlines logo]()
$664
This Kiwi.com deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/288:24 pm -
1 stop21h 56m
Sun 11/112:40 pm -
2 stops19h 33m
Deal found 10/15![Multiple Airlines logo]()
$713
This Kiwi.com deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/288:24 pm -
1 stop21h 56m
Mon 11/212:40 pm -
1 stop7h 32m
Deal found 10/15![Multiple Airlines logo]()
$714
This Delta deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/298:05 am -
1 stop4h 35m
Sun 11/11:55 pm -
1 stop6h 26m
Deal found 10/17![Delta logo]()
$866
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:00 am -
1 stop14h 00m
Sun 11/112:55 pm -
1 stop6h 47m
Deal found 10/16![American Airlines logo]()
$871
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/15:05 am -
1 stop6h 18m
Fri 11/612:54 pm -
1 stop11h 05m
Deal found 10/20![American Airlines logo]()
$736
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/27:41 pm -
1 stop15h 42m
Thu 11/512:18 pm -
1 stop8h 41m
Deal found 10/16![American Airlines logo]()
$746
This United Airlines deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/56:30 am -
1 stop10h 00m
Tue 11/105:45 pm -
1 stop22h 34m
Deal found 10/17![United Airlines logo]()
$718
This American Airlines deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/57:01 am -
2 stops12h 57m
Tue 11/1012:55 pm -
2 stops9h 56m
Deal found 10/17![American Airlines logo]()
$769
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/106:20 am -
1 stop5h 03m
Tue 11/1712:18 pm -
1 stop10h 41m
Deal found 10/19![American Airlines logo]()
$697
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/117:41 pm -
1 stop15h 42m
Mon 11/168:23 am -
1 stop15h 29m
Deal found 10/15![American Airlines logo]()
$724
One-way flights from South Carolina to Cayman IslandsSearch for one-way flight options from South Carolina to Cayman Islands. Find affordable one-way fares based on user searches. Data last updated October 20, 2026.
Search for one-way flight options from South Carolina to Cayman Islands. Find affordable one-way fares based on user searches. Data last updated October 20, 2026.
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/58:02 am -
2 stops11h 59m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/19![American Airlines logo]()
$328
This American Airlines deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/18:32 pm -
1 stop14h 51m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/17![American Airlines logo]()
$342
This Kiwi.com deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/110:13 pm -
3 stops41h 52m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/17![Multiple Airlines logo]()
$359
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/18:32 pm -
1 stop14h 51m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/19![American Airlines logo]()
$448
This United Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/17:54 pm -
3 stops20h 36m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/19![United Airlines logo]()
$3,864
Find flight deals from South Carolina to Cayman Islands
Keep the following information in mind while searching for South Carolina to Cayman Islands flight deals. Data was last updated October 20, 2026.
Round-trip from | $596 (American Airlines) |
|---|---|
One-way from | $328 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Cayman Islands that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 20, 2026.
Use the filters below to find and compare flights from South Carolina to the Cayman Islands that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlestonGeorge Town
CHS Charleston - GCM George Town Owen Roberts Intl
CHSGCM
Charleston
Sat 12/5
8:02 am-8:01 pm
2 stops11h 59m
George Town Owen Roberts Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$328
CharlestonGeorge Town
CHS Charleston - GCM George Town Owen Roberts Intl
CHSGCM
Charleston
Sun 11/1
8:32 pm-11:23 am
1 stop14h 51m
George Town Owen Roberts Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$342
ColumbiaGeorge Town
CAE Columbia Metropolitan - GCM George Town Owen Roberts Intl
CAEGCM
Columbia Metropolitan
Sun 11/1
8:32 pm-11:55 am
2 stops15h 23m
George Town Owen Roberts Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$448
GreenvilleGeorge Town
GSP Greenville - GCM George Town Owen Roberts Intl
GSPGCM
Greenville
Wed 2/24
10:37 am-7:48 pm
2 stops9h 11m
George Town Owen Roberts Intl
Wed 3/3
12:49 pm-9:31 pm
2 stops8h 42m
$605
CharlestonGeorge Town
CHS Charleston - GCM George Town Owen Roberts Intl
CHSGCM
Charleston
Tue 2/9
6:00 am-1:15 pm
1 stop7h 15m
George Town Owen Roberts Intl
Mon 2/15
5:45 pm-4:12 pm
1 stop22h 27m
$608
CharlestonGeorge Town
CHS Charleston - GCM George Town Owen Roberts Intl
CHSGCM
Charleston
Tue 4/13
6:05 am-12:45 pm
1 stop7h 40m
George Town Owen Roberts Intl
Mon 4/19
1:35 pm-9:54 pm
1 stop7h 19m
$634
GreenvilleGeorge Town
GSP Greenville - GCM George Town Owen Roberts Intl
GSPGCM
Greenville
Thu 1/14
10:12 am-5:20 pm
1 stop7h 08m
George Town Owen Roberts Intl
Mon 1/18
12:40 pm-8:17 pm
1 stop7h 37m
$655
GreenvilleGeorge Town
GSP Greenville - GCM George Town Owen Roberts Intl
GSPGCM
Greenville
Tue 12/22
6:30 am-1:45 pm
1 stop7h 15m
George Town Owen Roberts Intl
Mon 12/28
2:55 pm-9:33 am
1 stop18h 38m
$680
CharlestonGeorge Town
CHS Charleston - GCM George Town Owen Roberts Intl
CHSGCM
Charleston
Tue 4/13
8:16 pm-11:00 am
2 stops15h 44m
George Town Owen Roberts Intl
Mon 4/19
12:00 pm-7:05 pm
1 stop6h 05m
$693
ColumbiaGeorge Town
CAE Columbia Metropolitan - GCM George Town Owen Roberts Intl
CAEGCM
Columbia Metropolitan
Tue 11/10
6:20 am-11:23 am
1 stop5h 03m
George Town Owen Roberts Intl
Tue 11/17
12:18 pm-10:59 pm
1 stop10h 41m
$697
Showing 1-10 of 21 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Cayman Islands
Have a flexible travel schedule? Discover the best time to fly to Cayman Islands from South Carolina with our price prediction graph.
GSP-GCM
CAE-GCM
CHS-GCM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to the Cayman Islands
USSC-KY0
GSP-GCM
CAE-GCM
CHS-GCM
No data available for this route at this time. Please check back soon.
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Cayman Islands. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for South Carolina to Cayman Islands
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Cayman Islands by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Cayman Islands by cabin class
Find flights from South Carolina to Cayman Islands, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Cayman Islands flights
Browse other South Carolina and Cayman Islands flight options. Last updated on October 20, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Fly to Cayman Islands regions
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Top 2 airlines flying from South Carolina to Cayman Islands
Discover the top 2 airlines that operate flights from South Carolina to Cayman Islands. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 20, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$287 | Average$455 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$289 | Average$703 | FlexibilityNo cancel fee | On-time71% |