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Cayman Islands

$313+ Cheap flights from South Carolina to the Cayman Islands

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/16. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — GCM
Jun 21 — Jun 281
Sat 6/21
Sat 6/28
1 adult, Economy
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Cheap flight deals from South Carolina to Cayman Islands

Keep the following information in mind while searching for South Carolina to Cayman Islands flight deals. Data was last updated June 16, 2025.

Round-trip from

$484
(Kiwi.com)

One-way from

$313
(American Airlines)
From South Carolina to Cayman Islands
Search Deals
One-way flight from South Carolina to Cayman Islands
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Find flight deals from South Carolina to Cayman Islands

Cheapest flights from South Carolina to Cayman Islands
Explore the most affordable flight options available from South Carolina to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 16, 2025.

This Kiwi.com deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/103:28 pmCLT - GCM
1 stop6h 52mMultiple Airlines
Thu 7/174:45 pmGCM - CLT
1 stop20h 50mMultiple Airlines
Deal found 6/13$484
This American Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/158:47 pmCHS - GCM
1 stop15h 13mAmerican Airlines
Sat 11/222:20 pmGCM - CHS
1 stop4h 52mAmerican Airlines
Deal found 6/15$497
This American Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/86:29 amGSP - GCM
1 stop5h 41mAmerican Airlines
Sat 7/123:30 pmGCM - GSP
1 stop7h 49mAmerican Airlines
Deal found 6/15$519
This Delta deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/308:05 amCAE - GCM
1 stop4h 32mDelta
Fri 9/512:50 pmGCM - CAE
1 stop5h 23mDelta
Deal found 6/15$540
This Delta deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/205:23 amSAV - GCM
1 stop6h 59mDelta
Wed 7/2312:37 pmGCM - SAV
1 stop7h 26mDelta
Deal found 6/14$550
This American Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/249:30 amCLT - GCM
Nonstop2h 55mAmerican Airlines
Mon 9/2912:25 pmGCM - CLT
Nonstop3h 12mAmerican Airlines
Deal found 6/16$560
This United Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/297:00 amCLT - GCM
1 stop6h 30mUnited Airlines
Tue 8/51:35 pmGCM - CLT
1 stop7h 22mUnited Airlines
Deal found 6/14$625
This American Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/304:21 pmCAE - GCM
2 stops19h 49mAmerican Airlines
Fri 9/512:10 pmGCM - CAE
2 stops10h 33mAmerican Airlines
Deal found 6/15$644
This Delta deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/75:36 amCLT - GCM
1 stop6h 46mDelta
Sun 8/1012:37 pmGCM - CLT
1 stop9h 15mDelta
Deal found 6/14$650
This American Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/208:33 pmSAV - GCM
2 stops15h 37mAmerican Airlines
Wed 7/2312:10 pmGCM - SAV
2 stops9h 26mAmerican Airlines
Deal found 6/14$694
This United Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/1511:25 amCHS - GCM
2 stops29h 00mUnited Airlines
Sat 11/222:40 pmGCM - CHS
2 stops24h 29mUnited Airlines
Deal found 6/16$794
This United Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/179:10 amSAV - GCM
1 stop28h 20mUnited Airlines
Sat 6/212:40 pmGCM - SAV
1 stop8h 19mUnited Airlines
Deal found 6/16$901

Cheapflights Fare Finder

Customize your flight search to find flights from South Carolina to Cayman Islands that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 16, 2025.
Use the filters below to find and compare flights from South Carolina to the Cayman Islands that are best for you.

Fly from

South Carolina

Fly to

Cayman Islands

Route

Depart

Return

Price

CharlotteGeorge Town

CLT - GCM

CLTGCM

Charlotte Douglas

Thu 7/10

3:28 pm-9:20 pm

1 stop6h 52m

George Town Owen Roberts Intl

Thu 7/17

4:45 pm-2:35 pm

1 stop20h 50m

$484

CharlestonGeorge Town

CHS - GCM

CHSGCM

Charleston

Sat 11/15

8:47 pm-12:00 pm

1 stop15h 13m

George Town Owen Roberts Intl

Sat 11/22

2:20 pm-7:12 pm

1 stop4h 52m

$497

GreenvilleGeorge Town

GSP - GCM

GSPGCM

Greenville

Tue 7/8

6:29 am-11:10 am

1 stop5h 41m

George Town Owen Roberts Intl

Sat 7/12

3:30 pm-12:19 am

1 stop7h 49m

$519

ColumbiaGeorge Town

CAE - GCM

CAEGCM

Columbia Metropolitan

Sat 8/30

8:05 am-11:37 am

1 stop4h 32m

George Town Owen Roberts Intl

Fri 9/5

12:50 pm-7:13 pm

1 stop5h 23m

$540

SavannahGeorge Town

SAV - GCM

SAVGCM

Savannah/Hilton Head

Sun 7/20

5:23 am-11:22 am

1 stop6h 59m

George Town Owen Roberts Intl

Wed 7/23

12:37 pm-9:03 pm

1 stop7h 26m

$550

CharlotteGeorge Town

CLT - GCM

CLTGCM

Charlotte Douglas

Wed 9/24

9:30 am-11:25 am

Nonstop2h 55m

George Town Owen Roberts Intl

Mon 9/29

12:25 pm-4:37 pm

Nonstop3h 12m

$560

CharlotteGeorge Town

CLT - GCM

CLTGCM

Charlotte Douglas

Tue 7/29

7:00 am-12:30 pm

1 stop6h 30m

George Town Owen Roberts Intl

Tue 8/5

1:35 pm-9:57 pm

1 stop7h 22m

$625

ColumbiaGeorge Town

CAE - GCM

CAEGCM

Columbia Metropolitan

Sat 8/30

4:21 pm-11:10 am

2 stops19h 49m

George Town Owen Roberts Intl

Fri 9/5

12:10 pm-11:43 pm

2 stops10h 33m

$644

CharlotteGeorge Town

CLT - GCM

CLTGCM

Charlotte Douglas

Thu 8/7

5:36 am-11:22 am

1 stop6h 46m

George Town Owen Roberts Intl

Sun 8/10

12:37 pm-10:52 pm

1 stop9h 15m

$650

SavannahGeorge Town

SAV - GCM

SAVGCM

Savannah/Hilton Head

Sun 7/20

8:33 pm-11:10 am

2 stops15h 37m

George Town Owen Roberts Intl

Wed 7/23

12:10 pm-10:36 pm

2 stops9h 26m

$694

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/14

Showing 1-10 of 19 results
1
2

Best time to book a flight from South Carolina to Cayman Islands

Have a flexible travel schedule? Discover the best time to fly to Cayman Islands from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to the Cayman Islands

What is the cheapest month to book a flight from South Carolina to Cayman Islands?

Currently, January is the cheapest month in which you can book a flight from South Carolina to Cayman Islands (average of $467). Flying from South Carolina to Cayman Islands in March is currently the most expensive (average of $594). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Cayman Islands

Get insights into the airlines that provide service to Cayman Islands. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Cayman Islands. Reviews last updated June 16, 2025.
Read reviews from past customers who have flown Delta, United Airlines and American Airlines from South Carolina to Cayman Islands. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,963 reviews

Entertainment

7.9

Comfort

7.9

Food

7.3

Overall

8.0

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,963 reviews
Delta
8.0
Very good
7,963 reviews

Entertainment

7.9

Comfort

7.9

Food

7.3

Overall

8.0

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,801 reviews
Delta
8.0
Very good
7,963 reviews

Entertainment

7.9

Comfort

7.9

Food

7.3

Overall

8.0

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,963 reviews

Entertainment

7.9

Comfort

7.9

Food

7.3

Overall

8.0

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
WestJet
7.2
Good
2,873 reviews
Delta
8.0
Very good
7,963 reviews

Entertainment

7.9

Comfort

7.9

Food

7.3

Overall

8.0

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Air Canada
7.1
Good
9,563 reviews
Delta
8.0
Very good
7,963 reviews

Entertainment

7.9

Comfort

7.9

Food

7.3

Overall

8.0

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Cayman Islands. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines to fly from South Carolina to Cayman Islands one-way?

    One-way options have recently been found by users for as low as $313 on American Airlines. Other airlines that offer cheap prices include Air Canada from $443 and United Airlines from $2,363 one-way.

  • Can I find deals for flights from South Carolina to Cayman Islands that include hotel bookings?

    Yes. In addition to deals on South Carolina to Cayman Islands flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Cayman Islands?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Cayman Islands.

  • Can I find deals for business class flights from South Carolina to Cayman Islands?

    Yes. Cheapflights offers flight deals from South Carolina to Cayman Islands by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Cayman Islands?

    Currently, January is the cheapest month in which you can book a flight from South Carolina to Cayman Islands (average of $467). Flying from South Carolina to Cayman Islands in March is currently the most expensive (average of $594). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

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Top 2 airlines flying from South Carolina to Cayman Islands

Discover the top 2 airlines that operate flights from South Carolina to Cayman Islands. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$414Average$603FlexibilityNo cancel feeOn-time71%
DeltaCheapest$460Average$627FlexibilityNo cancel feeOn-timeN/A

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