$154+ Cheap flights from South Carolina to the Cayman Islands
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/7. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — GCM
Sep 24 — Oct 11
Round-trip
1 adult, Economy
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Find cheap flights from South Carolina to Cayman Islands with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from South Carolina to Cayman IslandsExplore the most affordable flight options available from South Carolina to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 25, 2026.
Explore the most affordable flight options available from South Carolina to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 25, 2026.
This Travelocity deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/75:10 pm -
1 stop19h 00m
Sat 11/141:10 pm -
1 stop7h 56m
Deal found 8/24![Air Canada logo]()
$389
This Expedia deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/55:10 pm -
1 stop19h 00m
Sun 11/81:10 pm -
1 stop27h 16m
Deal found 8/20![Air Canada logo]()
$393
This Justfly.com deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/58:55 am -
1 stop27h 15m
Sat 11/71:10 pm -
1 stop7h 56m
Deal found 8/20![Air Canada logo]()
$402
This Air Canada deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/35:10 pm -
1 stop19h 00m
Sun 11/81:10 pm -
1 stop27h 16m
Deal found 8/20![Air Canada logo]()
$403
This Air Canada deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/215:10 pm -
1 stop19h 00m
Thu 11/261:10 pm -
1 stop7h 56m
Deal found 8/24![Air Canada logo]()
$413
This Air Canada deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/95:10 pm -
1 stop19h 00m
Sun 12/131:10 pm -
1 stop7h 56m
Deal found 8/24![Air Canada logo]()
$431
This Air Canada deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/55:10 pm -
1 stop19h 00m
Fri 12/111:10 pm -
1 stop7h 56m
Deal found 8/20![Air Canada logo]()
$444
This Air Canada deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/55:10 pm -
1 stop19h 00m
Thu 12/101:10 pm -
1 stop7h 56m
Deal found 8/21![Air Canada logo]()
$462
This Kiwi.com deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/19:59 pm -
1 stop14h 36m
Sat 10/38:50 am -
1 stop8h 32m
Deal found 8/24![Multiple Airlines logo]()
$508
This Travelocity deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/38:55 am -
1 stop27h 15m
Sun 12/61:10 pm -
1 stop7h 56m
Deal found 8/20![Air Canada logo]()
$513
This Kiwi.com deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/267:27 pm -
1 stop17h 08m
Tue 9/2911:30 am -
1 stop8h 44m
Deal found 8/23![Multiple Airlines logo]()
$531
This Kiwi.com deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/1211:50 am -
2 stops29h 15m
Mon 10/197:00 am -
1 stop12h 56m
Deal found 8/20![Multiple Airlines logo]()
$532
Best flights from South Carolina to Cayman IslandsDiscover carefully curated flight deals from South Carolina to Cayman Islands that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 25, 2026.
Discover carefully curated flight deals from South Carolina to Cayman Islands that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 25, 2026.
This American Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/1210:34 am -
1 stop9h 49m
Tue 2/912:55 pm -
Nonstop3h 00m
Deal found 8/24![American Airlines logo]()
$621
This FlightHub deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/255:10 pm -
1 stop19h 00m
Sun 11/291:10 pm -
1 stop27h 16m
Deal found 8/23![Air Canada logo]()
$624
This Delta deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/176:05 am -
1 stop6h 35m
Fri 10/2312:55 pm -
1 stop7h 13m
Deal found 8/22![Delta logo]()
$681
This United Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/104:59 pm -
1 stop20h 46m
Wed 1/132:25 pm -
1 stop9h 00m
Deal found 8/19![United Airlines logo]()
$743
This Southwest deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/216:05 am -
2 stops9h 05m
Wed 11/251:30 pm -
2 stops9h 30m
Deal found 8/22![Southwest logo]()
$809
This American Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/196:50 am -
1 stop5h 40m
Tue 10/2012:00 pm -
1 stop10h 59m
Deal found 8/24![American Airlines logo]()
$621
This Delta deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/25:30 am -
1 stop7h 10m
Sun 10/41:00 pm -
1 stop6h 13m
Deal found 8/21![Delta logo]()
$711
This American Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/55:30 am -
1 stop14h 28m
Thu 12/1012:55 pm -
1 stop10h 57m
Deal found 8/21![American Airlines logo]()
$650
This United Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/106:30 am -
1 stop7h 15m
Wed 1/132:25 pm -
1 stop8h 54m
Deal found 8/19![United Airlines logo]()
$745
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/67:25 pm -
2 stops16h 35m
Tue 10/138:00 am -
1 stop13h 52m
Deal found 8/22![American Airlines logo]()
$656
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:50 am -
1 stop5h 40m
Wed 10/1412:35 pm -
2 stops10h 24m
Deal found 8/22![American Airlines logo]()
$659
This United Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/116:30 am -
1 stop7h 15m
Wed 1/132:55 pm -
1 stop25h 50m
Deal found 8/19![United Airlines logo]()
$813
This American Airlines deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:00 am -
1 stop14h 00m
Sun 10/1812:35 pm -
1 stop8h 15m
Deal found 8/23![American Airlines logo]()
$664
This United Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/26:40 am -
1 stop9h 50m
Wed 11/45:45 pm -
1 stop17h 04m
Deal found 8/24![United Airlines logo]()
$837
This American Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/88:32 pm -
1 stop14h 51m
Sat 11/1412:10 pm -
1 stop10h 49m
Deal found 8/24![American Airlines logo]()
$664
This American Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/18:32 pm -
1 stop14h 51m
Fri 11/612:55 pm -
1 stop6h 39m
Deal found 8/20![American Airlines logo]()
$664
This United Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/46:40 am -
1 stop9h 50m
Sat 11/75:45 pm -
1 stop17h 04m
Deal found 8/20![United Airlines logo]()
$885
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1610:44 pm -
1 stop15h 26m
Tue 10/2012:00 pm -
1 stop6h 45m
Deal found 8/22![American Airlines logo]()
$671
This American Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/48:28 pm -
1 stop16h 02m
Sun 10/1112:35 pm -
1 stop8h 16m
Deal found 8/20![American Airlines logo]()
$679
This American Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/176:25 pm -
1 stop17h 06m
Sat 12/263:25 pm -
1 stop9h 17m
Deal found 8/20![American Airlines logo]()
$696
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/178:34 am -
2 stops11h 26m
Fri 10/2312:00 pm -
1 stop6h 27m
Deal found 8/22![American Airlines logo]()
$701
This American Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/196:00 am -
1 stop13h 58m
Thu 11/263:45 pm -
1 stop8h 10m
Deal found 8/21![American Airlines logo]()
$704
This American Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/308:35 pm -
1 stop15h 30m
Fri 12/48:15 am -
1 stop15h 37m
Deal found 8/20![American Airlines logo]()
$713
This American Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/84:40 pm -
2 stops19h 20m
Sat 9/1911:55 am -
2 stops46h 34m
Deal found 8/21![American Airlines logo]()
$788
This American Airlines deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/76:00 am -
1 stop8h 10m
Fri 9/1812:36 pm -
1 stop5h 23m
Deal found 8/23![American Airlines logo]()
$827
This American Airlines deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/195:00 am -
2 stops9h 25m
Wed 12/233:30 pm -
1 stop20h 55m
Deal found 8/23![American Airlines logo]()
$882
This American Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/199:03 am -
Nonstop3h 01m
Sat 12/2612:59 pm -
Nonstop3h 06m
Deal found 8/24![American Airlines logo]()
$1,030
This American Airlines deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/245:30 am -
1 stop14h 36m
Sat 11/288:15 am -
1 stop10h 55m
Deal found 8/23![American Airlines logo]()
$1,049
Last-minute flights from South Carolina to Cayman IslandsDiscover last-minute flight deals from South Carolina to Cayman Islands. Data last updated August 25, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Cayman Islands. Data last updated August 25, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/71:58 pm -
1 stop27h 07m
Sat 9/128:50 am -
1 stop8h 32m
Deal found 8/20![Multiple Airlines logo]()
$620
This American Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/76:00 am -
1 stop8h 10m
Fri 9/1812:36 pm -
1 stop5h 23m
Deal found 8/21![American Airlines logo]()
$790
This American Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/87:00 am -
1 stop7h 10m
Sat 9/1911:55 am -
2 stops46h 34m
Deal found 8/21![American Airlines logo]()
$788
This Kiwi.com deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/119:59 pm -
2 stops17h 51m
Sat 9/198:50 am -
1 stop8h 32m
Deal found 8/23![Multiple Airlines logo]()
$572
This Orbitz deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/119:15 am -
1 stop25h 30m
Sat 9/1910:40 am -
1 stop9h 17m
Deal found 8/22![Air Canada logo]()
$673
This American Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/176:22 am -
1 stop6h 05m
Sun 9/2012:36 pm -
1 stop6h 08m
Deal found 8/20![American Airlines logo]()
$736
This Kiwi.com deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/198:08 pm -
2 stops22h 12m
Sat 9/268:50 am -
1 stop8h 32m
Deal found 8/20![Multiple Airlines logo]()
$576
This American Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/199:32 am -
Nonstop2h 55m
Sat 9/2611:55 am -
1 stop8h 04m
Deal found 8/20![American Airlines logo]()
$687
This Kiwi.com deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/267:27 pm -
1 stop17h 08m
Tue 9/2911:30 am -
1 stop8h 44m
Deal found 8/23![Multiple Airlines logo]()
$531
This American Airlines deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/269:32 am -
Nonstop2h 55m
Tue 9/2912:00 pm -
1 stop7h 59m
Deal found 8/23![American Airlines logo]()
$667
This Kissandfly.com deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kissandfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/267:40 am -
1 stop5h 00m
Mon 9/281:00 pm -
1 stop6h 13m
Deal found 8/23![KLM logo]()
$698
This Delta deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/267:40 am -
1 stop5h 00m
Mon 9/281:00 pm -
1 stop6h 13m
Deal found 8/23![Delta logo]()
$702
One-way flights from South Carolina to Cayman IslandsSearch for one-way flight options from South Carolina to Cayman Islands. Find affordable one-way fares based on user searches. Data last updated August 25, 2026.
Search for one-way flight options from South Carolina to Cayman Islands. Find affordable one-way fares based on user searches. Data last updated August 25, 2026.
This Trip.com deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/73:00 pm -
1 stop21h 35m
Deal found 8/23![Multiple Airlines logo]()
$154
This Orbitz deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/198:55 am -
1 stop27h 15m
Deal found 8/20![Air Canada logo]()
$160
This Air Canada deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/165:10 pm -
1 stop19h 00m
Deal found 8/20![Air Canada logo]()
$165
This Expedia deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/218:55 am -
1 stop27h 15m
Deal found 8/22![Air Canada logo]()
$169
This Kiwi.com deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/69:59 pm -
1 stop19h 06m
Deal found 8/21![Multiple Airlines logo]()
$182
This Kiwi.com deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/249:59 pm -
1 stop14h 36m
Deal found 8/24![Multiple Airlines logo]()
$201
This Kiwi.com deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/59:59 pm -
1 stop19h 06m
Deal found 8/21![Multiple Airlines logo]()
$203
This Kiwi.com deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/1911:50 am -
2 stops29h 15m
Deal found 8/21![Multiple Airlines logo]()
$206
This Kiwi.com deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/58:32 pm -
3 stops44h 33m
Deal found 8/21![Multiple Airlines logo]()
$238
This Kiwi.com deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1612:23 pm -
2 stops29h 57m
Deal found 8/20![Multiple Airlines logo]()
$254
This American Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/57:00 am -
1 stop12h 58m
Deal found 8/20![American Airlines logo]()
$309
This Delta deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/55:45 am -
1 stop6h 55m
Deal found 8/21![Delta logo]()
$313
Find flight deals from South Carolina to Cayman Islands
Keep the following information in mind while searching for South Carolina to Cayman Islands flight deals. Data was last updated August 25, 2026.
Round-trip from | $393 (Expedia) |
|---|---|
One-way from | $154 (Trip.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Cayman Islands that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 25, 2026.
Use the filters below to find and compare flights from South Carolina to the Cayman Islands that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlotteGeorge Town
CLT Charlotte Douglas - GCM George Town Owen Roberts Intl
CLTGCM
Charlotte Douglas
Tue 1/12
10:34 am-8:23 pm
1 stop9h 49m
George Town Owen Roberts Intl
Tue 2/9
12:55 pm-3:55 pm
Nonstop3h 00m
$621
SavannahGeorge Town
SAV Savannah/Hilton Head - GCM George Town Owen Roberts Intl
SAVGCM
Savannah/Hilton Head
Mon 10/19
6:50 am-11:30 am
1 stop5h 40m
George Town Owen Roberts Intl
Tue 10/20
12:00 pm-11:59 pm
1 stop10h 59m
$621
CharlotteGeorge Town
CLT Charlotte Douglas - GCM George Town Owen Roberts Intl
CLTGCM
Charlotte Douglas
Wed 11/25
5:10 pm-12:10 pm
1 stop19h 00m
George Town Owen Roberts Intl
Sun 11/29
1:10 pm-4:26 pm
1 stop27h 16m
$624
GreenvilleGeorge Town
GSP Greenville - GCM George Town Owen Roberts Intl
GSPGCM
Greenville
Sat 12/5
5:30 am-7:58 pm
1 stop14h 28m
George Town Owen Roberts Intl
Thu 12/10
12:55 pm-11:52 pm
1 stop10h 57m
$650
GreenvilleGeorge Town
GSP Greenville - GCM George Town Owen Roberts Intl
GSPGCM
Greenville
Tue 10/6
7:25 pm-11:00 am
2 stops16h 35m
George Town Owen Roberts Intl
Tue 10/13
8:00 am-10:52 pm
1 stop13h 52m
$656
SavannahGeorge Town
SAV Savannah/Hilton Head - GCM George Town Owen Roberts Intl
SAVGCM
Savannah/Hilton Head
Wed 10/7
6:50 am-11:30 am
1 stop5h 40m
George Town Owen Roberts Intl
Wed 10/14
12:35 pm-11:59 pm
2 stops10h 24m
$659
CharlestonGeorge Town
CHS Charleston - GCM George Town Owen Roberts Intl
CHSGCM
Charleston
Fri 10/16
6:00 am-7:00 pm
1 stop14h 00m
George Town Owen Roberts Intl
Sun 10/18
12:35 pm-9:50 pm
1 stop8h 15m
$664
CharlestonGeorge Town
CHS Charleston - GCM George Town Owen Roberts Intl
CHSGCM
Charleston
Sun 11/8
8:32 pm-11:23 am
1 stop14h 51m
George Town Owen Roberts Intl
Sat 11/14
12:10 pm-10:59 pm
1 stop10h 49m
$664
CharlestonGeorge Town
CHS Charleston - GCM George Town Owen Roberts Intl
CHSGCM
Charleston
Sun 11/1
8:32 pm-11:23 am
1 stop14h 51m
George Town Owen Roberts Intl
Fri 11/6
12:55 pm-7:34 pm
1 stop6h 39m
$664
CharlotteGeorge Town
CLT Charlotte Douglas - GCM George Town Owen Roberts Intl
CLTGCM
Charlotte Douglas
Fri 10/16
10:44 pm-1:10 pm
1 stop15h 26m
George Town Owen Roberts Intl
Tue 10/20
12:00 pm-7:45 pm
1 stop6h 45m
$671
Showing 1-10 of 46 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Cayman Islands
Have a flexible travel schedule? Discover the best time to fly to Cayman Islands from South Carolina with our price prediction graph.
CLT-GCM
SAV-GCM
GSP-GCM
CHS-GCM
CAE-GCM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to the Cayman Islands
USSC-KY0
CLT-GCM
SAV-GCM
GSP-GCM
CHS-GCM
What is the cheapest month to book a flight from South Carolina to Cayman Islands?
Currently, January is the cheapest month in which you can book a flight from South Carolina to Cayman Islands (average of $309). Flying from South Carolina to Cayman Islands in September is currently the most expensive (average of $999). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Cayman Islands. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Alternative routes for South Carolina to Cayman Islands
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Cayman Islands by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Cayman Islands by cabin class
Find flights from South Carolina to Cayman Islands, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Cayman Islands flights
Browse other South Carolina and Cayman Islands flight options. Last updated on August 25, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Fly to Cayman Islands regions
Consider these flights traveling to Cayman Islands regions.
Top 2 airlines flying from South Carolina to Cayman Islands
Discover the top 2 airlines that operate flights from South Carolina to Cayman Islands. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 25, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$287 | Average$455 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$289 | Average$696 | FlexibilityNo cancel fee | On-time71% |