$290+ Cheap flights from South Carolina to the Cayman Islands
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/16. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — GCM
Nov 29 — Dec 61
Round-trip
1 adult, Economy
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Find cheap flights from South Carolina to Cayman Islands with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from South Carolina to Cayman Islands
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Cheapest flights from South Carolina to Cayman IslandsExplore the most affordable flight options available from South Carolina to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2026.
Explore the most affordable flight options available from South Carolina to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2026.
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/106:30 am -
1 stop10h 00m
Thu 12/172:25 pm -
1 stop9h 34m
Deal found 10/26![United Airlines logo]()
$606
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/68:31 pm -
1 stop14h 55m
Thu 12/1012:55 pm -
1 stop6h 07m
Deal found 10/27![American Airlines logo]()
$610
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1710:12 am -
1 stop7h 08m
Mon 12/2112:40 pm -
1 stop7h 32m
Deal found 10/27![Multiple Airlines logo]()
$625
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/196:47 pm -
1 stop17h 11m
Wed 12/232:27 pm -
1 stop9h 27m
Deal found 10/27![Delta logo]()
$646
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/105:04 am -
2 stops14h 57m
Thu 12/1712:42 pm -
1 stop12h 08m
Deal found 10/26![American Airlines logo]()
$650
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/47:56 pm -
1 stop20h 39m
Mon 12/75:45 pm -
1 stop22h 33m
Deal found 10/29![United Airlines logo]()
$668
This deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/238:00 am -
1 stop5h 12m
Wed 12/303:51 pm -
1 stop5h 46m
Deal found 10/26![Delta logo]()
$670
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/196:47 pm -
1 stop17h 11m
Mon 12/212:27 pm -
1 stop8h 00m
Deal found 10/27![Delta logo]()
$686
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/411:41 am -
1 stop8h 20m
Mon 12/78:15 am -
2 stops8h 42m
Deal found 10/29![American Airlines logo]()
$690
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/106:30 am -
1 stop10h 00m
Mon 12/145:45 pm -
1 stop21h 32m
Deal found 10/26![United Airlines logo]()
$706
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/196:36 pm -
1 stop17h 22m
Tue 12/221:13 pm -
1 stop8h 43m
Deal found 10/27![Delta logo]()
$710
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/188:52 pm -
1 stop19h 13m
Mon 12/2112:40 pm -
1 stop7h 32m
Deal found 10/27![Multiple Airlines logo]()
$713
Best flights from South Carolina to Cayman IslandsDiscover carefully curated flight deals from South Carolina to Cayman Islands that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 30, 2026.
Discover carefully curated flight deals from South Carolina to Cayman Islands that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 30, 2026.
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/178:14 pm -
1 stop15h 34m
Thu 1/214:07 pm -
1 stop7h 52m
Deal found 10/28![American Airlines logo]()
$546
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/106:30 am -
1 stop10h 00m
Thu 12/172:25 pm -
1 stop9h 34m
Deal found 10/26![United Airlines logo]()
$606
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/2810:12 am -
1 stop7h 08m
Mon 2/112:40 pm -
1 stop7h 37m
Deal found 10/27![Multiple Airlines logo]()
$624
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/196:47 pm -
1 stop17h 11m
Wed 12/232:27 pm -
1 stop9h 27m
Deal found 10/27![Delta logo]()
$646
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/68:31 pm -
1 stop14h 55m
Thu 12/1012:55 pm -
1 stop6h 07m
Deal found 10/27![American Airlines logo]()
$610
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/226:05 am -
1 stop7h 10m
Mon 3/12:25 pm -
1 stop26h 57m
Deal found 10/27![United Airlines logo]()
$615
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/186:45 am -
1 stop5h 55m
Thu 2/252:05 pm -
1 stop6h 09m
Deal found 10/29![Delta logo]()
$691
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/178:05 am -
2 stops11h 45m
Fri 1/228:25 am -
2 stops10h 09m
Deal found 10/28![American Airlines logo]()
$630
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/47:56 pm -
1 stop20h 39m
Mon 12/75:45 pm -
1 stop22h 33m
Deal found 10/29![United Airlines logo]()
$668
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/197:55 pm -
1 stop15h 05m
Thu 2/252:05 pm -
1 stop7h 16m
Deal found 10/29![Delta logo]()
$691
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/228:00 am -
2 stops11h 55m
Mon 3/11:05 pm -
1 stop10h 38m
Deal found 10/27![American Airlines logo]()
$650
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/2511:30 am -
1 stop25h 45m
Mon 3/12:25 pm -
1 stop20h 24m
Deal found 10/30![United Airlines logo]()
$671
This deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/246:15 am -
1 stop8h 21m
Wed 12/303:51 pm -
1 stop5h 46m
Deal found 10/26![Delta logo]()
$710
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/108:35 pm -
2 stops15h 20m
Thu 12/173:20 pm -
2 stops8h 39m
Deal found 10/26![American Airlines logo]()
$650
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/316:15 am -
1 stop7h 30m
Sat 2/65:10 pm -
1 stop26h 14m
Deal found 10/29![United Airlines logo]()
$686
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/196:36 pm -
1 stop17h 22m
Wed 12/233:51 pm -
1 stop5h 46m
Deal found 10/27![Delta logo]()
$710
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/45:04 am -
2 stops9h 41m
Mon 12/712:55 pm -
2 stops9h 56m
Deal found 10/29![American Airlines logo]()
$690
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/175:10 am -
1 stop7h 15m
Tue 12/223:51 pm -
1 stop6h 36m
Deal found 10/27![Delta logo]()
$744
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/259:11 am -
1 stop5h 14m
Mon 3/14:04 pm -
2 stops18h 10m
Deal found 10/30![American Airlines logo]()
$706
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/186:15 am -
1 stop7h 30m
Fri 2/262:55 pm -
1 stop23h 01m
Deal found 10/29![United Airlines logo]()
$793
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/198:57 am -
2 stops10h 58m
Fri 2/263:21 pm -
1 stop7h 59m
Deal found 10/29![American Airlines logo]()
$706
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/186:37 am -
1 stop7h 08m
Fri 2/262:55 pm -
1 stop19h 02m
Deal found 10/29![United Airlines logo]()
$807
This deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/2910:04 am -
1 stop4h 32m
Thu 12/313:51 pm -
1 stop6h 42m
Deal found 10/26![Delta logo]()
$828
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/258:18 pm -
1 stop18h 36m
Sun 2/281:05 pm -
1 stop6h 27m
Deal found 10/30![American Airlines logo]()
$707
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/146:30 am -
1 stop7h 15m
Mon 1/182:55 pm -
1 stop19h 06m
Deal found 10/26![United Airlines logo]()
$811
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/105:00 am -
1 stop6h 26m
Thu 12/173:30 pm -
1 stop8h 22m
Deal found 10/26![American Airlines logo]()
$742
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/66:00 am -
2 stops9h 15m
Sun 1/104:07 pm -
2 stops20h 18m
Deal found 10/29![American Airlines logo]()
$756
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/185:35 am -
1 stop6h 59m
Wed 12/233:51 pm -
1 stop8h 00m
Deal found 10/27![Delta logo]()
$1,082
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/66:15 am -
1 stop7h 30m
Sun 1/102:25 pm -
1 stop21h 23m
Deal found 10/29![United Airlines logo]()
$1,075
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/96:10 am -
1 stop5h 13m
Sat 11/1412:10 pm -
2 stops12h 09m
Deal found 10/29![American Airlines logo]()
$820
Last-minute flights from South Carolina to Cayman IslandsDiscover last-minute flight deals from South Carolina to Cayman Islands. Data last updated October 30, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Cayman Islands. Data last updated October 30, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/298:05 am -
1 stop4h 35m
Sun 11/11:55 pm -
1 stop6h 26m
Deal found 10/26![Delta logo]()
$886
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2911:07 am -
2 stops8h 53m
Sun 11/112:18 pm -
2 stops8h 35m
Deal found 10/26![American Airlines logo]()
$895
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/17:00 am -
1 stop7h 45m
Fri 11/612:18 pm -
1 stop9h 35m
Deal found 10/26![American Airlines logo]()
$736
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/88:32 pm -
1 stop14h 51m
Sat 11/1412:10 pm -
1 stop10h 49m
Deal found 10/27![American Airlines logo]()
$816
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/86:25 pm -
1 stop22h 55m
Sat 11/1411:25 am -
1 stop24h 49m
Deal found 10/29![Multiple Airlines logo]()
$1,091
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/96:12 am -
1 stop5h 11m
Sat 11/1412:10 pm -
1 stop10h 34m
Deal found 10/28![American Airlines logo]()
$862
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/96:20 am -
1 stop5h 03m
Sat 11/1412:10 pm -
1 stop10h 48m
Deal found 10/29![American Airlines logo]()
$862
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/97:54 pm -
3 stops20h 36m
Sat 11/145:45 pm -
2 stops20h 32m
Deal found 10/29![United Airlines logo]()
$5,334
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/106:12 am -
1 stop5h 11m
Sat 11/143:45 pm -
2 stops18h 36m
Deal found 10/25![American Airlines logo]()
$821
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:10 am -
1 stop5h 13m
Sun 11/153:45 pm -
1 stop19h 16m
Deal found 10/26![American Airlines logo]()
$783
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/218:47 pm -
1 stop20h 33m
Sat 11/2811:25 am -
1 stop22h 07m
Deal found 10/28![Multiple Airlines logo]()
$1,240
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/219:35 am -
2 stops10h 54m
Sat 11/288:15 am -
1 stop13h 35m
Deal found 10/28![American Airlines logo]()
$1,273
One-way flights from South Carolina to Cayman IslandsSearch for one-way flight options from South Carolina to Cayman Islands. Find affordable one-way fares based on user searches. Data last updated October 30, 2026.
Search for one-way flight options from South Carolina to Cayman Islands. Find affordable one-way fares based on user searches. Data last updated October 30, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/164:57 pm -
3 stops47h 08m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/29![Multiple Airlines logo]()
$290
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/58:02 am -
1 stop6h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/27![American Airlines logo]()
$338
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/167:03 am -
1 stop12h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/29![American Airlines logo]()
$352
This Mytrip deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/196:51 am -
2 stops29h 19m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/30![Air Canada logo]()
$1,001
This Mytrip deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/1911:55 am -
3 stops27h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/30![Multiple Airlines logo]()
$1,208
Find flight deals from South Carolina to Cayman Islands
Keep the following information in mind while searching for South Carolina to Cayman Islands flight deals. Data was last updated October 30, 2026.
Round-trip from | $546 (American Airlines) |
|---|---|
One-way from | $290 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Cayman Islands that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 30, 2026.
Use the filters below to find and compare flights from South Carolina to the Cayman Islands that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
CharlestonGeorge Town
CHS Charleston - GCM George Town Owen Roberts Intl
CHSGCM
Charleston
Sat 12/5
8:02 am-2:02 pm
1 stop6h 00m
George Town Owen Roberts Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$338
CharlestonGeorge Town
CHS Charleston - GCM George Town Owen Roberts Intl
CHSGCM
Charleston
Mon 11/16
7:03 am-7:53 pm
1 stop12h 50m
George Town Owen Roberts Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$352
CharlestonGeorge Town
CHS Charleston - GCM George Town Owen Roberts Intl
CHSGCM
Charleston
Sun 1/17
8:14 pm-11:48 am
1 stop15h 34m
George Town Owen Roberts Intl
Thu 1/21
4:07 pm-11:59 pm
1 stop7h 52m
$546
CharlestonGeorge Town
CHS Charleston - GCM George Town Owen Roberts Intl
CHSGCM
Charleston
Thu 12/10
6:30 am-4:30 pm
1 stop10h 00m
George Town Owen Roberts Intl
Thu 12/17
2:25 pm-11:59 pm
1 stop9h 34m
$606
GreenvilleGeorge Town
GSP Greenville - GCM George Town Owen Roberts Intl
GSPGCM
Greenville
Sun 12/6
8:31 pm-11:26 am
1 stop14h 55m
George Town Owen Roberts Intl
Thu 12/10
12:55 pm-7:02 pm
1 stop6h 07m
$610
CharlestonGeorge Town
CHS Charleston - GCM George Town Owen Roberts Intl
CHSGCM
Charleston
Mon 2/22
6:05 am-1:15 pm
1 stop7h 10m
George Town Owen Roberts Intl
Mon 3/1
2:25 pm-5:22 pm
1 stop26h 57m
$615
GreenvilleGeorge Town
GSP Greenville - GCM George Town Owen Roberts Intl
GSPGCM
Greenville
Thu 1/28
10:12 am-5:20 pm
1 stop7h 08m
George Town Owen Roberts Intl
Mon 2/1
12:40 pm-8:17 pm
1 stop7h 37m
$624
CharlestonGeorge Town
CHS Charleston - GCM George Town Owen Roberts Intl
CHSGCM
Charleston
Sun 1/17
8:05 am-7:50 pm
2 stops11h 45m
George Town Owen Roberts Intl
Fri 1/22
8:25 am-6:34 pm
2 stops10h 09m
$630
CharlestonGeorge Town
CHS Charleston - GCM George Town Owen Roberts Intl
CHSGCM
Charleston
Sat 12/19
6:47 pm-11:58 am
1 stop17h 11m
George Town Owen Roberts Intl
Wed 12/23
2:27 pm-11:54 pm
1 stop9h 27m
$646
CharlestonGeorge Town
CHS Charleston - GCM George Town Owen Roberts Intl
CHSGCM
Charleston
Mon 2/22
8:00 am-7:55 pm
2 stops11h 55m
George Town Owen Roberts Intl
Mon 3/1
1:05 pm-11:43 pm
1 stop10h 38m
$650
Showing 1-10 of 32 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Cayman Islands
Have a flexible travel schedule? Discover the best time to fly to Cayman Islands from South Carolina with our price prediction graph.
CHS-GCM
GSP-GCM
MYR-GCM
CAE-GCM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to the Cayman Islands
USSC-KY0
CHS-GCM
GSP-GCM
MYR-GCM
CAE-GCM
No data available for this route at this time. Please check back soon.
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Cayman Islands. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for South Carolina to Cayman Islands
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Complete your trip
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Search flights from South Carolina to Cayman Islands by cabin class
Find flights from South Carolina to Cayman Islands, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Cayman Islands flights
Browse other South Carolina and Cayman Islands flight options. Last updated on October 30, 2026.
Popular flight searches
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Fly to Cayman Islands regions
Consider these flights traveling to Cayman Islands regions.
Top 2 airlines flying from South Carolina to Cayman Islands
Discover the top 2 airlines that operate flights from South Carolina to Cayman Islands. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 30, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$287 | Average$455 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$289 | Average$703 | FlexibilityNo cancel fee | On-time71% |