$244+ Cheap flights from South Carolina to the Cayman Islands
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/31. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — GCM
Oct 22 — Oct 291
Round-trip
1 adult, Economy
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Find cheap flights from South Carolina to Cayman Islands with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from South Carolina to Cayman IslandsExplore the most affordable flight options available from South Carolina to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 22, 2026.
Explore the most affordable flight options available from South Carolina to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 22, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/510:12 am -
1 stop7h 08m
Sat 11/1411:25 am -
1 stop8h 19m
Deal found 9/20![Multiple Airlines logo]()
$576
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:30 am -
1 stop10h 00m
Fri 11/135:45 pm -
1 stop22h 34m
Deal found 9/21![United Airlines logo]()
$597
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/15:05 am -
1 stop6h 18m
Fri 11/612:54 pm -
1 stop11h 05m
Deal found 9/18![American Airlines logo]()
$605
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:12 pm -
2 stops44h 23m
Fri 10/3011:25 am -
1 stop23h 19m
Deal found 9/22![Multiple Airlines logo]()
$605
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/110:12 am -
1 stop8h 08m
Sat 10/311:25 am -
1 stop7h 19m
Deal found 9/21![Multiple Airlines logo]()
$613
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/257:21 am -
1 stop12h 45m
Thu 12/312:18 pm -
1 stop9h 35m
Deal found 9/20![American Airlines logo]()
$620
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/56:25 pm -
1 stop21h 40m
Thu 11/123:35 pm -
2 stops44h 09m
Deal found 9/21![Multiple Airlines logo]()
$625
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/110:12 am -
1 stop8h 08m
Mon 10/512:40 pm -
1 stop25h 49m
Deal found 9/21![Multiple Airlines logo]()
$625
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:12 pm -
2 stops44h 23m
Thu 10/2912:40 pm -
1 stop22h 04m
Deal found 9/22![Multiple Airlines logo]()
$627
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/176:31 am -
2 stops7h 54m
Thu 12/2412:36 pm -
2 stops9h 52m
Deal found 9/22![American Airlines logo]()
$632
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/287:08 am -
1 stop5h 22m
Wed 11/43:45 pm -
1 stop6h 05m
Deal found 9/21![American Airlines logo]()
$634
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/218:10 am -
1 stop6h 26m
Thu 12/243:51 pm -
1 stop6h 52m
Deal found 9/21![Delta logo]()
$639
Best flights from South Carolina to Cayman IslandsDiscover carefully curated flight deals from South Carolina to Cayman Islands that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 22, 2026.
Discover carefully curated flight deals from South Carolina to Cayman Islands that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 22, 2026.
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:30 am -
1 stop10h 00m
Fri 11/135:45 pm -
1 stop22h 34m
Deal found 9/21![United Airlines logo]()
$597
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/15:05 am -
1 stop6h 18m
Fri 11/612:54 pm -
1 stop11h 05m
Deal found 9/20![American Airlines logo]()
$605
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/258:10 am -
1 stop6h 26m
Wed 12/303:51 pm -
1 stop8h 03m
Deal found 9/21![Delta logo]()
$605
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/56:25 pm -
1 stop21h 40m
Thu 11/123:35 pm -
2 stops44h 09m
Deal found 9/21![Multiple Airlines logo]()
$625
This American Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/85:05 am -
1 stop6h 18m
Sat 11/141:25 pm -
1 stop7h 17m
Deal found 9/19![American Airlines logo]()
$605
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:12 pm -
2 stops44h 23m
Thu 10/2912:40 pm -
1 stop22h 04m
Deal found 9/22![Multiple Airlines logo]()
$627
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/257:10 am -
1 stop7h 26m
Mon 12/283:51 pm -
1 stop8h 03m
Deal found 9/21![Delta logo]()
$645
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/146:30 am -
1 stop7h 15m
Mon 1/182:55 pm -
1 stop18h 56m
Deal found 9/22![United Airlines logo]()
$663
This American Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/135:05 am -
2 stops6h 50m
Mon 11/1612:55 pm -
2 stops10h 57m
Deal found 9/19![American Airlines logo]()
$650
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/298:05 am -
1 stop4h 35m
Thu 11/51:55 pm -
1 stop6h 26m
Deal found 9/21![Delta logo]()
$669
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/286:12 am -
1 stop5h 47m
Fri 2/512:54 pm -
1 stop7h 54m
Deal found 9/18![American Airlines logo]()
$661
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/286:49 am -
1 stop9h 41m
Fri 11/65:45 pm -
1 stop21h 29m
Deal found 9/21![United Airlines logo]()
$753
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:49 am -
1 stop9h 41m
Tue 11/35:45 pm -
1 stop28h 14m
Deal found 9/21![United Airlines logo]()
$753
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/55:00 am -
1 stop6h 23m
Thu 11/1212:18 pm -
1 stop7h 49m
Deal found 9/21![American Airlines logo]()
$689
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/56:43 pm -
2 stops20h 02m
Thu 11/1212:55 pm -
2 stops11h 00m
Deal found 9/21![American Airlines logo]()
$694
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:49 am -
1 stop9h 41m
Sun 11/15:45 pm -
1 stop22h 25m
Deal found 9/21![United Airlines logo]()
$801
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/226:30 am -
1 stop6h 00m
Thu 10/2912:25 pm -
1 stop8h 37m
Deal found 9/22![American Airlines logo]()
$701
This United Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/136:30 am -
1 stop10h 00m
Wed 12/165:45 pm -
1 stop28h 04m
Deal found 9/18![United Airlines logo]()
$825
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/56:53 am -
2 stops7h 52m
Sat 11/143:45 pm -
2 stops7h 09m
Deal found 9/20![American Airlines logo]()
$714
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/216:00 am -
1 stop10h 45m
Fri 12/2512:36 pm -
2 stops9h 16m
Deal found 9/21![American Airlines logo]()
$741
This American Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/48:30 pm -
1 stop16h 00m
Sun 10/1112:35 pm -
1 stop8h 27m
Deal found 9/19![American Airlines logo]()
$746
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/268:33 pm -
2 stops15h 27m
Thu 11/58:23 am -
1 stop11h 19m
Deal found 9/21![American Airlines logo]()
$754
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/145:30 am -
1 stop9h 45m
Mon 1/181:09 pm -
1 stop7h 37m
Deal found 9/20![American Airlines logo]()
$775
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/57:54 pm -
3 stops20h 36m
Thu 11/125:45 pm -
3 stops20h 32m
Deal found 9/21![United Airlines logo]()
$5,753
Last-minute flights from South Carolina to Cayman IslandsDiscover last-minute flight deals from South Carolina to Cayman Islands. Data last updated September 22, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Cayman Islands. Data last updated September 22, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/308:24 pm -
1 stop21h 56m
Sat 10/311:25 am -
1 stop21h 07m
Deal found 9/21![Multiple Airlines logo]()
$674
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/110:12 am -
1 stop8h 08m
Sat 10/311:25 am -
1 stop7h 19m
Deal found 9/21![Multiple Airlines logo]()
$613
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/110:12 am -
1 stop8h 08m
Mon 10/512:40 pm -
1 stop25h 49m
Deal found 9/21![Multiple Airlines logo]()
$625
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/110:12 am -
1 stop8h 08m
Sun 10/412:40 pm -
2 stops29h 00m
Deal found 9/21![Multiple Airlines logo]()
$663
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/228:10 pm -
2 stops41h 35m
Fri 10/3011:25 am -
1 stop23h 19m
Deal found 9/22![Multiple Airlines logo]()
$676
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:12 pm -
2 stops44h 23m
Fri 10/3011:25 am -
1 stop23h 19m
Deal found 9/22![Multiple Airlines logo]()
$605
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:12 pm -
2 stops44h 23m
Thu 10/2912:40 pm -
1 stop22h 04m
Deal found 9/22![Multiple Airlines logo]()
$627
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/287:08 am -
1 stop5h 22m
Wed 11/43:45 pm -
1 stop6h 05m
Deal found 9/21![American Airlines logo]()
$634
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/288:24 pm -
1 stop21h 56m
Sun 11/112:40 pm -
2 stops19h 35m
Deal found 9/21![Multiple Airlines logo]()
$669
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2910:12 am -
1 stop8h 08m
Sun 11/112:40 pm -
2 stops19h 35m
Deal found 9/21![Multiple Airlines logo]()
$644
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2910:12 am -
1 stop8h 08m
Mon 11/212:40 pm -
1 stop7h 32m
Deal found 9/21![Multiple Airlines logo]()
$658
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/308:52 pm -
1 stop20h 13m
Mon 11/212:40 pm -
1 stop7h 32m
Deal found 9/21![Multiple Airlines logo]()
$652
One-way flights from South Carolina to Cayman IslandsSearch for one-way flight options from South Carolina to Cayman Islands. Find affordable one-way fares based on user searches. Data last updated September 22, 2026.
Search for one-way flight options from South Carolina to Cayman Islands. Find affordable one-way fares based on user searches. Data last updated September 22, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/3110:12 am -
1 stop7h 08m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![Multiple Airlines logo]()
$244
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/26:00 am -
1 stop7h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![United Airlines logo]()
$295
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/15:40 am -
1 stop7h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![Delta logo]()
$297
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/26:50 am -
2 stops13h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![American Airlines logo]()
$305
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/410:12 am -
1 stop7h 08m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![Multiple Airlines logo]()
$313
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/56:00 am -
1 stop6h 43m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![Delta logo]()
$314
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/305:40 am -
1 stop8h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![Delta logo]()
$322
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/51:46 pm -
2 stops28h 06m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![Multiple Airlines logo]()
$365
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/36:24 am -
2 stops13h 26m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![American Airlines logo]()
$370
Find flight deals from South Carolina to Cayman Islands
Keep the following information in mind while searching for South Carolina to Cayman Islands flight deals. Data was last updated September 22, 2026.
Round-trip from | $545 (United Airlines) |
|---|---|
One-way from | $244 (Kiwi.com) |
Popular in | September |
Cheapest in | January |
Average price | $999 |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Cayman Islands that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 22, 2026.
Use the filters below to find and compare flights from South Carolina to the Cayman Islands that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
GreenvilleGeorge Town
GSP Greenville - GCM George Town Owen Roberts Intl
GSPGCM
Greenville
Tue 2/2
6:00 am-1:15 pm
1 stop7h 15m
George Town Owen Roberts Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$295
GreenvilleGeorge Town
GSP Greenville - GCM George Town Owen Roberts Intl
GSPGCM
Greenville
Tue 2/2
5:40 am-12:40 pm
1 stop7h 00m
George Town Owen Roberts Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$297
GreenvilleGeorge Town
GSP Greenville - GCM George Town Owen Roberts Intl
GSPGCM
Greenville
Mon 2/1
5:40 am-12:40 pm
1 stop7h 00m
George Town Owen Roberts Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$297
GreenvilleGeorge Town
GSP Greenville - GCM George Town Owen Roberts Intl
GSPGCM
Greenville
Thu 2/4
10:12 am-5:20 pm
1 stop7h 08m
George Town Owen Roberts Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$313
CharlestonGeorge Town
CHS Charleston - GCM George Town Owen Roberts Intl
CHSGCM
Charleston
Sat 12/5
7:50 am-7:58 pm
2 stops12h 08m
George Town Owen Roberts Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$314
Quickest round-trip
CharlestonGeorge Town
CHS Charleston - GCM George Town Owen Roberts Intl
CHSGCM
Charleston
Sat 12/5
6:00 am-12:43 pm
1 stop6h 43m
George Town Owen Roberts Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$314
GreenvilleGeorge Town
GSP Greenville - GCM George Town Owen Roberts Intl
GSPGCM
Greenville
Sat 1/30
5:40 am-2:15 pm
1 stop8h 35m
George Town Owen Roberts Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$322
GreenvilleGeorge Town
GSP Greenville - GCM George Town Owen Roberts Intl
GSPGCM
Greenville
Sun 1/31
3:57 pm-5:20 pm
3 stops25h 23m
George Town Owen Roberts Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$379
CharlestonGeorge Town
CHS Charleston - GCM George Town Owen Roberts Intl
CHSGCM
Charleston
Fri 11/6
6:30 am-4:30 pm
1 stop10h 00m
George Town Owen Roberts Intl
Fri 11/13
5:45 pm-4:19 pm
1 stop22h 34m
$597
CharlestonGeorge Town
CHS Charleston - GCM George Town Owen Roberts Intl
CHSGCM
Charleston
Sun 11/1
5:05 am-11:23 am
1 stop6h 18m
George Town Owen Roberts Intl
Fri 11/6
12:54 pm-11:59 pm
1 stop11h 05m
$605
Showing 1-10 of 32 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Cayman Islands
Have a flexible travel schedule? Discover the best time to fly to Cayman Islands from South Carolina with our price prediction graph.
MYR-GCM
GSP-GCM
CHS-GCM
CAE-GCM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to the Cayman Islands
USSC-KY0
MYR-GCM
GSP-GCM
CHS-GCM
CAE-GCM
What is the cheapest month to book a flight from South Carolina to Cayman Islands?
Currently, January is the cheapest month in which you can book a flight from South Carolina to Cayman Islands (average of $309). Flying from South Carolina to Cayman Islands in September is currently the most expensive (average of $999). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Cayman Islands. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for South Carolina to Cayman Islands
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Cayman Islands by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Cayman Islands by cabin class
Find flights from South Carolina to Cayman Islands, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Cayman Islands flights
Browse other South Carolina and Cayman Islands flight options. Last updated on September 22, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Fly to Cayman Islands regions
Consider these flights traveling to Cayman Islands regions.
Top 2 airlines flying from South Carolina to Cayman Islands
Discover the top 2 airlines that operate flights from South Carolina to Cayman Islands. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 22, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$287 | Average$455 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$289 | Average$703 | FlexibilityNo cancel fee | On-time71% |