HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Cayman Islands

$106+ Cheap flights from Missouri to the Cayman Islands

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/23. Fares are subject to change and may not be available on all flights or dates of travel.
STL — GCM
Feb 14 — Feb 211
Sat 2/14
Sat 2/21
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Missouri to Cayman Islands with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Missouri to Cayman Islands

Keep the following information in mind while searching for Missouri to Cayman Islands flight deals. Data was last updated January 15, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$317
(American Airlines)

One-way from

$106
(American Airlines)

Popular in

March

Cheapest in

September

Average price

$571
Provider with most accurate pricing for Lambert-St Louis-George Town Owen Roberts Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-George Town Owen Roberts Intl flights.
Search Deals
From Missouri to Cayman Islands
Search Deals
One-way flight from Missouri to Cayman Islands
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($58 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($15 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Find flight deals from Missouri to Cayman Islands

Cheapest flights from Missouri to Cayman Islands
Explore the most affordable flight options available from Missouri to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 15, 2026.

This Air Canada deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/184:05 pm
STL
-
GCM
1 stop19h 05m
Air Canada
Sat 5/212:25 pm
GCM
-
STL
1 stop7h 39m
Air Canada
Deal found 1/14$361
This Delta deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/235:35 am
MCI
-
GCM
1 stop5h 54m
Delta
Wed 3/41:54 pm
GCM
-
MCI
1 stop10h 46m
Delta
Deal found 1/14$387
This American Airlines deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/185:14 am
STL
-
GCM
1 stop14h 01m
American Airlines
Wed 3/44:25 pm
GCM
-
STL
1 stop17h 30m
American Airlines
Deal found 1/14$387
This Kiwi.com deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/254:24 pm
MCI
-
GCM
2 stops20h 19m
Spirit Airlines
Thu 3/52:49 pm
GCM
-
MCI
1 stop20h 41m
Spirit Airlines
Deal found 1/14$391
This American Airlines deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/15:30 am
MCI
-
GCM
2 stops13h 45m
American Airlines
Thu 3/512:50 pm
GCM
-
MCI
1 stop10h 59m
American Airlines
Deal found 1/13$392
This Kiwi.com deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/2310:55 am
MCI
-
GCM
2 stops28h 10m
Multiple Airlines
Thu 3/52:49 pm
GCM
-
MCI
1 stop20h 41m
Multiple Airlines
Deal found 1/14$394
This Air Canada deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/284:05 pm
STL
-
GCM
1 stop19h 20m
Air Canada
Thu 2/191:30 pm
GCM
-
STL
1 stop26h 59m
Air Canada
Deal found 1/14$405
This Gotogate deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/61:00 pm
STL
-
GCM
2 stops46h 30m
Air Canada
Sat 6/1312:25 pm
GCM
-
STL
1 stop23h 41m
Air Canada
Deal found 1/14$408
This Delta deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/265:35 am
MCI
-
GCM
1 stop5h 54m
Delta
Tue 3/31:54 pm
GCM
-
MCI
1 stop7h 47m
Delta
Deal found 1/14$412
This Kiwi.com deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/287:00 am
MCI
-
GCM
2 stops29h 43m
Spirit Airlines
Thu 3/52:49 pm
GCM
-
MCI
1 stop20h 41m
Spirit Airlines
Deal found 1/14$413
This American Airlines deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/96:28 pm
MCI
-
GCM
2 stops18h 43m
American Airlines
Sat 5/164:03 pm
GCM
-
MCI
1 stop7h 15m
American Airlines
Deal found 1/13$417
This American Airlines deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/186:53 pm
STL
-
GCM
2 stops18h 18m
American Airlines
Sat 5/22:10 pm
GCM
-
STL
2 stops18h 18m
American Airlines
Deal found 1/14$417

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Cayman Islands that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 15, 2026.
Use the filters below to find and compare flights from Missouri to the Cayman Islands that are best for you.

Fly from

Missouri

Fly to

Cayman Islands

Route

Depart

Return

Price

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

Sat 4/18

4:05 pm-11:10 am

1 stop19h 05m

George Town Owen Roberts Intl

Sat 5/2

12:25 pm-8:04 pm

1 stop7h 39m

$361

Kansas CityGeorge Town

MCI - GCM

MCIGCM

Kansas City

Mon 2/23

5:35 am-12:29 pm

1 stop5h 54m

George Town Owen Roberts Intl

Tue 3/3

1:54 pm-8:41 pm

1 stop7h 47m

$387

Kansas CityGeorge Town

MCI - GCM

MCIGCM

Kansas City

Mon 2/23

5:35 am-12:29 pm

1 stop5h 54m

George Town Owen Roberts Intl

Thu 3/5

1:54 pm-8:07 pm

1 stop7h 13m

$387

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

Wed 2/18

7:05 am-8:15 pm

2 stops12h 10m

George Town Owen Roberts Intl

Wed 3/4

8:45 am-11:56 pm

1 stop16h 11m

$392

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

Sat 6/6

1:00 pm-11:30 am

2 stops46h 30m

George Town Owen Roberts Intl

Sat 6/13

12:25 pm-12:06 pm

1 stop23h 41m

$408

Kansas CityGeorge Town

MCI - GCM

MCIGCM

Kansas City

Thu 2/26

5:35 am-12:29 pm

1 stop5h 54m

George Town Owen Roberts Intl

Tue 3/3

1:54 pm-8:41 pm

1 stop7h 47m

$412

Kansas CityGeorge Town

MCI - GCM

MCIGCM

Kansas City

Fri 2/27

6:16 pm-11:00 am

1 stop15h 44m

George Town Owen Roberts Intl

Tue 3/3

1:54 pm-8:41 pm

1 stop7h 47m

$412

Kansas CityGeorge Town

MCI - GCM

MCIGCM

Kansas City

Sat 2/28

5:35 am-2:15 pm

1 stop7h 40m

George Town Owen Roberts Intl

Thu 3/5

1:54 pm-8:07 pm

1 stop7h 13m

$412

Kansas CityGeorge Town

MCI - GCM

MCIGCM

Kansas City

Sat 5/9

6:28 pm-1:11 pm

2 stops18h 43m

George Town Owen Roberts Intl

Sat 5/16

4:03 pm-11:18 pm

1 stop7h 15m

$417

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

Sat 4/18

6:53 pm-11:00 am

2 stops16h 07m

George Town Owen Roberts Intl

Sat 5/2

3:13 pm-11:04 pm

1 stop7h 51m

$417

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/15

Showing 1-10 of 26 results
1
2
3

Best time to book a flight from Missouri to Cayman Islands

Have a flexible travel schedule? Discover the best time to fly to Cayman Islands from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to the Cayman Islands

What is the cheapest month to book a flight from Missouri to Cayman Islands?

Currently, May is the cheapest month in which you can book a flight from Missouri to Cayman Islands (average of $239). Flying from Missouri to Cayman Islands in March is currently the most expensive (average of $500). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Cayman Islands. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Missouri to Cayman Islands?

    Departing from Missouri to Cayman Islands will take you 5h 54m. The distance between Missouri and Cayman Islands is about 1594 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Missouri to Cayman Islands that include hotel bookings?

    Yes. In addition to deals on Missouri to Cayman Islands flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Cayman Islands?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Cayman Islands.

  • Can I find deals for business class flights from Missouri to Cayman Islands?

    Yes. Cheapflights offers flight deals from Missouri to Cayman Islands by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Cayman Islands?

    Currently, May is the cheapest month in which you can book a flight from Missouri to Cayman Islands (average of $239). Flying from Missouri to Cayman Islands in March is currently the most expensive (average of $500). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Missouri to Cayman Islands

See prices for flight routes from nearby airports that may be better suited for you.
John F Kennedy Intl to Luis Munoz Marin Intl flights
Newark to Luis Munoz Marin Intl flights
LaGuardia to Luis Munoz Marin Intl flights
Newark to Punta Cana flights
John F Kennedy Intl to Punta Cana flights
Dulles Intl to Luis Munoz Marin Intl flights
John F Kennedy Intl to Santo Domingo flights
Newark to Santiago de los Caballeros flights
O'Hare Intl to Luis Munoz Marin Intl flights
Philadelphia to Luis Munoz Marin Intl flights
Boston to Luis Munoz Marin Intl flights
John F Kennedy Intl to Santiago de los Caballeros flights
Newark to Santo Domingo flights
Newark to Oranjestad flights
Reagan-National to Luis Munoz Marin Intl flights
Baltimore to Luis Munoz Marin Intl flights
John F Kennedy Intl to Oranjestad flights
Dallas/Fort Worth to Luis Munoz Marin Intl flights
LaGuardia to Punta Cana flights
Fort Lauderdale to Luis Munoz Marin Intl flights
Orlando to Luis Munoz Marin Intl flights
Hartford to Luis Munoz Marin Intl flights
John F Kennedy Intl to Montego Bay flights
Atlanta to Luis Munoz Marin Intl flights
Newark to Nassau flights
O'Hare Intl to Punta Cana flights
Boston to Oranjestad flights
Orlando to Punta Cana flights
John F Kennedy Intl to Nassau flights
Dulles Intl to Punta Cana flights
Raleigh to Luis Munoz Marin Intl flights
Tampa to Luis Munoz Marin Intl flights
LaGuardia to Santo Domingo flights
Newark to Montego Bay flights
Newark to Simpson Bay flights
John F Kennedy Intl to Port of Spain flights
Boston to Punta Cana flights
Minneapolis to Luis Munoz Marin Intl flights
John F Kennedy Intl to Simpson Bay flights
LaGuardia to Oranjestad flights
Detroit to Luis Munoz Marin Intl flights
Hobby to Luis Munoz Marin Intl flights
John F Kennedy Intl to Providenciales flights
Newark to Providenciales flights
Midway to Luis Munoz Marin Intl flights
John F Kennedy Intl to Saint Thomas Island flights
Newark to Saint Thomas Island flights
LaGuardia to Nassau flights
LaGuardia to Santiago de los Caballeros flights
Miami to Luis Munoz Marin Intl flights

Top 4 airlines flying from Missouri to Cayman Islands

Discover the top 4 airlines that operate flights from Missouri to Cayman Islands. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 15, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$198Average$584FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$238Average$618FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$421Average$578FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$429Average$585FlexibilityNo cancel feeOn-time63%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.