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Cayman Islands

$446+ Cheap flights from Missouri to the Cayman Islands

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/15. Fares are subject to change and may not be available on all flights or dates of travel.
STL — GCM
oct. 22 — oct. 291
mié. 10/22
mié. 10/29
1 adult, Economy
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Cheap flight deals from Missouri to Cayman Islands

Keep the following information in mind while searching for Missouri to Cayman Islands flight deals. Data was last updated septiembre 22, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$446
(Delta)

Popular in

August

Cheapest in

July

Average price

$527
Provider with most accurate pricing for Kansas City-George Town Owen Roberts Intl flight deals.
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Provider most trusted by Cheapflights users for Kansas City-George Town Owen Roberts Intl flights.
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From Missouri to Cayman Islands
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High demand for flights, 4% potential price rise
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Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Missouri to Cayman Islands

Cheapest flights from Missouri to Cayman Islands
Explore the most affordable flight options available from Missouri to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septiembre 22, 2025.

This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/155:45 amMCI - GCM
1 stop5h 50mDelta
mar. 12/233:42 pmGCM - MCI
1 stop9h 15mDelta
Deal found 9/21$446
This Delta deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/296:00 amSTL - GCM
1 stop5h 37mDelta
mar. 12/301:52 pmGCM - STL
1 stop10h 47mDelta
Deal found 9/22$446
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 10/116:35 pmMCI - GCM
1 stop16h 50mAmerican Airlines
mar. 10/148:25 amGCM - MCI
2 stops14h 25mAmerican Airlines
Deal found 9/20$450
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 11/56:04 pmSTL - GCM
1 stop16h 53mAmerican Airlines
mié. 11/121:20 pmGCM - STL
1 stop10h 07mAmerican Airlines
Deal found 9/21$460
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 11/55:20 pmMCI - GCM
2 stops17h 53mAmerican Airlines
mié. 11/123:36 pmGCM - MCI
2 stops18h 00mAmerican Airlines
Deal found 9/21$475
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 10/187:16 amSTL - GCM
2 stops12h 04mAmerican Airlines
sáb. 10/258:25 amGCM - STL
1 stop15h 31mAmerican Airlines
Deal found 9/20$478
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/155:45 amMCI - GCM
1 stop5h 50mDelta
vie. 12/261:52 pmGCM - MCI
1 stop8h 03mDelta
Deal found 9/21$491
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 11/196:00 amMCI - GCM
2 stops13h 28mAmerican Airlines
mié. 12/173:45 pmGCM - MCI
1 stop9h 40mAmerican Airlines
Deal found 9/21$495
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/65:04 amMCI - GCM
1 stop6h 09mAmerican Airlines
lun. 11/109:00 amGCM - MCI
1 stop15h 59mAmerican Airlines
Deal found 9/20$496
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/165:05 amMCI - GCM
1 stop6h 05mAmerican Airlines
jue. 12/254:30 pmGCM - MCI
1 stop7h 24mAmerican Airlines
Deal found 9/21$536
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/84:54 pmMCI - GCM
2 stops18h 31mAmerican Airlines
mié. 10/1512:25 pmGCM - MCI
2 stops10h 34mAmerican Airlines
Deal found 9/22$539
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/156:15 amMCI - GCM
1 stop9h 15mUnited Airlines
jue. 12/255:10 pmGCM - MCI
2 stops17h 08mUnited Airlines
Deal found 9/21$540

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Cayman Islands that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 22, 2025.
Use the filters below to find and compare flights from Missouri to the Cayman Islands that are best for you.

Fly from

Missouri

Fly to

Cayman Islands

Route

Depart

Return

Price

Kansas CityGeorge Town

MCI - GCM

MCIGCM

Kansas City

lun. 12/15

5:45 am-12:35 pm

1 stop5h 50m

George Town Owen Roberts Intl

mar. 12/23

3:42 pm-11:57 pm

1 stop9h 15m

$446

Kansas CityGeorge Town

MCI - GCM

MCIGCM

Kansas City

sáb. 10/11

6:35 pm-11:25 am

1 stop16h 50m

George Town Owen Roberts Intl

mar. 10/14

8:25 am-10:59 pm

1 stop14h 34m

$446

Kansas CityGeorge Town

MCI - GCM

MCIGCM

Kansas City

lun. 12/15

5:45 am-12:35 pm

1 stop5h 50m

George Town Owen Roberts Intl

mié. 12/24

3:42 pm-11:57 pm

1 stop9h 15m

$446

Kansas CityGeorge Town

MCI - GCM

MCIGCM

Kansas City

lun. 12/15

5:45 am-12:35 pm

1 stop5h 50m

George Town Owen Roberts Intl

jue. 12/25

1:52 pm-11:57 pm

1 stop11h 05m

$446

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

lun. 12/29

6:00 am-12:37 pm

1 stop5h 37m

George Town Owen Roberts Intl

mié. 12/31

3:42 pm-11:39 pm

1 stop8h 57m

$446

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

mar. 12/30

6:00 am-12:37 pm

1 stop5h 37m

George Town Owen Roberts Intl

mié. 12/31

3:42 pm-11:39 pm

1 stop8h 57m

$446

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

lun. 12/29

6:00 am-12:37 pm

1 stop5h 37m

George Town Owen Roberts Intl

jue. 1/1

1:52 pm-11:39 pm

1 stop10h 47m

$446

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

mié. 11/5

5:58 pm-11:57 am

2 stops16h 59m

George Town Owen Roberts Intl

mié. 11/12

1:05 pm-11:07 pm

1 stop11h 02m

$464

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

sáb. 10/18

8:42 am-7:20 pm

2 stops10h 38m

George Town Owen Roberts Intl

sáb. 10/25

8:25 am-8:53 pm

2 stops12h 28m

$478

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

jue. 2/5

6:30 am-1:45 pm

1 stop6h 15m

George Town Owen Roberts Intl

mar. 2/10

2:25 pm-2:30 pm

2 stops25h 05m

$488

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/21

Showing 1-10 of 18 results
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Best time to book a flight from Missouri to Cayman Islands

Have a flexible travel schedule? Discover the best time to fly to Cayman Islands from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to the Cayman Islands

What is the cheapest month to book a flight from Missouri to Cayman Islands?

Currently, January is the cheapest month in which you can book a flight from Missouri to Cayman Islands (average of $467). Flying from Missouri to Cayman Islands in March is currently the most expensive (average of $594). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to KY?

Find hourly flight availability from Missouri to Cayman Islands. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated septiembre 22, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Missouri to Cayman Islands as you normally would.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Cayman Islands. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Missouri to Cayman Islands?

    Departing from Missouri to Cayman Islands will take you 5h 50m. The distance between Missouri and Cayman Islands is about 1594 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Missouri to Cayman Islands that include hotel bookings?

    Yes. In addition to deals on Missouri to Cayman Islands flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Cayman Islands?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Cayman Islands.

  • Can I find deals for business class flights from Missouri to Cayman Islands?

    Yes. Cheapflights offers flight deals from Missouri to Cayman Islands by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Cayman Islands?

    Currently, January is the cheapest month in which you can book a flight from Missouri to Cayman Islands (average of $467). Flying from Missouri to Cayman Islands in March is currently the most expensive (average of $594). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Missouri to Cayman Islands

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Missouri to Cayman Islands

Discover the top 4 airlines that operate flights from Missouri to Cayman Islands. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 22, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$216Average$587FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$238Average$629FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$429Average$638FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$439Average$630FlexibilityNo cancel feeOn-time71%

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