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Cayman Islands

$190+ Cheap flights from Missouri to the Cayman Islands

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/29. Fares are subject to change and may not be available on all flights or dates of travel.
STL — GCM
Dec 30 — Jan 61
Tue 12/30
Tue 1/6
1 adult, Economy
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Find flight deals from Missouri to Cayman Islands

Cheapest flights from Missouri to Cayman Islands
Explore the most affordable flight options available from Missouri to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 30, 2025.

This Delta deal was found by Cheapflights users on 11/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/306:00 amSTL - GCM
1 stop5h 36mDelta
Wed 12/311:52 pmGCM - STL
1 stop10h 46mDelta
Deal found 11/28$367
This Kiwi.com deal was found by Cheapflights users on 11/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1911:13 amMCI - GCM
2 stops28h 42mMultiple Airlines
Sun 12/282:40 pmGCM - MCI
1 stop27h 30mMultiple Airlines
Deal found 11/26$397
This American Airlines deal was found by Cheapflights users on 11/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/295:30 amSTL - GCM
2 stops29h 35mAmerican Airlines
Wed 12/3112:55 pmGCM - STL
1 stop7h 35mAmerican Airlines
Deal found 11/28$442
This Kiwi.com deal was found by Cheapflights users on 11/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/196:15 pmMCI - GCM
1 stop21h 40mSpirit Airlines
Sun 12/282:40 pmGCM - MCI
1 stop27h 30mSpirit Airlines
Deal found 11/26$456
This United Airlines deal was found by Cheapflights users on 11/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/293:10 pmSTL - GCM
1 stop21h 35mUnited Airlines
Wed 12/315:45 pmGCM - STL
1 stop29h 10mUnited Airlines
Deal found 11/28$477
This Delta deal was found by Cheapflights users on 11/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/238:00 amMCI - GCM
1 stop5h 27mDelta
Thu 1/11:52 pmGCM - MCI
1 stop6h 46mDelta
Deal found 11/27$484
This Delta deal was found by Cheapflights users on 11/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/218:00 amMCI - GCM
1 stop5h 27mDelta
Fri 12/261:52 pmGCM - MCI
1 stop7h 20mDelta
Deal found 11/28$510
This American Airlines deal was found by Cheapflights users on 11/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/195:12 amMCI - GCM
1 stop8h 23mAmerican Airlines
Tue 12/2312:50 pmGCM - MCI
1 stop13h 04mAmerican Airlines
Deal found 11/28$585
This United Airlines deal was found by Cheapflights users on 11/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/217:40 amMCI - GCM
1 stop29h 05mUnited Airlines
Fri 12/265:10 pmGCM - MCI
2 stops17h 08mUnited Airlines
Deal found 11/28$607
This American Airlines deal was found by Cheapflights users on 11/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/111:40 amMCI - GCM
1 stop7h 48mAmerican Airlines
Mon 12/223:11 pmGCM - MCI
1 stop9h 42mAmerican Airlines
Deal found 11/28$629

Cheap flight deals from Missouri to Cayman Islands

Keep the following information in mind while searching for Missouri to Cayman Islands flight deals. Data was last updated November 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$306
(Kiwi.com)

One-way from

$190
(United Airlines)

Popular in

March

Cheapest in

September

Average price

$544
Provider with most accurate pricing for Lambert-St Louis-George Town Owen Roberts Intl flight deals.
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Provider most trusted by Cheapflights users for Lambert-St Louis-George Town Owen Roberts Intl flights.
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From Missouri to Cayman Islands
Search Deals
One-way flight from Missouri to Cayman Islands
Search Deals
Highest demand for flights based on searches. 10% potential increase in price ($72 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($15 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Cayman Islands that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 30, 2025.
Use the filters below to find and compare flights from Missouri to the Cayman Islands that are best for you.

Fly from

Missouri

Fly to

Cayman Islands

Route

Depart

Return

Price

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

Tue 12/30

6:00 am-12:36 pm

1 stop5h 36m

George Town Owen Roberts Intl

Wed 12/31

3:42 pm-11:38 pm

1 stop8h 56m

$367

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

Fri 1/23

6:57 pm-10:57 am

1 stop15h 00m

George Town Owen Roberts Intl

Wed 1/28

2:05 pm-11:37 pm

1 stop10h 32m

$397

Kansas CityGeorge Town

MCI - GCM

MCIGCM

Kansas City

Sun 1/25

5:50 am-12:40 pm

1 stop5h 50m

George Town Owen Roberts Intl

Thu 1/29

2:05 pm-8:02 pm

1 stop6h 57m

$475

Kansas CityGeorge Town

MCI - GCM

MCIGCM

Kansas City

Mon 1/26

5:50 am-12:40 pm

1 stop5h 50m

George Town Owen Roberts Intl

Tue 1/27

2:05 pm-10:02 pm

1 stop8h 57m

$475

Kansas CityGeorge Town

MCI - GCM

MCIGCM

Kansas City

Mon 1/26

5:50 am-12:40 pm

1 stop5h 50m

George Town Owen Roberts Intl

Wed 1/28

2:05 pm-10:02 pm

1 stop8h 57m

$476

Kansas CityGeorge Town

MCI - GCM

MCIGCM

Kansas City

Sun 1/25

5:50 am-12:40 pm

1 stop5h 50m

George Town Owen Roberts Intl

Wed 1/28

2:05 pm-11:51 pm

1 stop10h 46m

$476

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

Mon 12/29

6:35 pm-1:45 pm

1 stop18h 10m

George Town Owen Roberts Intl

Wed 12/31

5:45 pm-5:54 pm

2 stops25h 09m

$477

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

Tue 12/30

6:00 am-4:00 pm

1 stop9h 00m

George Town Owen Roberts Intl

Wed 12/31

5:10 pm-2:26 pm

2 stops22h 16m

$479

Kansas CityGeorge Town

MCI - GCM

MCIGCM

Kansas City

Sun 2/8

5:50 am-12:40 pm

1 stop5h 50m

George Town Owen Roberts Intl

Thu 2/12

1:54 pm-9:58 pm

1 stop9h 04m

$484

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

Wed 12/31

6:00 am-2:27 pm

1 stop7h 27m

George Town Owen Roberts Intl

Thu 1/1

3:42 pm-11:38 pm

1 stop8h 56m

$486

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/29

Showing 1-10 of 23 results
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Best time to book a flight from Missouri to Cayman Islands

Have a flexible travel schedule? Discover the best time to fly to Cayman Islands from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to the Cayman Islands

What is the cheapest month to book a flight from Missouri to Cayman Islands?

Currently, May is the cheapest month in which you can book a flight from Missouri to Cayman Islands (average of $239). Flying from Missouri to Cayman Islands in March is currently the most expensive (average of $526). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to KY?

Find hourly flight availability from Missouri to Cayman Islands. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 30, 2025.

When flying from Missouri to Cayman Islands, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 26% versus a flight in the morning.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Cayman Islands. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Missouri to Cayman Islands?

    Departing from Missouri to Cayman Islands will take you 5h 36m. The distance between Missouri and Cayman Islands is about 1448 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Missouri to Cayman Islands one-way?

    One-way options have recently been found by users for as low as $190 on United Airlines. Other airlines that offer cheap prices include American Airlines from $190 and Spirit Airlines from $204 one-way.

  • Can I find deals for flights from Missouri to Cayman Islands that include hotel bookings?

    Yes. In addition to deals on Missouri to Cayman Islands flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Cayman Islands?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Cayman Islands.

  • Can I find deals for business class flights from Missouri to Cayman Islands?

    Yes. Cheapflights offers flight deals from Missouri to Cayman Islands by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Cayman Islands?

    Currently, May is the cheapest month in which you can book a flight from Missouri to Cayman Islands (average of $239). Flying from Missouri to Cayman Islands in March is currently the most expensive (average of $526). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Missouri to Cayman Islands

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Missouri to Cayman Islands

Discover the top 4 airlines that operate flights from Missouri to Cayman Islands. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$238Average$630FlexibilityNo cancel feeOn-time69%
DeltaCheapest$266Average$588FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$424Average$579FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$429Average$636FlexibilityNo cancel feeOn-time63%

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