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Cayman Islands

$177+ Cheap flights from Missouri to the Cayman Islands

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/27. Fares are subject to change and may not be available on all flights or dates of travel.
STL — GCM
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheap flight deals from Missouri to Cayman Islands

Keep the following information in mind while searching for Missouri to Cayman Islands flight deals. Data was last updated September 15, 2025.

Round-trip from

$446
(Delta)

One-way from

$177
(Southwest)

Popular in

August

Cheapest in

July

Average price

$527
From Missouri to Cayman Islands
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One-way flight from Missouri to Cayman Islands
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High demand for flights, 4% potential price rise
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Cheapest flight prices on average. 1% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Missouri to Cayman Islands

Cheapest flights from Missouri to Cayman Islands
Explore the most affordable flight options available from Missouri to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2112:51 pmSTL - GCM
1 stop22h 29mAmerican Airlines
Tue 10/2812:25 pmGCM - STL
1 stop10h 40mAmerican Airlines
Deal found 9/14$447
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/76:52 amSTL - GCM
1 stop6h 18mAmerican Airlines
Wed 11/121:20 pmGCM - STL
1 stop10h 07mAmerican Airlines
Deal found 9/15$460
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/185:20 amSTL - GCM
1 stop6h 05mAmerican Airlines
Sat 10/258:25 amGCM - STL
1 stop15h 31mAmerican Airlines
Deal found 9/15$474
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/145:10 amMCI - GCM
1 stop6h 25mSouthwest
Sun 12/211:30 pmGCM - MCI
2 stops10h 20mSouthwest
Deal found 9/14$495
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/65:04 amMCI - GCM
1 stop6h 07mAmerican Airlines
Mon 11/101:15 pmGCM - MCI
1 stop11h 44mAmerican Airlines
Deal found 9/13$536
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/196:00 amSTL - GCM
1 stop5h 35mDelta
Mon 10/2712:55 pmGCM - STL
1 stop10h 46mDelta
Deal found 9/14$536
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/246:00 amSTL - GCM
1 stop5h 35mDelta
Mon 10/2712:55 pmGCM - STL
1 stop10h 46mDelta
Deal found 9/14$538
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/195:23 amSTL - GCM
1 stop5h 47mAmerican Airlines
Fri 10/3112:25 pmGCM - STL
1 stop6h 21mAmerican Airlines
Deal found 9/14$540
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/85:38 pmMCI - GCM
1 stop17h 47mAmerican Airlines
Wed 10/158:25 amGCM - MCI
1 stop14h 34mAmerican Airlines
Deal found 9/15$547
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/35:06 amMCI - GCM
1 stop6h 04mAmerican Airlines
Fri 10/108:25 amGCM - MCI
1 stop14h 34mAmerican Airlines
Deal found 9/14$580
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/106:02 amMCI - GCM
2 stops13h 18mAmerican Airlines
Fri 10/1712:25 pmGCM - MCI
1 stop11h 44mAmerican Airlines
Deal found 9/13$614
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/237:00 amMCI - GCM
1 stop6h 27mDelta
Thu 1/13:42 pmGCM - MCI
1 stop9h 15mDelta
Deal found 9/14$618

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Cayman Islands that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Missouri to the Cayman Islands that are best for you.

Fly from

Missouri

Fly to

Cayman Islands

Route

Depart

Return

Price

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

Mon 1/26

6:00 am-12:35 pm

1 stop5h 35m

George Town Owen Roberts Intl

Wed 1/28

2:00 pm-11:40 pm

1 stop10h 40m

$446

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

Fri 11/7

6:52 am-2:10 pm

1 stop6h 18m

George Town Owen Roberts Intl

Wed 11/12

1:20 pm-11:07 pm

2 stops10h 47m

$464

Kansas CityGeorge Town

MCI - GCM

MCIGCM

Kansas City

Fri 1/30

6:30 am-2:30 pm

1 stop7h 00m

George Town Owen Roberts Intl

Fri 2/6

3:45 pm-11:04 pm

1 stop8h 19m

$491

Kansas CityGeorge Town

MCI - GCM

MCIGCM

Kansas City

Sun 12/14

5:10 am-12:35 pm

1 stop6h 25m

George Town Owen Roberts Intl

Sun 12/21

1:30 pm-10:50 pm

2 stops10h 20m

$495

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

Fri 2/20

6:45 am-1:45 pm

1 stop6h 00m

George Town Owen Roberts Intl

Fri 2/27

2:50 pm-9:00 pm

1 stop7h 10m

$501

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

Fri 1/23

7:05 pm-11:00 am

1 stop14h 55m

George Town Owen Roberts Intl

Thu 1/29

2:00 pm-8:39 pm

1 stop7h 39m

$501

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

Fri 1/23

7:05 pm-11:00 am

1 stop14h 55m

George Town Owen Roberts Intl

Tue 2/3

2:00 pm-11:40 pm

1 stop10h 40m

$501

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

Fri 1/23

7:05 pm-12:50 pm

2 stops16h 45m

George Town Owen Roberts Intl

Fri 1/30

3:45 pm-11:10 pm

1 stop8h 25m

$505

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

Sat 1/24

7:30 am-1:47 pm

1 stop5h 17m

George Town Owen Roberts Intl

Thu 1/29

2:00 pm-8:39 pm

1 stop7h 39m

$530

Kansas CityGeorge Town

MCI - GCM

MCIGCM

Kansas City

Sat 1/31

5:27 am-2:30 pm

1 stop8h 03m

George Town Owen Roberts Intl

Sat 2/7

4:40 pm-10:25 pm

1 stop6h 45m

$536

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Showing 1-10 of 21 results
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Best time to book a flight from Missouri to Cayman Islands

Have a flexible travel schedule? Discover the best time to fly to Cayman Islands from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to the Cayman Islands

What is the cheapest month to book a flight from Missouri to Cayman Islands?

Currently, January is the cheapest month in which you can book a flight from Missouri to Cayman Islands (average of $467). Flying from Missouri to Cayman Islands in March is currently the most expensive (average of $594). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to KY?

Find hourly flight availability from Missouri to Cayman Islands. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Missouri to Cayman Islands as you normally would.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Cayman Islands. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Missouri to Cayman Islands?

    Departing from Missouri to Cayman Islands will take you 5h 35m. The distance between Missouri and Cayman Islands is about 1448 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Missouri to Cayman Islands that include hotel bookings?

    Yes. In addition to deals on Missouri to Cayman Islands flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Cayman Islands?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Cayman Islands.

  • Can I find deals for business class flights from Missouri to Cayman Islands?

    Yes. Cheapflights offers flight deals from Missouri to Cayman Islands by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Cayman Islands?

    Currently, January is the cheapest month in which you can book a flight from Missouri to Cayman Islands (average of $467). Flying from Missouri to Cayman Islands in March is currently the most expensive (average of $594). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Missouri to Cayman Islands

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Missouri to Cayman Islands

Discover the top 4 airlines that operate flights from Missouri to Cayman Islands. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$216Average$587FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$238Average$628FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$429Average$638FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$439Average$631FlexibilityNo cancel feeOn-time71%

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