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$232+ Cheap flights from Santo Domingo (SDQ) to Buffalo (BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/18. Fares are subject to change and may not be available on all flights or dates of travel.
SDQ — BUF
Apr 12 — Apr 191
Sun 4/12
Sun 4/19
1 adult, Economy
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Cheap flight deals from Santo Domingo to Buffalo

Cheapest flights from Santo Domingo to Buffalo
Explore the most affordable flight options available from Santo Domingo to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 13, 2026.

This Delta deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/57:35 pm
SDQ
-
BUF
1 stop14h 10m
Delta
Sun 6/1411:15 am
BUF
-
SDQ
1 stop12h 40m
Delta
Deal found 3/12$405
This United Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/301:10 pm
SDQ
-
BUF
2 stops20h 43m
United Airlines
Mon 5/45:55 pm
BUF
-
SDQ
2 stops20h 15m
United Airlines
Deal found 3/10$452
This JetBlue deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/305:40 am
SDQ
-
BUF
1 stop9h 19m
JetBlue
Mon 5/47:39 pm
BUF
-
SDQ
1 stop6h 48m
JetBlue
Deal found 3/12$456
This American Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/57:00 am
SDQ
-
BUF
2 stops14h 50m
American Airlines
Sun 6/148:29 am
BUF
-
SDQ
2 stops14h 26m
American Airlines
Deal found 3/12$547

Find flight deals from Santo Domingo to Buffalo

Discover tips and strategies to find the most affordable flight options for your journey from Santo Domingo (SDQ) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 13, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$405
(Delta)

One-way from

$232
(American Airlines)
Provider with most accurate pricing for Santo Domingo Las Americas-Buffalo flight deals.
Search Deals
Provider most trusted by Cheapflights users for Santo Domingo Las Americas-Buffalo flights.
Search Deals
From Santo Domingo Las Americas to Buffalo
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One-way flight from Santo Domingo Las Americas to Buffalo
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Santo Domingo to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 13, 2026.
Use the filters below to find and compare flights from Santo Domingo to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Santo DomingoBuffalo

SDQ - BUF

SDQBUF

Santo Domingo Las Americas

Fri 6/5

7:35 pm-9:45 am

1 stop14h 10m

Buffalo

Sun 6/14

11:15 am-11:55 pm

1 stop12h 40m

$405

Santo DomingoBuffalo

SDQ - BUF

SDQBUF

Santo Domingo Las Americas

Thu 4/30

1:10 pm-9:53 am

2 stops20h 43m

Buffalo

Mon 5/4

5:55 pm-2:10 pm

2 stops20h 15m

$452
Quickest round-trip

Santo DomingoBuffalo

SDQ - BUF

SDQBUF

Santo Domingo Las Americas

Thu 4/30

5:40 am-2:59 pm

1 stop9h 19m

Buffalo

Mon 5/4

6:00 am-2:42 pm

1 stop8h 42m

$456

Santo DomingoBuffalo

SDQ - BUF

SDQBUF

Santo Domingo Las Americas

Fri 6/5

7:00 am-9:50 pm

2 stops14h 50m

Buffalo

Sun 6/14

8:29 am-10:55 pm

2 stops14h 26m

$547
Cheapest one-way

Santo DomingoBuffalo

SDQ - BUF

SDQBUF

Santo Domingo Las Americas

Wed 3/18

6:00 am-11:50 pm

2 stops17h 50m

$232
Quickest one-way

Santo DomingoBuffalo

SDQ - BUF

SDQBUF

Santo Domingo Las Americas

Tue 6/30

3:34 pm-11:58 pm

1 stop8h 24m

$238

Santo DomingoBuffalo

SDQ - BUF

SDQBUF

Santo Domingo Las Americas

Tue 4/14

6:00 am-4:32 pm

2 stops10h 32m

$273

Santo DomingoBuffalo

SDQ - BUF

SDQBUF

Santo Domingo Las Americas

Tue 6/30

7:00 am-9:02 pm

2 stops14h 02m

$314

Santo DomingoBuffalo

SDQ - BUF

SDQBUF

Santo Domingo Las Americas

Wed 3/18

8:56 pm-9:04 am

1 stop12h 08m

$329

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/9

Sorted by cheapest first
  • Most accurate provider: When it comes to deals on Santo Domingo-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santo Domingo-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santo Domingo-Buffalo flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santo Domingo-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santo Domingo-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santo Domingo to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Santo Domingo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santo Domingo to Buffalo?

    Departing from Santo Domingo to Buffalo will take you 9h 19m. The distance between Santo Domingo and Buffalo is about 1773 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Santo Domingo to Buffalo that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to Buffalo.

  • Can I find deals for business class flights from Santo Domingo to Buffalo?

    Yes. Cheapflights offers flight deals from Santo Domingo to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Cheektowaga
Batavia
Williamsville
Orchard Park
Eden
Amherst
West Seneca

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