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$300+ Cheap flights from Panama to Buffalo (BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/25. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — BUF
Aug 25 — Sep 11
Mon 8/25
Mon 9/1
1 adult, Economy
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Cheap flight deals from Panama to Buffalo

Keep the following information in mind while searching for Panama to Buffalo flight deals. Data was last updated August 20, 2025.

Round-trip from

$535
(United Airlines)

One-way from

$300
(United Airlines)
From Panama to Buffalo
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One-way flight from Panama to Buffalo
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Find flight deals from Panama to Buffalo

Cheapest flights from Panama to Buffalo
Explore the most affordable flight options available from Panama to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 20, 2025.

This United Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/253:30 pmPTY - BUF
2 stops20h 52mUnited Airlines
Fri 9/267:45 pmBUF - PTY
2 stops23h 52mUnited Airlines
Deal found 8/20$535
This United Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/319:30 amPTY - BUF
2 stops23h 33mUnited Airlines
Tue 11/46:00 amBUF - PTY
1 stop7h 55mUnited Airlines
Deal found 8/19$542
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/313:15 pmPTY - BUF
2 stops18h 26mAmerican Airlines
Wed 11/512:57 pmBUF - PTY
2 stops24h 39mAmerican Airlines
Deal found 8/18$548
This American Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/123:15 pmPTY - BUF
2 stops22h 29mAmerican Airlines
Tue 10/146:23 pmBUF - PTY
2 stops20h 40mAmerican Airlines
Deal found 8/19$553
This United Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/410:00 amPTY - BUF
2 stops22h 43mUnited Airlines
Sat 10/118:20 amBUF - PTY
2 stops11h 17mUnited Airlines
Deal found 8/20$585
This Delta deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/192:10 pmPTY - BUF
1 stop8h 27mDelta
Fri 9/266:00 amBUF - PTY
1 stop7h 55mDelta
Deal found 8/20$641
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/312:21 pmPTY - BUF
1 stop8h 18mDelta
Wed 11/56:00 amBUF - PTY
1 stop7h 56mDelta
Deal found 8/18$649
This United Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/313:41 pmPTY - BUF
2 stops17h 22mUnited Airlines
Wed 11/56:00 amBUF - PTY
1 stop7h 55mUnited Airlines
Deal found 8/18$769
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/193:30 pmPTY - BUF
2 stops21h 34mAmerican Airlines
Mon 9/86:28 pmBUF - PTY
2 stops19h 27mAmerican Airlines
Deal found 8/18$788
This Kiwi.com deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/199:34 amPTY - BUF
2 stops31h 40mMultiple Airlines
Fri 9/266:59 pmBUF - PTY
1 stop23h 11mMultiple Airlines
Deal found 8/20$842

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 20, 2025.
Use the filters below to find and compare flights from Panama to Buffalo that are best for you.

Fly from

Panama

Fly to

Buffalo

Route

Depart

Return

Price

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sun 10/12

2:21 pm-11:39 pm

1 stop8h 18m

Buffalo

Tue 10/14

6:00 am-12:56 pm

1 stop7h 56m

$535

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Fri 9/19

3:30 pm-11:59 pm

2 stops31h 29m

Buffalo

Fri 9/26

7:45 pm-6:37 pm

2 stops23h 52m

$535

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Fri 10/31

2:21 pm-11:39 pm

1 stop8h 18m

Buffalo

Tue 11/4

6:00 am-1:56 pm

1 stop7h 56m

$535

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Fri 10/31

9:30 am-10:03 am

2 stops23h 33m

Buffalo

Tue 11/4

6:00 am-1:55 pm

1 stop7h 55m

$542

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Fri 10/31

3:15 pm-10:41 am

2 stops18h 26m

Buffalo

Wed 11/5

12:57 pm-1:36 pm

2 stops24h 39m

$548

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Fri 10/31

3:15 pm-5:01 pm

2 stops24h 46m

Buffalo

Tue 11/4

5:26 pm-1:36 pm

2 stops20h 10m

$548

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sun 10/12

3:15 pm-2:44 pm

2 stops22h 29m

Buffalo

Tue 10/14

6:23 pm-2:03 pm

2 stops20h 40m

$553

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sat 10/4

10:00 am-9:43 am

2 stops22h 43m

Buffalo

Sat 10/11

8:20 am-6:37 pm

2 stops11h 17m

$585

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Fri 9/19

2:10 pm-11:37 pm

1 stop8h 27m

Buffalo

Fri 9/26

6:00 am-12:55 pm

1 stop7h 55m

$641

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Fri 10/31

2:21 pm-11:39 pm

1 stop8h 18m

Buffalo

Wed 11/5

6:00 am-1:56 pm

1 stop7h 56m

$649

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/20

Showing 1-10 of 17 results
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Best time to book a flight from Panama to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to Buffalo
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Panama to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Buffalo from Panama?

    Buffalo (BUF), located 8.3 mi from the city center, is the airport you fly into when you book flights from Panama to Buffalo.

  • How long is the flight from Panama to Buffalo?

    For as low as $535, Delta can have you in Buffalo from Panama in 8h 18m. Panama and Buffalo are separated by a distance of 2339 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Panama to Buffalo that include hotel bookings?

    Yes. In addition to deals on Panama to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to Buffalo.

  • Can I find deals for business class flights from Panama to Buffalo?

    Yes. Cheapflights offers flight deals from Panama to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to Buffalo?

    Currently, January is the cheapest month in which you can book a flight from Panama to Buffalo (average of $256). Flying from Panama to Buffalo in December is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Orchard Park
Batavia
Williamsville
Eden
Amherst
West Seneca

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