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$385+ Cheap flights from Panama to Buffalo (BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/25. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — BUF
aug. 22 — aug. 291
lør. 8/22
lør. 8/29
1 adult, Economy
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Cheap flight deals from Panama to Buffalo

Cheapest flights from Panama to Buffalo
Explore the most affordable flight options available from Panama to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on juli 23, 2026.

This United Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lør. 9/199:45 am
PTY
-
BUF
1 stop12h 27m
United Airlines
ons. 9/236:00 am
BUF
-
PTY
1 stop14h 31m
United Airlines
Deal found 7/22$763
This United Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
tor. 7/3010:55 pm
PTY
-
BUF
1 stop18h 09m
United Airlines
tor. 12/36:00 am
BUF
-
PTY
1 stop14h 02m
United Airlines
Deal found 7/21$782
This Travelocity deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ons. 7/223:50 pm
PTY
-
BUF
2 stops22h 09m
Multiple Airlines
ons. 7/297:21 pm
BUF
-
PTY
2 stops16h 09m
Multiple Airlines
Deal found 7/21$795
This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
tor. 7/301:14 pm
PTY
-
BUF
2 stops22h 01m
American Airlines
tor. 12/33:32 pm
BUF
-
PTY
2 stops22h 16m
American Airlines
Deal found 7/22$821
This United Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ons. 7/223:30 pm
PTY
-
BUF
2 stops25h 52m
United Airlines
ons. 7/296:00 am
BUF
-
PTY
1 stop23h 04m
United Airlines
Deal found 7/21$825

Find flight deals from Panama to Buffalo

Keep the following information in mind while searching for Panama to Buffalo flight deals. Data was last updated juli 23, 2026.

Round-trip from

$763
(United Airlines)

One-way from

$385
(FlightHub)
From Panama to Buffalo
Search Deals
One-way flight from Panama to Buffalo
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated juli 23, 2026.
Use the filters below to find and compare flights from Panama to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

lør. 9/19

9:45 am-11:12 pm

1 stop12h 27m

Buffalo

ons. 9/23

6:00 am-7:31 pm

1 stop14h 31m

$763
Cheapest one-way
Quickest one-way

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

tor. 9/10

2:23 pm-11:52 pm

1 stop8h 29m

$416

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

man. 8/3

9:45 am-11:06 pm

1 stop12h 21m

$441

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

lør. 9/12

2:23 pm-11:10 am

1 stop19h 47m

$445

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

fre. 9/11

2:23 pm-11:10 am

1 stop19h 47m

$467

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/22

Sorted by cheapest first

Best time to book a flight from Panama to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to Buffalo

No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Panama to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Buffalo from Panama?

    Buffalo (BUF), located 8.3 mi from the city center, is the airport you fly into when you book flights from Panama to Buffalo.

  • How long is the flight from Panama to Buffalo?

    For as low as $763, United Airlines can have you in Buffalo from Panama in 12h 27m. Panama and Buffalo are separated by a distance of 2339 mi.

  • Can I find deals for flights from Panama to Buffalo that include hotel bookings?

    Yes. In addition to deals on Panama to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to Buffalo.

  • Can I find deals for business class flights from Panama to Buffalo?

    Yes. Cheapflights offers flight deals from Panama to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Cheektowaga
Amherst
Williamsville
Orchard Park
Eden
Bowmansville

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