HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Buffalo

$286+ Cheap flights from Panama to Buffalo (BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/30. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — BUF
Apr 27 — May 41
Mon 4/27
Mon 5/4
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Panama to Buffalo with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Panama to Buffalo

Cheapest flights from Panama to Buffalo
Explore the most affordable flight options available from Panama to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 28, 2026.

This Kiwi.com deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2010:26 am
PTY
-
BUF
1 stop25h 16m
Multiple Airlines
Mon 4/2712:32 pm
BUF
-
PTY
1 stop9h 02m
Multiple Airlines
Deal found 3/23$642
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/163:30 pm
PTY
-
BUF
2 stops24h 16m
United Airlines
Sun 6/215:58 pm
BUF
-
PTY
2 stops23h 14m
United Airlines
Deal found 3/24$669
This United Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/23:30 pm
PTY
-
BUF
2 stops20h 43m
United Airlines
Sun 4/57:00 am
BUF
-
PTY
2 stops22h 04m
United Airlines
Deal found 3/26$675
This KAYAK deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/223:30 pm
PTY
-
BUF
2 stops17h 46m
Copa Airlines
Thu 6/256:00 am
BUF
-
PTY
1 stop23h 04m
Copa Airlines
Deal found 3/27$701
This Gurufare deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gurufare is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/1410:55 pm
PTY
-
BUF
1 stop22h 36m
Multiple Airlines
Tue 8/116:00 am
BUF
-
PTY
1 stop23h 04m
Multiple Airlines
Deal found 3/23$702
This Ovago deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/29:45 am
PTY
-
BUF
1 stop12h 48m
Multiple Airlines
Sun 4/57:00 am
BUF
-
PTY
2 stops22h 04m
Multiple Airlines
Deal found 3/26$754
This Gurufare deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gurufare is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/1410:00 am
PTY
-
BUF
2 stops23h 20m
Copa Airlines
Tue 8/116:00 am
BUF
-
PTY
1 stop23h 04m
Copa Airlines
Deal found 3/23$786
This United Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/227:55 am
PTY
-
BUF
2 stops25h 21m
United Airlines
Thu 6/255:52 pm
BUF
-
PTY
2 stops23h 20m
United Airlines
Deal found 3/27$791
This KAYAK deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/229:45 am
PTY
-
BUF
1 stop11h 46m
Avianca
Thu 6/256:00 am
BUF
-
PTY
1 stop23h 04m
Avianca
Deal found 3/27$826
This BusinessClass deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/29:45 am
PTY
-
BUF
1 stop12h 48m
Copa Airlines
Sun 4/56:00 am
BUF
-
PTY
1 stop23h 04m
Copa Airlines
Deal found 3/26$835

Find flight deals from Panama to Buffalo

Keep the following information in mind while searching for Panama to Buffalo flight deals. Data was last updated March 28, 2026.

Round-trip from

$613
(Expedia)

One-way from

$286
(Kiwi.com)
From Panama to Buffalo
Search Deals
One-way flight from Panama to Buffalo
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 28, 2026.
Use the filters below to find and compare flights from Panama to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Mon 4/20

10:26 am-12:42 pm

1 stop25h 16m

Buffalo

Mon 4/27

12:32 pm-8:34 pm

1 stop9h 02m

$642

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Tue 7/14

10:55 pm-8:41 pm

2 stops20h 46m

Buffalo

Tue 8/11

5:52 pm-2:14 pm

2 stops21h 22m

$669

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Tue 6/16

3:30 pm-4:46 pm

2 stops24h 16m

Buffalo

Sun 6/21

5:58 pm-4:12 pm

2 stops23h 14m

$669

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Mon 4/20

10:55 pm-9:47 am

1 stop9h 52m

Buffalo

Mon 4/27

6:02 pm-4:12 pm

2 stops23h 10m

$675

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Mon 6/22

3:30 pm-10:16 am

2 stops17h 46m

Buffalo

Thu 6/25

6:00 am-4:04 am

1 stop23h 04m

$701

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Tue 7/14

10:00 am-10:20 am

2 stops23h 20m

Buffalo

Tue 8/11

6:00 am-4:04 am

1 stop23h 04m

$786
Quickest round-trip

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Tue 4/21

10:55 pm-9:47 am

1 stop9h 52m

Buffalo

Wed 4/22

6:55 pm-4:04 am

1 stop10h 09m

$1,230

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sat 4/11

8:11 am-6:46 pm

1 stop9h 35m

Buffalo

Sat 4/11

8:52 pm-12:35 am

2 stops28h 43m

$1,329
Cheapest one-way

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Thu 4/30

3:10 pm-11:23 am

3 stops19h 13m

$286

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Mon 4/13

3:30 pm-2:17 pm

2 stops21h 47m

$371

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/25

Showing 1-10 of 15 resultsSorted by cheapest first
1
2

Best time to book a flight from Panama to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to Buffalo
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Panama to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Buffalo from Panama?

    Buffalo (BUF), located 8.3 mi from the city center, is the airport you fly into when you book flights from Panama to Buffalo.

  • How long is the flight from Panama to Buffalo?

    For as low as $701, United Airlines can have you in Buffalo from Panama in 17h 46m. Panama and Buffalo are separated by a distance of 2339 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Panama to Buffalo that include hotel bookings?

    Yes. In addition to deals on Panama to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to Buffalo.

  • Can I find deals for business class flights from Panama to Buffalo?

    Yes. Cheapflights offers flight deals from Panama to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Cheektowaga
Batavia
Williamsville
Orchard Park
Eden
Amherst
West Seneca

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.