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$381+ Cheap flights from Panama to Buffalo (BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/21. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — BUF
Jul 2 — Jul 91
Thu 7/2
Thu 7/9
1 adult, Economy
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Cheap flight deals from Panama to Buffalo

Cheapest flights from Panama to Buffalo
Explore the most affordable flight options available from Panama to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 2, 2026.

This United Airlines deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/289:45 am
PTY
-
BUF
1 stop8h 23m
United Airlines
Thu 10/16:30 am
BUF
-
PTY
1 stop14h 01m
United Airlines
Deal found 5/28$731
This United Airlines deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/1410:55 pm
PTY
-
BUF
1 stop9h 58m
United Airlines
Tue 7/2110:34 am
BUF
-
PTY
2 stops18h 30m
United Airlines
Deal found 5/30$736
This Expedia deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/163:50 pm
PTY
-
BUF
2 stops22h 05m
Multiple Airlines
Thu 6/183:50 pm
BUF
-
PTY
2 stops19h 40m
Multiple Airlines
Deal found 5/30$747
This United Airlines deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/299:30 am
PTY
-
BUF
2 stops23h 19m
United Airlines
Sat 10/316:45 pm
BUF
-
PTY
2 stops21h 00m
United Airlines
Deal found 5/31$750
This United Airlines deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/303:30 pm
PTY
-
BUF
2 stops24h 11m
United Airlines
Sun 8/210:34 am
BUF
-
PTY
2 stops18h 30m
United Airlines
Deal found 5/28$846
This United Airlines deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/169:45 am
PTY
-
BUF
1 stop11h 55m
United Airlines
Thu 6/186:00 am
BUF
-
PTY
1 stop14h 31m
United Airlines
Deal found 5/30$869
This United Airlines deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/2311:55 pm
PTY
-
BUF
1 stop10h 31m
United Airlines
Sat 12/267:30 pm
BUF
-
PTY
2 stops24h 32m
United Airlines
Deal found 5/30$1,183
This FlightHub deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/95:30 am
PTY
-
BUF
2 stops12h 33m
Avianca
Mon 6/157:52 pm
BUF
-
PTY
3 stops20h 03m
Avianca
Deal found 6/1$1,385
This American Airlines deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/161:15 pm
PTY
-
BUF
2 stops9h 41m
American Airlines
Thu 6/187:32 pm
BUF
-
PTY
3 stops17h 41m
American Airlines
Deal found 5/30$2,617

Find flight deals from Panama to Buffalo

Keep the following information in mind while searching for Panama to Buffalo flight deals. Data was last updated June 2, 2026.

Round-trip from

$731
(United Airlines)

One-way from

$495
(FlightHub)
From Panama to Buffalo
Search Deals
One-way flight from Panama to Buffalo
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 2, 2026.
Use the filters below to find and compare flights from Panama to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Mon 9/28

9:45 am-7:08 pm

1 stop8h 23m

Buffalo

Thu 10/1

6:30 am-7:31 pm

1 stop14h 01m

$731

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Tue 7/14

9:45 am-10:31 pm

1 stop11h 46m

Buffalo

Tue 7/21

6:00 am-4:04 am

1 stop23h 04m

$736

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Thu 7/30

3:30 pm-4:41 pm

2 stops24h 11m

Buffalo

Sun 8/2

7:00 pm-4:04 am

1 stop10h 04m

$736

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sun 7/12

10:55 pm-11:59 pm

2 stops24h 04m

Buffalo

Sun 7/19

6:04 pm-4:12 pm

2 stops23h 08m

$736

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Thu 10/29

9:30 am-9:49 am

2 stops23h 19m

Buffalo

Sat 10/31

11:40 am-7:02 pm

1 stop8h 22m

$750
Cheapest one-way
Quickest one-way

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sun 6/21

3:50 pm-8:00 am

2 stops15h 10m

$381

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sun 6/21

10:55 pm-10:40 pm

1 stop22h 45m

$408

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Fri 6/19

11:25 am-8:00 am

3 stops19h 35m

$495

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/1

Sorted by cheapest first

Best time to book a flight from Panama to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to Buffalo
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Panama to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Buffalo from Panama?

    Buffalo (BUF), located 8.3 mi from the city center, is the airport you fly into when you book flights from Panama to Buffalo.

  • How long is the flight from Panama to Buffalo?

    For as low as $731, United Airlines can have you in Buffalo from Panama in 8h 23m. Panama and Buffalo are separated by a distance of 2339 mi.

  • Can I find deals for flights from Panama to Buffalo that include hotel bookings?

    Yes. In addition to deals on Panama to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to Buffalo.

  • Can I find deals for business class flights from Panama to Buffalo?

    Yes. Cheapflights offers flight deals from Panama to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Cheektowaga
Amherst
Batavia
Williamsville
Orchard Park
Eden

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