$426+ Cheap flights from Panama to Buffalo (BUF)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/19. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — BUF
Sep 24 — Oct 11
Round-trip
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Panama to Buffalo
Cheapest
Best
One-way
Cheapest flights from Panama to BuffaloExplore the most affordable flight options available from Panama to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 25, 2026.
Explore the most affordable flight options available from Panama to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 25, 2026.
This Expedia deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3011:25 am -
3 stops20h 02m
Wed 11/43:30 pm -
2 stops19h 00m
Deal found 8/20![Multiple Airlines logo]()
$588
This United Airlines deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/710:00 am -
2 stops12h 50m
Wed 10/143:05 pm -
2 stops28h 32m
Deal found 8/23![United Airlines logo]()
$765
This United Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/303:41 pm -
2 stops20h 36m
Wed 11/48:55 pm -
1 stop23h 07m
Deal found 8/20![United Airlines logo]()
$776
This United Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/19:45 am -
1 stop12h 26m
Mon 10/57:59 pm -
2 stops24h 32m
Deal found 8/20![United Airlines logo]()
$822
Best flights from Panama to BuffaloDiscover carefully curated flight deals from Panama to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 25, 2026.
Discover carefully curated flight deals from Panama to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 25, 2026.
This Expedia deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3011:25 am -
3 stops20h 02m
Wed 11/43:30 pm -
2 stops19h 00m
Deal found 8/20![Multiple Airlines logo]()
$588
This United Airlines deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/710:00 am -
2 stops12h 50m
Wed 10/143:05 pm -
2 stops28h 32m
Deal found 8/23![United Airlines logo]()
$765
This United Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/303:41 pm -
2 stops20h 36m
Wed 11/48:55 pm -
1 stop23h 07m
Deal found 8/20![United Airlines logo]()
$776
This United Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/19:45 am -
1 stop12h 26m
Mon 10/57:59 pm -
2 stops24h 32m
Deal found 8/21![United Airlines logo]()
$822
One-way flights from Panama to BuffaloSearch for one-way flight options from Panama to Buffalo. Find affordable one-way fares based on user searches. Data last updated August 25, 2026.
Search for one-way flight options from Panama to Buffalo. Find affordable one-way fares based on user searches. Data last updated August 25, 2026.
This United Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/194:41 pm -
2 stops24h 06m
Deal found 8/24![United Airlines logo]()
$426
This American Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates ” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/194:46 pm -
1 stop30h 10m
Deal found 8/24![American Airlines logo]()
$448
This Expedia deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/2011:30 am -
3 stops36h 17m
Deal found 8/24![Multiple Airlines logo]()
$450
This United Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/219:45 am -
1 stop12h 27m
Deal found 8/22![United Airlines logo]()
$459
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/211:16 pm -
2 stops21h 23m
Deal found 8/22![American Airlines logo]()
$467
This Kiwi.com deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/213:39 pm -
3 stops25h 10m
Deal found 8/22![Multiple Airlines logo]()
$543
This Booking.com deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/2611:30 am -
3 stops30h 56m
Deal found 8/24![Avianca logo]()
$901
Find flight deals from Panama to Buffalo
Keep the following information in mind while searching for Panama to Buffalo flight deals. Data was last updated August 25, 2026.
Round-trip from | $588 (Expedia) |
|---|---|
One-way from | $426 (United Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 25, 2026.
Use the filters below to find and compare flights from Panama to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Panama CityBuffalo
PTY Panama City Tocumen Intl - BUF Buffalo
PTYBUF
Panama City Tocumen Intl
Fri 10/30
11:25 am-8:27 am
3 stops20h 02m
Buffalo
Wed 11/4
3:30 pm-10:30 am
2 stops19h 00m
$588
Panama CityBuffalo
PTY Panama City Tocumen Intl - BUF Buffalo
PTYBUF
Panama City Tocumen Intl
Wed 10/7
10:00 am-11:50 pm
2 stops12h 50m
Buffalo
Wed 10/14
3:05 pm-6:37 pm
2 stops28h 32m
$765
Panama CityBuffalo
PTY Panama City Tocumen Intl - BUF Buffalo
PTYBUF
Panama City Tocumen Intl
Fri 10/30
3:41 pm-1:17 pm
2 stops20h 36m
Buffalo
Wed 11/4
8:55 pm-8:02 pm
1 stop23h 07m
$776
Quickest round-trip
Panama CityBuffalo
PTY Panama City Tocumen Intl - BUF Buffalo
PTYBUF
Panama City Tocumen Intl
Thu 10/1
9:45 am-11:11 pm
1 stop12h 26m
Buffalo
Mon 10/5
7:59 pm-7:31 pm
2 stops24h 32m
$822
Cheapest one-way
Panama CityBuffalo
PTY Panama City Tocumen Intl - BUF Buffalo
PTYBUF
Panama City Tocumen Intl
Mon 9/21
3:30 pm-11:12 pm
2 stops30h 42m
$426
Quickest one-way
Panama CityBuffalo
PTY Panama City Tocumen Intl - BUF Buffalo
PTYBUF
Panama City Tocumen Intl
Tue 1/26
3:20 pm-11:55 pm
1 stop8h 35m
$426
Panama CityBuffalo
PTY Panama City Tocumen Intl - BUF Buffalo
PTYBUF
Panama City Tocumen Intl
Tue 1/19
4:41 pm-4:47 pm
2 stops24h 06m
$426
Panama CityBuffalo
PTY Panama City Tocumen Intl - BUF Buffalo
PTYBUF
Panama City Tocumen Intl
Wed 1/20
4:41 pm-3:16 pm
2 stops22h 35m
$426
Panama CityBuffalo
PTY Panama City Tocumen Intl - BUF Buffalo
PTYBUF
Panama City Tocumen Intl
Tue 1/19
4:46 pm-10:56 pm
1 stop30h 10m
$448
Panama CityBuffalo
PTY Panama City Tocumen Intl - BUF Buffalo
PTYBUF
Panama City Tocumen Intl
Mon 9/21
1:16 pm-11:39 am
2 stops21h 23m
$467
Showing 1-10 of 11 resultsSorted by cheapest first
Best time to book a flight from Panama to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from Panama with our price prediction graph.
PTY-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama to Buffalo
PA0-BUF
PTY-BUF
No data available for this route at this time. Please check back soon.
Related info for your journey
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Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsLockport
Cheektowaga
Amherst
Williamsville
Orchard Park
Eden
Bowmansville
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