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$337+ Cheap flights from Panama to Buffalo (BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/16. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — BUF
Apr 13 — Apr 201
Mon 4/13
Mon 4/20
1 adult, Economy
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Cheap flight deals from Panama to Buffalo

Cheapest flights from Panama to Buffalo
Explore the most affordable flight options available from Panama to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 14, 2026.

This Kiwi.com deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/2510:26 am
PTY
-
BUF
1 stop23h 43m
Multiple Airlines
Sat 5/21:11 pm
BUF
-
PTY
1 stop8h 23m
Multiple Airlines
Deal found 3/11$611
This Expedia deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/13:50 pm
PTY
-
BUF
2 stops19h 07m
Multiple Airlines
Mon 10/57:59 pm
BUF
-
PTY
2 stops15h 31m
Multiple Airlines
Deal found 3/11$629
This United Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/253:30 pm
PTY
-
BUF
2 stops17h 35m
United Airlines
Sat 5/25:55 pm
BUF
-
PTY
2 stops21h 19m
United Airlines
Deal found 3/11$632
This United Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/239:45 am
PTY
-
BUF
2 stops23h 25m
United Airlines
Sun 4/2610:30 am
BUF
-
PTY
1 stop10h 01m
United Airlines
Deal found 3/9$646
This American Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/291:49 pm
PTY
-
BUF
2 stops23h 32m
American Airlines
Wed 5/65:32 pm
BUF
-
PTY
2 stops20h 14m
American Airlines
Deal found 3/10$655
This United Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/910:00 am
PTY
-
BUF
2 stops23h 00m
United Airlines
Mon 4/136:55 pm
BUF
-
PTY
1 stop10h 09m
United Airlines
Deal found 3/13$661

Find flight deals from Panama to Buffalo

Keep the following information in mind while searching for Panama to Buffalo flight deals. Data was last updated March 14, 2026.

Round-trip from

$611
(Kiwi.com)

One-way from

$337
(Travelocity)
From Panama to Buffalo
Search Deals
One-way flight from Panama to Buffalo
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 14, 2026.
Use the filters below to find and compare flights from Panama to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Wed 4/29

2:27 pm-11:37 pm

1 stop8h 10m

Buffalo

Wed 5/6

6:00 am-1:02 pm

1 stop8h 02m

$632

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sat 4/25

3:30 pm-10:05 am

2 stops17h 35m

Buffalo

Sat 5/2

10:45 am-7:31 pm

1 stop9h 46m

$632

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Thu 4/9

7:55 am-10:00 am

2 stops25h 05m

Buffalo

Mon 4/13

7:45 pm-6:37 pm

2 stops23h 52m

$632

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Thu 4/23

9:45 am-10:10 am

2 stops23h 25m

Buffalo

Sun 4/26

10:30 am-7:31 pm

1 stop10h 01m

$646
Cheapest one-way

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Fri 6/12

9:45 am-11:59 pm

2 stops13h 14m

$349
Quickest one-way

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Thu 4/16

10:55 pm-9:47 am

1 stop9h 52m

$354

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sat 6/13

3:30 pm-10:05 am

2 stops17h 35m

$355

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Fri 6/19

10:55 pm-9:03 pm

2 stops21h 08m

$355

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Wed 4/8

3:30 pm-10:12 am

2 stops17h 42m

$355

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Thu 4/16

10:10 am-11:13 am

3 stops24h 03m

$388

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/12

Showing 1-10 of 13 resultsSorted by cheapest first
1
2

Best time to book a flight from Panama to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to Buffalo
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Panama to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Buffalo from Panama?

    Buffalo (BUF), located 8.3 mi from the city center, is the airport you fly into when you book flights from Panama to Buffalo.

  • How long is the flight from Panama to Buffalo?

    For as low as $632, Delta can have you in Buffalo from Panama in 8h 10m. Panama and Buffalo are separated by a distance of 2339 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Panama to Buffalo that include hotel bookings?

    Yes. In addition to deals on Panama to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to Buffalo.

  • Can I find deals for business class flights from Panama to Buffalo?

    Yes. Cheapflights offers flight deals from Panama to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Cheektowaga
Batavia
Williamsville
Orchard Park
Eden
Amherst
West Seneca

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