HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Buffalo

$370+ Cheap flights from Panama to Buffalo (BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/16. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — BUF
May 3 — May 101
Sun 5/3
Sun 5/10
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Panama to Buffalo with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Panama to Buffalo

Cheapest flights from Panama to Buffalo
Explore the most affordable flight options available from Panama to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 3, 2026.

This United Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/1510:00 am
PTY
-
BUF
2 stops22h 41m
United Airlines
Fri 5/227:00 am
BUF
-
PTY
2 stops22h 04m
United Airlines
Deal found 3/31$675
This United Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/210:00 am
PTY
-
BUF
2 stops23h 49m
United Airlines
Wed 11/45:50 pm
BUF
-
PTY
2 stops20h 55m
United Airlines
Deal found 3/30$682
This KAYAK deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/63:30 pm
PTY
-
BUF
2 stops17h 40m
Copa Airlines
Wed 4/810:30 am
BUF
-
PTY
1 stop10h 01m
Copa Airlines
Deal found 4/2$701
This Expedia deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/1511:25 am
PTY
-
BUF
3 stops33h 02m
Multiple Airlines
Fri 5/226:05 am
BUF
-
PTY
2 stops29h 25m
Multiple Airlines
Deal found 3/31$707
This United Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/223:30 pm
PTY
-
BUF
2 stops24h 16m
United Airlines
Tue 6/307:52 pm
BUF
-
PTY
2 stops21h 20m
United Airlines
Deal found 4/2$798
This United Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/610:55 pm
PTY
-
BUF
1 stop9h 52m
United Airlines
Wed 4/810:30 am
BUF
-
PTY
1 stop10h 01m
United Airlines
Deal found 4/2$803
This KAYAK deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/2710:55 pm
PTY
-
BUF
1 stop9h 58m
Copa Airlines
Sat 7/47:00 am
BUF
-
PTY
2 stops12h 37m
Copa Airlines
Deal found 3/31$811
This United Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/17:55 am
PTY
-
BUF
2 stops12h 08m
United Airlines
Wed 6/310:34 am
BUF
-
PTY
1 stop9h 57m
United Airlines
Deal found 4/2$812
This KAYAK deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/2710:55 pm
PTY
-
BUF
1 stop9h 58m
Multiple Airlines
Sat 7/46:00 am
BUF
-
PTY
1 stop23h 04m
Multiple Airlines
Deal found 3/31$822
This KAYAK deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/229:45 am
PTY
-
BUF
1 stop11h 46m
Copa Airlines
Tue 6/307:00 am
BUF
-
PTY
2 stops12h 37m
Copa Airlines
Deal found 4/2$1,081
This Expedia deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/63:10 pm
PTY
-
BUF
2 stops27h 50m
Multiple Airlines
Wed 4/88:59 pm
BUF
-
PTY
3 stops18h 56m
Multiple Airlines
Deal found 4/2$1,129

Find flight deals from Panama to Buffalo

Keep the following information in mind while searching for Panama to Buffalo flight deals. Data was last updated April 3, 2026.

Round-trip from

$675
(United Airlines)

One-way from

$370
(Kiwi.com)
From Panama to Buffalo
Search Deals
One-way flight from Panama to Buffalo
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 3, 2026.
Use the filters below to find and compare flights from Panama to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Fri 5/15

10:00 am-9:41 am

2 stops22h 41m

Buffalo

Fri 5/22

7:00 am-4:04 am

2 stops22h 04m

$675

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Fri 5/15

11:25 am-9:27 pm

3 stops33h 02m

Buffalo

Fri 5/22

6:05 am-10:30 am

2 stops29h 25m

$707

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Mon 6/22

3:30 pm-4:46 pm

2 stops24h 16m

Buffalo

Tue 6/30

7:52 pm-4:12 pm

2 stops21h 20m

$798

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sat 6/27

3:30 pm-10:20 am

2 stops17h 50m

Buffalo

Sat 7/4

7:00 am-6:37 pm

2 stops12h 37m

$811

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Mon 6/1

3:30 pm-4:46 pm

2 stops24h 16m

Buffalo

Wed 6/3

7:52 pm-7:31 pm

2 stops24h 39m

$811

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sat 6/27

10:55 pm-9:53 am

1 stop9h 58m

Buffalo

Sat 7/4

6:00 am-4:04 am

1 stop23h 04m

$822
Quickest round-trip

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Mon 6/22

9:45 am-10:31 pm

1 stop11h 46m

Buffalo

Tue 6/30

7:00 am-6:37 pm

2 stops12h 37m

$1,081

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Mon 6/22

9:45 am-10:31 pm

1 stop11h 46m

Buffalo

Tue 6/30

6:00 am-7:31 pm

1 stop14h 31m

$1,256
Cheapest one-way
Quickest one-way

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Thu 4/16

2:27 pm-11:37 pm

1 stop8h 10m

$371

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Thu 4/16

9:45 am-11:50 pm

2 stops13h 05m

$371

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/31

Showing 1-10 of 12 resultsSorted by cheapest first
1
2

Best time to book a flight from Panama to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to Buffalo
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Panama to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Buffalo from Panama?

    Buffalo (BUF), located 8.3 mi from the city center, is the airport you fly into when you book flights from Panama to Buffalo.

  • How long is the flight from Panama to Buffalo?

    For as low as $811, United Airlines can have you in Buffalo from Panama in 17h 50m. Panama and Buffalo are separated by a distance of 2339 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Panama to Buffalo that include hotel bookings?

    Yes. In addition to deals on Panama to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to Buffalo.

  • Can I find deals for business class flights from Panama to Buffalo?

    Yes. Cheapflights offers flight deals from Panama to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Cheektowaga
Batavia
Williamsville
Orchard Park
Eden
Amherst
West Seneca

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.