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$301+ Cheap flights from Panama to Buffalo (BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/20. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — BUF
Dec 13 — Dec 201
Sat 12/13
Sat 12/20
1 adult, Economy
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Find flight deals from Panama to Buffalo

Cheapest flights from Panama to Buffalo
Explore the most affordable flight options available from Panama to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 13, 2025.

This United Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/138:55 amPTY - BUF
2 stops14h 03mUnited Airlines
Sun 11/166:25 amBUF - PTY
2 stops13h 13mUnited Airlines
Deal found 11/11$535
This United Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/284:41 pmPTY - BUF
2 stops20h 43mUnited Airlines
Sun 1/47:48 pmBUF - PTY
2 stops21h 19mUnited Airlines
Deal found 11/12$542
This American Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/264:55 pmPTY - BUF
2 stops23h 29mAmerican Airlines
Thu 1/15:22 pmBUF - PTY
2 stops22h 32mAmerican Airlines
Deal found 11/11$558
This United Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/2610:00 amPTY - BUF
1 stop8h 34mUnited Airlines
Thu 1/15:41 pmBUF - PTY
2 stops25h 57mUnited Airlines
Deal found 11/12$654
This Delta deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/133:37 pmPTY - BUF
1 stop8h 13mDelta
Sun 11/166:10 amBUF - PTY
1 stop8h 02mDelta
Deal found 11/11$661
This Delta deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/133:37 pmPTY - BUF
1 stop8h 13mDelta
Mon 11/177:59 pmBUF - PTY
2 stops18h 13mDelta
Deal found 11/11$760
This Delta deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/288:00 amPTY - BUF
1 stop15h 47mDelta
Sun 1/46:00 amBUF - PTY
1 stop14h 00mDelta
Deal found 11/12$845
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/122:55 amPTY - BUF
2 stops32h 49mMultiple Airlines
Mon 11/172:42 pmBUF - PTY
1 stop29h 01mMultiple Airlines
Deal found 11/11$871
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/159:25 amPTY - BUF
1 stop28h 22mMultiple Airlines
Sun 11/166:59 pmBUF - PTY
2 stops22h 17mMultiple Airlines
Deal found 11/11$988
This Delta deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/158:05 amPTY - BUF
1 stop9h 14mDelta
Sun 11/166:25 pmBUF - PTY
1 stop19h 47mDelta
Deal found 11/11$1,001

Cheap flight deals from Panama to Buffalo

Keep the following information in mind while searching for Panama to Buffalo flight deals. Data was last updated November 13, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$535
(United Airlines)

One-way from

$301
(Delta)
Provider with most accurate pricing for Panama City Tocumen Intl-Buffalo flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Buffalo flights.
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From Panama to Buffalo
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One-way flight from Panama to Buffalo
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 13, 2025.
Use the filters below to find and compare flights from Panama to Buffalo that are best for you.

Fly from

Panama

Fly to

Buffalo

Route

Depart

Return

Price

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Tue 11/25

4:41 pm-2:20 pm

2 stops21h 39m

Buffalo

Tue 12/2

6:00 am-1:55 pm

1 stop7h 55m

$535

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sun 12/28

4:41 pm-1:24 pm

2 stops20h 43m

Buffalo

Sun 1/4

6:00 am-1:55 pm

1 stop7h 55m

$535

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Fri 12/26

10:00 am-6:34 pm

1 stop8h 34m

Buffalo

Thu 1/1

6:30 am-2:45 pm

2 stops32h 15m

$535

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Tue 1/13

2:27 pm-10:57 am

2 stops20h 30m

Buffalo

Mon 1/19

5:27 pm-1:27 pm

2 stops20h 00m

$558

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Tue 1/13

3:20 pm-11:58 pm

1 stop8h 38m

Buffalo

Mon 1/19

6:00 am-1:55 pm

1 stop7h 55m

$661

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Thu 11/20

4:41 pm-2:20 pm

2 stops21h 39m

$301

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Mon 11/24

3:37 pm-11:50 pm

1 stop8h 13m

$301

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Mon 11/24

8:55 am-10:58 pm

2 stops14h 03m

$301

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Fri 11/21

3:37 pm-11:50 pm

1 stop8h 13m

$301

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Fri 11/21

11:25 am-9:29 am

3 stops22h 04m

$358

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/13

Showing 1-10 of 12 results
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Best time to book a flight from Panama to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to Buffalo
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Panama to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Buffalo from Panama?

    Buffalo (BUF), located 8.3 mi from the city center, is the airport you fly into when you book flights from Panama to Buffalo.

  • How long is the flight from Panama to Buffalo?

    For as low as $535, United Airlines can have you in Buffalo from Panama in 21h 39m. Panama and Buffalo are separated by a distance of 2339 mi.

  • Can I find deals for flights from Panama to Buffalo that include hotel bookings?

    Yes. In addition to deals on Panama to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to Buffalo.

  • Can I find deals for business class flights from Panama to Buffalo?

    Yes. Cheapflights offers flight deals from Panama to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Cheektowaga
Orchard Park
Batavia
Williamsville
Eden
Amherst
West Seneca

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