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$328+ Cheap flights from Panama to Buffalo (BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/26. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — BUF
Mar 22 — Mar 291
Sun 3/22
Sun 3/29
1 adult, Economy
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Cheap flight deals from Panama to Buffalo

Cheapest flights from Panama to Buffalo
Explore the most affordable flight options available from Panama to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 20, 2026.

This United Airlines deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/263:20 pm
PTY
-
BUF
2 stops24h 27m
United Airlines
Sat 8/297:03 pm
BUF
-
PTY
1 stop10h 01m
United Airlines
Deal found 2/16$582
This United Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/264:41 pm
PTY
-
BUF
2 stops21h 32m
United Airlines
Wed 3/411:29 am
BUF
-
PTY
1 stop8h 33m
United Airlines
Deal found 2/20$589
This United Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/163:30 pm
PTY
-
BUF
2 stops17h 46m
United Airlines
Thu 6/257:00 am
BUF
-
PTY
2 stops12h 37m
United Airlines
Deal found 2/17$662
This Faresmojo deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Faresmojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/142:20 pm
PTY
-
BUF
1 stop8h 38m
JetBlue
Thu 6/186:00 am
BUF
-
PTY
1 stop8h 05m
JetBlue
Deal found 2/18$809
This Expedia deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/272:55 am
PTY
-
BUF
2 stops19h 16m
Multiple Airlines
Sun 3/17:35 pm
BUF
-
PTY
2 stops23h 20m
Multiple Airlines
Deal found 2/20$821
This American Airlines deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/141:14 pm
PTY
-
BUF
2 stops20h 19m
American Airlines
Thu 6/187:31 pm
BUF
-
PTY
2 stops17h 43m
American Airlines
Deal found 2/18$840
This Expedia deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/262:55 pm
PTY
-
BUF
2 stops32h 37m
Multiple Airlines
Wed 3/47:41 pm
BUF
-
PTY
3 stops19h 14m
Multiple Airlines
Deal found 2/20$852
This Ovago deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/1410:55 pm
PTY
-
BUF
1 stop18h 10m
Copa Airlines
Thu 6/186:00 am
BUF
-
PTY
2 stops13h 37m
Copa Airlines
Deal found 2/18$1,045
This Kiwi.com deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/165:55 pm
PTY
-
BUF
2 stops41h 21m
Multiple Airlines
Thu 6/251:55 pm
BUF
-
PTY
1 stop31h 39m
Multiple Airlines
Deal found 2/17$1,061

Find flight deals from Panama to Buffalo

Keep the following information in mind while searching for Panama to Buffalo flight deals. Data was last updated February 20, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$662
(United Airlines)
Provider with most accurate pricing for Panama City Tocumen Intl-Buffalo flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Buffalo flights.
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From Panama to Buffalo
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2026.
Use the filters below to find and compare flights from Panama to Buffalo that are best for you.

Fly from

Panama

Fly to

Buffalo

Route

Depart

Return

Price

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Tue 6/16

3:30 pm-10:16 am

2 stops17h 46m

Buffalo

Thu 6/25

7:00 am-6:37 pm

2 stops12h 37m

$662

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sun 6/14

2:20 pm-11:58 pm

1 stop8h 38m

Buffalo

Thu 6/18

6:00 am-1:05 pm

1 stop8h 05m

$809

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sun 6/14

1:14 pm-10:33 am

2 stops20h 19m

Buffalo

Thu 6/18

7:31 pm-12:14 pm

2 stops17h 43m

$840

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sun 6/14

10:55 pm-6:05 pm

1 stop18h 10m

Buffalo

Thu 6/18

6:00 am-6:37 pm

2 stops13h 37m

$1,045

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sun 6/14

11:25 am-2:57 pm

3 stops26h 32m

Buffalo

Thu 6/18

6:00 am-9:15 am

2 stops28h 15m

$1,805

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Tue 6/16

2:20 pm-11:58 pm

1 stop8h 38m

Buffalo

Thu 6/25

6:00 am-1:05 pm

1 stop8h 05m

$1,876

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Tue 6/16

1:14 pm-11:56 pm

2 stops9h 42m

Buffalo

Thu 6/25

7:31 pm-12:14 pm

3 stops17h 43m

$2,912

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Thu 2/26

3:15 pm-11:26 pm

1 stop8h 11m

$328

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Thu 2/26

4:41 pm-2:13 pm

2 stops21h 32m

$328

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Fri 5/1

2:27 pm-11:37 pm

1 stop8h 10m

$328

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/20

Showing 1-10 of 12 results
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Best time to book a flight from Panama to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to Buffalo
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Panama to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Buffalo from Panama?

    Buffalo (BUF), located 8.3 mi from the city center, is the airport you fly into when you book flights from Panama to Buffalo.

  • How long is the flight from Panama to Buffalo?

    For as low as $809, United Airlines can have you in Buffalo from Panama in 8h 38m. Panama and Buffalo are separated by a distance of 2339 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Panama to Buffalo that include hotel bookings?

    Yes. In addition to deals on Panama to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to Buffalo.

  • Can I find deals for business class flights from Panama to Buffalo?

    Yes. Cheapflights offers flight deals from Panama to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Cheektowaga
Batavia
Williamsville
Orchard Park
Eden
Amherst
West Seneca

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Alternative routes for Panama to Buffalo

See prices for flight routes from nearby airports that may be better suited for you.
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