How long is the flight from Panama to Buffalo?

For as low as $535, Delta can have you in Buffalo from Panama in 11h 59m. Panama and Buffalo are separated by a distance of 2339 mi. Both multi-stop and nonstop flights can be found to your destination and back.

In terms of precipitation, rainfall in Buffalo ranges from 2.5 - 4.0 inches per month. November is typically the wettest month, when rainfall can reach 4.0 in. February is typically the driest time to visit Buffalo when rainfall is around 2.5 in.

If weather is an important factor for your trip to Buffalo, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 71.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 24.8 F).

What is the cheapest time of day to fly from PA to BUF?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama to Buffalo as you normally would.

What airport do you fly into for flights to Buffalo from Panama?

Buffalo (BUF), located 8.3 mi from the city center, is the airport you fly into when you book flights from Panama to Buffalo.

Can I find deals for flights from Panama to Buffalo that include hotel bookings?

Yes. In addition to deals on Panama to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Panama to Buffalo?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to Buffalo.

Can I find deals for business class flights from Panama to Buffalo?

Yes. Cheapflights offers flight deals from Panama to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$301+ Flights from Panama to Buffalo

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Cheap flight deals from Panama to Buffalo

Cheapest flights from Panama to Buffalo
Explore the most affordable flight options available from Panama to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on diciembre 4, 2025.

vie. 12/268:00 amPTY - BUF

2 stops15h 28mDelta

jue. 1/16:00 amBUF - PTY

1 stop14h 00mDelta

Deal found 12/4

$535

vie. 12/264:55 pmPTY - BUF

2 stops23h 29mAmerican Airlines

jue. 1/17:15 pmBUF - PTY

2 stops20h 39mAmerican Airlines

Deal found 12/2

$611

jue. 12/1111:55 pmPTY - BUF

2 stops21h 20mUnited Airlines

mar. 12/166:00 amBUF - PTY

1 stop7h 55mUnited Airlines

Deal found 12/2

$654

vie. 12/264:25 pmPTY - BUF

3 stops18h 10mMultiple Airlines

jue. 1/16:10 amBUF - PTY

3 stops14h 20mMultiple Airlines

Deal found 12/3

$1,098

jue. 12/119:11 amPTY - BUF

1 stop9h 53mCopa Airlines

mar. 12/1610:10 amBUF - PTY

1 stop10h 25mCopa Airlines

Deal found 12/2

$1,337

Best flights from Panama to Buffalo
Discover carefully curated flight deals from Panama to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated diciembre 4, 2025.

vie. 12/268:00 amPTY - BUF

2 stops15h 28mDelta

jue. 1/16:00 amBUF - PTY

1 stop14h 00mDelta

Deal found 12/4

$535

jue. 12/1111:35 amPTY - BUF

2 stops11h 59mUnited Airlines

mar. 12/1610:10 amBUF - PTY

2 stops28h 35mUnited Airlines

Deal found 12/2

$535

mar. 1/132:27 pmPTY - BUF

2 stops24h 50mAmerican Airlines

lun. 1/196:00 amBUF - PTY

2 stops9h 38mAmerican Airlines

Deal found 12/2

$559

lun. 1/124:41 pmPTY - BUF

2 stops27h 48mUnited Airlines

dom. 1/181:59 pmBUF - PTY

2 stops27h 08mUnited Airlines

Deal found 12/2

$535

mié. 1/214:41 pmPTY - BUF

2 stops27h 48mUnited Airlines

dom. 1/2511:24 amBUF - PTY

1 stop8h 38mUnited Airlines

Deal found 12/3

$548

vie. 12/2611:55 pmPTY - BUF

2 stops16h 59mUnited Airlines

jue. 1/16:00 amBUF - PTY

1 stop7h 55mUnited Airlines

Deal found 12/2

$654

Last-minute flights from Panama to Buffalo
Discover last-minute flight deals from Panama to Buffalo. Data last updated diciembre 4, 2025 and is based on user searches.

jue. 12/1111:55 pmPTY - BUF

2 stops21h 20mUnited Airlines

mar. 12/166:00 amBUF - PTY

1 stop7h 55mUnited Airlines

Deal found 12/2

$654

jue. 12/119:11 amPTY - BUF

1 stop9h 53mCopa Airlines

mar. 12/1610:10 amBUF - PTY

1 stop10h 25mCopa Airlines

Deal found 12/2

$1,337

vie. 12/268:00 amPTY - BUF

2 stops15h 28mDelta

jue. 1/16:00 amBUF - PTY

1 stop14h 00mDelta

Deal found 12/4

$535

vie. 12/264:55 pmPTY - BUF

2 stops23h 29mAmerican Airlines

jue. 1/17:15 pmBUF - PTY

2 stops20h 39mAmerican Airlines

Deal found 12/2

$611

vie. 12/264:25 pmPTY - BUF

3 stops18h 10mMultiple Airlines

jue. 1/16:10 amBUF - PTY

3 stops14h 20mMultiple Airlines

Deal found 12/3

$1,098

dom. 1/112:55 amPTY - BUF

2 stops16h 30mAvianca

dom. 1/182:49 pmBUF - PTY

3 stops28h 06mAvianca

Deal found 12/2

$2,193

mar. 1/132:27 pmPTY - BUF

2 stops24h 50mAmerican Airlines

lun. 1/196:00 amBUF - PTY

2 stops9h 38mAmerican Airlines

Deal found 12/2

$559

mar. 1/133:20 pmPTY - BUF

1 stop8h 36mDelta

lun. 1/196:00 amBUF - PTY

1 stop7h 55mDelta

Deal found 12/3

$787

mié. 1/214:41 pmPTY - BUF

2 stops20h 43mUnited Airlines

dom. 1/258:30 amBUF - PTY

2 stops30h 15mUnited Airlines

Deal found 12/3

$548

One-way flights from Panama to Buffalo
Search for one-way flight options from Panama to Buffalo. Find affordable one-way fares based on user searches. Data last updated diciembre 4, 2025.

jue. 12/188:55 amPTY - BUF

2 stops11h 59mUnited Airlines

Deal found 12/3

$301

mar. 1/2010:28 pmPTY - BUF

3 stops44h 36mMultiple Airlines

Deal found 12/3

$365

jue. 12/187:50 pmPTY - BUF

3 stops47h 39mMultiple Airlines

Deal found 12/3

$370

mar. 1/203:20 pmPTY - BUF

1 stop8h 08mDelta

Deal found 12/3

$427

Find flight deals from Panama to Buffalo

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$535 (Delta)
One-way from	$301 (United Airlines)

Provider with most accurate pricing for Panama City Tocumen Intl-Buffalo flight deals.

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From Panama to Buffalo

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One-way flight from Panama to Buffalo

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Fly from

Fly to

Route

Depart

Return

Price

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

vie. 12/26

8:00 am-11:28 pm

2 stops15h 28m

Buffalo

jue. 1/1

6:00 am-8:00 pm

1 stop14h 00m

$535

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

jue. 12/11

11:35 am-11:34 pm

2 stops11h 59m

Buffalo

mar. 12/16

10:10 am-2:45 pm

2 stops28h 35m

$535

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

lun. 1/12

4:41 pm-8:29 pm

2 stops27h 48m

Buffalo

dom. 1/18

1:59 pm-5:07 pm

2 stops27h 08m

$535

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

mié. 1/21

4:41 pm-8:29 pm

2 stops27h 48m

Buffalo

dom. 1/25

11:24 am-8:02 pm

1 stop8h 38m

$548

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

mar. 1/13

2:27 pm-3:17 pm

2 stops24h 50m

Buffalo

lun. 1/19

6:00 am-3:38 pm

2 stops9h 38m

$559

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

vie. 12/26

11:55 pm-4:54 pm

2 stops16h 59m

Buffalo

jue. 1/1

6:00 am-1:55 pm

1 stop7h 55m

$654

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

mar. 1/20

4:41 pm-2:14 pm

2 stops21h 33m

$301

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

jue. 12/18

3:46 pm-11:59 pm

1 stop8h 13m

$301

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

jue. 12/18

8:55 am-8:54 pm

2 stops11h 59m

$301

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

mar. 1/20

10:28 pm-7:04 pm

3 stops44h 36m

$365

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/3

Showing 1-10 of 12 results

Best time to book a flight from Panama to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Panama with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

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Everything you need to know about your flight from Panama to Buffalo

No data available for this route at this time. Please check back soon.

Related info for your journey

What airport do you fly into for flights to Buffalo from Panama?
Buffalo (BUF), located 8.3 mi from the city center, is the airport you fly into when you book flights from Panama to Buffalo.
How long is the flight from Panama to Buffalo?
For as low as $535, Delta can have you in Buffalo from Panama in 11h 59m. Panama and Buffalo are separated by a distance of 2339 mi. Both multi-stop and nonstop flights can be found to your destination and back.
Can I find deals for flights from Panama to Buffalo that include hotel bookings?
Yes. In addition to deals on Panama to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Panama to Buffalo?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to Buffalo.
Can I find deals for business class flights from Panama to Buffalo?
Yes. Cheapflights offers flight deals from Panama to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

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$301+ Cheap flights from Panama to Buffalo (BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/20. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Panama to Buffalo with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Panama to Buffalo

Cheapest flights from Panama to BuffaloExplore the most affordable flight options available from Panama to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on diciembre 4, 2025.

Explore the most affordable flight options available from Panama to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on diciembre 4, 2025.

Find flight deals from Panama to Buffalo

Keep the following information in mind while searching for Panama to Buffalo flight deals. Data was last updated diciembre 4, 2025.

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Round-trip from

One-way from

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Use the filters below to find and compare flights from Panama to Buffalo that are best for you.

Best time to book a flight from Panama to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Panama with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Panama to Buffalo

Related info for your journey

Find useful and relevant information for your journey from Panama to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly into for flights to Buffalo from Panama?

How long is the flight from Panama to Buffalo?

Can I find deals for flights from Panama to Buffalo that include hotel bookings?

How can I find direct flights from Panama to Buffalo?

Can I find deals for business class flights from Panama to Buffalo?

Traveling to a place near Buffalo?

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Cheapest flights from Panama to Buffalo
Explore the most affordable flight options available from Panama to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on diciembre 4, 2025.