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$426+ Cheap flights from Panama to Buffalo (BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/26. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — BUF
Sep 10 — Sep 171
Thu 9/10
Thu 9/17
1 adult, Economy
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Cheap flight deals from Panama to Buffalo

Cheapest flights from Panama to Buffalo
Explore the most affordable flight options available from Panama to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 11, 2026.

This Avianca deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/37:50 pm -
2 stops12h 37m
Sat 11/78:00 pm -
2 stops14h 30m
Deal found 8/8$513
This Travelocity deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/193:50 pm -
2 stops15h 20m
Wed 9/233:33 pm -
2 stops19h 57m
Deal found 8/6$599
This Orbitz deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/105:30 am -
2 stops32h 13m
Sat 10/36:00 am -
2 stops29h 30m
Deal found 8/7$667
This United Airlines deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/310:00 am -
1 stop12h 59m
Sat 11/78:55 pm -
1 stop23h 07m
Deal found 8/8$776
This United Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/299:45 am -
1 stop12h 26m
Fri 10/26:30 am -
1 stop14h 01m
Deal found 8/10$785
This Delta deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/102:23 pm -
2 stops17h 01m
Sun 10/47:44 pm -
2 stops18h 14m
Deal found 8/7$786
This United Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/109:45 am -
2 stops12h 59m
Fri 10/26:00 am -
2 stops14h 31m
Deal found 8/7$797
This Delta deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/192:23 pm -
1 stop8h 29m
Wed 9/236:05 am -
1 stop7h 53m
Deal found 8/6$818
This United Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/210:55 pm -
2 stops17h 01m
Sun 9/65:58 pm -
2 stops26h 33m
Deal found 8/6$821

Find flight deals from Panama to Buffalo

Keep the following information in mind while searching for Panama to Buffalo flight deals. Data was last updated August 11, 2026.

Round-trip from

$513
(Avianca)

One-way from

$426
From Panama to Buffalo
Search Deals
One-way flight from Panama to Buffalo
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 11, 2026.
Use the filters below to find and compare flights from Panama to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityBuffalo

PTY Panama City Tocumen Intl - BUF Buffalo

PTYBUF

Panama City Tocumen Intl

Sat 9/19

3:50 pm-8:10 am

2 stops15h 20m

Buffalo

Wed 9/23

3:33 pm-10:30 am

2 stops19h 57m

$599

Panama CityBuffalo

PTY Panama City Tocumen Intl - BUF Buffalo

PTYBUF

Panama City Tocumen Intl

Tue 11/3

6:15 pm-12:18 pm

2 stops18h 03m

Buffalo

Sat 11/7

1:13 pm-8:31 pm

1 stop31h 18m

$775

Panama CityBuffalo

PTY Panama City Tocumen Intl - BUF Buffalo

PTYBUF

Panama City Tocumen Intl

Tue 9/29

9:45 am-11:11 pm

1 stop12h 26m

Buffalo

Fri 10/2

6:30 am-7:31 pm

1 stop14h 01m

$785

Panama CityBuffalo

PTY Panama City Tocumen Intl - BUF Buffalo

PTYBUF

Panama City Tocumen Intl

Thu 9/10

9:45 am-11:12 pm

1 stop12h 27m

Buffalo

Fri 10/2

7:59 pm-2:14 pm

2 stops19h 15m

$797
Quickest round-trip

Panama CityBuffalo

PTY Panama City Tocumen Intl - BUF Buffalo

PTYBUF

Panama City Tocumen Intl

Sat 9/19

2:23 pm-11:52 pm

1 stop8h 29m

Buffalo

Wed 9/23

6:05 am-12:58 pm

1 stop7h 53m

$818

Panama CityBuffalo

PTY Panama City Tocumen Intl - BUF Buffalo

PTYBUF

Panama City Tocumen Intl

Sat 9/19

9:45 am-11:12 pm

1 stop12h 27m

Buffalo

Wed 9/23

7:00 am-6:37 pm

2 stops12h 37m

$818

Panama CityBuffalo

PTY Panama City Tocumen Intl - BUF Buffalo

PTYBUF

Panama City Tocumen Intl

Wed 9/2

9:45 am-11:12 pm

1 stop12h 27m

Buffalo

Sun 9/6

7:59 pm-7:31 pm

2 stops24h 32m

$821
Cheapest one-way
Quickest one-way

Panama CityBuffalo

PTY Panama City Tocumen Intl - BUF Buffalo

PTYBUF

Panama City Tocumen Intl

Thu 1/28

3:20 pm-11:55 pm

1 stop8h 35m

$426

Panama CityBuffalo

PTY Panama City Tocumen Intl - BUF Buffalo

PTYBUF

Panama City Tocumen Intl

Wed 1/27

10:00 am-10:37 pm

1 stop12h 37m

$426

Panama CityBuffalo

PTY Panama City Tocumen Intl - BUF Buffalo

PTYBUF

Panama City Tocumen Intl

Tue 1/26

10:00 am-10:37 pm

1 stop12h 37m

$426

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/7

Showing 1-10 of 11 resultsSorted by cheapest first
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Best time to book a flight from Panama to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to Buffalo

No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Panama to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Buffalo from Panama?

    Buffalo (BUF), located 8.3 mi from the city center, is the airport you fly into when you book flights from Panama to Buffalo.

  • How long is the flight from Panama to Buffalo?

    For as low as $785, United Airlines can have you in Buffalo from Panama in 12h 26m. Panama and Buffalo are separated by a distance of 2339 mi.

  • Can I find deals for flights from Panama to Buffalo that include hotel bookings?

    Yes. In addition to deals on Panama to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to Buffalo.

  • Can I find deals for business class flights from Panama to Buffalo?

    Yes. Cheapflights offers flight deals from Panama to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Cheektowaga
Amherst
Williamsville
Orchard Park
Eden
Bowmansville

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