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$535+ Cheap flights from Panama to Buffalo (BUF)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/16. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — BUF
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheap flight deals from Panama to Buffalo

Keep the following information in mind while searching for Panama to Buffalo flight deals. Data was last updated September 17, 2025.

Round-trip from

$535
(Delta)
From Panama to Buffalo
Search Deals

Find flight deals from Panama to Buffalo

Cheapest flights from Panama to Buffalo
Explore the most affordable flight options available from Panama to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/134:41 pmPTY - BUF
2 stops20h 31mUnited Airlines
Sat 1/105:23 pmBUF - PTY
2 stops21h 22mUnited Airlines
Deal found 9/15$535
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1811:55 pmPTY - BUF
2 stops21h 22mUnited Airlines
Sat 1/1011:24 amBUF - PTY
1 stop8h 38mUnited Airlines
Deal found 9/15$542
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/162:50 pmPTY - BUF
2 stops21h 15mAmerican Airlines
Mon 1/124:31 pmBUF - PTY
2 stops20h 39mAmerican Airlines
Deal found 9/15$548
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/178:55 amPTY - BUF
2 stops12h 12mUnited Airlines
Tue 1/131:59 pmBUF - PTY
2 stops27h 08mUnited Airlines
Deal found 9/15$550
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/1511:55 pmPTY - BUF
2 stops16h 58mUnited Airlines
Sun 1/116:00 amBUF - PTY
1 stop7h 55mUnited Airlines
Deal found 9/15$585
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1811:55 pmPTY - BUF
2 stops21h 22mUnited Airlines
Sun 1/116:00 amBUF - PTY
1 stop7h 55mUnited Airlines
Deal found 9/15$592
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/1311:55 pmPTY - BUF
2 stops14h 27mUnited Airlines
Wed 1/141:59 pmBUF - PTY
2 stops24h 46mUnited Airlines
Deal found 9/15$629
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1810:00 amPTY - BUF
1 stop8h 40mUnited Airlines
Tue 1/131:59 pmBUF - PTY
2 stops27h 08mUnited Airlines
Deal found 9/15$636
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1910:00 amPTY - BUF
1 stop8h 40mUnited Airlines
Sat 1/1011:24 amBUF - PTY
1 stop8h 38mUnited Airlines
Deal found 9/15$653
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/193:46 pmPTY - BUF
1 stop19h 22mDelta
Sun 1/116:50 pmBUF - PTY
1 stop19h 12mDelta
Deal found 9/15$661
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/132:50 pmPTY - BUF
2 stops21h 10mAmerican Airlines
Sun 1/1111:56 amBUF - PTY
2 stops25h 14mAmerican Airlines
Deal found 9/15$666
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/144:37 pmPTY - BUF
2 stops24h 12mAmerican Airlines
Sun 1/116:21 amBUF - PTY
2 stops9h 14mAmerican Airlines
Deal found 9/15$671

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Panama to Buffalo that are best for you.

Fly from

Panama

Fly to

Buffalo

Route

Depart

Return

Price

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Tue 12/16

8:55 am-9:15 pm

2 stops12h 20m

Buffalo

Sat 1/10

1:59 pm-2:45 pm

2 stops24h 46m

$535

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sun 12/14

8:05 am-11:55 pm

1 stop15h 50m

Buffalo

Sun 1/11

6:00 am-2:02 pm

1 stop8h 02m

$535

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sat 12/13

8:05 am-10:57 pm

2 stops14h 52m

Buffalo

Thu 1/15

6:50 pm-2:02 pm

1 stop19h 12m

$535

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sun 12/14

4:41 pm-9:48 am

2 stops17h 07m

Buffalo

Sat 1/10

5:23 pm-2:45 pm

2 stops21h 22m

$535

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Tue 12/16

3:46 pm-11:55 pm

1 stop8h 09m

Buffalo

Thu 1/15

6:50 pm-2:02 pm

1 stop19h 12m

$535

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Mon 12/15

11:55 pm-1:12 pm

2 stops13h 17m

Buffalo

Sat 1/10

1:59 pm-2:45 pm

2 stops24h 46m

$535

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sat 12/13

8:05 am-10:57 pm

2 stops14h 52m

Buffalo

Fri 1/9

6:25 am-8:04 pm

2 stops13h 39m

$535

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sat 12/13

4:41 pm-1:12 pm

2 stops20h 31m

Buffalo

Sat 1/10

5:23 pm-2:45 pm

2 stops21h 22m

$535

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sun 12/14

8:05 am-11:04 am

1 stop26h 59m

Buffalo

Fri 1/9

6:16 am-8:04 pm

2 stops13h 48m

$535

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sat 12/13

8:05 am-10:57 pm

2 stops14h 52m

Buffalo

Mon 1/12

6:50 pm-2:02 pm

1 stop19h 12m

$535

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 11 results
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Best time to book a flight from Panama to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to Buffalo
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Panama to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Buffalo from Panama?

    Buffalo (BUF), located 8.3 mi from the city center, is the airport you fly into when you book flights from Panama to Buffalo.

  • How long is the flight from Panama to Buffalo?

    For as low as $535, United Airlines can have you in Buffalo from Panama in 12h 20m. Panama and Buffalo are separated by a distance of 2339 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Panama to Buffalo that include hotel bookings?

    Yes. In addition to deals on Panama to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to Buffalo.

  • Can I find deals for business class flights from Panama to Buffalo?

    Yes. Cheapflights offers flight deals from Panama to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to Buffalo?

    Currently, January is the cheapest month in which you can book a flight from Panama to Buffalo (average of $256). Flying from Panama to Buffalo in December is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Orchard Park
Batavia
Williamsville
Eden
Amherst
West Seneca

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Alternative routes for Panama to Buffalo

See prices for flight routes from nearby airports that may be better suited for you.
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