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$599+ Cheap flights from Panama to Buffalo (BUF)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/25. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — BUF
Jun 17 — Jun 241
Wed 6/17
Wed 6/24
1 adult, Economy
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Cheap flight deals from Panama to Buffalo

Cheapest flights from Panama to Buffalo
Explore the most affordable flight options available from Panama to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 18, 2026.

This Orbitz deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/253:50 pm
PTY
-
BUF
2 stops15h 34m
Multiple Airlines
Mon 9/288:00 pm
BUF
-
PTY
2 stops15h 30m
Multiple Airlines
Deal found 5/14$599
This United Airlines deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/239:45 am
PTY
-
BUF
2 stops23h 04m
United Airlines
Sat 9/265:50 pm
BUF
-
PTY
2 stops21h 24m
United Airlines
Deal found 5/17$728
This United Airlines deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/183:30 pm
PTY
-
BUF
2 stops17h 30m
United Airlines
Fri 7/246:04 pm
BUF
-
PTY
2 stops25h 33m
United Airlines
Deal found 5/16$757
This United Airlines deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/33:30 pm
PTY
-
BUF
2 stops28h 33m
United Airlines
Sun 6/76:04 pm
BUF
-
PTY
2 stops25h 33m
United Airlines
Deal found 5/13$760
This Delta deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/252:21 pm
PTY
-
BUF
1 stop8h 37m
Delta
Mon 9/286:00 am
BUF
-
PTY
1 stop7h 56m
Delta
Deal found 5/14$889
This Delta deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/182:27 pm
PTY
-
BUF
1 stop8h 15m
Delta
Fri 7/246:00 am
BUF
-
PTY
1 stop8h 05m
Delta
Deal found 5/16$936

Find flight deals from Panama to Buffalo

Keep the following information in mind while searching for Panama to Buffalo flight deals. Data was last updated May 18, 2026.

Round-trip from

$599
(Orbitz)
From Panama to Buffalo
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 18, 2026.
Use the filters below to find and compare flights from Panama to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Fri 9/25

11:25 am-8:24 am

3 stops19h 59m

Buffalo

Mon 9/28

8:00 pm-10:30 am

2 stops15h 30m

$606

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Wed 9/23

9:45 am-9:49 am

2 stops23h 04m

Buffalo

Sat 9/26

5:50 pm-2:14 pm

2 stops21h 24m

$728

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Wed 6/3

3:30 pm-9:03 pm

2 stops28h 33m

Buffalo

Sun 6/7

6:04 pm-6:37 pm

2 stops25h 33m

$760
Quickest round-trip

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sat 7/18

2:27 pm-11:42 pm

1 stop8h 15m

Buffalo

Fri 7/24

6:00 am-1:05 pm

1 stop8h 05m

$936

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/14

Sorted by cheapest first

Best time to book a flight from Panama to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to Buffalo
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Panama to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Buffalo from Panama?

    Buffalo (BUF), located 8.3 mi from the city center, is the airport you fly into when you book flights from Panama to Buffalo.

  • How long is the flight from Panama to Buffalo?

    For as low as $728, United Airlines can have you in Buffalo from Panama in 23h 04m. Panama and Buffalo are separated by a distance of 2339 mi.

  • Can I find deals for flights from Panama to Buffalo that include hotel bookings?

    Yes. In addition to deals on Panama to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to Buffalo.

  • Can I find deals for business class flights from Panama to Buffalo?

    Yes. Cheapflights offers flight deals from Panama to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Cheektowaga
Amherst
Batavia
Williamsville
Orchard Park
Eden
West Seneca

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