$344+ Cheap flights from Panama to Buffalo (BUF)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/19. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — BUF
Oct 18 — Oct 251
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Panama to BuffaloExplore the most affordable flight options available from Panama to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 18, 2026.
Explore the most affordable flight options available from Panama to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 18, 2026.
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/263:41 pm -
2 stops20h 35m
Mon 11/166:00 am -
1 stop14h 02m
Deal found 9/16![United Airlines logo]()
$680
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/242:24 pm -
1 stop8h 35m
Sun 11/86:00 am -
1 stop7h 59m
Deal found 9/13![Delta logo]()
$745
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/233:30 pm -
2 stops16h 38m
Mon 10/267:52 pm -
2 stops24h 10m
Deal found 9/14![United Airlines logo]()
$746
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/263:41 pm -
2 stops27h 28m
Mon 11/97:52 pm -
2 stops24h 10m
Deal found 9/15![United Airlines logo]()
$751
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/13:30 pm -
2 stops24h 13m
Mon 10/57:42 pm -
2 stops19h 32m
Deal found 9/13![United Airlines logo]()
$754
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/242:02 pm -
2 stops19h 46m
Sun 11/87:01 pm -
2 stops19h 12m
Deal found 9/15![American Airlines logo]()
$758
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/69:45 am -
2 stops13h 05m
Sun 10/116:00 am -
2 stops14h 31m
Deal found 9/17![United Airlines logo]()
$767
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/249:45 am -
1 stop12h 20m
Sun 11/85:58 pm -
2 stops26h 04m
Deal found 9/13![United Airlines logo]()
$772
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/23:24 pm -
1 stop8h 35m
Tue 11/106:00 am -
1 stop8h 02m
Deal found 9/14![Delta logo]()
$799
This Orbitz deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/243:50 pm -
2 stops15h 18m
Sun 11/87:59 pm -
3 stops19h 01m
Deal found 9/15![Multiple Airlines logo]()
$820
Best flights from Panama to BuffaloDiscover carefully curated flight deals from Panama to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 18, 2026.
Discover carefully curated flight deals from Panama to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 18, 2026.
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/262:24 pm -
1 stop8h 35m
Mon 11/166:00 am -
1 stop8h 02m
Deal found 9/16![Delta logo]()
$680
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/263:41 pm -
2 stops20h 35m
Mon 11/166:00 am -
1 stop14h 02m
Deal found 9/16![United Airlines logo]()
$680
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/242:24 pm -
1 stop8h 35m
Sun 11/86:00 am -
1 stop7h 59m
Deal found 9/13![Delta logo]()
$745
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/233:30 pm -
2 stops16h 38m
Mon 10/2610:51 am -
1 stop9h 11m
Deal found 9/14![United Airlines logo]()
$746
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/263:41 pm -
2 stops27h 28m
Mon 11/97:52 pm -
2 stops24h 10m
Deal found 9/15![United Airlines logo]()
$751
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/24:41 pm -
2 stops20h 36m
Tue 11/105:58 pm -
2 stops26h 04m
Deal found 9/14![United Airlines logo]()
$751
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/13:30 pm -
2 stops24h 13m
Mon 10/57:42 pm -
2 stops19h 32m
Deal found 9/13![United Airlines logo]()
$754
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/69:45 am -
2 stops13h 05m
Sun 10/116:00 am -
2 stops14h 31m
Deal found 9/17![United Airlines logo]()
$767
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/249:45 am -
1 stop12h 20m
Sun 11/85:58 pm -
2 stops26h 04m
Deal found 9/13![United Airlines logo]()
$772
Last-minute flights from Panama to BuffaloDiscover last-minute flight deals from Panama to Buffalo. Data last updated September 18, 2026 and is based on user searches.
Discover last-minute flight deals from Panama to Buffalo. Data last updated September 18, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/13:30 pm -
2 stops24h 13m
Mon 10/57:42 pm -
2 stops19h 32m
Deal found 9/13![United Airlines logo]()
$754
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/69:45 am -
2 stops13h 05m
Sun 10/116:00 am -
2 stops14h 31m
Deal found 9/17![United Airlines logo]()
$767
This Orbitz deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/63:50 pm -
2 stops15h 10m
Sun 10/116:00 am -
3 stops33h 55m
Deal found 9/17![Multiple Airlines logo]()
$827
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/233:30 pm -
2 stops16h 38m
Mon 10/2610:51 am -
1 stop9h 11m
Deal found 9/14![United Airlines logo]()
$746
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/242:24 pm -
1 stop8h 35m
Sun 11/86:00 am -
1 stop7h 59m
Deal found 9/13![Delta logo]()
$745
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/242:02 pm -
2 stops19h 46m
Sun 11/87:01 pm -
2 stops19h 12m
Deal found 9/15![American Airlines logo]()
$758
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/249:45 am -
1 stop12h 20m
Sun 11/85:58 pm -
2 stops26h 04m
Deal found 9/13![United Airlines logo]()
$772
This Orbitz deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/243:50 pm -
2 stops15h 18m
Sun 11/87:59 pm -
3 stops19h 01m
Deal found 9/15![Multiple Airlines logo]()
$820
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/263:41 pm -
2 stops20h 35m
Mon 11/166:00 am -
1 stop14h 02m
Deal found 9/16![United Airlines logo]()
$680
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/263:41 pm -
2 stops27h 28m
Mon 11/97:52 pm -
2 stops24h 10m
Deal found 9/15![United Airlines logo]()
$751
One-way flights from Panama to BuffaloSearch for one-way flight options from Panama to Buffalo. Find affordable one-way fares based on user searches. Data last updated September 18, 2026.
Search for one-way flight options from Panama to Buffalo. Find affordable one-way fares based on user searches. Data last updated September 18, 2026.
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/194:41 pm -
2 stops24h 16m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![United Airlines logo]()
$344
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/193:20 pm -
1 stop8h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Delta logo]()
$438
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/194:55 pm -
1 stop30h 17m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![American Airlines logo]()
$452
This Avianca deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/1911:30 am -
3 stops30h 56m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![Avianca logo]()
$3,375
Find flight deals from Panama to Buffalo
Keep the following information in mind while searching for Panama to Buffalo flight deals. Data was last updated September 18, 2026.
Round-trip from | $680 (United Airlines) |
|---|---|
One-way from | $344 (United Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 18, 2026.
Use the filters below to find and compare flights from Panama to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Panama CityBuffalo
PTY Panama City Tocumen Intl - BUF Buffalo
PTYBUF
Panama City Tocumen Intl
Tue 1/19
4:41 pm-4:57 pm
2 stops24h 16m
Buffalo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$344
Quickest round-trip
Panama CityBuffalo
PTY Panama City Tocumen Intl - BUF Buffalo
PTYBUF
Panama City Tocumen Intl
Tue 1/19
3:20 pm-11:55 pm
1 stop8h 35m
Buffalo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$438
Panama CityBuffalo
PTY Panama City Tocumen Intl - BUF Buffalo
PTYBUF
Panama City Tocumen Intl
Mon 10/26
2:24 pm-11:59 pm
1 stop8h 35m
Buffalo
Mon 11/16
6:00 am-2:02 pm
1 stop8h 02m
$680
Panama CityBuffalo
PTY Panama City Tocumen Intl - BUF Buffalo
PTYBUF
Panama City Tocumen Intl
Mon 10/26
3:41 pm-1:16 pm
2 stops20h 35m
Buffalo
Mon 11/16
6:00 am-8:02 pm
1 stop14h 02m
$680
Panama CityBuffalo
PTY Panama City Tocumen Intl - BUF Buffalo
PTYBUF
Panama City Tocumen Intl
Sat 10/24
2:24 pm-11:59 pm
1 stop8h 35m
Buffalo
Sun 11/8
6:00 am-1:59 pm
1 stop7h 59m
$745
Panama CityBuffalo
PTY Panama City Tocumen Intl - BUF Buffalo
PTYBUF
Panama City Tocumen Intl
Fri 10/23
3:30 pm-9:08 am
2 stops16h 38m
Buffalo
Mon 10/26
10:51 am-7:02 pm
1 stop9h 11m
$746
Panama CityBuffalo
PTY Panama City Tocumen Intl - BUF Buffalo
PTYBUF
Panama City Tocumen Intl
Mon 10/26
3:41 pm-8:09 pm
2 stops27h 28m
Buffalo
Mon 11/9
7:52 pm-8:02 pm
2 stops24h 10m
$751
Panama CityBuffalo
PTY Panama City Tocumen Intl - BUF Buffalo
PTYBUF
Panama City Tocumen Intl
Mon 11/2
4:41 pm-1:17 pm
2 stops20h 36m
Buffalo
Tue 11/10
5:58 pm-8:02 pm
2 stops26h 04m
$751
Panama CityBuffalo
PTY Panama City Tocumen Intl - BUF Buffalo
PTYBUF
Panama City Tocumen Intl
Thu 10/1
3:30 pm-4:43 pm
2 stops24h 13m
Buffalo
Mon 10/5
7:42 pm-2:14 pm
2 stops19h 32m
$754
Panama CityBuffalo
PTY Panama City Tocumen Intl - BUF Buffalo
PTYBUF
Panama City Tocumen Intl
Tue 10/6
9:45 am-11:50 pm
2 stops13h 05m
Buffalo
Sun 10/11
6:00 am-7:31 pm
2 stops14h 31m
$767
Showing 1-10 of 12 resultsSorted by cheapest first
Best time to book a flight from Panama to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from Panama with our price prediction graph.
PTY-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama to Buffalo
PA0-BUF
PTY-BUF
No data available for this route at this time. Please check back soon.
Related info for your journey
Find useful and relevant information for your journey from Panama to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsCheektowaga
Lockport
Amherst
Williamsville
Orchard Park
Eden
Bowmansville
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