How long is the flight from Panama to Buffalo?

For as low as $549, United Airlines can have you in Buffalo from Panama in 25h 49m. Panama and Buffalo are separated by a distance of 2339 mi.

In terms of precipitation, rainfall in Buffalo ranges from 2.5 - 4.0 inches per month. November is typically the wettest month, when rainfall can reach 4.0 in. February is typically the driest time to visit Buffalo when rainfall is around 2.5 in.

If weather is an important factor for your trip to Buffalo, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 71.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 24.8 F).

What is the cheapest time of day to fly from PA to BUF?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama to Buffalo as you normally would.

What airport do you fly into for flights to Buffalo from Panama?

Buffalo (BUF), located 8.3 mi from the city center, is the airport you fly into when you book flights from Panama to Buffalo.

Can I find deals for flights from Panama to Buffalo that include hotel bookings?

Yes. In addition to deals on Panama to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Panama to Buffalo?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to Buffalo.

Can I find deals for business class flights from Panama to Buffalo?

Yes. Cheapflights offers flight deals from Panama to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$307+ Flights from Panama to Buffalo

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Cheap flight deals from Panama to Buffalo

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$536 (Delta)
One-way from	$307 (United Airlines)

Provider with most accurate pricing for Panama City Tocumen Intl-Buffalo flight deals.

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Cheapest flights from Panama to Buffalo
Explore the most affordable flight options available from Panama to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 6, 2026.

Tue 1/133:20 pmPTY - BUF

1 stop8h 36mDelta

Mon 1/196:00 amBUF - PTY

1 stop7h 55mDelta

Deal found 1/5

$536

Thu 1/2911:35 amPTY - BUF

2 stops25h 49mUnited Airlines

Mon 2/28:30 amBUF - PTY

2 stops32h 37mUnited Airlines

Deal found 1/3

$549

Tue 1/134:41 pmPTY - BUF

2 stops20h 43mUnited Airlines

Mon 1/1911:24 amBUF - PTY

1 stop8h 38mUnited Airlines

Deal found 1/4

$655

Tue 1/132:27 pmPTY - BUF

2 stops27h 20mAmerican Airlines

Mon 1/195:12 amBUF - PTY

2 stops10h 26mAmerican Airlines

Deal found 1/5

$693

Best flights from Panama to Buffalo
Discover carefully curated flight deals from Panama to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated January 6, 2026.

Thu 1/2911:35 amPTY - BUF

2 stops25h 49mUnited Airlines

Mon 2/28:30 amBUF - PTY

2 stops32h 37mUnited Airlines

Deal found 1/3

$549

Last-minute flights from Panama to Buffalo
Discover last-minute flight deals from Panama to Buffalo. Data last updated January 6, 2026 and is based on user searches.

Tue 1/133:20 pmPTY - BUF

1 stop8h 36mDelta

Mon 1/196:00 amBUF - PTY

1 stop7h 55mDelta

Deal found 1/5

$536

Tue 1/134:41 pmPTY - BUF

2 stops20h 43mUnited Airlines

Mon 1/1911:24 amBUF - PTY

1 stop8h 38mUnited Airlines

Deal found 1/4

$655

Tue 1/132:27 pmPTY - BUF

2 stops27h 20mAmerican Airlines

Mon 1/195:12 amBUF - PTY

2 stops10h 26mAmerican Airlines

Deal found 1/5

$693

Thu 1/2911:35 amPTY - BUF

2 stops25h 49mUnited Airlines

Mon 2/28:30 amBUF - PTY

2 stops32h 37mUnited Airlines

Deal found 1/3

$549

One-way flights from Panama to Buffalo
Search for one-way flight options from Panama to Buffalo. Find affordable one-way fares based on user searches. Data last updated January 6, 2026.

Sat 4/253:30 pmPTY - BUF

2 stops28h 13mUnited Airlines

Deal found 1/5

$307

Sat 4/252:20 pmPTY - BUF

1 stop8h 37mDelta

Deal found 1/5

$466

Fly from

Fly to

Route

Depart

Return

Price

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Thu 1/29

11:35 am-1:24 pm

2 stops25h 49m

Buffalo

Mon 2/2

8:30 am-5:07 pm

2 stops32h 37m

$549

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sat 4/25

3:30 pm-8:43 pm

2 stops28h 13m

$307

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sat 4/25

2:20 pm-11:57 pm

1 stop8h 37m

$466

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/5

Best time to book a flight from Panama to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Panama with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to Buffalo

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Related info for your journey

What airport do you fly into for flights to Buffalo from Panama?
Buffalo (BUF), located 8.3 mi from the city center, is the airport you fly into when you book flights from Panama to Buffalo.
How long is the flight from Panama to Buffalo?
For as low as $549, United Airlines can have you in Buffalo from Panama in 25h 49m. Panama and Buffalo are separated by a distance of 2339 mi.
Can I find deals for flights from Panama to Buffalo that include hotel bookings?
Yes. In addition to deals on Panama to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Panama to Buffalo?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to Buffalo.
Can I find deals for business class flights from Panama to Buffalo?
Yes. Cheapflights offers flight deals from Panama to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

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$307+ Cheap flights from Panama to Buffalo (BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/25. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Panama to Buffalo with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Panama to Buffalo

Keep the following information in mind while searching for Panama to Buffalo flight deals. Data was last updated January 6, 2026.

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Round-trip from

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Find flight deals from Panama to Buffalo

Cheapest flights from Panama to BuffaloExplore the most affordable flight options available from Panama to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 6, 2026.

Explore the most affordable flight options available from Panama to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 6, 2026.

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Use the filters below to find and compare flights from Panama to Buffalo that are best for you.

Best time to book a flight from Panama to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Panama with our price prediction graph.

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Everything you need to know about your flight from Panama to Buffalo

Related info for your journey

Find useful and relevant information for your journey from Panama to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly into for flights to Buffalo from Panama?

How long is the flight from Panama to Buffalo?

Can I find deals for flights from Panama to Buffalo that include hotel bookings?

How can I find direct flights from Panama to Buffalo?

Can I find deals for business class flights from Panama to Buffalo?

Traveling to a place near Buffalo?

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Cheapest flights from Panama to Buffalo
Explore the most affordable flight options available from Panama to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 6, 2026.