$328+ Cheap flights from Panama to Buffalo (BUF)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/4. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — BUF
ago. 11 — ago. 181
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Panama to Buffalo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Panama to Buffalo
Cheapest
Best
Last-minute
One-way
Cheapest flights from Panama to BuffaloExplore the most affordable flight options available from Panama to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 12, 2026.
Explore the most affordable flight options available from Panama to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 12, 2026.
This oojo deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 8/163:50 pm
PTY
- BUF
2 stops22h 06m
Multiple Airlines
dom. 8/239:15 am
BUF
- PTY
2 stops26h 15m
Multiple Airlines
Deal found 7/8![Multiple Airlines logo]()
$577
This oojo deal was found by Cheapflights users on 7/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 7/303:50 pm
PTY
- BUF
2 stops21h 47m
Multiple Airlines
jue. 12/37:30 pm
BUF
- PTY
2 stops23h 25m
Multiple Airlines
Deal found 7/9![Multiple Airlines logo]()
$590
This American Airlines deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 9/181:16 pm
PTY
- BUF
2 stops21h 50m
American Airlines
lun. 9/215:18 pm
BUF
- PTY
2 stops20h 06m
American Airlines
Deal found 7/10![American Airlines logo]()
$714
This United Airlines deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 9/309:45 am
PTY
- BUF
1 stop12h 26m
United Airlines
dom. 10/43:52 pm
BUF
- PTY
1 stop28h 39m
United Airlines
Deal found 7/7![United Airlines logo]()
$725
This Delta deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 9/182:23 pm
PTY
- BUF
1 stop8h 31m
Delta
lun. 9/216:05 am
BUF
- PTY
1 stop7h 53m
Delta
Deal found 7/10![Delta logo]()
$733
This United Airlines deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 9/1810:00 am
PTY
- BUF
2 stops22h 52m
United Airlines
lun. 9/216:00 am
BUF
- PTY
1 stop14h 31m
United Airlines
Deal found 7/10![United Airlines logo]()
$746
Best flights from Panama to BuffaloDiscover carefully curated flight deals from Panama to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated julio 12, 2026.
Discover carefully curated flight deals from Panama to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated julio 12, 2026.
This oojo deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 7/303:50 pm
PTY
- BUF
2 stops15h 02m
Multiple Airlines
jue. 12/37:30 pm
BUF
- PTY
2 stops23h 25m
Multiple Airlines
Deal found 7/8![Multiple Airlines logo]()
$590
This United Airlines deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 9/309:45 am
PTY
- BUF
1 stop12h 26m
United Airlines
dom. 10/43:52 pm
BUF
- PTY
1 stop28h 39m
United Airlines
Deal found 7/11![United Airlines logo]()
$725
This Delta deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 9/182:23 pm
PTY
- BUF
1 stop8h 31m
Delta
lun. 9/216:05 am
BUF
- PTY
1 stop7h 53m
Delta
Deal found 7/10![Delta logo]()
$733
This Expedia deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 8/1611:25 am
PTY
- BUF
3 stops26h 31m
Multiple Airlines
dom. 8/238:02 pm
BUF
- PTY
3 stops19h 53m
Multiple Airlines
Deal found 7/8![Multiple Airlines logo]()
$653
This United Airlines deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 9/1810:00 am
PTY
- BUF
2 stops22h 52m
United Airlines
lun. 9/216:00 am
BUF
- PTY
1 stop14h 31m
United Airlines
Deal found 7/10![United Airlines logo]()
$746
Last-minute flights from Panama to BuffaloDiscover last-minute flight deals from Panama to Buffalo. Data last updated julio 12, 2026 and is based on user searches.
Discover last-minute flight deals from Panama to Buffalo. Data last updated julio 12, 2026 and is based on user searches.
This oojo deal was found by Cheapflights users on 7/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 7/303:50 pm
PTY
- BUF
2 stops21h 47m
Multiple Airlines
jue. 12/37:30 pm
BUF
- PTY
2 stops23h 25m
Multiple Airlines
Deal found 7/9![Multiple Airlines logo]()
$590
This United Airlines deal was found by Cheapflights users on 7/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 7/3010:55 pm
PTY
- BUF
1 stop18h 09m
United Airlines
jue. 12/36:00 am
BUF
- PTY
1 stop14h 02m
United Airlines
Deal found 7/9![United Airlines logo]()
$870
This American Airlines deal was found by Cheapflights users on 7/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 7/301:14 pm
PTY
- BUF
2 stops9h 45m
American Airlines
jue. 12/37:20 pm
BUF
- PTY
3 stops18h 28m
American Airlines
Deal found 7/9![American Airlines logo]()
$2,478
This United Airlines deal was found by Cheapflights users on 7/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 8/810:55 pm
PTY
- BUF
1 stop23h 11m
United Airlines
vie. 8/146:00 am
BUF
- PTY
1 stop23h 04m
United Airlines
Deal found 7/9![United Airlines logo]()
$803
This oojo deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 8/163:50 pm
PTY
- BUF
2 stops22h 06m
Multiple Airlines
dom. 8/239:15 am
BUF
- PTY
2 stops26h 15m
Multiple Airlines
Deal found 7/8![Multiple Airlines logo]()
$577
One-way flights from Panama to BuffaloSearch for one-way flight options from Panama to Buffalo. Find affordable one-way fares based on user searches. Data last updated julio 12, 2026.
Search for one-way flight options from Panama to Buffalo. Find affordable one-way fares based on user searches. Data last updated julio 12, 2026.
This oojo deal was found by Cheapflights users on 7/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 9/43:50 pm
PTY
- BUF
2 stops14h 32m
Multiple Airlines
Deal found 7/9![Multiple Airlines logo]()
$328
This FlightHub deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 7/2911:25 am
PTY
- BUF
3 stops19h 27m
Multiple Airlines
Deal found 7/11![Multiple Airlines logo]()
$340
This Travelocity deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 7/193:50 pm
PTY
- BUF
2 stops15h 01m
Multiple Airlines
Deal found 7/11![Multiple Airlines logo]()
$342
This Kiwi.com deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 9/109:33 pm
PTY
- BUF
2 stops13h 48m
Multiple Airlines
Deal found 7/8![Multiple Airlines logo]()
$374
This Kiwi.com deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 9/119:33 pm
PTY
- BUF
2 stops13h 48m
Multiple Airlines
Deal found 7/8![Multiple Airlines logo]()
$382
This Delta deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 9/102:23 pm
PTY
- BUF
1 stop8h 31m
Delta
Deal found 7/8![Delta logo]()
$405
This Delta deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 8/32:20 pm
PTY
- BUF
1 stop8h 39m
Delta
Deal found 7/8![Delta logo]()
$426
This United Airlines deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 8/310:55 pm
PTY
- BUF
1 stop9h 58m
United Airlines
Deal found 7/10![United Airlines logo]()
$431
This United Airlines deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 7/2610:55 pm
PTY
- BUF
1 stop9h 58m
United Airlines
Deal found 7/11![United Airlines logo]()
$439
This American Airlines deal was found by Cheapflights users on 7/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 9/41:39 pm
PTY
- BUF
2 stops20h 41m
American Airlines
Deal found 7/9![American Airlines logo]()
$441
Find flight deals from Panama to Buffalo
Keep the following information in mind while searching for Panama to Buffalo flight deals. Data was last updated julio 12, 2026.
Round-trip from | $577 (oojo) |
|---|---|
One-way from | $328 (oojo) |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated julio 12, 2026.
Use the filters below to find and compare flights from Panama to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Panama CityBuffalo
PTY - BUF
PTYBUF
Panama City Tocumen Intl
jue. 7/30
3:50 pm-7:52 am
2 stops15h 02m
Buffalo
jue. 12/3
7:30 pm-6:55 pm
2 stops23h 25m
$590
Panama CityBuffalo
PTY - BUF
PTYBUF
Panama City Tocumen Intl
dom. 8/16
11:25 am-2:56 pm
3 stops26h 31m
Buffalo
dom. 8/23
8:02 pm-2:55 pm
3 stops19h 53m
$653
Panama CityBuffalo
PTY - BUF
PTYBUF
Panama City Tocumen Intl
mié. 9/30
9:45 am-11:11 pm
1 stop12h 26m
Buffalo
dom. 10/4
3:52 pm-7:31 pm
1 stop28h 39m
$725
Quickest round-trip
Panama CityBuffalo
PTY - BUF
PTYBUF
Panama City Tocumen Intl
vie. 9/18
2:23 pm-11:54 pm
1 stop8h 31m
Buffalo
lun. 9/21
6:05 am-12:58 pm
1 stop7h 53m
$733
Panama CityBuffalo
PTY - BUF
PTYBUF
Panama City Tocumen Intl
vie. 9/18
10:00 am-9:52 am
2 stops22h 52m
Buffalo
lun. 9/21
6:00 am-7:31 pm
1 stop14h 31m
$746
Cheapest one-way
Panama CityBuffalo
PTY - BUF
PTYBUF
Panama City Tocumen Intl
vie. 9/4
3:50 pm-7:22 am
2 stops14h 32m
$328
Panama CityBuffalo
PTY - BUF
PTYBUF
Panama City Tocumen Intl
jue. 9/10
9:33 pm-12:21 pm
2 stops13h 48m
$374
Panama CityBuffalo
PTY - BUF
PTYBUF
Panama City Tocumen Intl
vie. 9/11
9:33 pm-12:21 pm
2 stops13h 48m
$382
Quickest one-way
Panama CityBuffalo
PTY - BUF
PTYBUF
Panama City Tocumen Intl
jue. 9/10
2:23 pm-11:54 pm
1 stop8h 31m
$405
Panama CityBuffalo
PTY - BUF
PTYBUF
Panama City Tocumen Intl
lun. 8/3
2:20 pm-11:59 pm
1 stop8h 39m
$426
Showing 1-10 of 13 resultsSorted by cheapest first
Best time to book a flight from Panama to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from Panama with our price prediction graph.
PTY-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama to Buffalo
PA0-BUF
PTY-BUF
No data available for this route at this time. Please check back soon.
Related info for your journey
Find useful and relevant information for your journey from Panama to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsLockport
Cheektowaga
Batavia
Amherst
Williamsville
Orchard Park
Eden
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Buffalo flight routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights