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$646+ Cheap flights from Lyon (LYS) to Buffalo (BUF)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/4. Fares are subject to change and may not be available on all flights or dates of travel.
LYS — BUF
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheap flight deals from Lyon to Buffalo

Discover tips and strategies to find the most affordable flight options for your journey from Lyon (LYS) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 15, 2025.

Round-trip from

$646
(American Airlines)
From Lyon-Saint Exupéry to Buffalo
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Find flight deals from Lyon to Buffalo

Cheapest flights from Lyon to Buffalo
Explore the most affordable flight options available from Lyon to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/49:35 amLYS - BUF
2 stops20h 04mAmerican Airlines
Mon 12/84:46 pmBUF - LYS
2 stops14h 29mAmerican Airlines
Deal found 9/14$646
This British Airways deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure British Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/49:35 amLYS - BUF
2 stops20h 04mBritish Airways
Mon 12/82:50 pmBUF - LYS
2 stops16h 25mBritish Airways
Deal found 9/13$648
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/410:40 amLYS - BUF
2 stops43h 16mAmerican Airlines
Sat 10/115:27 pmBUF - LYS
2 stops21h 28mAmerican Airlines
Deal found 9/14$705
This British Airways deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure British Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/47:15 pmLYS - BUF
2 stops34h 41mBritish Airways
Sat 10/1111:12 amBUF - LYS
2 stops21h 18mBritish Airways
Deal found 9/13$766
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/2612:00 pmLYS - BUF
2 stops16h 57mDelta
Sun 1/45:48 pmBUF - LYS
2 stops13h 37mDelta
Deal found 9/14$862

Cheapflights Fare Finder

 
Customize your flight search to find flights from Lyon to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Lyon to Buffalo that are best for you.

Fly from

Lyon

Fly to

Buffalo

Route

Depart

Return

Price

LyonBuffalo

LYS - BUF

LYSBUF

Lyon-Saint Exupéry

Thu 12/4

9:35 am-11:39 pm

2 stops20h 04m

Buffalo

Mon 12/8

4:46 pm-1:15 pm

2 stops14h 29m

$646

LyonBuffalo

LYS - BUF

LYSBUF

Lyon-Saint Exupéry

Thu 12/4

9:35 am-10:54 pm

2 stops19h 19m

Buffalo

Mon 12/8

4:46 pm-5:30 pm

2 stops18h 44m

$648

LyonBuffalo

LYS - BUF

LYSBUF

Lyon-Saint Exupéry

Sat 10/4

10:40 am-11:56 pm

2 stops43h 16m

Buffalo

Sat 10/11

5:27 pm-8:55 pm

2 stops21h 28m

$705

LyonBuffalo

LYS - BUF

LYSBUF

Lyon-Saint Exupéry

Sat 10/4

7:15 pm-11:56 pm

2 stops34h 41m

Buffalo

Sat 10/11

11:12 am-2:30 pm

2 stops21h 18m

$766

LyonBuffalo

LYS - BUF

LYSBUF

Lyon-Saint Exupéry

Fri 12/26

12:00 pm-10:57 pm

2 stops16h 57m

Buffalo

Sun 1/4

5:48 pm-1:25 pm

2 stops13h 37m

$862

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Best time to book a flight from Lyon to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Lyon with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Lyon to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Lyon to Buffalo?

    Airlines like American Airlines and British Airways fly from Lyon to Buffalo in about 19h 19m. The time it takes to get you to your destination can typically vary by up to 45m. The distance from Lyon to Buffalo is about 3944 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Lyon to Buffalo that include hotel bookings?

    Yes. In addition to deals on Lyon to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Lyon to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Lyon to Buffalo.

  • Can I find deals for business class flights from Lyon to Buffalo?

    Yes. Cheapflights offers flight deals from Lyon to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Lyon to Buffalo?

    Currently, January is the cheapest month in which you can book a flight from Lyon to Buffalo (average of $256). Flying from Lyon to Buffalo in December is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Orchard Park
Batavia
Williamsville
Eden
Amherst
West Seneca

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