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$176+ Cheap flights from Key West to Buffalo (EYW - BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/18. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — BUF
Aug 26 — Sep 21
Tue 8/26
Tue 9/2
1 adult, Economy
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Cheap flight deals from Key West to Buffalo

Discover tips and strategies to find the most affordable flight options for your journey from Key West (EYW) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 21, 2025.

Round-trip from

$269
(Delta)

One-way from

$176
(Kiwi.com)

Popular in

February

Cheapest in

October

Average price

$323
From Key West to Buffalo
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One-way flight from Key West to Buffalo
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Highest demand for flights based on searches. 30% potential increase in price ($189 potential increase over avg. RT price).
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Cheapest flight prices on average. 15% potential price decrease ($56 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from Key West to Buffalo

Cheapest flights from Key West to Buffalo
Explore the most affordable flight options available from Key West to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 21, 2025.

This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/186:00 pmEYW - BUF
1 stop5h 55mDelta
Tue 1/66:00 amBUF - EYW
1 stop5h 03mDelta
Deal found 8/18$269
This American Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/205:09 pmEYW - BUF
1 stop5h 43mAmerican Airlines
Wed 11/2611:34 amBUF - EYW
2 stops10h 13mAmerican Airlines
Deal found 8/20$314
This Delta deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/196:00 pmEYW - BUF
1 stop5h 55mDelta
Mon 1/56:16 amBUF - EYW
1 stop7h 33mDelta
Deal found 8/19$324
This American Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/311:25 amEYW - BUF
2 stops10h 18mAmerican Airlines
Sun 9/76:00 amBUF - EYW
2 stops8h 17mAmerican Airlines
Deal found 8/19$329
This American Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/245:23 pmEYW - BUF
1 stop5h 12mAmerican Airlines
Wed 1/76:16 amBUF - EYW
1 stop7h 39mAmerican Airlines
Deal found 8/19$349
This Delta deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/206:00 pmEYW - BUF
1 stop5h 55mDelta
Wed 11/2612:09 pmBUF - EYW
1 stop7h 35mDelta
Deal found 8/20$373
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/186:00 pmEYW - BUF
1 stop5h 55mDelta
Fri 1/96:00 amBUF - EYW
1 stop7h 12mDelta
Deal found 8/18$374
This American Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/231:25 pmEYW - BUF
1 stop4h 33mAmerican Airlines
Tue 1/611:56 amBUF - EYW
1 stop6h 39mAmerican Airlines
Deal found 8/19$389
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/227:35 pmEYW - BUF
1 stop4h 38mAmerican Airlines
Wed 1/76:21 amBUF - EYW
1 stop6h 56mAmerican Airlines
Deal found 8/18$394

Cheapflights Fare Finder

 
Customize your flight search to find flights from Key West to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 21, 2025.
Use the filters below to find and compare flights from Key West to Buffalo that are best for you.

Fly from

Key West

Fly to

Buffalo

Route

Depart

Return

Price

Key WestBuffalo

EYW - BUF

EYWBUF

Key West

Thu 12/18

6:00 pm-11:55 pm

1 stop5h 55m

Buffalo

Mon 1/5

6:16 am-1:49 pm

1 stop7h 33m

$269

Key WestBuffalo

EYW - BUF

EYWBUF

Key West

Thu 12/18

6:00 pm-11:55 pm

1 stop5h 55m

Buffalo

Tue 1/6

6:00 am-11:03 am

1 stop5h 03m

$269

Key WestBuffalo

EYW - BUF

EYWBUF

Key West

Thu 12/18

6:00 pm-11:55 pm

1 stop5h 55m

Buffalo

Sun 1/4

6:00 am-12:08 pm

1 stop6h 08m

$294

Key WestBuffalo

EYW - BUF

EYWBUF

Key West

Thu 12/18

6:00 pm-11:55 pm

1 stop5h 55m

Buffalo

Wed 1/7

6:00 am-11:03 am

1 stop5h 03m

$294

Key WestBuffalo

EYW - BUF

EYWBUF

Key West

Thu 11/20

2:35 pm-10:53 pm

1 stop8h 18m

Buffalo

Fri 11/28

12:03 pm-6:27 pm

1 stop6h 24m

$314

Key WestBuffalo

EYW - BUF

EYWBUF

Key West

Thu 11/20

5:09 pm-10:52 pm

1 stop5h 43m

Buffalo

Wed 11/26

11:34 am-9:47 pm

2 stops10h 13m

$314

Key WestBuffalo

EYW - BUF

EYWBUF

Key West

Sat 12/20

6:00 pm-12:41 am

1 stop6h 41m

Buffalo

Sun 1/4

6:00 am-12:08 pm

1 stop6h 08m

$319

Key WestBuffalo

EYW - BUF

EYWBUF

Key West

Thu 9/18

12:29 pm-6:14 pm

2 stops29h 45m

$176

Key WestBuffalo

EYW - BUF

EYWBUF

Key West

Sun 9/7

12:29 pm-6:14 pm

3 stops29h 45m

$220

Key WestBuffalo

EYW - BUF

EYWBUF

Key West

Wed 11/12

5:09 pm-11:43 pm

1 stop6h 34m

$239

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/19

Showing 1-10 of 16 results
1
2

Best time to book a flight from Key West to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Key West with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Buffalo

Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated August 21, 2025.
Read reviews from past customers who have flown Delta and American Airlines from Key West to Buffalo. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,982 reviews

Food

7.3

Overall

8.0

Crew

8.5

Entertainment

7.9

Comfort

7.9

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
Delta
8.0
Very good
7,982 reviews
Delta
8.0
Very good
7,982 reviews

Food

7.3

Overall

8.0

Crew

8.5

Entertainment

7.9

Comfort

7.9

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,982 reviews

Food

7.3

Overall

8.0

Crew

8.5

Entertainment

7.9

Comfort

7.9

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

Related info for your journey

Find useful and relevant information for your journey from Key West to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Key West to Buffalo?

    Delta can get you from Key West to Buffalo in just under 5h 55m. Your travel time can differ by up to . Key West and Buffalo are separated by a distance of 1281 mi.

  • What are the cheapest airlines flying from Key West to Buffalo round-trip?

    Flying on American Airlines is currently your cheapest option to Buffalo, with prices starting at $208. Another option worth looking into is Delta, starting at $259 round trip. American Airlines is currently priced 50% below the average price you’ll pay for this route.

  • Can I find deals for flights from Key West to Buffalo that include hotel bookings?

    Yes. In addition to deals on Key West to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key West to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key West to Buffalo.

  • Can I find deals for business class flights from Key West to Buffalo?

    Yes. Cheapflights offers flight deals from Key West to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key West to Buffalo?

    Currently, January is the cheapest month in which you can book a flight from Key West to Buffalo (average of $256). Flying from Key West to Buffalo in December is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Orchard Park
Batavia
Williamsville
Eden
Amherst
West Seneca

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Top 2 airlines flying from Key West to Buffalo

Discover the top 2 airlines that operate flights from Key West to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 21, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$208Average$408FlexibilityNo cancel feeOn-time71%
DeltaCheapest$259Average$323FlexibilityNo cancel feeOn-timeN/A

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