HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Buffalo

$157+ Cheap flights from Myrtle Beach to Buffalo (MYR - BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/20. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — BUF
Apr 21 — Apr 281
Tue 4/21
Tue 4/28
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Myrtle Beach to Buffalo with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Myrtle Beach to Buffalo

Cheapest flights from Myrtle Beach to Buffalo
Explore the most affordable flight options available from Myrtle Beach to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 22, 2026.

This American Airlines deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/87:20 pm
MYR
-
BUF
1 stop3h 59m
American Airlines
Wed 4/155:00 am
BUF
-
MYR
1 stop7h 16m
American Airlines
Deal found 3/18$319
This Southwest deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/237:15 pm
MYR
-
BUF
1 stop4h 10m
Southwest
Tue 5/264:00 pm
BUF
-
MYR
1 stop4h 30m
Southwest
Deal found 3/18$326
This Delta deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/46:00 am
MYR
-
BUF
1 stop5h 01m
Delta
Mon 5/116:25 am
BUF
-
MYR
1 stop4h 12m
Delta
Deal found 3/20$333
This Delta deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2811:43 am
MYR
-
BUF
1 stop7h 01m
Delta
Sat 5/306:25 am
BUF
-
MYR
1 stop4h 12m
Delta
Deal found 3/18$360
This Kiwi.com deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/143:53 pm
MYR
-
BUF
1 stop26h 53m
Multiple Airlines
Mon 5/187:31 pm
BUF
-
MYR
2 stops24h 02m
Multiple Airlines
Deal found 3/20$362
This American Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/410:28 am
MYR
-
BUF
1 stop6h 34m
American Airlines
Mon 5/115:32 pm
BUF
-
MYR
2 stops6h 25m
American Airlines
Deal found 3/20$366
This Delta deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/246:00 am
MYR
-
BUF
1 stop9h 30m
Delta
Mon 6/296:00 am
BUF
-
MYR
1 stop8h 57m
Delta
Deal found 3/18$367
This Southwest deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/143:45 pm
MYR
-
BUF
2 stops7h 35m
Southwest
Mon 5/185:00 am
BUF
-
MYR
2 stops8h 05m
Southwest
Deal found 3/20$370
This Southwest deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/58:10 pm
MYR
-
BUF
1 stop4h 00m
Southwest
Mon 6/87:35 am
BUF
-
MYR
2 stops11h 55m
Southwest
Deal found 3/19$371
This Delta deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/246:00 am
MYR
-
BUF
1 stop9h 30m
Delta
Sun 6/286:00 am
BUF
-
MYR
1 stop4h 09m
Delta
Deal found 3/18$377

Find flight deals from Myrtle Beach to Buffalo

Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 22, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$319
(American Airlines)

One-way from

$137
(Kiwi.com)

Popular in

March

Cheapest in

January

Average price

$584
Provider with most accurate pricing for Myrtle Beach Intl-Buffalo flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Buffalo flights.
Search Deals
From Myrtle Beach Intl to Buffalo
Search Deals
One-way flight from Myrtle Beach Intl to Buffalo
Search Deals
Highest demand for flights based on searches. 14% potential increase in price ($67 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($18 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 22, 2026.
Use the filters below to find and compare flights from Myrtle Beach to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Mon 5/4

6:00 am-11:01 am

1 stop5h 01m

Buffalo

Mon 5/11

6:25 am-10:37 am

1 stop4h 12m

$333

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Thu 5/14

3:53 pm-6:46 pm

1 stop26h 53m

Buffalo

Mon 5/18

7:31 pm-7:33 pm

2 stops24h 02m

$362

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Wed 6/24

6:00 am-3:30 pm

1 stop9h 30m

Buffalo

Mon 6/29

6:00 am-2:57 pm

1 stop8h 57m

$367

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Thu 5/14

3:45 pm-11:20 pm

2 stops7h 35m

Buffalo

Mon 5/18

5:00 am-1:05 pm

2 stops8h 05m

$370

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Wed 6/24

6:00 am-3:30 pm

1 stop9h 30m

Buffalo

Sun 6/28

6:00 am-10:09 am

1 stop4h 09m

$377

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Fri 6/26

8:10 pm-12:10 am

1 stop4h 00m

Buffalo

Mon 6/29

7:35 am-7:30 pm

2 stops11h 55m

$408

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Wed 4/8

5:00 am-11:58 am

2 stops6h 58m

Buffalo

Wed 4/15

5:30 am-1:27 pm

2 stops7h 57m

$422

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Fri 4/10

3:15 pm-8:43 pm

1 stop5h 28m

Buffalo

Sun 4/12

6:00 am-11:14 am

1 stop5h 14m

$427

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Wed 4/29

3:15 pm-8:43 pm

1 stop5h 28m

Buffalo

Sat 5/2

6:00 am-11:04 am

1 stop5h 04m

$459

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Wed 6/24

3:08 pm-11:59 pm

2 stops8h 51m

Buffalo

Sat 6/27

6:00 am-9:59 am

1 stop3h 59m

$462

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/21

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

Compare providers for flights from Myrtle Beach to Buffalo

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to Buffalo in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Myrtle Beach-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Myrtle Beach-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Myrtle Beach-Buffalo flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Myrtle Beach-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Myrtle Beach to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Buffalo

What is the cheapest month to book a flight from Myrtle Beach to Buffalo?

Currently, August is the cheapest month in which you can book a flight from Myrtle Beach to Buffalo (average of $46). Flying from Myrtle Beach to Buffalo in March is currently the most expensive (average of $135). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Buffalo

Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated March 22, 2026.
Get a feel of what it's like to fly with Southwest and American Airlines from Myrtle Beach to Buffalo by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,324 reviews

Comfort

8.0

Overall

8.0

Food

7.0

Entertainment

7.5

Boarding

8.1

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
Southwest
8.0
Very good
4,324 reviews
Southwest
8.0
Very good
4,324 reviews

Comfort

8.0

Overall

8.0

Food

7.0

Entertainment

7.5

Boarding

8.1

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
American Airlines
7.1
Good
11,487 reviews
Southwest
8.0
Very good
4,324 reviews

Comfort

8.0

Overall

8.0

Food

7.0

Entertainment

7.5

Boarding

8.1

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Myrtle Beach to Buffalo?

    There are many flights that can get you from Myrtle Beach to Buffalo in 3h 59m. Fly via American Airlines, Southwest, or Delta to get the fastest option. There are 639 mi between Myrtle Beach and Buffalo. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Myrtle Beach to Buffalo round-trip?

    According to our current data, American Airlines ($195), and Southwest ($286) offers the cheapest pricing from Myrtle Beach to Buffalo. American Airlines is priced at 49% lower than the current average price of a flight leaving 3 months from now.

  • What are the cheapest airlines to fly from Myrtle Beach to Buffalo one-way?

    To fly one-way, consider booking your trip with Southwest, which is currently one of the cheapest options available, starting at $108. Delta flights start at $108 while deals on American Airlines start at $128 one-way.

  • Can I find deals for flights from Myrtle Beach to Buffalo that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Buffalo.

  • Can I find deals for business class flights from Myrtle Beach to Buffalo?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to Buffalo?

    Currently, August is the cheapest month in which you can book a flight from Myrtle Beach to Buffalo (average of $46). Flying from Myrtle Beach to Buffalo in March is currently the most expensive (average of $135). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Cheektowaga
Batavia
Williamsville
Orchard Park
Eden
Amherst
West Seneca

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Myrtle Beach to Buffalo

See prices for flight routes from nearby airports that may be better suited for you.
Charlotte to John F Kennedy Intl flights
Charlotte to LaGuardia flights
Charlotte to Newark flights
Charleston to Newark flights
Charleston to John F Kennedy Intl flights
Greenville to LaGuardia flights
Charleston to LaGuardia flights
Savannah to John F Kennedy Intl flights
Greenville to John F Kennedy Intl flights
Savannah to LaGuardia flights
Savannah to Newark flights
Greenville to Newark flights
Columbia to LaGuardia flights
Myrtle Beach to John F Kennedy Intl flights
Columbia to Newark flights
Myrtle Beach to Newark flights
Columbia to John F Kennedy Intl flights
Myrtle Beach to LaGuardia flights
Charleston to White Plains flights
Charlotte to Albany flights
Charlotte to Buffalo flights
Charlotte to Syracuse flights
Hilton Head Island to Newark flights
Savannah to Albany flights
Charleston to Stewart flights
Charlotte to Rochester flights
Charleston to Buffalo flights
Myrtle Beach to Stewart flights
Myrtle Beach to White Plains flights
Greenville to Buffalo flights
Augusta to Newark flights
Charleston to Islip flights
Savannah to Rochester flights
Augusta to LaGuardia flights
Savannah to Buffalo flights
Charlotte to Stewart flights
Charlotte to Islip flights
Greenville to Stewart flights
Columbia to Syracuse flights
Greenville to Albany flights
Charlotte to White Plains flights
Columbia to Albany flights
Savannah to Syracuse flights
Charleston to Albany flights
Savannah to White Plains flights
Myrtle Beach to Syracuse flights
Columbia to Buffalo flights

Top 2 airlines flying from Myrtle Beach to Buffalo

Discover the top 2 airlines that operate flights from Myrtle Beach to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 22, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$195Average$354FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$286Average$376FlexibilityNo cancel feeOn-time63%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.