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$118+ Cheap flights from Myrtle Beach to Buffalo (MYR - BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/21. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — BUF
Apr 4 — Apr 111
Sat 4/4
Sat 4/11
1 adult, Economy
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Cheap flight deals from Myrtle Beach to Buffalo

Cheapest flights from Myrtle Beach to Buffalo
Explore the most affordable flight options available from Myrtle Beach to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 5, 2026.

This Kiwi.com deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/3010:27 am
MYR
-
BUF
1 stop23h 40m
Multiple Airlines
Sun 5/312:32 pm
BUF
-
MYR
2 stops23h 11m
Multiple Airlines
Deal found 3/2$306
This United Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/13:15 pm
MYR
-
BUF
1 stop5h 28m
United Airlines
Wed 4/157:00 am
BUF
-
MYR
1 stop7h 17m
United Airlines
Deal found 3/3$315
This Delta deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/16:54 pm
MYR
-
BUF
1 stop4h 52m
Delta
Wed 4/154:59 pm
BUF
-
MYR
1 stop7h 15m
Delta
Deal found 3/3$317
This American Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/16:00 am
MYR
-
BUF
2 stops6h 14m
American Airlines
Wed 4/155:00 am
BUF
-
MYR
1 stop7h 16m
American Airlines
Deal found 3/3$322
This United Airlines deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/93:15 pm
MYR
-
BUF
1 stop5h 28m
United Airlines
Tue 4/147:00 am
BUF
-
MYR
1 stop7h 17m
United Airlines
Deal found 3/4$325
This Southwest deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/301:45 pm
MYR
-
BUF
1 stop6h 00m
Southwest
Sun 5/32:55 pm
BUF
-
MYR
1 stop6h 45m
Southwest
Deal found 3/2$340
This United Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/211:00 am
MYR
-
BUF
1 stop6h 10m
United Airlines
Sun 4/127:00 am
BUF
-
MYR
1 stop7h 17m
United Airlines
Deal found 3/5$350
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/186:28 pm
MYR
-
BUF
2 stops17h 37m
Multiple Airlines
Sun 3/229:47 pm
BUF
-
MYR
1 stop12h 13m
Multiple Airlines
Deal found 3/3$351
This United Airlines deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/103:15 pm
MYR
-
BUF
1 stop5h 28m
United Airlines
Tue 4/147:00 am
BUF
-
MYR
1 stop7h 17m
United Airlines
Deal found 3/4$352
This American Airlines deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/99:14 am
MYR
-
BUF
2 stops7h 18m
American Airlines
Tue 4/143:55 pm
BUF
-
MYR
2 stops7h 07m
American Airlines
Deal found 3/4$356
This American Airlines deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/246:01 am
MYR
-
BUF
1 stop6h 50m
American Airlines
Tue 3/246:39 pm
BUF
-
MYR
1 stop4h 17m
American Airlines
Deal found 3/1$367

Find flight deals from Myrtle Beach to Buffalo

Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 5, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$306
(Kiwi.com)

One-way from

$118
(Kiwi.com)

Popular in

February

Cheapest in

January

Average price

$346
Provider with most accurate pricing for Myrtle Beach Intl-Buffalo flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Buffalo flights.
Search Deals
From Myrtle Beach Intl to Buffalo
Search Deals
One-way flight from Myrtle Beach Intl to Buffalo
Search Deals
Highest demand for flights based on searches. 0% potential increase in price ($2 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 5, 2026.
Use the filters below to find and compare flights from Myrtle Beach to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Fri 4/10

3:15 pm-8:43 pm

1 stop5h 28m

Buffalo

Tue 4/14

7:00 am-2:17 pm

1 stop7h 17m

$352
Quickest round-trip

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Fri 6/5

7:50 am-12:05 pm

1 stop4h 15m

Buffalo

Mon 6/8

5:55 pm-9:40 pm

1 stop3h 45m

$367

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Fri 3/27

6:54 pm-11:46 pm

1 stop4h 52m

Buffalo

Mon 3/30

7:38 pm-12:04 am

1 stop4h 26m

$370

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Tue 6/9

2:10 pm-9:25 pm

2 stops7h 15m

Buffalo

Thu 6/11

5:55 pm-9:40 pm

1 stop3h 45m

$372

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Fri 6/5

2:05 pm-12:10 am

2 stops10h 05m

Buffalo

Wed 6/10

12:45 pm-9:45 pm

2 stops9h 00m

$377

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Thu 3/19

12:27 pm-4:51 pm

1 stop4h 24m

Buffalo

Mon 3/23

6:02 am-11:47 am

1 stop5h 45m

$380

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Wed 4/29

3:15 pm-11:52 pm

2 stops8h 37m

Buffalo

Sat 5/2

10:45 am-5:13 pm

1 stop6h 28m

$380

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Wed 3/18

6:54 pm-11:46 pm

1 stop4h 52m

Buffalo

Mon 3/23

4:47 pm-12:04 am

1 stop7h 17m

$380

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Wed 4/1

10:40 am-7:20 pm

2 stops8h 40m

Buffalo

Wed 4/15

9:45 am-5:35 pm

2 stops7h 50m

$380

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Thu 6/25

2:05 pm-12:10 am

2 stops10h 05m

Buffalo

Mon 6/29

5:55 pm-9:40 pm

1 stop3h 45m

$382

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/3

Showing 1-10 of 21 resultsSorted by cheapest first
1
2
3

Compare providers for flights from Myrtle Beach to Buffalo

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to Buffalo in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Myrtle Beach-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Myrtle Beach-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Myrtle Beach-Buffalo flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Myrtle Beach-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Myrtle Beach to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Buffalo

What is the cheapest month to book a flight from Myrtle Beach to Buffalo?

Currently, August is the cheapest month in which you can book a flight from Myrtle Beach to Buffalo (average of $46). Flying from Myrtle Beach to Buffalo in March is currently the most expensive (average of $139). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Buffalo

Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated March 5, 2026.
Get a feel of what it's like to fly with Southwest and American Airlines from Myrtle Beach to Buffalo by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,307 reviews

Boarding

8.1

Overall

8.0

Entertainment

7.5

Crew

8.6

Comfort

8.0

Food

7.0

Reviews

1 / 20
10.0
Excellent

Anonymous,Mar 2026

KOA - HNL

pretty smooth and fast service ever, that flight is very helpful each and everyone for price and also fright for free..
Southwest
8.0
Very good
4,307 reviews
Southwest
8.0
Very good
4,307 reviews

Boarding

8.1

Overall

8.0

Entertainment

7.5

Crew

8.6

Comfort

8.0

Food

7.0

Reviews

1 / 20
10.0
Excellent

Anonymous,Mar 2026

KOA - HNL

pretty smooth and fast service ever, that flight is very helpful each and everyone for price and also fright for free..
American Airlines
7.2
Good
11,381 reviews
Southwest
8.0
Very good
4,307 reviews

Boarding

8.1

Overall

8.0

Entertainment

7.5

Crew

8.6

Comfort

8.0

Food

7.0

Reviews

1 / 20
10.0
Excellent

Anonymous,Mar 2026

KOA - HNL

pretty smooth and fast service ever, that flight is very helpful each and everyone for price and also fright for free..

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Myrtle Beach to Buffalo?

    There are many flights that can get you from Myrtle Beach to Buffalo in 4h 15m. Fly via United Airlines, Southwest, or Delta to get the fastest option. There are 639 mi between Myrtle Beach and Buffalo. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Myrtle Beach to Buffalo round-trip?

    According to our current data, American Airlines ($195), and Southwest ($276) offers the cheapest pricing from Myrtle Beach to Buffalo. American Airlines is priced at 46% lower than the current average price of a flight leaving 3 months from now.

  • What are the cheapest airlines to fly from Myrtle Beach to Buffalo one-way?

    To fly one-way, consider booking your trip with Southwest, which is currently one of the cheapest options available, starting at $108. Delta flights start at $108 while deals on American Airlines start at $128 one-way.

  • Can I find deals for flights from Myrtle Beach to Buffalo that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Buffalo.

  • Can I find deals for business class flights from Myrtle Beach to Buffalo?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to Buffalo?

    Currently, August is the cheapest month in which you can book a flight from Myrtle Beach to Buffalo (average of $46). Flying from Myrtle Beach to Buffalo in March is currently the most expensive (average of $139). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Cheektowaga
Batavia
Williamsville
Orchard Park
Eden
Amherst
West Seneca

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Top 2 airlines flying from Myrtle Beach to Buffalo

Discover the top 2 airlines that operate flights from Myrtle Beach to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 5, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$195Average$354FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$276Average$375FlexibilityNo cancel feeOn-time63%

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