$170+ Cheap flights from Myrtle Beach to Buffalo (MYR - BUF)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/24. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — BUF
Oct 4 — Oct 111
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Myrtle Beach to Buffalo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Myrtle Beach to Buffalo
Cheapest
Best
Last-minute
One-way
Cheapest flights from Myrtle Beach to BuffaloExplore the most affordable flight options available from Myrtle Beach to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 4, 2026.
Explore the most affordable flight options available from Myrtle Beach to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 4, 2026.
This Delta deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/56:56 pm -
1 stop4h 56m
Wed 10/76:00 am -
1 stop4h 07m
Deal found 9/1![Delta logo]()
$309
This Southwest deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/235:05 pm -
1 stop4h 05m
Wed 9/3012:35 pm -
2 stops6h 50m
Deal found 9/2![Southwest logo]()
$314
This Southwest deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/241:10 pm -
1 stop7h 35m
Fri 10/302:20 pm -
1 stop4h 55m
Deal found 9/3![Southwest logo]()
$317
This Delta deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:58 pm -
1 stop5h 01m
Fri 10/306:15 am -
1 stop4h 27m
Deal found 9/3![Delta logo]()
$325
This Kiwi.com deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/52:41 pm -
1 stop27h 08m
Fri 10/92:44 pm -
2 stops21h 00m
Deal found 9/1![Multiple Airlines logo]()
$327
This Kiwi.com deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/52:41 pm -
1 stop27h 08m
Sat 10/101:44 pm -
2 stops19h 03m
Deal found 9/1![Multiple Airlines logo]()
$328
This American Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/107:19 pm -
1 stop4h 35m
Sat 9/125:30 am -
1 stop3h 54m
Deal found 8/30![American Airlines logo]()
$331
This Delta deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/111:34 am -
1 stop3h 39m
Sun 10/46:20 am -
1 stop4h 17m
Deal found 9/2![Delta logo]()
$336
This Delta deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:58 pm -
1 stop5h 01m
Thu 10/296:00 am -
1 stop4h 07m
Deal found 9/3![Delta logo]()
$337
Best flights from Myrtle Beach to BuffaloDiscover carefully curated flight deals from Myrtle Beach to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 4, 2026.
Discover carefully curated flight deals from Myrtle Beach to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 4, 2026.
This Delta deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/286:56 pm -
1 stop4h 56m
Tue 9/296:59 pm -
1 stop4h 29m
Deal found 9/1![Delta logo]()
$309
This Southwest deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/241:10 pm -
1 stop7h 35m
Fri 10/302:20 pm -
1 stop4h 55m
Deal found 9/3![Southwest logo]()
$317
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:54 pm -
1 stop5h 05m
Wed 11/1110:51 am -
1 stop6h 20m
Deal found 9/3![United Airlines logo]()
$463
This Delta deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/111:34 am -
1 stop3h 39m
Sun 10/46:05 am -
1 stop4h 02m
Deal found 9/1![Delta logo]()
$336
This Southwest deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/153:55 pm -
2 stops7h 50m
Sun 10/189:00 am -
1 stop6h 25m
Deal found 9/1![Southwest logo]()
$349
This Delta deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:58 pm -
1 stop5h 01m
Thu 10/296:00 am -
1 stop4h 07m
Deal found 9/3![Delta logo]()
$337
This Southwest deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/238:15 am -
1 stop6h 05m
Fri 9/253:55 pm -
1 stop3h 50m
Deal found 8/31![Southwest logo]()
$361
This Southwest deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/223:55 pm -
2 stops7h 50m
Sun 10/255:50 am -
1 stop5h 00m
Deal found 8/31![Southwest logo]()
$367
This Southwest deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/13:55 pm -
2 stops7h 45m
Sun 10/412:20 pm -
2 stops9h 45m
Deal found 9/1![Southwest logo]()
$429
Last-minute flights from Myrtle Beach to BuffaloDiscover last-minute flight deals from Myrtle Beach to Buffalo. Data last updated September 4, 2026 and is based on user searches.
Discover last-minute flight deals from Myrtle Beach to Buffalo. Data last updated September 4, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/107:19 pm -
1 stop4h 35m
Sat 9/125:30 am -
1 stop3h 54m
Deal found 8/30![American Airlines logo]()
$331
This Southwest deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/235:05 pm -
1 stop4h 05m
Wed 9/3012:35 pm -
2 stops6h 50m
Deal found 9/2![Southwest logo]()
$314
This Delta deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/111:34 am -
1 stop3h 39m
Sun 10/46:20 am -
1 stop4h 17m
Deal found 9/2![Delta logo]()
$336
This Delta deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/56:56 pm -
1 stop4h 56m
Tue 10/66:00 am -
1 stop4h 07m
Deal found 9/1![Delta logo]()
$309
This Kiwi.com deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/52:41 pm -
1 stop27h 08m
Fri 10/92:44 pm -
2 stops21h 00m
Deal found 9/1![Multiple Airlines logo]()
$327
This Kiwi.com deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/52:41 pm -
1 stop27h 08m
Sat 10/101:44 pm -
2 stops19h 03m
Deal found 9/1![Multiple Airlines logo]()
$328
This Delta deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:58 pm -
1 stop5h 01m
Fri 10/306:15 am -
1 stop4h 27m
Deal found 9/3![Delta logo]()
$325
This Delta deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:58 pm -
1 stop5h 01m
Thu 10/296:00 am -
1 stop4h 07m
Deal found 9/3![Delta logo]()
$337
This Southwest deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/241:10 pm -
1 stop7h 35m
Fri 10/302:20 pm -
1 stop4h 55m
Deal found 9/3![Southwest logo]()
$317
One-way flights from Myrtle Beach to BuffaloSearch for one-way flight options from Myrtle Beach to Buffalo. Find affordable one-way fares based on user searches. Data last updated September 4, 2026.
Search for one-way flight options from Myrtle Beach to Buffalo. Find affordable one-way fares based on user searches. Data last updated September 4, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/246:25 pm -
2 stops42h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 8/31![Multiple Airlines logo]()
$170
This Southwest deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/246:40 am -
1 stop4h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 8/31![Southwest logo]()
$181
This American Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/207:15 am -
1 stop3h 26m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/2![American Airlines logo]()
$239
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/202:46 pm -
2 stops22h 09m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/2![Multiple Airlines logo]()
$263
This KAYAK deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/47:15 am -
1 stop3h 26m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![American Airlines logo]()
$284
This KAYAK deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/47:35 am -
2 stops15h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 8/31![Southwest logo]()
$335
Find flight deals from Myrtle Beach to Buffalo
Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 4, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $309 (Delta) |
One-way from | $170 (Kiwi.com) |
Popular in | July |
Cheapest in | January |
Average price | $375 |
Cheapflights Fare Finder
Customize your flight search to find flights from Myrtle Beach to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 4, 2026.
Use the filters below to find and compare flights from Myrtle Beach to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Myrtle BeachBuffalo
MYR Myrtle Beach Intl - BUF Buffalo
MYRBUF
Myrtle Beach Intl
Thu 9/24
11:59 am-12:55 pm
3 stops24h 56m
Buffalo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$173
Myrtle BeachBuffalo
MYR Myrtle Beach Intl - BUF Buffalo
MYRBUF
Myrtle Beach Intl
Thu 9/24
6:40 am-11:10 am
1 stop4h 30m
Buffalo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$181
Myrtle BeachBuffalo
MYR Myrtle Beach Intl - BUF Buffalo
MYRBUF
Myrtle Beach Intl
Sun 9/20
2:46 pm-12:55 pm
2 stops22h 09m
Buffalo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$263
Quickest round-trip
Myrtle BeachBuffalo
MYR Myrtle Beach Intl - BUF Buffalo
MYRBUF
Myrtle Beach Intl
Sun 10/4
7:15 am-10:41 am
1 stop3h 26m
Buffalo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$284
Myrtle BeachBuffalo
MYR Myrtle Beach Intl - BUF Buffalo
MYRBUF
Myrtle Beach Intl
Mon 9/28
6:56 pm-11:52 pm
1 stop4h 56m
Buffalo
Tue 9/29
6:59 pm-11:28 pm
1 stop4h 29m
$309
Myrtle BeachBuffalo
MYR Myrtle Beach Intl - BUF Buffalo
MYRBUF
Myrtle Beach Intl
Sat 10/24
1:10 pm-8:45 pm
1 stop7h 35m
Buffalo
Fri 10/30
2:20 pm-7:15 pm
1 stop4h 55m
$317
Myrtle BeachBuffalo
MYR Myrtle Beach Intl - BUF Buffalo
MYRBUF
Myrtle Beach Intl
Sun 10/4
7:35 am-9:45 pm
3 stops14h 10m
Buffalo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$335
Myrtle BeachBuffalo
MYR Myrtle Beach Intl - BUF Buffalo
MYRBUF
Myrtle Beach Intl
Thu 10/1
11:34 am-3:13 pm
1 stop3h 39m
Buffalo
Sun 10/4
6:05 am-10:07 am
1 stop4h 02m
$336
Myrtle BeachBuffalo
MYR Myrtle Beach Intl - BUF Buffalo
MYRBUF
Myrtle Beach Intl
Fri 10/23
6:58 pm-11:59 pm
1 stop5h 01m
Buffalo
Thu 10/29
6:00 am-10:07 am
1 stop4h 07m
$337
Myrtle BeachBuffalo
MYR Myrtle Beach Intl - BUF Buffalo
MYRBUF
Myrtle Beach Intl
Thu 10/15
3:55 pm-11:45 pm
2 stops7h 50m
Buffalo
Sun 10/18
9:00 am-3:25 pm
1 stop6h 25m
$349
Showing 1-10 of 14 resultsSorted by cheapest first
Compare providers for flights from Myrtle Beach to Buffalo
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to Buffalo in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Myrtle Beach-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Myrtle Beach-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Myrtle Beach-Buffalo flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Myrtle Beach-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Myrtle Beach to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from Myrtle Beach with our price prediction graph.
MYR-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Myrtle Beach to Buffalo
What is the cheapest month to book a flight from Myrtle Beach to Buffalo?
Currently, January is the cheapest month in which you can book a flight from Myrtle Beach to Buffalo (average of $290). Flying from Myrtle Beach to Buffalo in July is currently the most expensive (average of $583). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Myrtle Beach to Buffalo?
Airfare is typical for this route at the moment.
Myrtle Beach to Buffalo flights typically cost between $309 and $550 in October.The cheapest round-trip price found within the last 5 days was $309 on Delta (Oct 5-Oct 7).
Reviews of airlines servicing Buffalo
Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated September 4, 2026.
Get a feel of what it's like to fly with Southwest and American Airlines from Myrtle Beach to Buffalo by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Crew
8.6
Entertainment
7.5
Food
7.0
Overall
8.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentCourtney,Sep 2026
DEN - STL
Comfort
8.0
Crew
8.6
Entertainment
7.5
Food
7.0
Overall
8.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentCourtney,Sep 2026
DEN - STL
Comfort
8.0
Crew
8.6
Entertainment
7.5
Food
7.0
Overall
8.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentCourtney,Sep 2026
DEN - STL
Related info for your journey
Find useful and relevant information for your journey from Myrtle Beach to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsLockport
Cheektowaga
Amherst
Williamsville
Orchard Park
Eden
Bowmansville
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Buffalo flight routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from Myrtle Beach
Popular flights
Alternative routes for Myrtle Beach to Buffalo
See prices for flight routes from nearby airports that may be better suited for you.
Other flights to Buffalo
Explore flights to Buffalo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 4, 2026.
Complete your trip
Complete your trip to Buffalo by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Myrtle Beach to Buffalo by cabin class
Find flights from Myrtle Beach to Buffalo, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Myrtle Beach and Buffalo flights
Browse other Myrtle Beach and Buffalo flight options. Last updated on September 4, 2026.
Other flights from Myrtle Beach
Browse through other flights departing from Myrtle Beach. Flights are based on user searches made on Cheapflights and were last updated on September 4, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Myrtle Beach to Buffalo
Discover the top 2 airlines that operate flights from Myrtle Beach to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 4, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$250 | Average$426 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$308 | Average$396 | FlexibilityNo cancel fee | On-time63% |