$139+ Cheap flights from Myrtle Beach to Buffalo (MYR - BUF)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/21. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — BUF
Sep 18 — Sep 251
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Myrtle Beach to Buffalo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Myrtle Beach to Buffalo
Cheapest
Best
Last-minute
One-way
Cheapest flights from Myrtle Beach to BuffaloExplore the most affordable flight options available from Myrtle Beach to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 19, 2026.
Explore the most affordable flight options available from Myrtle Beach to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 19, 2026.
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/156:58 pm -
1 stop4h 54m
Mon 9/216:59 pm -
1 stop4h 29m
Deal found 8/17![Delta logo]()
$277
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/186:56 pm -
1 stop4h 56m
Mon 9/216:20 am -
1 stop4h 16m
Deal found 8/17![Delta logo]()
$290
This Southwest deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2110:25 am -
1 stop4h 10m
Sat 10/2410:10 am -
2 stops9h 20m
Deal found 8/18![Southwest logo]()
$295
This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/18:08 am -
1 stop3h 58m
Tue 9/86:50 am -
1 stop4h 34m
Deal found 8/16![American Airlines logo]()
$298
This Southwest deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/142:10 pm -
2 stops8h 00m
Sat 10/1712:30 pm -
1 stop7h 00m
Deal found 8/17![Southwest logo]()
$301
This United Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/110:08 am -
2 stops8h 52m
Tue 9/87:00 am -
1 stop7h 17m
Deal found 8/16![United Airlines logo]()
$303
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/95:45 pm -
1 stop6h 07m
Wed 9/166:05 am -
1 stop4h 02m
Deal found 8/17![Delta logo]()
$305
This Southwest deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/106:40 am -
1 stop4h 30m
Tue 9/1510:35 am -
2 stops8h 40m
Deal found 8/17![Southwest logo]()
$310
This Kiwi.com deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1510:45 am -
1 stop7h 04m
Fri 9/251:40 pm -
2 stops43h 12m
Deal found 8/17![Multiple Airlines logo]()
$313
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/105:45 pm -
1 stop6h 07m
Thu 9/176:05 am -
1 stop4h 02m
Deal found 8/17![Delta logo]()
$318
This Southwest deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/111:40 pm -
2 stops9h 40m
Mon 12/145:55 am -
1 stop4h 10m
Deal found 8/18![Southwest logo]()
$319
Best flights from Myrtle Beach to BuffaloDiscover carefully curated flight deals from Myrtle Beach to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 19, 2026.
Discover carefully curated flight deals from Myrtle Beach to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 19, 2026.
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/286:58 pm -
1 stop5h 01m
Sat 10/316:00 am -
1 stop5h 44m
Deal found 8/17![Delta logo]()
$277
This Southwest deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/227:50 pm -
1 stop3h 50m
Sat 10/2410:10 am -
2 stops9h 20m
Deal found 8/18![Southwest logo]()
$295
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/79:22 am -
1 stop5h 44m
Sat 10/1012:15 pm -
2 stops7h 12m
Deal found 8/14![American Airlines logo]()
$402
This Delta deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/77:01 pm -
1 stop4h 58m
Mon 10/126:10 am -
1 stop4h 32m
Deal found 8/14![Delta logo]()
$277
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/226:58 pm -
1 stop5h 01m
Sat 10/246:15 am -
1 stop4h 05m
Deal found 8/18![Delta logo]()
$277
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:58 pm -
1 stop5h 01m
Sat 10/316:15 am -
1 stop4h 05m
Deal found 8/17![Delta logo]()
$277
This Southwest deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/217:50 am -
2 stops10h 30m
Sat 10/2410:10 am -
2 stops9h 20m
Deal found 8/18![Southwest logo]()
$340
This Southwest deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/97:50 pm -
1 stop3h 50m
Mon 10/129:40 am -
1 stop5h 40m
Deal found 8/15![Southwest logo]()
$355
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/110:15 am -
2 stops7h 14m
Tue 9/86:50 am -
1 stop4h 34m
Deal found 8/18![American Airlines logo]()
$402
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/286:00 am -
1 stop5h 16m
Sun 11/16:15 am -
1 stop4h 27m
Deal found 8/17![Delta logo]()
$320
This Southwest deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/18:15 am -
2 stops7h 00m
Tue 9/88:05 am -
2 stops8h 00m
Deal found 8/16![Southwest logo]()
$361
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:58 pm -
1 stop5h 01m
Sun 11/16:15 am -
1 stop4h 27m
Deal found 8/17![Delta logo]()
$333
Last-minute flights from Myrtle Beach to BuffaloDiscover last-minute flight deals from Myrtle Beach to Buffalo. Data last updated August 19, 2026 and is based on user searches.
Discover last-minute flight deals from Myrtle Beach to Buffalo. Data last updated August 19, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/18:08 am -
1 stop3h 58m
Tue 9/86:50 am -
1 stop4h 34m
Deal found 8/16![American Airlines logo]()
$298
This United Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/110:08 am -
2 stops8h 52m
Tue 9/87:00 am -
1 stop7h 17m
Deal found 8/16![United Airlines logo]()
$303
This Delta deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/111:43 am -
1 stop4h 22m
Sat 9/55:13 pm -
1 stop4h 36m
Deal found 8/16![Delta logo]()
$326
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/95:45 pm -
1 stop6h 07m
Tue 9/156:59 pm -
1 stop4h 29m
Deal found 8/17![Delta logo]()
$305
This Southwest deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/106:40 am -
1 stop4h 30m
Tue 9/1510:35 am -
2 stops8h 40m
Deal found 8/17![Southwest logo]()
$310
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/105:45 pm -
1 stop6h 07m
Thu 9/176:05 am -
1 stop4h 02m
Deal found 8/17![Delta logo]()
$318
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/156:58 pm -
1 stop4h 54m
Tue 9/226:05 am -
1 stop4h 02m
Deal found 8/17![Delta logo]()
$277
This Kiwi.com deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1510:45 am -
1 stop7h 04m
Fri 9/251:40 pm -
2 stops43h 12m
Deal found 8/17![Multiple Airlines logo]()
$313
This Kiwi.com deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1510:45 am -
1 stop7h 04m
Wed 9/231:40 pm -
2 stops46h 04m
Deal found 8/17![Multiple Airlines logo]()
$325
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/186:56 pm -
1 stop4h 56m
Wed 9/236:05 am -
1 stop4h 02m
Deal found 8/17![Delta logo]()
$290
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/245:45 pm -
1 stop4h 02m
Sun 9/272:23 pm -
1 stop4h 26m
Deal found 8/14![American Airlines logo]()
$320
One-way flights from Myrtle Beach to BuffaloSearch for one-way flight options from Myrtle Beach to Buffalo. Find affordable one-way fares based on user searches. Data last updated August 19, 2026.
Search for one-way flight options from Myrtle Beach to Buffalo. Find affordable one-way fares based on user searches. Data last updated August 19, 2026.
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/216:56 pm -
1 stop4h 56m
Deal found 8/18![Delta logo]()
$139
This Southwest deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/227:50 am -
2 stops9h 55m
Deal found 8/18![Southwest logo]()
$144
This Kiwi.com deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:25 pm -
2 stops42h 25m
Deal found 8/17![Multiple Airlines logo]()
$145
This American Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/17:20 pm -
1 stop4h 36m
Deal found 8/17![American Airlines logo]()
$160
This Kiwi.com deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/122:41 pm -
2 stops46h 18m
Deal found 8/15![Multiple Airlines logo]()
$164
This Southwest deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/18:15 am -
2 stops7h 00m
Deal found 8/17![Southwest logo]()
$165
This Kiwi.com deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/84:13 pm -
2 stops20h 42m
Deal found 8/15![Multiple Airlines logo]()
$166
This Southwest deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/2311:00 am -
2 stops10h 10m
Deal found 8/15![Southwest logo]()
$172
This Kiwi.com deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/42:46 pm -
2 stops22h 09m
Deal found 8/15![Multiple Airlines logo]()
$174
This Southwest deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/17:50 pm -
1 stop3h 50m
Deal found 8/17![Southwest logo]()
$176
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/175:45 pm -
1 stop4h 02m
Deal found 8/18![American Airlines logo]()
$182
This Southwest deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/172:30 pm -
2 stops8h 15m
Deal found 8/18![Southwest logo]()
$184
Find flight deals from Myrtle Beach to Buffalo
Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 19, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $277 (Delta) |
One-way from | $139 (Delta) |
Popular in | July |
Cheapest in | January |
Average price | $525 |
Cheapflights Fare Finder
Customize your flight search to find flights from Myrtle Beach to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 19, 2026.
Use the filters below to find and compare flights from Myrtle Beach to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Myrtle BeachBuffalo
MYR Myrtle Beach Intl - BUF Buffalo
MYRBUF
Myrtle Beach Intl
Wed 10/28
6:58 pm-11:59 pm
1 stop5h 01m
Buffalo
Sat 10/31
6:00 am-11:44 am
1 stop5h 44m
$277
Myrtle BeachBuffalo
MYR Myrtle Beach Intl - BUF Buffalo
MYRBUF
Myrtle Beach Intl
Wed 10/7
7:01 pm-11:59 pm
1 stop4h 58m
Buffalo
Mon 10/12
6:10 am-10:42 am
1 stop4h 32m
$277
Quickest round-trip
Myrtle BeachBuffalo
MYR Myrtle Beach Intl - BUF Buffalo
MYRBUF
Myrtle Beach Intl
Thu 10/22
6:58 pm-11:59 pm
1 stop5h 01m
Buffalo
Sat 10/24
6:15 am-10:20 am
1 stop4h 05m
$277
Myrtle BeachBuffalo
MYR Myrtle Beach Intl - BUF Buffalo
MYRBUF
Myrtle Beach Intl
Thu 10/29
6:58 pm-11:59 pm
1 stop5h 01m
Buffalo
Sat 10/31
6:15 am-10:20 am
1 stop4h 05m
$277
Myrtle BeachBuffalo
MYR Myrtle Beach Intl - BUF Buffalo
MYRBUF
Myrtle Beach Intl
Thu 10/22
7:50 pm-11:40 pm
1 stop3h 50m
Buffalo
Sat 10/24
10:10 am-7:30 pm
2 stops9h 20m
$295
Myrtle BeachBuffalo
MYR Myrtle Beach Intl - BUF Buffalo
MYRBUF
Myrtle Beach Intl
Wed 10/28
6:00 am-11:16 am
1 stop5h 16m
Buffalo
Sun 11/1
6:15 am-10:42 am
1 stop4h 27m
$320
Myrtle BeachBuffalo
MYR Myrtle Beach Intl - BUF Buffalo
MYRBUF
Myrtle Beach Intl
Fri 10/30
6:58 pm-11:59 pm
1 stop5h 01m
Buffalo
Sun 11/1
6:15 am-10:42 am
1 stop4h 27m
$333
Myrtle BeachBuffalo
MYR Myrtle Beach Intl - BUF Buffalo
MYRBUF
Myrtle Beach Intl
Wed 10/21
7:50 am-6:20 pm
2 stops10h 30m
Buffalo
Sat 10/24
10:10 am-7:30 pm
2 stops9h 20m
$340
Myrtle BeachBuffalo
MYR Myrtle Beach Intl - BUF Buffalo
MYRBUF
Myrtle Beach Intl
Fri 10/9
7:50 pm-11:40 pm
1 stop3h 50m
Buffalo
Mon 10/12
9:40 am-3:20 pm
1 stop5h 40m
$355
Myrtle BeachBuffalo
MYR Myrtle Beach Intl - BUF Buffalo
MYRBUF
Myrtle Beach Intl
Tue 9/1
8:15 am-3:15 pm
2 stops7h 00m
Buffalo
Tue 9/8
8:05 am-4:05 pm
2 stops8h 00m
$361
Showing 1-10 of 22 resultsSorted by cheapest first
Compare providers for flights from Myrtle Beach to Buffalo
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to Buffalo in August.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Myrtle Beach-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Myrtle Beach-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Myrtle Beach-Buffalo flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Myrtle Beach-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Myrtle Beach to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from Myrtle Beach with our price prediction graph.
MYR-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Myrtle Beach to Buffalo
Reviews of airlines servicing Buffalo
Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated August 19, 2026.
Get a feel of what it's like to fly with Southwest and American Airlines from Myrtle Beach to Buffalo by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
8.0
Crew
8.6
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Food
7.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Overall
8.0
Crew
8.6
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Food
7.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Overall
8.0
Crew
8.6
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Food
7.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Related info for your journey
Find useful and relevant information for your journey from Myrtle Beach to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsLockport
Cheektowaga
Amherst
Williamsville
Orchard Park
Eden
Bowmansville
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Buffalo flight routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from Myrtle Beach
Popular flights
Alternative routes for Myrtle Beach to Buffalo
See prices for flight routes from nearby airports that may be better suited for you.
Other flights to Buffalo
Explore flights to Buffalo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on August 19, 2026.
Complete your trip
Complete your trip to Buffalo by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Myrtle Beach to Buffalo by cabin class
Find flights from Myrtle Beach to Buffalo, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Myrtle Beach and Buffalo flights
Browse other Myrtle Beach and Buffalo flight options. Last updated on August 19, 2026.
Other flights from Myrtle Beach
Browse through other flights departing from Myrtle Beach. Flights are based on user searches made on Cheapflights and were last updated on August 19, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Myrtle Beach to Buffalo
Discover the top 2 airlines that operate flights from Myrtle Beach to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 19, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$250 | Average$397 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$308 | Average$396 | FlexibilityNo cancel fee | On-time63% |