HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Buffalo

$126+ Cheap flights from Myrtle Beach to Buffalo (MYR - BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/15. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — BUF
Oct 16 — Oct 231
Thu 10/16
Thu 10/23
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Myrtle Beach to Buffalo with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Myrtle Beach to Buffalo

Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 16, 2025.

Round-trip from

$251
(Southwest)

One-way from

$126
(United Airlines)

Popular in

May

Cheapest in

September

Average price

$300
From Myrtle Beach Intl to Buffalo
Search Deals
One-way flight from Myrtle Beach Intl to Buffalo
Search Deals
Highest demand for flights based on searches. 12% potential increase in price ($55 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($8 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in September 2025
Search Deals

Find flight deals from Myrtle Beach to Buffalo

Cheapest flights from Myrtle Beach to Buffalo
Explore the most affordable flight options available from Myrtle Beach to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/87:10 amMYR - BUF
1 stop5h 30mSouthwest
Wed 10/154:15 pmBUF - MYR
1 stop3h 40mSouthwest
Deal found 9/15$251
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/86:00 amMYR - BUF
2 stops5h 22mAmerican Airlines
Wed 10/154:25 pmBUF - MYR
1 stop6h 29mAmerican Airlines
Deal found 9/15$256
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/138:20 pmMYR - BUF
1 stop3h 55mAmerican Airlines
Fri 10/177:38 pmBUF - MYR
1 stop4h 21mAmerican Airlines
Deal found 9/16$288
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/138:20 pmMYR - BUF
1 stop3h 55mAmerican Airlines
Mon 10/205:14 amBUF - MYR
1 stop6h 42mAmerican Airlines
Deal found 9/15$297
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/38:05 pmMYR - BUF
1 stop3h 45mSouthwest
Sun 10/56:00 amBUF - MYR
1 stop3h 35mSouthwest
Deal found 9/14$332
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/296:55 pmMYR - BUF
1 stop4h 42mDelta
Fri 10/34:43 pmBUF - MYR
1 stop7h 06mDelta
Deal found 9/14$355
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/36:24 pmMYR - BUF
1 stop4h 40mAmerican Airlines
Sun 10/56:00 amBUF - MYR
1 stop4h 13mAmerican Airlines
Deal found 9/15$377
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/267:42 pmMYR - BUF
1 stop3h 50mAmerican Airlines
Mon 12/296:15 amBUF - MYR
1 stop4h 17mAmerican Airlines
Deal found 9/15$394

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from Myrtle Beach to Buffalo that are best for you.

Fly from

Myrtle Beach

Fly to

Buffalo

Route

Depart

Return

Price

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Wed 10/8

6:00 am-11:22 am

2 stops5h 22m

Buffalo

Wed 10/15

4:25 pm-10:54 pm

1 stop6h 29m

$256

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Wed 1/7

8:15 am-12:30 pm

1 stop4h 15m

Buffalo

Mon 1/12

5:50 am-10:15 am

1 stop4h 25m

$265

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Mon 10/13

8:20 pm-12:15 am

1 stop3h 55m

Buffalo

Fri 10/17

7:38 pm-11:59 pm

1 stop4h 21m

$288

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Fri 10/3

8:05 pm-11:50 pm

1 stop3h 45m

Buffalo

Sun 10/5

6:00 am-9:35 am

1 stop3h 35m

$332

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Fri 10/3

6:24 pm-11:04 pm

1 stop4h 40m

Buffalo

Sun 10/5

5:38 am-10:48 am

1 stop5h 10m

$332

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Mon 9/29

6:55 pm-11:37 pm

1 stop4h 42m

Buffalo

Fri 10/3

4:43 pm-11:49 pm

1 stop7h 06m

$355

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Wed 11/5

6:00 am-11:01 am

1 stop5h 01m

$126

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Wed 10/15

5:57 pm-10:42 pm

1 stop4h 45m

$126

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Wed 10/15

6:00 am-11:22 am

2 stops5h 22m

$131

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Thu 10/9

5:59 pm-12:15 am

1 stop6h 16m

$149

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/16

Showing 1-10 of 14 results
1
2

Best time to book a flight from Myrtle Beach to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Buffalo

What is the cheapest month to book a flight from Myrtle Beach to Buffalo?

Currently, January is the cheapest month in which you can book a flight from Myrtle Beach to Buffalo (average of $256). Flying from Myrtle Beach to Buffalo in December is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MYR to BUF?

Find hourly flight availability from Myrtle Beach to Buffalo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 16, 2025.

It’s typically best to fly out from Myrtle Beach to Buffalo in the afternoon. Doing so could potentially save you 11% on the flight price compared to flying at noon, which is usually more expensive.

Reviews of airlines servicing Buffalo

Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated September 16, 2025.
Get a feel of what it's like to fly with Southwest, Delta, and American Airlines from Myrtle Beach to Buffalo by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,242 reviews

Food

7.0

Comfort

8.0

Entertainment

7.5

Overall

8.0

Boarding

8.1

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,242 reviews
Southwest
8.0
Very good
4,242 reviews

Food

7.0

Comfort

8.0

Entertainment

7.5

Overall

8.0

Boarding

8.1

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
8.0
Very good
7,957 reviews
Southwest
8.0
Very good
4,242 reviews

Food

7.0

Comfort

8.0

Entertainment

7.5

Overall

8.0

Boarding

8.1

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,242 reviews

Food

7.0

Comfort

8.0

Entertainment

7.5

Overall

8.0

Boarding

8.1

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Myrtle Beach to Buffalo?

    There are many flights that can get you from Myrtle Beach to Buffalo in 4h 15m. Fly via American Airlines or Southwest to get the fastest option. There are 639 mi between Myrtle Beach and Buffalo. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Myrtle Beach to Buffalo round-trip?

    According to our current data, American Airlines ($195), Delta ($256), and Southwest ($277) offers the cheapest pricing from Myrtle Beach to Buffalo. American Airlines is priced at 47% lower than the current average price of a flight leaving 3 months from now.

  • What are the cheapest airlines to fly from Myrtle Beach to Buffalo one-way?

    To fly one-way, consider booking your trip with Delta, which is currently one of the cheapest options available, starting at $126. United Airlines flights start at $126 while deals on American Airlines start at $131 one-way.

  • Can I find deals for flights from Myrtle Beach to Buffalo that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Buffalo.

  • Can I find deals for business class flights from Myrtle Beach to Buffalo?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to Buffalo?

    Currently, January is the cheapest month in which you can book a flight from Myrtle Beach to Buffalo (average of $256). Flying from Myrtle Beach to Buffalo in December is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Orchard Park
Batavia
Williamsville
Eden
Amherst
West Seneca

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Myrtle Beach to Buffalo

See prices for flight routes from nearby airports that may be better suited for you.
Charlotte to John F Kennedy Intl flights
Charlotte to LaGuardia flights
Charlotte to Newark flights
Charleston to John F Kennedy Intl flights
Charleston to Newark flights
Greenville to Newark flights
Greenville to John F Kennedy Intl flights
Charleston to LaGuardia flights
Savannah to John F Kennedy Intl flights
Greenville to LaGuardia flights
Savannah to LaGuardia flights
Savannah to Newark flights
Columbia to John F Kennedy Intl flights
Columbia to LaGuardia flights
Charlotte to Buffalo flights
Myrtle Beach to Newark flights
Myrtle Beach to John F Kennedy Intl flights
Myrtle Beach to LaGuardia flights
Charlotte to Albany flights
Charleston to White Plains flights
Charlotte to Syracuse flights
Charlotte to Rochester flights
Columbia to Newark flights
Myrtle Beach to White Plains flights
Charleston to Buffalo flights
Charleston to Stewart flights
Myrtle Beach to Stewart flights
Charlotte to Stewart flights
Hilton Head Island to LaGuardia flights
Greenville to Buffalo flights
Augusta to John F Kennedy Intl flights
Savannah to White Plains flights
Greenville to Albany flights
Augusta to LaGuardia flights
Charleston to Islip flights
Columbia to Rochester flights
Hilton Head Island to Newark flights
Greenville to Syracuse flights
Myrtle Beach to Syracuse flights
Hilton Head Island to John F Kennedy Intl flights
Greenville to Stewart flights
Savannah to Albany flights
Charlotte to White Plains flights
Charleston to Albany flights
Columbia to Buffalo flights
Augusta to Newark flights
Columbia to Albany flights
Columbia to Syracuse flights
Greenville to White Plains flights

Top 3 airlines flying from Myrtle Beach to Buffalo

Discover the top 3 airlines that operate flights from Myrtle Beach to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$195Average$353FlexibilityNo cancel feeOn-time71%
DeltaCheapest$256Average$316FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$277Average$396FlexibilityNo cancel feeOn-time63%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.