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$180+ Cheap flights from Myrtle Beach to Buffalo (MYR - BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/11. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — BUF
nov. 21 — nov. 281
vie. 11/21
vie. 11/28
1 adult, Economy
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Find flight deals from Myrtle Beach to Buffalo

Cheapest flights from Myrtle Beach to Buffalo
Explore the most affordable flight options available from Myrtle Beach to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on octubre 22, 2025.

This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 11/1911:13 amMYR - BUF
2 stops23h 32mMultiple Airlines
sáb. 11/2211:47 amBUF - MYR
1 stop8h 16mMultiple Airlines
Deal found 10/21$198
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 11/1911:13 amMYR - BUF
2 stops23h 32mMultiple Airlines
dom. 11/2312:20 pmBUF - MYR
1 stop7h 43mMultiple Airlines
Deal found 10/21$220
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 11/216:15 amMYR - BUF
1 stop8h 28mMultiple Airlines
vie. 11/2811:52 amBUF - MYR
1 stop8h 11mMultiple Airlines
Deal found 10/22$260
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 11/196:23 amMYR - BUF
1 stop5h 44mAmerican Airlines
sáb. 11/227:13 pmBUF - MYR
1 stop4h 42mAmerican Airlines
Deal found 10/21$297
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/192:34 pmMYR - BUF
1 stop3h 56mAmerican Airlines
mar. 12/237:15 pmBUF - MYR
1 stop4h 40mAmerican Airlines
Deal found 10/20$303
This Southwest deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/2012:55 pmMYR - BUF
1 stop4h 35mSouthwest
mar. 12/235:30 amBUF - MYR
1 stop4h 15mSouthwest
Deal found 10/20$304
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/2012:37 pmMYR - BUF
1 stop4h 20mAmerican Airlines
mar. 12/237:15 pmBUF - MYR
1 stop4h 40mAmerican Airlines
Deal found 10/20$323
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 12/216:00 amMYR - BUF
2 stops6h 20mAmerican Airlines
mar. 12/237:15 pmBUF - MYR
1 stop4h 40mAmerican Airlines
Deal found 10/20$328
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 11/196:05 pmMYR - BUF
1 stop3h 55mSouthwest
dom. 11/233:40 pmBUF - MYR
1 stop5h 50mSouthwest
Deal found 10/21$332

Cheap flight deals from Myrtle Beach to Buffalo

Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated octubre 22, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$198
(Kiwi.com)

One-way from

$180
(American Airlines)

Popular in

May

Cheapest in

September

Average price

$354
Provider with most accurate pricing for Myrtle Beach Intl-Buffalo flight deals.
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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Buffalo flights.
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From Myrtle Beach Intl to Buffalo
Search Deals
One-way flight from Myrtle Beach Intl to Buffalo
Search Deals
Highest demand for flights based on searches. 11% potential increase in price ($49 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 22, 2025.
Use the filters below to find and compare flights from Myrtle Beach to Buffalo that are best for you.

Fly from

Myrtle Beach

Fly to

Buffalo

Route

Depart

Return

Price

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

mié. 11/19

11:13 am-10:45 am

2 stops23h 32m

Buffalo

sáb. 11/22

11:47 am-8:03 pm

1 stop8h 16m

$198

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

mié. 11/19

11:13 am-10:45 am

2 stops23h 32m

Buffalo

dom. 11/23

12:20 pm-8:03 pm

1 stop7h 43m

$220

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

vie. 11/21

2:46 pm-9:29 am

2 stops18h 43m

Buffalo

vie. 11/28

11:52 am-8:03 pm

1 stop8h 11m

$284

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

mié. 11/19

6:23 am-12:07 pm

1 stop5h 44m

Buffalo

sáb. 11/22

7:13 pm-11:55 pm

1 stop4h 42m

$297

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

vie. 12/19

2:34 pm-6:30 pm

1 stop3h 56m

Buffalo

mar. 12/23

7:15 pm-11:55 pm

1 stop4h 40m

$303

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

sáb. 12/20

12:55 pm-5:30 pm

1 stop4h 35m

Buffalo

mar. 12/23

5:30 am-9:45 am

1 stop4h 15m

$304

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

dom. 12/21

4:01 pm-11:09 pm

1 stop7h 08m

Buffalo

mar. 12/23

7:15 pm-11:55 pm

1 stop4h 40m

$323

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

sáb. 12/20

12:37 pm-4:57 pm

1 stop4h 20m

Buffalo

mar. 12/23

7:15 pm-11:55 pm

1 stop4h 40m

$323

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

mié. 11/19

6:05 pm-10:00 pm

1 stop3h 55m

Buffalo

dom. 11/23

3:40 pm-9:30 pm

1 stop5h 50m

$332

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

jue. 11/13

6:00 am-11:00 am

1 stop5h 00m

Buffalo

mar. 11/18

6:00 am-11:31 am

1 stop5h 31m

$342

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/20

Showing 1-10 of 13 results
1
2

Compare providers for flights from Myrtle Beach to Buffalo

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to Buffalo in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Myrtle Beach-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Myrtle Beach-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Myrtle Beach-Buffalo flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Myrtle Beach-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Myrtle Beach to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Buffalo

What is the cheapest month to book a flight from Myrtle Beach to Buffalo?

Currently, August is the cheapest month in which you can book a flight from Myrtle Beach to Buffalo (average of $46). Flying from Myrtle Beach to Buffalo in March is currently the most expensive (average of $181). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MYR to BUF?

Find hourly flight availability from Myrtle Beach to Buffalo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated octubre 22, 2025.

It’s typically best to fly out from Myrtle Beach to Buffalo in the afternoon. Doing so could potentially save you 10% on the flight price compared to flying at noon, which is usually more expensive.

Reviews of airlines servicing Buffalo

Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated octubre 22, 2025.
Get a feel of what it's like to fly with Southwest, Delta, and American Airlines from Myrtle Beach to Buffalo by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,237 reviews

Entertainment

7.5

Food

7.0

Boarding

8.1

Comfort

8.0

Overall

8.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,237 reviews
Southwest
8.0
Very good
4,237 reviews

Entertainment

7.5

Food

7.0

Boarding

8.1

Comfort

8.0

Overall

8.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
7.9
Good
7,981 reviews
Southwest
8.0
Very good
4,237 reviews

Entertainment

7.5

Food

7.0

Boarding

8.1

Comfort

8.0

Overall

8.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
11,028 reviews
Southwest
8.0
Very good
4,237 reviews

Entertainment

7.5

Food

7.0

Boarding

8.1

Comfort

8.0

Overall

8.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Myrtle Beach to Buffalo?

    There are many flights that can get you from Myrtle Beach to Buffalo in 5h 44m. Fly via American Airlines to get the fastest option. There are 639 mi between Myrtle Beach and Buffalo.

  • What are the cheapest airlines flying from Myrtle Beach to Buffalo round-trip?

    According to our current data, American Airlines ($195), Delta ($256), and Southwest ($286) offers the cheapest pricing from Myrtle Beach to Buffalo. American Airlines is priced at 47% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Myrtle Beach to Buffalo that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Buffalo.

  • Can I find deals for business class flights from Myrtle Beach to Buffalo?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to Buffalo?

    Currently, August is the cheapest month in which you can book a flight from Myrtle Beach to Buffalo (average of $46). Flying from Myrtle Beach to Buffalo in March is currently the most expensive (average of $181). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Cheektowaga
Orchard Park
Batavia
Williamsville
Eden
Amherst
West Seneca

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Alternative routes for Myrtle Beach to Buffalo

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Myrtle Beach to Buffalo

Discover the top 3 airlines that operate flights from Myrtle Beach to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 22, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$195Average$353FlexibilityNo cancel feeOn-time71%
DeltaCheapest$256Average$316FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$286Average$396FlexibilityNo cancel feeOn-time63%

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