$125+ Cheap flights from Myrtle Beach to Buffalo (MYR - BUF)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/11. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — BUF
May 3 — May 101
Round-trip
1 adult, Economy
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Find cheap flights from Myrtle Beach to Buffalo with Cheapflights
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Cheapest flights from Myrtle Beach to BuffaloExplore the most affordable flight options available from Myrtle Beach to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 3, 2026.
Explore the most affordable flight options available from Myrtle Beach to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 3, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/173:20 pm
MYR
- BUF
1 stop19h 29m
Multiple Airlines
Mon 4/2012:32 pm
BUF
- MYR
2 stops27h 59m
Multiple Airlines
Deal found 4/1![Multiple Airlines logo]()
$280
This Kiwi.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/2310:27 am
MYR
- BUF
1 stop23h 40m
Multiple Airlines
Sun 4/2612:07 pm
BUF
- MYR
2 stops8h 59m
Multiple Airlines
Deal found 3/29![Multiple Airlines logo]()
$283
This Kiwi.com deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/910:24 am
MYR
- BUF
2 stops32h 43m
Multiple Airlines
Sat 6/1310:05 pm
BUF
- MYR
1 stop11h 45m
Multiple Airlines
Deal found 3/30![Multiple Airlines logo]()
$297
This Kiwi.com deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/1610:27 am
MYR
- BUF
1 stop8h 46m
Multiple Airlines
Mon 4/2012:32 pm
BUF
- MYR
2 stops51h 11m
Multiple Airlines
Deal found 4/1![Multiple Airlines logo]()
$318
This Delta deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/67:02 pm
MYR
- BUF
1 stop4h 35m
Delta
Tue 5/126:15 am
BUF
- MYR
1 stop4h 24m
Delta
Deal found 4/2![Delta logo]()
$319
This Kiwi.com deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/122:42 pm
MYR
- BUF
1 stop28h 25m
Multiple Airlines
Tue 8/188:57 pm
BUF
- MYR
1 stop12h 08m
Multiple Airlines
Deal found 3/30![Multiple Airlines logo]()
$323
This Delta deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/94:54 pm
MYR
- BUF
1 stop7h 05m
Delta
Tue 5/127:39 pm
BUF
- MYR
1 stop4h 19m
Delta
Deal found 3/31![Delta logo]()
$326
This United Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/93:14 pm
MYR
- BUF
2 stops8h 41m
United Airlines
Tue 5/126:00 am
BUF
- MYR
1 stop5h 04m
United Airlines
Deal found 3/31![United Airlines logo]()
$331
This Kiwi.com deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/304:23 pm
MYR
- BUF
2 stops43h 50m
Multiple Airlines
Thu 5/78:49 pm
BUF
- MYR
1 stop12h 16m
Multiple Airlines
Deal found 3/30![Multiple Airlines logo]()
$333
This Kiwi.com deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/122:42 pm
MYR
- BUF
1 stop28h 25m
Multiple Airlines
Wed 8/197:52 pm
BUF
- MYR
1 stop13h 58m
Multiple Airlines
Deal found 3/30![Multiple Airlines logo]()
$335
This American Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/306:31 pm
MYR
- BUF
1 stop4h 48m
American Airlines
Thu 5/77:28 pm
BUF
- MYR
1 stop4h 29m
American Airlines
Deal found 3/30![American Airlines logo]()
$343
Best flights from Myrtle Beach to BuffaloDiscover carefully curated flight deals from Myrtle Beach to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 3, 2026.
Discover carefully curated flight deals from Myrtle Beach to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 3, 2026.
This Delta deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/67:02 pm
MYR
- BUF
1 stop4h 35m
Delta
Tue 5/126:15 am
BUF
- MYR
1 stop4h 24m
Delta
Deal found 4/2![Delta logo]()
$319
This Southwest deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/81:45 pm
MYR
- BUF
2 stops9h 00m
Southwest
Tue 5/126:05 am
BUF
- MYR
2 stops7h 25m
Southwest
Deal found 3/31![Southwest logo]()
$363
This American Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/176:10 pm
MYR
- BUF
1 stop4h 26m
American Airlines
Mon 7/206:03 am
BUF
- MYR
1 stop6h 43m
American Airlines
Deal found 4/2![American Airlines logo]()
$397
This United Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/53:14 pm
MYR
- BUF
1 stop5h 47m
United Airlines
Wed 5/67:00 am
BUF
- MYR
1 stop7h 18m
United Airlines
Deal found 4/1![United Airlines logo]()
$399
This Delta deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/94:54 pm
MYR
- BUF
1 stop7h 05m
Delta
Tue 5/127:39 pm
BUF
- MYR
1 stop4h 19m
Delta
Deal found 3/31![Delta logo]()
$326
This Southwest deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/151:45 pm
MYR
- BUF
1 stop6h 00m
Southwest
Sun 5/175:50 am
BUF
- MYR
1 stop3h 55m
Southwest
Deal found 4/1![Southwest logo]()
$387
This Delta deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1110:55 am
MYR
- BUF
1 stop13h 03m
Delta
Wed 8/197:40 pm
BUF
- MYR
1 stop14h 29m
Delta
Deal found 3/30![Delta logo]()
$367
This Delta deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/126:00 am
MYR
- BUF
1 stop17h 58m
Delta
Thu 8/206:00 am
BUF
- MYR
1 stop17h 39m
Delta
Deal found 3/30![Delta logo]()
$367
This Delta deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/146:00 am
MYR
- BUF
1 stop12h 43m
Delta
Thu 8/207:40 pm
BUF
- MYR
1 stop14h 29m
Delta
Deal found 3/30![Delta logo]()
$367
This Delta deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/106:00 am
MYR
- BUF
1 stop17h 58m
Delta
Wed 8/197:40 pm
BUF
- MYR
1 stop14h 29m
Delta
Deal found 3/30![Delta logo]()
$367
This Delta deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/106:00 am
MYR
- BUF
2 stops17h 56m
Delta
Mon 8/177:40 pm
BUF
- MYR
1 stop14h 29m
Delta
Deal found 3/30![Delta logo]()
$372
Last-minute flights from Myrtle Beach to BuffaloDiscover last-minute flight deals from Myrtle Beach to Buffalo. Data last updated April 3, 2026 and is based on user searches.
Discover last-minute flight deals from Myrtle Beach to Buffalo. Data last updated April 3, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/1610:27 am
MYR
- BUF
1 stop8h 46m
Multiple Airlines
Mon 4/2012:32 pm
BUF
- MYR
2 stops51h 11m
Multiple Airlines
Deal found 4/1![Multiple Airlines logo]()
$318
This Kiwi.com deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/173:20 pm
MYR
- BUF
1 stop19h 29m
Multiple Airlines
Mon 4/2012:32 pm
BUF
- MYR
2 stops27h 59m
Multiple Airlines
Deal found 4/1![Multiple Airlines logo]()
$280
This Kiwi.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/2310:27 am
MYR
- BUF
1 stop23h 40m
Multiple Airlines
Sun 4/2612:07 pm
BUF
- MYR
2 stops8h 59m
Multiple Airlines
Deal found 3/29![Multiple Airlines logo]()
$283
This Kiwi.com deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/304:23 pm
MYR
- BUF
2 stops43h 50m
Multiple Airlines
Thu 5/78:49 pm
BUF
- MYR
1 stop12h 16m
Multiple Airlines
Deal found 3/30![Multiple Airlines logo]()
$333
This American Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/306:31 pm
MYR
- BUF
1 stop4h 48m
American Airlines
Thu 5/77:28 pm
BUF
- MYR
1 stop4h 29m
American Airlines
Deal found 3/30![American Airlines logo]()
$343
This Delta deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/67:02 pm
MYR
- BUF
1 stop4h 35m
Delta
Tue 5/126:15 am
BUF
- MYR
1 stop4h 24m
Delta
Deal found 4/2![Delta logo]()
$319
This American Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/810:28 am
MYR
- BUF
1 stop6h 34m
American Airlines
Tue 5/125:30 am
BUF
- MYR
1 stop4h 28m
American Airlines
Deal found 3/31![American Airlines logo]()
$353
This Southwest deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/81:45 pm
MYR
- BUF
2 stops9h 00m
Southwest
Tue 5/124:00 pm
BUF
- MYR
1 stop4h 30m
Southwest
Deal found 3/31![Southwest logo]()
$358
This Delta deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/94:54 pm
MYR
- BUF
1 stop7h 05m
Delta
Tue 5/127:39 pm
BUF
- MYR
1 stop4h 19m
Delta
Deal found 3/31![Delta logo]()
$326
This United Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/93:14 pm
MYR
- BUF
2 stops8h 41m
United Airlines
Tue 5/126:00 am
BUF
- MYR
1 stop5h 04m
United Airlines
Deal found 3/31![United Airlines logo]()
$331
One-way flights from Myrtle Beach to BuffaloSearch for one-way flight options from Myrtle Beach to Buffalo. Find affordable one-way fares based on user searches. Data last updated April 3, 2026.
Search for one-way flight options from Myrtle Beach to Buffalo. Find affordable one-way fares based on user searches. Data last updated April 3, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/116:00 am
MYR
- BUF
2 stops28h 41m
Multiple Airlines
Deal found 4/2![Multiple Airlines logo]()
$125
This Kiwi.com deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2011:52 am
MYR
- BUF
2 stops24h 50m
Multiple Airlines
Deal found 4/2![Multiple Airlines logo]()
$145
This Kiwi.com deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/199:18 am
MYR
- BUF
3 stops51h 24m
Multiple Airlines
Deal found 4/1![Multiple Airlines logo]()
$150
This Kiwi.com deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/89:52 pm
MYR
- BUF
2 stops40h 03m
Multiple Airlines
Deal found 4/2![Multiple Airlines logo]()
$155
This Kiwi.com deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/109:50 pm
MYR
- BUF
2 stops36h 51m
Multiple Airlines
Deal found 3/30![Multiple Airlines logo]()
$159
This American Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/188:20 pm
MYR
- BUF
1 stop3h 49m
American Airlines
Deal found 3/31![American Airlines logo]()
$160
This Southwest deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/187:50 am
MYR
- BUF
2 stops9h 55m
Southwest
Deal found 3/31![Southwest logo]()
$165
This Kiwi.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/2611:52 am
MYR
- BUF
2 stops23h 55m
Multiple Airlines
Deal found 3/29![Multiple Airlines logo]()
$171
This Kiwi.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/1912:25 pm
MYR
- BUF
2 stops32h 55m
Multiple Airlines
Deal found 3/29![Multiple Airlines logo]()
$184
This American Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/109:14 am
MYR
- BUF
1 stop3h 51m
American Airlines
Deal found 3/30![American Airlines logo]()
$194
Find flight deals from Myrtle Beach to Buffalo
Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 3, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $280 (Kiwi.com) |
One-way from | $125 (Kiwi.com) |
Popular in | March |
Cheapest in | January |
Average price | $360 |
Cheapflights Fare Finder
Customize your flight search to find flights from Myrtle Beach to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 3, 2026.
Use the filters below to find and compare flights from Myrtle Beach to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Myrtle BeachBuffalo
MYR - BUF
MYRBUF
Myrtle Beach Intl
Wed 5/6
7:02 pm-11:37 pm
1 stop4h 35m
Buffalo
Tue 5/12
6:15 am-10:39 am
1 stop4h 24m
$319
Myrtle BeachBuffalo
MYR - BUF
MYRBUF
Myrtle Beach Intl
Sat 5/9
4:54 pm-11:59 pm
1 stop7h 05m
Buffalo
Tue 5/12
7:39 pm-11:58 pm
1 stop4h 19m
$326
Myrtle BeachBuffalo
MYR - BUF
MYRBUF
Myrtle Beach Intl
Fri 5/8
1:45 pm-10:45 pm
2 stops9h 00m
Buffalo
Tue 5/12
6:05 am-1:30 pm
2 stops7h 25m
$363
Myrtle BeachBuffalo
MYR - BUF
MYRBUF
Myrtle Beach Intl
Tue 8/11
10:55 am-11:58 pm
1 stop13h 03m
Buffalo
Wed 8/19
7:40 pm-10:09 am
1 stop14h 29m
$367
Myrtle BeachBuffalo
MYR - BUF
MYRBUF
Myrtle Beach Intl
Wed 8/12
6:00 am-11:58 pm
1 stop17h 58m
Buffalo
Thu 8/20
6:00 am-11:39 pm
1 stop17h 39m
$367
Myrtle BeachBuffalo
MYR - BUF
MYRBUF
Myrtle Beach Intl
Fri 8/14
6:00 am-6:43 pm
1 stop12h 43m
Buffalo
Thu 8/20
7:40 pm-10:09 am
1 stop14h 29m
$367
Myrtle BeachBuffalo
MYR - BUF
MYRBUF
Myrtle Beach Intl
Mon 8/10
6:00 am-11:58 pm
1 stop17h 58m
Buffalo
Wed 8/19
7:40 pm-10:09 am
1 stop14h 29m
$367
Myrtle BeachBuffalo
MYR - BUF
MYRBUF
Myrtle Beach Intl
Mon 8/10
6:00 am-11:56 pm
2 stops17h 56m
Buffalo
Mon 8/17
7:40 pm-10:09 am
1 stop14h 29m
$372
Myrtle BeachBuffalo
MYR - BUF
MYRBUF
Myrtle Beach Intl
Fri 5/15
1:45 pm-7:45 pm
1 stop6h 00m
Buffalo
Sun 5/17
5:50 am-9:45 am
1 stop3h 55m
$387
Myrtle BeachBuffalo
MYR - BUF
MYRBUF
Myrtle Beach Intl
Fri 7/17
6:10 pm-10:36 pm
1 stop4h 26m
Buffalo
Mon 7/20
6:03 am-12:46 pm
1 stop6h 43m
$397
Showing 1-10 of 21 resultsSorted by cheapest first
Compare providers for flights from Myrtle Beach to Buffalo
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to Buffalo in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Myrtle Beach-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Myrtle Beach-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Myrtle Beach-Buffalo flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Myrtle Beach-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Myrtle Beach to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from Myrtle Beach with our price prediction graph.
MYR-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Myrtle Beach to Buffalo
What is the cheapest month to book a flight from Myrtle Beach to Buffalo?
Currently, August is the cheapest month in which you can book a flight from Myrtle Beach to Buffalo (average of $46). Flying from Myrtle Beach to Buffalo in March is currently the most expensive (average of $134). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Myrtle Beach to Buffalo?
Reviews of airlines servicing Buffalo
Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated April 3, 2026.
Get a feel of what it's like to fly with Southwest and American Airlines from Myrtle Beach to Buffalo by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Crew
8.6
Boarding
8.1
Food
7.0
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Crew
8.6
Boarding
8.1
Food
7.0
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Crew
8.6
Boarding
8.1
Food
7.0
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Myrtle Beach to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsLockport
Cheektowaga
Batavia
Williamsville
Orchard Park
Eden
Amherst
West Seneca
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Myrtle Beach and Buffalo flights
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Top 2 airlines flying from Myrtle Beach to Buffalo
Discover the top 2 airlines that operate flights from Myrtle Beach to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 3, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$195 | Average$354 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$286 | Average$378 | FlexibilityNo cancel fee | On-time63% |