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$484+ Cheap flights from South Carolina to Brussels

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/27. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — BRU
ene. 14 — ene. 211
mié. 1/14
mié. 1/21
1 adult, Economy
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Cheap flight deals from South Carolina to Brussels

Cheapest flights from South Carolina to Brussels
Explore the most affordable flight options available from South Carolina to Brussels. Find the lowest fares from popular airlines and budget airlines, with prices last updated on diciembre 15, 2025.

This Gotogate deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/304:59 pmCHS - BRU
2 stops32h 51mAir Canada
mié. 1/710:00 amBRU - CHS
2 stops53h 50mAir Canada
Deal found 12/13$847
This United Airlines deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/306:05 amCHS - BRU
1 stop20h 50mUnited Airlines
mié. 1/710:00 amBRU - CHS
2 stops34h 48mUnited Airlines
Deal found 12/13$860
This Air Canada deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/302:50 pmCHS - BRU
3 stops16h 25mMultiple Airlines
mié. 1/710:00 amBRU - CHS
2 stops32h 32mMultiple Airlines
Deal found 12/13$1,164
This United Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/312:54 pmCLT - BRU
2 stops16h 21mUnited Airlines
dom. 1/410:00 amBRU - CLT
2 stops29h 15mUnited Airlines
Deal found 12/15$1,338
This Expedia deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/276:50 pmCLT - BRU
1 stop21h 50mMultiple Airlines
sáb. 1/310:00 amBRU - CLT
2 stops54h 31mMultiple Airlines
Deal found 12/13$1,351
This United Airlines deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 12/286:50 pmCLT - BRU
1 stop16h 25mUnited Airlines
dom. 1/411:55 amBRU - CLT
1 stop18h 04mUnited Airlines
Deal found 12/13$1,409
This KAYAK deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 12/286:50 pmCLT - BRU
2 stops16h 40mLufthansa
dom. 1/411:55 amBRU - CLT
1 stop18h 04mLufthansa
Deal found 12/13$1,445
This United Airlines deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/276:20 amCLT - BRU
1 stop20h 35mUnited Airlines
dom. 1/411:55 amBRU - CLT
1 stop18h 04mUnited Airlines
Deal found 12/13$1,457
This Lufthansa deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Lufthansa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/276:50 pmCLT - BRU
1 stop21h 50mLufthansa
dom. 1/411:55 amBRU - CLT
1 stop18h 04mLufthansa
Deal found 12/13$1,459
This Cheapflightsfares deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/276:50 pmCLT - BRU
1 stop12h 20mLufthansa
sáb. 1/311:55 amBRU - CLT
1 stop18h 04mLufthansa
Deal found 12/13$1,549
This lastminute.com deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure lastminute.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/297:37 pmCAE - BRU
2 stops15h 38mLufthansa
vie. 1/211:55 amBRU - CAE
1 stop13h 04mLufthansa
Deal found 12/14$1,923
This United Airlines deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/292:30 pmCAE - BRU
1 stop12h 25mUnited Airlines
vie. 1/211:55 amBRU - CAE
1 stop13h 04mUnited Airlines
Deal found 12/14$1,972

Find flight deals from South Carolina to Brussels

Keep the following information in mind while searching for South Carolina to Brussels flight deals. Data was last updated diciembre 15, 2025.

Round-trip from

$484
(United Airlines)
From South Carolina to Brussels
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Brussels that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 15, 2025.
Use the filters below to find and compare flights from South Carolina to Brussels that are best for you.

Fly from

South Carolina

Fly to

Brussels

Route

Depart

Return

Price

Myrtle BeachBrussels

MYR - BRU

MYRBRU

Myrtle Beach Intl

mar. 1/27

1:25 pm-1:15 pm

2 stops17h 50m

Brussels Bruxelles-National

mar. 2/3

10:00 am-1:28 pm

2 stops33h 28m

$484

Myrtle BeachBrussels

MYR - BRU

MYRBRU

Myrtle Beach Intl

vie. 1/30

1:25 pm-1:15 pm

2 stops17h 50m

Brussels Bruxelles-National

mar. 2/3

10:00 am-1:28 pm

2 stops33h 28m

$484

ColumbiaBrussels

CAE - BRU

CAEBRU

Columbia Metropolitan

vie. 1/30

2:49 pm-1:15 pm

2 stops16h 26m

Brussels Bruxelles-National

mar. 2/3

10:00 am-2:14 pm

2 stops34h 14m

$484

ColumbiaBrussels

CAE - BRU

CAEBRU

Columbia Metropolitan

jue. 1/29

7:30 pm-7:15 am

1 stop29h 45m

Brussels Bruxelles-National

jue. 2/5

10:00 am-10:17 am

2 stops54h 17m

$488

Myrtle BeachBrussels

MYR - BRU

MYRBRU

Myrtle Beach Intl

mar. 1/27

1:25 pm-1:15 pm

3 stops17h 50m

Brussels Bruxelles-National

mar. 2/3

10:00 am-1:28 pm

2 stops33h 28m

$491

CharlestonBrussels

CHS - BRU

CHSBRU

Charleston

mié. 1/14

6:00 am-7:50 am

2 stops19h 50m

Brussels Bruxelles-National

dom. 1/18

10:00 am-11:44 pm

2 stops43h 44m

$491

ColumbiaBrussels

CAE - BRU

CAEBRU

Columbia Metropolitan

jue. 1/29

2:49 pm-7:15 am

1 stop10h 26m

Brussels Bruxelles-National

jue. 2/5

11:55 am-6:55 pm

1 stop13h 00m

$508

Myrtle BeachBrussels

MYR - BRU

MYRBRU

Myrtle Beach Intl

mié. 2/18

5:30 pm-8:55 am

2 stops33h 25m

Brussels Bruxelles-National

mié. 2/25

6:45 am-4:49 pm

2 stops16h 04m

$513

CharlestonBrussels

CHS - BRU

CHSBRU

Charleston

sáb. 3/14

7:47 pm-7:50 am

2 stops31h 03m

Brussels Bruxelles-National

dom. 3/22

10:00 am-11:30 pm

2 stops42h 30m

$525

CharlotteBrussels

CLT - BRU

CLTBRU

Charlotte Douglas

mar. 1/27

2:54 pm-7:15 am

1 stop10h 21m

Brussels Bruxelles-National

mar. 2/3

11:55 am-6:59 pm

1 stop13h 04m

$572

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/14

Showing 1-10 of 25 results
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Best time to book a flight from South Carolina to Brussels

Have a flexible travel schedule? Discover the best time to fly to Brussels from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Brussels

What is the cheapest time of day to fly from SC to BRU?

Find hourly flight availability from South Carolina to Brussels. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated diciembre 15, 2025.

A simple way to save on the total cost of your ticket is to fly from South Carolina to Brussels in the morning. If you’re flexible enough to do this you can expect to save up to 22% on your trip compared to booking a flight in the evening.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Brussels. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from South Carolina to Brussels?

    There are many flights that can get you from South Carolina to Brussels in 10h 21m. Fly via United Airlines, Air Canada, or Lufthansa to get the fastest option. South Carolina and Brussels are separated by a distance of 4194 mi. This flight may include one or multiple stops.

  • What are the most popular routes from South Carolina to Brussels?

    While some choose either Charleston - Brussels Bruxelles-National or Myrtle Beach Intl - Brussels Bruxelles-National, Charlotte Douglas - Brussels Bruxelles-National is the most popular route from South Carolina to Brussels.

  • Can I find deals for flights from South Carolina to Brussels that include hotel bookings?

    Yes. In addition to deals on South Carolina to Brussels flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Brussels?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Brussels.

  • Can I find deals for business class flights from South Carolina to Brussels?

    Yes. Cheapflights offers flight deals from South Carolina to Brussels by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for South Carolina to Brussels

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from South Carolina to Brussels

Discover the top airline that operate flights from South Carolina to Brussels. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$591Average$1,054FlexibilityNo cancel feeOn-time69%

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