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$498+ Cheap flights from Knoxville (TYS) to Brussels

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/14. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — BRU
Dec 26 — Jan 21
Fri 12/26
Fri 1/2
1 adult, Economy
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Cheap flight deals from Knoxville to Brussels

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Brussels (BR1). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 26, 2025.

Round-trip from

$498
(Booking.com)
From Knoxville McGhee Tyson to Brussels
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Find flight deals from Knoxville to Brussels

Best flights from Knoxville to Brussels
Discover carefully curated flight deals from Knoxville to Brussels that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 26, 2025.

This Booking.com deal was found by Cheapflights users on 11/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/141:59 pmTYS - BRU
2 stops35h 51mMultiple Airlines
Wed 1/2110:10 amBRU - TYS
1 stop16h 42mMultiple Airlines
Deal found 11/25$498
This United Airlines deal was found by Cheapflights users on 11/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/182:21 pmTYS - BRU
2 stops16h 54mUnited Airlines
Sun 2/2210:00 amBRU - TYS
2 stops30h 49mUnited Airlines
Deal found 11/23$503
This FlightHub deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/111:59 pmTYS - BRU
1 stop12h 56mLufthansa
Wed 2/1811:55 amBRU - TYS
1 stop13h 34mLufthansa
Deal found 11/24$503
This United Airlines deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/85:29 pmTYS - BRU
2 stops33h 26mUnited Airlines
Thu 1/1510:00 amBRU - TYS
2 stops43h 44mUnited Airlines
Deal found 11/24$503
This United Airlines deal was found by Cheapflights users on 11/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/202:21 pmTYS - BRU
2 stops16h 54mUnited Airlines
Sat 2/2810:10 amBRU - TYS
1 stop17h 00mUnited Airlines
Deal found 11/25$503
This United Airlines deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/111:59 pmTYS - BRU
2 stops17h 16mUnited Airlines
Wed 2/1810:00 amBRU - TYS
2 stops17h 10mUnited Airlines
Deal found 11/24$503

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Brussels that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 26, 2025.
Use the filters below to find and compare flights from Knoxville to Brussels that are best for you.

Fly from

Knoxville

Fly to

Brussels

Route

Depart

Return

Price

KnoxvilleBrussels

TYS - BRU

TYSBRU

Knoxville McGhee Tyson

Wed 1/14

1:59 pm-7:50 am

2 stops35h 51m

Brussels Bruxelles-National

Wed 1/21

10:10 am-8:52 pm

1 stop16h 42m

$498

KnoxvilleBrussels

TYS - BRU

TYSBRU

Knoxville McGhee Tyson

Wed 2/18

2:21 pm-1:15 pm

2 stops16h 54m

Brussels Bruxelles-National

Sun 2/22

10:00 am-10:49 am

2 stops30h 49m

$503

KnoxvilleBrussels

TYS - BRU

TYSBRU

Knoxville McGhee Tyson

Wed 2/11

1:59 pm-8:55 am

1 stop12h 56m

Brussels Bruxelles-National

Wed 2/18

11:55 am-7:29 pm

1 stop13h 34m

$503

KnoxvilleBrussels

TYS - BRU

TYSBRU

Knoxville McGhee Tyson

Thu 1/8

5:29 pm-8:55 am

2 stops33h 26m

Brussels Bruxelles-National

Thu 1/15

10:00 am-11:44 pm

2 stops43h 44m

$503

KnoxvilleBrussels

TYS - BRU

TYSBRU

Knoxville McGhee Tyson

Fri 2/20

2:21 pm-1:15 pm

2 stops16h 54m

Brussels Bruxelles-National

Sat 2/28

10:10 am-9:10 pm

1 stop17h 00m

$503

KnoxvilleBrussels

TYS - BRU

TYSBRU

Knoxville McGhee Tyson

Wed 2/11

1:59 pm-1:15 pm

2 stops17h 16m

Brussels Bruxelles-National

Wed 2/18

10:00 am-9:10 pm

2 stops17h 10m

$503

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/25

Best time to book a flight from Knoxville to Brussels

Have a flexible travel schedule? Discover the best time to fly to Brussels from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Brussels

What is the cheapest time of day to fly from TYS to BRU?

Find hourly flight availability from Knoxville to Brussels. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 26, 2025.

A simple way to save on the total cost of your ticket is to fly from Knoxville to Brussels in the afternoon. If you’re flexible enough to do this you can expect to save up to 44% on your trip compared to booking a flight at noon.

Reviews of airlines servicing Brussels

Get insights into the airlines that provide service to Brussels. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Brussels. Reviews last updated November 26, 2025.
Peruse reviews from past customers who have flown with United Airlines from Knoxville to Brussels to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,046 reviews

Comfort

7.3

Crew

8.1

Overall

7.4

Food

6.6

Entertainment

7.1

Boarding

7.7

Reviews

1 / 20
2.0
Mediocre

Sebrena,Oct 2025

IAH - RSW

The worst that I have ever experienced in my life so bad if it was free I'm not ever going to use your Airline again I dont believe ..... very disappointed 😞 😔0000000000000
United Airlines
7.4
Good
9,046 reviews
United Airlines
7.4
Good
9,046 reviews

Comfort

7.3

Crew

8.1

Overall

7.4

Food

6.6

Entertainment

7.1

Boarding

7.7

Reviews

1 / 20
2.0
Mediocre

Sebrena,Oct 2025

IAH - RSW

The worst that I have ever experienced in my life so bad if it was free I'm not ever going to use your Airline again I dont believe ..... very disappointed 😞 😔0000000000000

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Brussels. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Brussels?

    Most people fly from Knoxville McGhee Tyson (TYS) if they book a flight from Knoxville to Brussels. On average, McGhee Tyson has 0 outbound flights to Brussels per day from 1 airline. Knoxville McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • How long is the flight from Knoxville to Brussels?

    A quick flight from Knoxville to Brussels can take about 16h 54m. United Airlines provides one of the quickest options available for as low as $503. Knoxville and Brussels are separated by a distance of 4289 mi.

  • What is the cheapest airline to fly from Knoxville to Brussels round-trip?

    Flying on United Airlines is currently your cheapest option to Brussels, with prices starting at $603.

  • Can I find deals for flights from Knoxville to Brussels that include hotel bookings?

    Yes. In addition to deals on Knoxville to Brussels flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Brussels?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Brussels.

  • Can I find deals for business class flights from Knoxville to Brussels?

    Yes. Cheapflights offers flight deals from Knoxville to Brussels by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for Knoxville to Brussels

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Knoxville to Brussels

Discover the top airline that operate flights from Knoxville to Brussels. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 26, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$603Average$1,314FlexibilityNo cancel feeOn-time69%

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