HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Brussels

$604+ Cheap flights from Knoxville (TYS) to Brussels

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/1. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — BRU
Nov 13 — Nov 201
Thu 11/13
Thu 11/20
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to Brussels with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Knoxville to Brussels

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Brussels (BR1). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 14, 2025.

Round-trip from

$604
(Mytrip)
From Knoxville McGhee Tyson to Brussels
Search Deals

Find flight deals from Knoxville to Brussels

Cheapest flights from Knoxville to Brussels
Explore the most affordable flight options available from Knoxville to Brussels. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 14, 2025.

This United Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/217:20 pmTYS - BRU
2 stops30h 30mUnited Airlines
Sun 11/3011:55 amBRU - TYS
1 stop18h 04mUnited Airlines
Deal found 10/13$1,213
This Mytrip deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/219:45 pmTYS - BRU
3 stops33h 30mMultiple Airlines
Sun 11/3010:15 amBRU - TYS
2 stops22h 16mMultiple Airlines
Deal found 10/13$1,546

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Brussels that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 14, 2025.
Use the filters below to find and compare flights from Knoxville to Brussels that are best for you.

Fly from

Knoxville

Fly to

Brussels

Route

Depart

Return

Price

KnoxvilleBrussels

TYS - BRU

TYSBRU

Knoxville McGhee Tyson

Wed 4/1

5:50 am-8:05 am

2 stops20h 15m

Brussels Bruxelles-National

Wed 4/8

8:30 am-11:59 pm

2 stops21h 29m

$604

KnoxvilleBrussels

TYS - BRU

TYSBRU

Knoxville McGhee Tyson

Wed 4/1

10:16 am-7:15 am

1 stop14h 59m

Brussels Bruxelles-National

Wed 4/8

12:00 pm-7:17 pm

1 stop13h 17m

$606

KnoxvilleBrussels

TYS - BRU

TYSBRU

Knoxville McGhee Tyson

Fri 3/27

4:00 pm-8:00 am

1 stop11h 00m

Brussels Bruxelles-National

Tue 3/31

10:45 am-9:43 pm

1 stop16h 58m

$656

KnoxvilleBrussels

TYS - BRU

TYSBRU

Knoxville McGhee Tyson

Fri 3/27

4:16 pm-1:40 pm

2 stops16h 24m

Brussels Bruxelles-National

Tue 3/31

10:55 am-9:14 pm

2 stops16h 19m

$872

KnoxvilleBrussels

TYS - BRU

TYSBRU

Knoxville McGhee Tyson

Wed 4/1

10:16 am-8:05 am

3 stops15h 49m

Brussels Bruxelles-National

Wed 4/8

7:00 am-7:17 pm

3 stops18h 17m

$905

KnoxvilleBrussels

TYS - BRU

TYSBRU

Knoxville McGhee Tyson

Fri 11/21

7:20 pm-7:50 am

2 stops30h 30m

Brussels Bruxelles-National

Sun 11/30

4:55 pm-11:59 pm

2 stops37h 04m

$1,232

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/13

Best time to book a flight from Knoxville to Brussels

Have a flexible travel schedule? Discover the best time to fly to Brussels from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Brussels

What is the cheapest time of day to fly from TYS to BRU?

Find hourly flight availability from Knoxville to Brussels. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 14, 2025.

A simple way to save on the total cost of your ticket is to fly from Knoxville to Brussels in the afternoon. If you’re flexible enough to do this you can expect to save up to 44% on your trip compared to booking a flight at noon.

Reviews of airlines servicing Brussels

Get insights into the airlines that provide service to Brussels. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Brussels. Reviews last updated October 14, 2025.
Peruse reviews from past customers who have flown with United Airlines from Knoxville to Brussels to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
8,976 reviews

Food

6.6

Overall

7.4

Boarding

7.7

Comfort

7.3

Crew

8.1

Entertainment

7.1

Reviews

1 / 20
4.0
Okay

Tim,Sep 2025

IAD - GSP

This was pretty bad. It’s chaos at the Dulles boarding gates for the small regional jets because they use one gate to board 3-4 flights at a time. So, it’s difficult knowing where and when to go. There is little space for any size of carrry-on, so most had to gate check their bags. However, the worst of it was that our single flight attendant fell asleep before we took off and the pilot couldn’t do so until she responded to his messages. My wife had to wake her up! So we were a little late leaving. Not to be thwarted, the flight attendant fell asleep right after take off and there was no sight of her during the flight. When the aircraft touched down, a tray of unsecured canned drinks came crashing onto the aisle up front. I can only assume someone didn’t do what they were supposed to. The pilot was great, but I’m sure he must not be happy with this crew member.
United Airlines
7.4
Good
8,976 reviews
United Airlines
7.4
Good
8,976 reviews

Food

6.6

Overall

7.4

Boarding

7.7

Comfort

7.3

Crew

8.1

Entertainment

7.1

Reviews

1 / 20
4.0
Okay

Tim,Sep 2025

IAD - GSP

This was pretty bad. It’s chaos at the Dulles boarding gates for the small regional jets because they use one gate to board 3-4 flights at a time. So, it’s difficult knowing where and when to go. There is little space for any size of carrry-on, so most had to gate check their bags. However, the worst of it was that our single flight attendant fell asleep before we took off and the pilot couldn’t do so until she responded to his messages. My wife had to wake her up! So we were a little late leaving. Not to be thwarted, the flight attendant fell asleep right after take off and there was no sight of her during the flight. When the aircraft touched down, a tray of unsecured canned drinks came crashing onto the aisle up front. I can only assume someone didn’t do what they were supposed to. The pilot was great, but I’m sure he must not be happy with this crew member.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Brussels. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Brussels?

    Most people fly from Knoxville McGhee Tyson (TYS) if they book a flight from Knoxville to Brussels. On average, McGhee Tyson has 0 outbound flights to Brussels per day from 1 airline. Knoxville McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • How long is the flight from Knoxville to Brussels?

    A quick flight from Knoxville to Brussels can take about 11h. United Airlines provides one of the quickest options available for as low as $656. Knoxville and Brussels are separated by a distance of 4289 mi. This flight may include one or multiple stops.

  • What is the cheapest airline to fly from Knoxville to Brussels round-trip?

    Flying on United Airlines is currently your cheapest option to Brussels, with prices starting at $676.

  • Can I find deals for flights from Knoxville to Brussels that include hotel bookings?

    Yes. In addition to deals on Knoxville to Brussels flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Brussels?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Brussels.

  • Can I find deals for business class flights from Knoxville to Brussels?

    Yes. Cheapflights offers flight deals from Knoxville to Brussels by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to Brussels

See prices for flight routes from nearby airports that may be better suited for you.
Nashville to Bruxelles-National flights
Memphis to Bruxelles-National flights
Knoxville to Bruxelles-National flights
Blountville to Bruxelles-National flights

Top airline flying from Knoxville to Brussels

Discover the top airline that operate flights from Knoxville to Brussels. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$676Average$1,314FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.