HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Brussels

$268+ Cheap flights from Knoxville (TYS) to Brussels

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/29. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — BRU
Feb 20 — Feb 271
Fri 2/20
Fri 2/27
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to Brussels with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Knoxville to Brussels

Cheapest flights from Knoxville to Brussels
Explore the most affordable flight options available from Knoxville to Brussels. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 21, 2026.

This oojo deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/87:00 am
TYS
-
BRU
2 stops26h 05m
British Airways
Wed 4/2211:00 am
BRU
-
TYS
2 stops16h 57m
British Airways
Deal found 1/19$458
This United Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/89:40 am
TYS
-
BRU
1 stop15h 35m
United Airlines
Wed 4/229:25 am
BRU
-
TYS
2 stops43h 04m
United Airlines
Deal found 1/19$487
This oojo deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/226:10 am
TYS
-
BRU
2 stops23h 40m
British Airways
Tue 3/3110:55 am
BRU
-
TYS
2 stops16h 29m
British Airways
Deal found 1/21$522
This KLM deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/2212:03 pm
TYS
-
BRU
1 stop14h 57m
KLM
Tue 3/319:45 am
BRU
-
TYS
1 stop14h 42m
KLM
Deal found 1/21$533
This United Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/195:48 pm
TYS
-
BRU
2 stops20h 12m
United Airlines
Mon 4/279:25 am
BRU
-
TYS
2 stops37h 27m
United Airlines
Deal found 1/20$534
This United Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/49:30 am
TYS
-
BRU
2 stops41h 25m
United Airlines
Sun 2/810:00 am
BRU
-
TYS
2 stops34h 49m
United Airlines
Deal found 1/19$535
This American Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/226:38 pm
TYS
-
BRU
2 stops18h 37m
American Airlines
Tue 3/3110:55 am
BRU
-
TYS
3 stops17h 53m
American Airlines
Deal found 1/21$549

Find flight deals from Knoxville to Brussels

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Brussels (BR1). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 21, 2026.

Round-trip from

$458
(oojo)

One-way from

$268
From Knoxville McGhee Tyson to Brussels
Search Deals
One-way flight from Knoxville McGhee Tyson to Brussels
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Brussels that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2026.
Use the filters below to find and compare flights from Knoxville to Brussels that are best for you.

Fly from

Knoxville

Fly to

Brussels

Route

Depart

Return

Price

KnoxvilleBrussels

TYS - BRU

TYSBRU

Knoxville McGhee Tyson

Wed 4/8

5:06 pm-3:05 pm

2 stops15h 59m

Brussels Bruxelles-National

Wed 4/22

11:00 am-9:57 pm

2 stops16h 57m

$458

KnoxvilleBrussels

TYS - BRU

TYSBRU

Knoxville McGhee Tyson

Wed 4/8

9:40 am-7:15 am

1 stop15h 35m

Brussels Bruxelles-National

Wed 4/22

9:25 am-10:29 pm

2 stops43h 04m

$487

KnoxvilleBrussels

TYS - BRU

TYSBRU

Knoxville McGhee Tyson

Sun 3/22

6:10 am-10:50 am

2 stops23h 40m

Brussels Bruxelles-National

Tue 3/31

10:55 am-9:24 pm

2 stops16h 29m

$522

KnoxvilleBrussels

TYS - BRU

TYSBRU

Knoxville McGhee Tyson

Sun 3/22

12:03 pm-8:00 am

1 stop14h 57m

Brussels Bruxelles-National

Tue 3/31

9:45 am-6:27 pm

1 stop14h 42m

$533

KnoxvilleBrussels

TYS - BRU

TYSBRU

Knoxville McGhee Tyson

Sun 4/19

5:48 pm-8:00 pm

2 stops20h 12m

Brussels Bruxelles-National

Mon 4/27

9:25 am-4:52 pm

2 stops37h 27m

$534

KnoxvilleBrussels

TYS - BRU

TYSBRU

Knoxville McGhee Tyson

Sun 3/22

7:00 am-7:55 am

1 stop19h 55m

Brussels Bruxelles-National

Tue 3/31

2:25 pm-10:08 am

2 stops25h 43m

$535

KnoxvilleBrussels

TYS - BRU

TYSBRU

Knoxville McGhee Tyson

Wed 2/4

9:30 am-8:55 am

2 stops41h 25m

Brussels Bruxelles-National

Sun 2/8

10:00 am-2:49 pm

2 stops34h 49m

$535

KnoxvilleBrussels

TYS - BRU

TYSBRU

Knoxville McGhee Tyson

Sun 3/29

2:25 pm-7:15 am

1 stop10h 50m

$268

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/18

Best time to book a flight from Knoxville to Brussels

Have a flexible travel schedule? Discover the best time to fly to Brussels from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Brussels
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing Brussels

Get insights into the airlines that provide service to Brussels. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Brussels. Reviews last updated January 21, 2026.
Peruse reviews from past customers who have flown with United Airlines from Knoxville to Brussels to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,191 reviews

Overall

7.4

Comfort

7.3

Crew

8.1

Entertainment

7.1

Food

6.6

Boarding

7.7

Reviews

1 / 20
10.0
Excellent

Dane,Jan 2026

TYS - IAD

It was a short flight, so no time for amenities. Just glad everything was quick and easy from boarding to arriving at my destination with my family
United Airlines
7.4
Good
9,191 reviews
United Airlines
7.4
Good
9,191 reviews

Overall

7.4

Comfort

7.3

Crew

8.1

Entertainment

7.1

Food

6.6

Boarding

7.7

Reviews

1 / 20
10.0
Excellent

Dane,Jan 2026

TYS - IAD

It was a short flight, so no time for amenities. Just glad everything was quick and easy from boarding to arriving at my destination with my family

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Brussels. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Brussels?

    Most people fly from Knoxville McGhee Tyson (TYS) if they book a flight from Knoxville to Brussels. On average, McGhee Tyson has 0 outbound flights to Brussels per day from 1 airline. Knoxville McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • How long is the flight from Knoxville to Brussels?

    A quick flight from Knoxville to Brussels can take about 15h 35m. British Airways provides one of the quickest options available for as low as $487. Knoxville and Brussels are separated by a distance of 4289 mi. This flight may include one or multiple stops.

  • What is the cheapest airline to fly from Knoxville to Brussels round-trip?

    Flying on United Airlines is currently your cheapest option to Brussels, with prices starting at $603.

  • Can I find deals for flights from Knoxville to Brussels that include hotel bookings?

    Yes. In addition to deals on Knoxville to Brussels flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Brussels?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Brussels.

  • Can I find deals for business class flights from Knoxville to Brussels?

    Yes. Cheapflights offers flight deals from Knoxville to Brussels by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to Brussels

See prices for flight routes from nearby airports that may be better suited for you.
Nashville to Bruxelles-National flights
Memphis to Bruxelles-National flights
Knoxville to Bruxelles-National flights
Blountville to Bruxelles-National flights

Top airline flying from Knoxville to Brussels

Discover the top airline that operate flights from Knoxville to Brussels. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$603Average$1,314FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.