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Biloxi

$475+ Cheap flights from Portland, ME (PWM) to Biloxi, MS

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/22. Fares are subject to change and may not be available on all flights or dates of travel.
PWM — MSY
Mar 8 — Mar 151
Sun 3/8
Sun 3/15
1 adult, Economy
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Cheap flight deals from Portland to Biloxi

Cheapest flights from Portland to Biloxi
Explore the most affordable flight options available from Portland to Biloxi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 6, 2026.

This Delta deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1011:25 am
PWM
-
GPT
2 stops11h 42m
Delta
Tue 10/136:00 pm
GPT
-
PWM
1 stop4h 48m
Delta
Deal found 2/5$476
This Delta deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:45 pm
PWM
-
GPT
1 stop15h 54m
Delta
Tue 10/136:00 pm
GPT
-
PWM
1 stop4h 48m
Delta
Deal found 2/5$522
This Delta deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:45 pm
PWM
-
GPT
1 stop15h 54m
Delta
Sat 10/106:00 pm
GPT
-
PWM
1 stop4h 48m
Delta
Deal found 2/5$583
This Delta deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/15:21 am
PWM
-
GPT
1 stop5h 03m
Delta
Mon 5/42:40 pm
GPT
-
PWM
2 stops9h 06m
Delta
Deal found 2/4$598
This Delta deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1011:25 am
PWM
-
GPT
2 stops11h 42m
Delta
Mon 10/126:00 am
GPT
-
PWM
1 stop5h 18m
Delta
Deal found 2/5$601
This Delta deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:45 pm
PWM
-
GPT
1 stop15h 54m
Delta
Mon 10/126:00 am
GPT
-
PWM
1 stop5h 18m
Delta
Deal found 2/5$647
This American Airlines deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/257:00 am
PWM
-
GPT
1 stop6h 03m
American Airlines
Sun 3/14:29 pm
GPT
-
PWM
1 stop5h 21m
American Airlines
Deal found 2/5$668

Find flight deals from Portland to Biloxi

Keep the following information in mind while searching for Portland to Biloxi flight deals. Data was last updated February 6, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$598
(Delta)

One-way from

$475
(Delta)
Provider with most accurate pricing for Portland-Gulfport Biloxi Regional flight deals.
Search Deals
Provider most trusted by Cheapflights users for Portland-Gulfport Biloxi Regional flights.
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From Portland to Biloxi
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One-way flight from Portland to Biloxi
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Portland to Biloxi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 6, 2026.
Use the filters below to find and compare flights from Portland to Biloxi that are best for you.

Fly from

Portland

Fly to

Biloxi

Route

Depart

Return

Price

PortlandGulfport

PWM - GPT

PWMGPT

Portland

Fri 5/1

5:21 am-9:24 am

1 stop5h 03m

Gulfport Biloxi Regional

Mon 5/4

2:40 pm-12:46 am

2 stops9h 06m

$598

PortlandGulfport

PWM - GPT

PWMGPT

Portland

Wed 2/25

7:00 am-12:03 pm

1 stop6h 03m

Gulfport Biloxi Regional

Sun 3/1

4:29 pm-10:50 pm

1 stop5h 21m

$668

PortlandGulfport

PWM - GPT

PWMGPT

Portland

Fri 4/24

6:13 pm-7:53 pm

2 stops26h 40m

Gulfport Biloxi Regional

Mon 4/27

5:15 pm-3:22 pm

2 stops21h 07m

$712

PortlandGulfport

PWM - GPT

PWMGPT

Portland

Fri 4/24

7:10 am-11:58 pm

1 stop17h 48m

Gulfport Biloxi Regional

Mon 4/27

6:10 pm-12:38 pm

1 stop17h 28m

$752

PortlandGulfport

PWM - GPT

PWMGPT

Portland

Wed 2/25

2:35 pm-9:54 pm

2 stops8h 19m

Gulfport Biloxi Regional

Sun 3/1

2:54 pm-12:18 am

2 stops8h 24m

$798

PortlandGulfport

PWM - GPT

PWMGPT

Portland

Wed 2/18

4:15 pm-1:20 pm

2 stops22h 05m

Gulfport Biloxi Regional

Sun 2/22

4:55 pm-11:20 pm

2 stops29h 25m

$977

PortlandGulfport

PWM - GPT

PWMGPT

Portland

Sun 5/31

5:20 am-9:27 pm

2 stops17h 07m

Gulfport Biloxi Regional

Thu 6/4

9:10 am-11:50 pm

2 stops13h 40m

$983

PortlandGulfport

PWM - GPT

PWMGPT

Portland

Wed 2/18

7:00 am-12:03 pm

1 stop6h 03m

Gulfport Biloxi Regional

Sun 2/22

4:29 pm-10:50 pm

1 stop5h 21m

$1,015

PortlandGulfport

PWM - GPT

PWMGPT

Portland

Sun 2/22

6:00 am-5:15 pm

2 stops12h 15m

$475

PortlandGulfport

PWM - GPT

PWMGPT

Portland

Sun 2/22

7:10 am-12:34 pm

1 stop6h 24m

$543

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/5

Showing 1-10 of 11 results
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Best time to book a flight from Portland to Biloxi

Have a flexible travel schedule? Discover the best time to fly to Biloxi from Portland with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Portland to Biloxi

What is the cheapest month to book a flight from Portland, Maine to Biloxi?

Currently, March is the cheapest month in which you can book a flight from Portland, Maine to Biloxi (average of $67). Flying from Portland, Maine to Biloxi in December is currently the most expensive (average of $138). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Portland to Biloxi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Portland to Biloxi?

    If you book a flight to Biloxi from Portland, you will be flying from Portland, which is the city’s only airport. Portland (PWM) is located 2.9 mi from the center of Portland. There are 0 flights from Portland to Biloxi per day from 5 different airlines.

  • How long is the flight from Portland, Maine to Biloxi?

    There are many flights that can get you from Portland, Maine to Biloxi in 5h 03m. Fly via Delta, American Airlines, or United Airlines to get the fastest option. The distance from Portland, Maine to Biloxi is about 1374 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Portland to Biloxi that include hotel bookings?

    Yes. In addition to deals on Portland to Biloxi flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Portland to Biloxi?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Portland to Biloxi.

  • Can I find deals for business class flights from Portland to Biloxi?

    Yes. Cheapflights offers flight deals from Portland to Biloxi by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Portland, Maine to Biloxi?

    Currently, March is the cheapest month in which you can book a flight from Portland, Maine to Biloxi (average of $67). Flying from Portland, Maine to Biloxi in December is currently the most expensive (average of $138). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top 5 airlines flying from Portland to Biloxi

Discover the top 5 airlines that operate flights from Portland to Biloxi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 6, 2026.
AirlineCheapestAverageFlexibilityOn-time
JetBlueCheapest$87Average$131FlexibilityNo cancel feeOn-time62%
DeltaCheapest$182Average$367FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$246Average$446FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$271Average$395FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$290Average$462FlexibilityNo cancel feeOn-time63%

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