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$271+ Cheap flights from Greenville (GSP) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/24. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — SCL
Jul 13 — Jul 201
Mon 7/13
Mon 7/20
1 adult, Economy
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Cheap flight deals from Greenville to Santiago

Cheapest flights from Greenville to Santiago
Explore the most affordable flight options available from Greenville to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 13, 2026.

This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/246:40 pm
GSP
-
SCL
1 stop12h 25m
American Airlines
Mon 8/318:50 pm
SCL
-
GSP
2 stops19h 20m
American Airlines
Deal found 6/10$890
This LATAM Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/241:26 pm
GSP
-
SCL
3 stops21h 23m
LATAM Airlines
Mon 8/317:50 am
SCL
-
GSP
2 stops15h 09m
LATAM Airlines
Deal found 6/10$915
This LATAM Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/45:05 pm
GSP
-
SCL
1 stop12h 35m
LATAM Airlines
Tue 12/811:10 pm
SCL
-
GSP
1 stop12h 15m
LATAM Airlines
Deal found 6/9$945
This Expedia deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/247:44 pm
GSP
-
SCL
2 stops41h 51m
LATAM Airlines
Fri 7/318:40 pm
SCL
-
GSP
1 stop22h 15m
LATAM Airlines
Deal found 6/12$1,008
This LATAM Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2411:25 am
GSP
-
SCL
3 stops23h 24m
LATAM Airlines
Mon 9/74:10 am
SCL
-
GSP
2 stops19h 49m
LATAM Airlines
Deal found 6/9$1,155
This Expedia deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/242:51 pm
GSP
-
SCL
1 stop16h 24m
LATAM Airlines
Mon 9/712:00 am
SCL
-
GSP
2 stops24h 38m
LATAM Airlines
Deal found 6/9$1,186
This American Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/248:00 pm
GSP
-
SCL
1 stop11h 00m
American Airlines
Fri 7/319:00 pm
SCL
-
GSP
1 stop20h 39m
American Airlines
Deal found 6/12$1,199

Find flight deals from Greenville to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 13, 2026.

Most accurate provider

Ovago
3 stars

Most trusted provider

Ovago
3 stars

Round-trip from

$890
(American Airlines)

One-way from

$271
(Kiwi.com)
Provider with most accurate pricing for Greenville-Santiago Arturo Merino Benitez flight deals.
Search Deals
Provider most trusted by Cheapflights users for Greenville-Santiago Arturo Merino Benitez flights.
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From Greenville to Santiago Arturo Merino Benitez
Search Deals
One-way flight from Greenville to Santiago Arturo Merino Benitez
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 13, 2026.
Use the filters below to find and compare flights from Greenville to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Mon 8/24

6:40 pm-7:05 am

1 stop12h 25m

Santiago Arturo Merino Benitez

Mon 9/7

9:50 pm-2:17 pm

2 stops17h 27m

$890

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Mon 8/24

2:42 pm-7:05 am

2 stops16h 23m

Santiago Arturo Merino Benitez

Mon 8/31

8:50 pm-4:10 pm

2 stops19h 20m

$890
Quickest round-trip

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Fri 12/4

5:05 pm-7:40 am

1 stop12h 35m

Santiago Arturo Merino Benitez

Tue 12/8

11:10 pm-9:25 am

1 stop12h 15m

$945

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Fri 7/24

7:44 pm-1:35 pm

2 stops41h 51m

Santiago Arturo Merino Benitez

Fri 7/31

11:00 pm-10:57 am

2 stops35h 57m

$1,024

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Fri 7/24

8:00 pm-7:00 am

1 stop11h 00m

Santiago Arturo Merino Benitez

Fri 7/31

9:00 pm-5:39 pm

1 stop20h 39m

$1,199

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Tue 7/21

11:42 am-6:00 am

2 stops18h 18m

Santiago Arturo Merino Benitez

Tue 7/28

7:55 pm-10:57 am

2 stops15h 02m

$1,255

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Tue 7/21

5:16 pm-7:15 am

1 stop13h 59m

Santiago Arturo Merino Benitez

Tue 7/28

7:55 pm-10:57 am

2 stops15h 02m

$1,255

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Tue 7/7

11:42 am-6:00 am

2 stops18h 18m

Santiago Arturo Merino Benitez

Tue 7/14

8:40 pm-10:57 am

1 stop14h 17m

$1,255
Cheapest one-way

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Mon 8/24

8:45 pm-3:00 am

2 stops30h 15m

$271

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Mon 7/13

8:45 pm-5:14 am

2 stops32h 29m

$365

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/9

Showing 1-10 of 11 resultsSorted by cheapest first
1
2

Compare providers for flights from Greenville to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Greenville to Santiago in June.
ProviderPrice AccuracyTrust Score*
OvagoPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Greenville-Santiago flights, users find the pricing of Ovago to be most consistent on Cheapflights vs. Ovago Users can find the same prices on Greenville-Santiago flight deals on Cheapflights vs. Ovago >95% of the time. Price accuracy is based on data collected from Greenville-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Greenville-Santiago flights, Cheapflights users trust Ovago the most. Ovago has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Greenville-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Greenville to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Greenville to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Greenville to Santiago?

    Departing from Greenville to Santiago will take you 12h 25m. Greenville and Santiago are separated by a distance of 4773 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Greenville to Santiago that include hotel bookings?

    Yes. In addition to deals on Greenville to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Santiago.

  • Can I find deals for business class flights from Greenville to Santiago?

    Yes. Cheapflights offers flight deals from Greenville to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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