$85+ Cheap flights from Des Moines (DSM) to Mesa, AZ
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/13. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — PHX
7月 14 — 7月 211
Round-trip
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Des Moines to Mesa are usually found in October or August, booked 53 days in advance, depart on a Wednesday or Saturday and return on a Saturday
Cheap flight deals from Des Moines to Mesa
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Best
Last-minute
One-way
Cheapest flights from Des Moines to MesaExplore the most affordable flight options available from Des Moines to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 6月 14, 2026.
Explore the most affordable flight options available from Des Moines to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 6月 14, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
月 7/1310:01 pm
DSM
- PHX
1 stop16h 58m
Multiple Airlines
水 7/229:58 pm
PHX
- DSM
1 stop20h 45m
Multiple Airlines
Deal found 6/13![Multiple Airlines logo]()
$164
This Kiwi.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
月 7/2710:01 pm
DSM
- PHX
1 stop16h 58m
Multiple Airlines
月 8/32:16 pm
PHX
- DSM
2 stops44h 43m
Multiple Airlines
Deal found 6/12![Multiple Airlines logo]()
$229
This Kiwi.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
月 8/1710:06 pm
DSM
- PHX
1 stop15h 18m
Multiple Airlines
金 8/217:45 am
PHX
- DSM
1 stop9h 03m
Multiple Airlines
Deal found 6/9![Multiple Airlines logo]()
$230
This Expedia deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
金 8/72:19 pm
DSM
- PHX
1 stop27h 25m
Frontier
火 8/114:49 pm
PHX
- DSM
1 stop18h 45m
Frontier
Deal found 6/10![Frontier logo]()
$240
This Kiwi.com deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
月 9/219:31 pm
DSM
- PHX
1 stop15h 18m
Multiple Airlines
水 9/3010:55 pm
PHX
- DSM
1 stop18h 31m
Multiple Airlines
Deal found 6/10![Multiple Airlines logo]()
$247
This Expedia deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
水 7/82:19 pm
DSM
- PHX
1 stop19h 21m
Frontier
月 7/136:40 am
PHX
- DSM
1 stop4h 54m
Frontier
Deal found 6/11![Frontier logo]()
$249
This Expedia deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
水 7/12:16 pm
DSM
- PHX
1 stop22h 05m
Frontier
火 7/74:48 pm
PHX
- DSM
1 stop18h 46m
Frontier
Deal found 6/12![Frontier logo]()
$250
This Orbitz deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
月 8/102:19 pm
DSM
- PHX
1 stop24h 58m
Frontier
木 8/136:53 pm
PHX
- DSM
1 stop16h 41m
Frontier
Deal found 6/11![Frontier logo]()
$258
This Expedia deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
水 8/262:16 pm
DSM
- PHX
1 stop19h 29m
Frontier
日 8/308:40 am
PHX
- DSM
1 stop26h 51m
Frontier
Deal found 6/11![Frontier logo]()
$260
This Kiwi.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
日 10/111:38 pm
DSM
- PHX
1 stop28h 57m
Multiple Airlines
木 10/1512:49 pm
PHX
- DSM
1 stop7h 12m
Multiple Airlines
Deal found 6/12![Multiple Airlines logo]()
$261
This Kiwi.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
月 6/299:56 pm
DSM
- PHX
1 stop16h 59m
Multiple Airlines
金 7/37:45 am
PHX
- DSM
1 stop11h 26m
Multiple Airlines
Deal found 6/9![Multiple Airlines logo]()
$262
Best flights from Des Moines to MesaDiscover carefully curated flight deals from Des Moines to Mesa that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated 6月 14, 2026.
Discover carefully curated flight deals from Des Moines to Mesa that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated 6月 14, 2026.
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
木 9/243:50 pm
DSM
- PHX
2 stops8h 05m
Southwest
火 9/2911:40 am
PHX
- DSM
2 stops7h 20m
Southwest
Deal found 6/11![Southwest logo]()
$311
This American Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
水 11/185:10 am
DSM
- PHX
Nonstop3h 14m
American Airlines
月 11/239:50 am
PHX
- DSM
Nonstop2h 59m
American Airlines
Deal found 6/14![American Airlines logo]()
$398
This United Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
金 7/313:24 pm
DSM
- PHX
1 stop9h 03m
United Airlines
水 8/51:28 pm
PHX
- DSM
1 stop5h 54m
United Airlines
Deal found 6/9![United Airlines logo]()
$438
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
土 9/512:10 pm
DSM
- PHX
2 stops9h 50m
Southwest
土 9/1212:25 pm
PHX
- DSM
1 stop6h 20m
Southwest
Deal found 6/9![Southwest logo]()
$316
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
水 12/912:10 pm
DSM
- PHX
2 stops7h 45m
Southwest
日 12/132:55 pm
PHX
- DSM
Nonstop2h 40m
Southwest
Deal found 6/10![Southwest logo]()
$344
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
水 8/261:35 pm
DSM
- PHX
2 stops9h 02m
United Airlines
土 8/296:09 am
PHX
- DSM
1 stop6h 05m
United Airlines
Deal found 6/11![United Airlines logo]()
$438
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
土 7/256:55 pm
DSM
- PHX
1 stop5h 00m
Southwest
火 7/287:30 am
PHX
- DSM
1 stop5h 35m
Southwest
Deal found 6/11![Southwest logo]()
$369
This Southwest deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
土 10/101:15 pm
DSM
- PHX
1 stop6h 50m
Southwest
火 10/137:10 am
PHX
- DSM
1 stop4h 40m
Southwest
Deal found 6/12![Southwest logo]()
$387
This Southwest deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
木 10/221:50 pm
DSM
- PHX
2 stops8h 00m
Southwest
月 10/262:15 pm
PHX
- DSM
1 stop7h 15m
Southwest
Deal found 6/12![Southwest logo]()
$392
This Southwest deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
水 7/83:45 pm
DSM
- PHX
2 stops8h 15m
Southwest
月 7/131:45 pm
PHX
- DSM
1 stop6h 40m
Southwest
Deal found 6/13![Southwest logo]()
$395
This Southwest deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
月 10/191:50 pm
DSM
- PHX
2 stops8h 10m
Southwest
金 11/67:25 am
PHX
- DSM
2 stops7h 25m
Southwest
Deal found 6/13![Southwest logo]()
$424
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
水 7/296:25 am
DSM
- PHX
2 stops8h 15m
Southwest
日 8/23:30 pm
PHX
- DSM
1 stop6h 20m
Southwest
Deal found 6/10![Southwest logo]()
$428
Last-minute flights from Des Moines to MesaDiscover last-minute flight deals from Des Moines to Mesa. Data last updated 6月 14, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Mesa. Data last updated 6月 14, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
月 6/299:56 pm
DSM
- PHX
1 stop16h 59m
Multiple Airlines
金 7/37:45 am
PHX
- DSM
1 stop11h 26m
Multiple Airlines
Deal found 6/9![Multiple Airlines logo]()
$262
This Expedia deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
水 7/12:16 pm
DSM
- PHX
1 stop22h 05m
Frontier
火 7/74:48 pm
PHX
- DSM
1 stop18h 46m
Frontier
Deal found 6/12![Frontier logo]()
$250
This Kiwi.com deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
水 7/11:49 pm
DSM
- PHX
1 stop11h 11m
Multiple Airlines
水 7/152:04 pm
PHX
- DSM
1 stop28h 39m
Multiple Airlines
Deal found 6/13![Multiple Airlines logo]()
$282
This Expedia deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
金 7/32:16 pm
DSM
- PHX
1 stop22h 05m
Frontier
月 7/66:40 am
PHX
- DSM
1 stop4h 54m
Frontier
Deal found 6/10![Frontier logo]()
$290
This Expedia deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
水 7/82:19 pm
DSM
- PHX
1 stop19h 21m
Frontier
月 7/136:40 am
PHX
- DSM
1 stop4h 54m
Frontier
Deal found 6/11![Frontier logo]()
$249
This Expedia deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
水 7/82:19 pm
DSM
- PHX
1 stop21h 52m
Frontier
木 7/164:48 pm
PHX
- DSM
1 stop18h 46m
Frontier
Deal found 6/10![Frontier logo]()
$289
This Expedia deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
金 7/102:19 pm
DSM
- PHX
1 stop27h 24m
Frontier
月 7/136:40 am
PHX
- DSM
1 stop4h 54m
Frontier
Deal found 6/11![Frontier logo]()
$269
This Frontier deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
金 7/102:19 pm
DSM
- PHX
1 stop9h 09m
Frontier
金 7/176:40 am
PHX
- DSM
1 stop4h 54m
Frontier
Deal found 6/10![Frontier logo]()
$270
This Kiwi.com deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
月 7/1310:01 pm
DSM
- PHX
1 stop16h 58m
Multiple Airlines
水 7/229:58 pm
PHX
- DSM
1 stop20h 45m
Multiple Airlines
Deal found 6/13![Multiple Airlines logo]()
$164
This Expedia deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
月 7/202:19 pm
DSM
- PHX
1 stop24h 58m
Frontier
木 7/236:53 pm
PHX
- DSM
1 stop16h 41m
Frontier
Deal found 6/10![Frontier logo]()
$268
This Kiwi.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
月 7/2710:01 pm
DSM
- PHX
1 stop16h 58m
Multiple Airlines
月 8/32:16 pm
PHX
- DSM
2 stops44h 43m
Multiple Airlines
Deal found 6/12![Multiple Airlines logo]()
$229
One-way flights from Des Moines to MesaSearch for one-way flight options from Des Moines to Mesa. Find affordable one-way fares based on user searches. Data last updated 6月 14, 2026.
Search for one-way flight options from Des Moines to Mesa. Find affordable one-way fares based on user searches. Data last updated 6月 14, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
月 7/1310:01 pm
DSM
- PHX
1 stop16h 58m
Multiple Airlines
Deal found 6/13![Multiple Airlines logo]()
$85
This Kiwi.com deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
月 9/149:31 pm
DSM
- PHX
1 stop26h 04m
Multiple Airlines
Deal found 6/13![Multiple Airlines logo]()
$89
This Trip.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
月 6/299:56 pm
DSM
- PHX
1 stop27h 04m
Multiple Airlines
Deal found 6/12![Multiple Airlines logo]()
$95
This Kiwi.com deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
水 8/52:19 pm
DSM
- PHX
1 stop21h 52m
Frontier
Deal found 6/10![Frontier logo]()
$104
This Super.com deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
水 7/82:19 pm
DSM
- PHX
1 stop21h 52m
Frontier
Deal found 6/13![Frontier logo]()
$119
This Kiwi.com deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
金 8/79:21 pm
DSM
- PHX
1 stop27h 44m
Multiple Airlines
Deal found 6/13![Multiple Airlines logo]()
$122
This Kiwi.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
金 7/1010:13 pm
DSM
- PHX
1 stop26h 52m
Multiple Airlines
Deal found 6/12![Multiple Airlines logo]()
$123
This Kiwi.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
金 7/310:01 pm
DSM
- PHX
1 stop15h 23m
Multiple Airlines
Deal found 6/9![Multiple Airlines logo]()
$125
Find flight deals from Des Moines to Mesa
Keep the following information in mind while searching for Des Moines to Mesa flight deals. Data was last updated 6月 14, 2026.
Round-trip from | $164 (Kiwi.com) |
|---|---|
One-way from | $85 (Kiwi.com) |
Popular in | July |
Cheapest in | October |
Average price | $382 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Mesa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated 6月 14, 2026.
Use the filters below to find and compare flights from Des Moines to Mesa that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesPhoenix
DSM - PHX
DSMPHX
Des Moines
木 9/24
3:50 pm-9:55 pm
2 stops8h 05m
Phoenix Sky Harbor Intl
火 9/29
11:40 am-9:00 pm
2 stops7h 20m
$311
Des MoinesPhoenix
DSM - PHX
DSMPHX
Des Moines
土 9/5
12:10 pm-8:00 pm
2 stops9h 50m
Phoenix Sky Harbor Intl
土 9/12
12:25 pm-8:45 pm
1 stop6h 20m
$316
Des MoinesPhoenix
DSM - PHX
DSMPHX
Des Moines
水 12/9
12:10 pm-6:55 pm
2 stops7h 45m
Phoenix Sky Harbor Intl
日 12/13
2:55 pm-6:35 pm
Nonstop2h 40m
$344
Des MoinesPhoenix
DSM - PHX
DSMPHX
Des Moines
土 7/25
6:55 pm-9:55 pm
1 stop5h 00m
Phoenix Sky Harbor Intl
火 7/28
7:30 am-3:05 pm
1 stop5h 35m
$369
Des MoinesPhoenix
DSM - PHX
DSMPHX
Des Moines
土 10/10
1:15 pm-6:05 pm
1 stop6h 50m
Phoenix Sky Harbor Intl
火 10/13
7:10 am-1:50 pm
1 stop4h 40m
$387
Des MoinesPhoenix
DSM - PHX
DSMPHX
Des Moines
木 10/22
1:50 pm-7:50 pm
2 stops8h 00m
Phoenix Sky Harbor Intl
月 10/26
2:15 pm-11:30 pm
1 stop7h 15m
$392
Des MoinesPhoenix
DSM - PHX
DSMPHX
Des Moines
水 7/8
3:45 pm-10:00 pm
2 stops8h 15m
Phoenix Sky Harbor Intl
月 7/13
1:45 pm-10:25 pm
1 stop6h 40m
$395
Quickest round-trip
Des MoinesPhoenix
DSM - PHX
DSMPHX
Des Moines
水 11/18
5:10 am-7:24 am
Nonstop3h 14m
Phoenix Sky Harbor Intl
月 11/23
9:50 am-1:49 pm
Nonstop2h 59m
$398
Des MoinesPhoenix
DSM - PHX
DSMPHX
Des Moines
月 10/19
1:50 pm-8:00 pm
2 stops8h 10m
Phoenix Sky Harbor Intl
金 11/6
7:25 am-3:50 pm
2 stops7h 25m
$424
Des MoinesPhoenix
DSM - PHX
DSMPHX
Des Moines
水 7/29
6:25 am-12:40 pm
2 stops8h 15m
Phoenix Sky Harbor Intl
日 8/2
3:30 pm-11:50 pm
1 stop6h 20m
$428
Showing 1-10 of 23 resultsSorted by cheapest first
Best time to book a flight from Des Moines to Mesa
Have a flexible travel schedule? Discover the best time to fly to Mesa from Des Moines with our price prediction graph.
DSM-PHX
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Mesa
DSM-MS9
DSM-PHX
What is the cheapest time of day to fly from DSM to MS9?
Find hourly flight availability from Des Moines to Mesa. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 6月 14, 2026.
One of the essential ways to save on airfare from Des Moines to Mesa is to remain as flexible as possible. Flights that are in the evening tend to be the most expensive. A flight at noon could potentially save you up to 39% on airfare.
Weekly flight availability from Des Moines to Mesa
Explore weekly flight availability from Des Moines to Mesa. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated 6月 14, 2026.
The most flights from DSM to MS9 are scheduled on a Wednesday (4 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (2 on average).
How much does it cost to fly round-trip from Des Moines to Mesa?
Reviews of airlines servicing Mesa
Get insights into the airlines that provide service to Mesa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mesa. Reviews last updated 6月 14, 2026.
Read reviews from past customers who have flown Southwest,United Airlines, andAllegiant Air from Des Moines to Mesa. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Crew
8.6
Entertainment
7.5
Food
7.0
Overall
7.9
Boarding
8.1
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Comfort
8.0
Crew
8.6
Entertainment
7.5
Food
7.0
Overall
7.9
Boarding
8.1
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Comfort
8.0
Crew
8.6
Entertainment
7.5
Food
7.0
Overall
7.9
Boarding
8.1
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Comfort
8.0
Crew
8.6
Entertainment
7.5
Food
7.0
Overall
7.9
Boarding
8.1
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Comfort
8.0
Crew
8.6
Entertainment
7.5
Food
7.0
Overall
7.9
Boarding
8.1
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Comfort
8.0
Crew
8.6
Entertainment
7.5
Food
7.0
Overall
7.9
Boarding
8.1
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Mesa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Des Moines to Mesa
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Complete your trip
Complete your trip to Mesa by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Des Moines to Mesa by cabin class
Find flights from Des Moines to Mesa, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Des Moines and Mesa flights
Browse other Des Moines and Mesa flight options. Last updated on 6月 14, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on 6月 14, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Des Moines to Mesa flights
Consider these flights traveling from Des Moines to Mesa.
Top 7 airlines flying from Des Moines to Mesa
Discover the top 7 airlines that operate flights from Des Moines to Mesa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated 6月 14, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$132 | Average$258 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$152 | Average$287 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$161 | Average$275 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$180 | Average$354 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$197 | Average$353 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$212 | Average$393 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$219 | Average$328 | FlexibilityNo cancel fee | On-time62% |