$238+ Cheap flights from Detroit Metropolitan Wayne County Airport to Florence, SC (DTW - FLO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/30. Fares are subject to change and may not be available on all flights or dates of travel.
DTW — FLO
Jul 10 — Jul 171
Round-trip
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Detroit to Florence
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Cheapest flights from Detroit to FlorenceExplore the most affordable flight options available from Detroit to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 10, 2026.
Explore the most affordable flight options available from Detroit to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 10, 2026.
This American Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/29:39 am
DTW
- FLO
2 stops13h 20m
American Airlines
Sun 9/69:00 am
FLO
- DTW
2 stops12h 38m
American Airlines
Deal found 6/9![American Airlines logo]()
$482
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/287:58 pm
DTW
- FLO
1 stop4h 17m
American Airlines
Mon 1/45:15 am
FLO
- DTW
1 stop5h 56m
American Airlines
Deal found 6/10![American Airlines logo]()
$555
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/167:58 pm
DTW
- FLO
1 stop3h 39m
American Airlines
Tue 7/212:35 pm
FLO
- DTW
1 stop4h 38m
American Airlines
Deal found 6/10![American Airlines logo]()
$557
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/216:45 am
DTW
- FLO
2 stops16h 52m
American Airlines
Sun 7/262:35 pm
FLO
- DTW
1 stop4h 43m
American Airlines
Deal found 6/10![American Airlines logo]()
$571
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/167:58 pm
DTW
- FLO
1 stop3h 39m
American Airlines
Sat 7/255:17 am
FLO
- DTW
1 stop4h 00m
American Airlines
Deal found 6/10![American Airlines logo]()
$578
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/216:45 am
DTW
- FLO
2 stops16h 52m
American Airlines
Sat 7/255:17 am
FLO
- DTW
1 stop4h 00m
American Airlines
Deal found 6/10![American Airlines logo]()
$592
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/186:49 am
DTW
- FLO
2 stops16h 48m
American Airlines
Tue 7/212:35 pm
FLO
- DTW
2 stops19h 30m
American Airlines
Deal found 6/10![American Airlines logo]()
$598
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/1610:38 am
DTW
- FLO
2 stops12h 59m
American Airlines
Thu 7/235:17 am
FLO
- DTW
1 stop4h 00m
American Airlines
Deal found 6/10![American Airlines logo]()
$600
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/2210:38 am
DTW
- FLO
2 stops12h 59m
American Airlines
Sat 7/255:17 am
FLO
- DTW
2 stops16h 27m
American Airlines
Deal found 6/10![American Airlines logo]()
$612
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/207:58 pm
DTW
- FLO
1 stop3h 39m
American Airlines
Sat 7/255:17 am
FLO
- DTW
1 stop4h 00m
American Airlines
Deal found 6/10![American Airlines logo]()
$619
Best flights from Detroit to FlorenceDiscover carefully curated flight deals from Detroit to Florence that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 10, 2026.
Discover carefully curated flight deals from Detroit to Florence that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 10, 2026.
This American Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/26:43 pm
DTW
- FLO
1 stop4h 16m
American Airlines
Sun 9/69:00 am
FLO
- DTW
1 stop3h 47m
American Airlines
Deal found 6/9![American Airlines logo]()
$528
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/1810:00 am
DTW
- FLO
1 stop4h 10m
American Airlines
Sat 7/255:17 am
FLO
- DTW
1 stop4h 00m
American Airlines
Deal found 6/10![American Airlines logo]()
$578
This American Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/510:00 am
DTW
- FLO
1 stop4h 10m
American Airlines
Sat 7/115:17 am
FLO
- DTW
1 stop4h 00m
American Airlines
Deal found 6/8![American Airlines logo]()
$598
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/1610:38 am
DTW
- FLO
2 stops12h 59m
American Airlines
Tue 7/212:35 pm
FLO
- DTW
1 stop4h 38m
American Airlines
Deal found 6/10![American Airlines logo]()
$600
This American Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/210:01 am
DTW
- FLO
1 stop4h 09m
American Airlines
Sun 7/55:17 am
FLO
- DTW
1 stop4h 00m
American Airlines
Deal found 6/9![American Airlines logo]()
$639
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/207:58 pm
DTW
- FLO
1 stop3h 39m
American Airlines
Sat 7/252:35 pm
FLO
- DTW
2 stops6h 55m
American Airlines
Deal found 6/10![American Airlines logo]()
$667
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/217:58 pm
DTW
- FLO
1 stop3h 39m
American Airlines
Fri 7/242:35 pm
FLO
- DTW
1 stop4h 43m
American Airlines
Deal found 6/10![American Airlines logo]()
$921
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/207:58 pm
DTW
- FLO
1 stop3h 39m
American Airlines
Thu 7/232:35 pm
FLO
- DTW
2 stops8h 09m
American Airlines
Deal found 6/10![American Airlines logo]()
$995
Last-minute flights from Detroit to FlorenceDiscover last-minute flight deals from Detroit to Florence. Data last updated June 10, 2026 and is based on user searches.
Discover last-minute flight deals from Detroit to Florence. Data last updated June 10, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/167:58 pm
DTW
- FLO
1 stop3h 39m
American Airlines
Tue 7/212:35 pm
FLO
- DTW
1 stop4h 38m
American Airlines
Deal found 6/10![American Airlines logo]()
$557
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/167:58 pm
DTW
- FLO
1 stop3h 39m
American Airlines
Sat 7/255:17 am
FLO
- DTW
1 stop4h 00m
American Airlines
Deal found 6/10![American Airlines logo]()
$578
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/1610:38 am
DTW
- FLO
2 stops12h 59m
American Airlines
Thu 7/235:17 am
FLO
- DTW
1 stop4h 00m
American Airlines
Deal found 6/10![American Airlines logo]()
$600
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/1610:38 am
DTW
- FLO
2 stops12h 59m
American Airlines
Wed 7/225:17 am
FLO
- DTW
2 stops17h 27m
American Airlines
Deal found 6/10![American Airlines logo]()
$620
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/175:32 pm
DTW
- FLO
2 stops20h 38m
American Airlines
Tue 7/212:35 pm
FLO
- DTW
2 stops19h 30m
American Airlines
Deal found 6/10![American Airlines logo]()
$633
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/186:49 am
DTW
- FLO
2 stops16h 48m
American Airlines
Tue 7/212:35 pm
FLO
- DTW
2 stops19h 30m
American Airlines
Deal found 6/10![American Airlines logo]()
$598
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/186:10 am
DTW
- FLO
2 stops8h 00m
American Airlines
Mon 7/205:17 am
FLO
- DTW
1 stop4h 00m
American Airlines
Deal found 6/10![American Airlines logo]()
$626
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/207:58 pm
DTW
- FLO
1 stop3h 39m
American Airlines
Sat 7/255:17 am
FLO
- DTW
1 stop4h 00m
American Airlines
Deal found 6/10![American Airlines logo]()
$619
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/216:45 am
DTW
- FLO
2 stops16h 52m
American Airlines
Sun 7/262:35 pm
FLO
- DTW
1 stop4h 43m
American Airlines
Deal found 6/10![American Airlines logo]()
$571
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/216:45 am
DTW
- FLO
2 stops16h 52m
American Airlines
Sat 7/255:17 am
FLO
- DTW
1 stop4h 00m
American Airlines
Deal found 6/10![American Airlines logo]()
$592
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/2210:38 am
DTW
- FLO
2 stops12h 59m
American Airlines
Sat 7/255:17 am
FLO
- DTW
2 stops16h 27m
American Airlines
Deal found 6/10![American Airlines logo]()
$612
One-way flights from Detroit to FlorenceSearch for one-way flight options from Detroit to Florence. Find affordable one-way fares based on user searches. Data last updated June 10, 2026.
Search for one-way flight options from Detroit to Florence. Find affordable one-way fares based on user searches. Data last updated June 10, 2026.
This American Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/3010:40 am
DTW
- FLO
2 stops11h 20m
American Airlines
Deal found 6/8![American Airlines logo]()
$238
This American Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/2010:01 am
DTW
- FLO
1 stop4h 09m
American Airlines
Deal found 6/7![American Airlines logo]()
$444
This American Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/286:45 am
DTW
- FLO
2 stops31h 25m
American Airlines
Deal found 6/7![American Airlines logo]()
$459
This American Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/271:02 pm
DTW
- FLO
2 stops25h 08m
American Airlines
Deal found 6/7![American Airlines logo]()
$469
This American Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/264:17 pm
DTW
- FLO
1 stop5h 43m
American Airlines
Deal found 6/8![American Airlines logo]()
$478
This American Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/226:00 am
DTW
- FLO
2 stops8h 10m
American Airlines
Deal found 6/7![American Airlines logo]()
$518
Find flight deals from Detroit to Florence
Discover tips and strategies to find the most affordable flight options for your journey from Detroit (DTW) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $482 (American Airlines) |
One-way from | $238 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Detroit to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 10, 2026.
Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to Florence that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
DetroitFlorence
DTW - FLO
DTWFLO
Detroit Metropolitan Wayne County
Wed 9/2
6:43 pm-10:59 pm
1 stop4h 16m
Florence
Sun 9/6
9:00 am-12:47 pm
1 stop3h 47m
$528
DetroitFlorence
DTW - FLO
DTWFLO
Detroit Metropolitan Wayne County
Sat 7/18
10:00 am-2:10 pm
1 stop4h 10m
Florence
Sat 7/25
5:17 am-9:17 am
1 stop4h 00m
$578
DetroitFlorence
DTW - FLO
DTWFLO
Detroit Metropolitan Wayne County
Sun 7/5
10:00 am-2:10 pm
1 stop4h 10m
Florence
Sat 7/11
5:17 am-9:17 am
1 stop4h 00m
$598
DetroitFlorence
DTW - FLO
DTWFLO
Detroit Metropolitan Wayne County
Thu 7/16
10:38 am-11:37 pm
2 stops12h 59m
Florence
Tue 7/21
2:35 pm-7:13 pm
1 stop4h 38m
$600
DetroitFlorence
DTW - FLO
DTWFLO
Detroit Metropolitan Wayne County
Thu 7/2
10:01 am-2:10 pm
1 stop4h 09m
Florence
Sun 7/5
5:17 am-9:17 am
1 stop4h 00m
$639
DetroitFlorence
DTW - FLO
DTWFLO
Detroit Metropolitan Wayne County
Mon 7/20
7:58 pm-11:37 pm
1 stop3h 39m
Florence
Sat 7/25
2:35 pm-9:30 pm
2 stops6h 55m
$667
DetroitFlorence
DTW - FLO
DTWFLO
Detroit Metropolitan Wayne County
Tue 7/21
7:58 pm-11:37 pm
1 stop3h 39m
Florence
Fri 7/24
2:35 pm-7:18 pm
1 stop4h 43m
$921
DetroitFlorence
DTW - FLO
DTWFLO
Detroit Metropolitan Wayne County
Mon 7/20
7:58 pm-11:37 pm
1 stop3h 39m
Florence
Thu 7/23
2:35 pm-10:44 pm
2 stops8h 09m
$995
Cheapest one-way
DetroitFlorence
DTW - FLO
DTWFLO
Detroit Metropolitan Wayne County
Tue 6/30
10:40 am-10:00 pm
2 stops11h 20m
$238
DetroitFlorence
DTW - FLO
DTWFLO
Detroit Metropolitan Wayne County
Sun 6/28
6:45 am-2:10 pm
2 stops31h 25m
$459
Showing 1-10 of 11 resultsSorted by cheapest first
Compare providers for flights from Detroit to Florence
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Detroit to Florence in June.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Detroit Metropolitan Wayne County Airport-Florence, South Carolina flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Detroit Metropolitan Wayne County Airport-Florence, South Carolina flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Detroit Metropolitan Wayne County Airport-Florence, South Carolina flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Detroit Metropolitan Wayne County Airport-Florence, South Carolina flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Detroit Metropolitan Wayne County Airport-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Detroit to Florence
Have a flexible travel schedule? Discover the best time to fly to Florence from Detroit with our price prediction graph.
DTW-FLO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Related info for your journey
Find useful and relevant information for your journey from Detroit to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Florence?
Book flights to Florence if you plan to visit one of these locationsSumter
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