South Carolina

$277+ Cheap flights from Missoula (MSO) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/21. Fares are subject to change and may not be available on all flights or dates of travel.
MSO — CHS
Apr 10 — Apr 171
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Cheap flight deals from Missoula to South Carolina

Cheapest flights from Missoula to South Carolina
Explore the most affordable flight options available from Missoula to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 11, 2026.

This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/61:08 pm
MSO
-
CLT
1 stop6h 47m
American Airlines
Sun 5/107:06 am
CLT
-
MSO
1 stop7h 32m
American Airlines
Deal found 3/9$369
This United Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/306:25 am
MSO
-
CLT
2 stops14h 43m
United Airlines
Sat 8/86:15 am
CLT
-
MSO
1 stop7h 17m
United Airlines
Deal found 3/7$390
This Delta deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/115:45 am
MSO
-
CLT
1 stop6h 21m
Delta
Tue 6/235:25 pm
CLT
-
MSO
1 stop8h 59m
Delta
Deal found 3/5$414
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/182:38 pm
MSO
-
CLT
1 stop6h 21m
United Airlines
Tue 4/218:06 am
CLT
-
MSO
1 stop7h 26m
United Airlines
Deal found 3/8$419
This Delta deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/115:45 am
MSO
-
CLT
1 stop6h 21m
Delta
Mon 6/225:25 pm
CLT
-
MSO
1 stop8h 59m
Delta
Deal found 3/5$445
This United Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/102:38 pm
MSO
-
CLT
1 stop6h 20m
United Airlines
Sun 4/194:17 pm
CLT
-
MSO
1 stop7h 13m
United Airlines
Deal found 3/6$448
This Delta deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/125:45 am
MSO
-
MYR
1 stop8h 44m
Delta
Wed 6/245:35 pm
MYR
-
MSO
1 stop8h 12m
Delta
Deal found 3/5$449
This Delta deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/125:45 am
MSO
-
CLT
1 stop6h 21m
Delta
Tue 6/233:00 pm
CLT
-
MSO
2 stops11h 24m
Delta
Deal found 3/5$450
This American Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/304:40 pm
MSO
-
CLT
1 stop11h 27m
American Airlines
Sat 8/84:24 pm
CLT
-
MSO
1 stop9h 04m
American Airlines
Deal found 3/7$469
This Delta deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/68:32 am
MSO
-
CLT
1 stop7h 37m
Delta
Sun 5/106:05 am
CLT
-
MSO
2 stops10h 35m
Delta
Deal found 3/9$474
This Delta deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/125:45 am
MSO
-
MYR
1 stop8h 44m
Delta
Tue 6/235:35 pm
MYR
-
MSO
1 stop8h 12m
Delta
Deal found 3/5$529
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/185:15 pm
MSO
-
MYR
2 stops19h 02m
United Airlines
Wed 4/2211:00 am
MYR
-
MSO
2 stops12h 30m
United Airlines
Deal found 3/8$553

Find flight deals from Missoula to South Carolina

Keep the following information in mind while searching for Missoula to South Carolina flight deals. Data was last updated March 11, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$369
(American Airlines)

One-way from

$277
(Kiwi.com)
Provider with most accurate pricing for Missoula Johnson-Bell Field-Myrtle Beach Intl flight deals.
Provider most trusted by Cheapflights users for Missoula Johnson-Bell Field-Myrtle Beach Intl flights.
From Missoula Johnson-Bell Field to South Carolina
One-way flight from Missoula Johnson-Bell Field to South Carolina

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missoula to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 11, 2026.
Use the filters below to find and compare flights from Missoula to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

MissoulaCharlotte

MSO - CLT

MSOCLT

Missoula Johnson-Bell Field

Fri 6/12

5:45 am-2:06 pm

1 stop6h 21m

Charlotte Douglas

Tue 6/23

5:25 pm-12:24 am

1 stop8h 59m

$414

MissoulaCharlotte

MSO - CLT

MSOCLT

Missoula Johnson-Bell Field

Thu 6/11

5:45 am-2:06 pm

1 stop6h 21m

Charlotte Douglas

Tue 6/23

5:25 pm-12:24 am

1 stop8h 59m

$414
Quickest round-trip

MissoulaCharlotte

MSO - CLT

MSOCLT

Missoula Johnson-Bell Field

Sat 4/18

2:38 pm-10:59 pm

1 stop6h 21m

Charlotte Douglas

Tue 4/21

8:06 am-1:32 pm

1 stop7h 26m

$419

MissoulaCharlotte

MSO - CLT

MSOCLT

Missoula Johnson-Bell Field

Thu 6/11

5:45 am-2:06 pm

1 stop6h 21m

Charlotte Douglas

Mon 6/22

5:25 pm-12:24 am

1 stop8h 59m

$445

MissoulaCharlotte

MSO - CLT

MSOCLT

Missoula Johnson-Bell Field

Wed 5/6

5:20 am-4:04 pm

1 stop8h 44m

Charlotte Douglas

Sun 5/10

6:05 am-2:40 pm

2 stops10h 35m

$474

MissoulaCharlotte

MSO - CLT

MSOCLT

Missoula Johnson-Bell Field

Wed 4/8

5:20 am-4:13 pm

1 stop8h 53m

Charlotte Douglas

Wed 4/15

5:15 pm-12:16 am

1 stop9h 01m

$480

MissoulaMyrtle Beach

MSO - MYR

MSOMYR

Missoula Johnson-Bell Field

Fri 6/12

5:45 am-4:29 pm

1 stop8h 44m

Myrtle Beach Intl

Mon 6/22

5:35 pm-11:47 pm

1 stop8h 12m

$529

MissoulaMyrtle Beach

MSO - MYR

MSOMYR

Missoula Johnson-Bell Field

Sat 4/18

5:15 pm-2:17 pm

2 stops19h 02m

Myrtle Beach Intl

Wed 4/22

11:00 am-9:30 pm

2 stops12h 30m

$553

MissoulaMyrtle Beach

MSO - MYR

MSOMYR

Missoula Johnson-Bell Field

Sat 6/13

3:27 pm-10:09 am

2 stops16h 42m

Myrtle Beach Intl

Mon 6/22

5:35 pm-11:47 pm

1 stop8h 12m

$666

MissoulaMyrtle Beach

MSO - MYR

MSOMYR

Missoula Johnson-Bell Field

Thu 6/11

5:45 am-4:29 pm

1 stop8h 44m

Myrtle Beach Intl

Tue 6/23

5:35 pm-11:47 pm

1 stop8h 12m

$670

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/8

Showing 1-10 of 18 resultsSorted by cheapest first
1
2

Best time to book a flight from Missoula to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Missoula with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missoula to South Carolina

What is the cheapest time of day to fly from MSO to SC?

Find hourly flight availability from Missoula to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 11, 2026.

When flying from Missoula to South Carolina, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 66% versus a flight in the morning.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated March 11, 2026.
See what other customers who have flown with United Airlines and American Airlines from Missoula to South Carolina have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Boarding

7.7

Crew

8.1

Comfort

7.3

Overall

7.4

Food

6.6

Entertainment

7.1

Reviews

1 / 20
10.0
Excellent

Dane,Jan 2026

TYS - IAD

It was a short flight, so no time for amenities. Just glad everything was quick and easy from boarding to arriving at my destination with my family

Boarding

7.7

Crew

8.1

Comfort

7.3

Overall

7.4

Food

6.6

Entertainment

7.1

Reviews

1 / 20
10.0
Excellent

Dane,Jan 2026

TYS - IAD

It was a short flight, so no time for amenities. Just glad everything was quick and easy from boarding to arriving at my destination with my family

Boarding

7.7

Crew

8.1

Comfort

7.3

Overall

7.4

Food

6.6

Entertainment

7.1

Reviews

1 / 20
10.0
Excellent

Dane,Jan 2026

TYS - IAD

It was a short flight, so no time for amenities. Just glad everything was quick and easy from boarding to arriving at my destination with my family

Related info for your journey

Find useful and relevant information for your journey from Missoula to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What airport do you fly from for flights from Missoula to South Carolina?

    Missoula Johnson-Bell Field (MSO), located 5.5 mi from the city center, is the airport you fly out of when you book flights from Missoula to South Carolina.

  • How long is the flight from Missoula to South Carolina?

    Airlines like Delta and United Airlines fly from Missoula to South Carolina in about 6h 21m. The time it takes to get you to your destination can typically vary by up to . Missoula and South Carolina are separated by a distance of 1887 mi.

  • Can I find deals for flights from Missoula to South Carolina that include hotel bookings?

    Yes. In addition to deals on Missoula to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missoula to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missoula to South Carolina.

  • Can I find deals for business class flights from Missoula to South Carolina?

    Yes. Cheapflights offers flight deals from Missoula to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top 2 airlines flying from Missoula to South Carolina

Discover the top 2 airlines that operate flights from Missoula to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 11, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$288Average$534FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$312Average$597FlexibilityNo cancel feeOn-time69%

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