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South Carolina

$599+ Cheap flights from Lyon (LYS) to South Carolina

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/27. Fares are subject to change and may not be available on all flights or dates of travel.
LYS — CHS
Mar 7 — Mar 141
Sat 3/7
Sat 3/14
1 adult, Economy
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Cheap flight deals from Lyon to South Carolina

Cheapest flights from Lyon to South Carolina
Explore the most affordable flight options available from Lyon to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 5, 2026.

This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/2712:25 pm
LYS
-
CLT
2 stops34h 07m
American Airlines
Tue 3/34:39 pm
CLT
-
LYS
2 stops16h 31m
American Airlines
Deal found 2/1$599
This Iberia deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Iberia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/127:10 pm
LYS
-
CLT
2 stops30h 59m
Iberia
Mon 2/164:40 pm
CLT
-
LYS
2 stops20h 00m
Iberia
Deal found 2/2$628
This British Airways deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure British Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2112:35 pm
LYS
-
CLT
1 stop12h 30m
British Airways
Fri 10/304:41 pm
CLT
-
LYS
2 stops15h 59m
British Airways
Deal found 2/2$666
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/276:10 am
LYS
-
GSP
2 stops22h 04m
American Airlines
Tue 3/312:06 pm
GSP
-
LYS
2 stops21h 04m
American Airlines
Deal found 2/1$684
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/56:10 am
LYS
-
CHS
2 stops22h 51m
American Airlines
Mon 3/96:45 pm
CHS
-
LYS
2 stops13h 30m
American Airlines
Deal found 2/1$685
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/277:10 pm
LYS
-
CAE
2 stops32h 11m
American Airlines
Tue 3/37:18 am
CAE
-
LYS
2 stops25h 52m
American Airlines
Deal found 2/1$695
This Expedia deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/106:10 am
LYS
-
CLT
1 stop16h 20m
Multiple Airlines
Wed 5/136:02 pm
CLT
-
LYS
2 stops16h 38m
Multiple Airlines
Deal found 2/3$738
This British Airways deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure British Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/187:00 pm
LYS
-
CHS
2 stops29h 22m
British Airways
Sun 2/222:42 pm
CHS
-
LYS
2 stops21h 28m
British Airways
Deal found 2/2$781
This British Airways deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure British Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/159:45 pm
LYS
-
CLT
1 stop24h 05m
British Airways
Sat 5/26:02 pm
CLT
-
LYS
2 stops14h 23m
British Airways
Deal found 2/2$797
This Flighttix deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flighttix is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/302:35 pm
LYS
-
CLT
2 stops15h 21m
Lufthansa
Sat 9/51:05 pm
CLT
-
LYS
2 stops17h 15m
Lufthansa
Deal found 2/2$800
This United Airlines deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/156:25 am
LYS
-
CLT
2 stops20h 50m
United Airlines
Sat 5/26:00 am
CLT
-
LYS
2 stops23h 40m
United Airlines
Deal found 2/4$804
This United Airlines deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/56:20 am
LYS
-
CHS
2 stops18h 40m
United Airlines
Mon 3/96:30 am
CHS
-
LYS
2 stops22h 35m
United Airlines
Deal found 2/4$840

Find flight deals from Lyon to South Carolina

Keep the following information in mind while searching for Lyon to South Carolina flight deals. Data was last updated February 5, 2026.

Round-trip from

$599
(American Airlines)
From Lyon-Saint Exupéry to South Carolina
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Lyon to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 5, 2026.
Use the filters below to find and compare flights from Lyon to South Carolina that are best for you.

Fly from

Lyon

Fly to

South Carolina

Route

Depart

Return

Price

LyonCharlotte

LYS - CLT

LYSCLT

Lyon-Saint Exupéry

Fri 2/27

6:10 am-9:36 pm

2 stops21h 26m

Charlotte Douglas

Tue 3/3

11:00 pm-2:10 pm

1 stop33h 10m

$599

LyonGreenville

LYS - GSP

LYSGSP

Lyon-Saint Exupéry

Fri 2/27

6:10 am-10:14 pm

2 stops22h 04m

Greenville

Tue 3/3

12:06 pm-3:10 pm

2 stops21h 04m

$684

LyonCharleston

LYS - CHS

LYSCHS

Lyon-Saint Exupéry

Thu 3/5

6:10 am-11:01 pm

2 stops22h 51m

Charleston

Mon 3/9

6:45 pm-1:15 pm

2 stops13h 30m

$685

LyonColumbia

LYS - CAE

LYSCAE

Lyon-Saint Exupéry

Fri 2/27

7:10 pm-9:21 pm

2 stops32h 11m

Columbia Metropolitan

Tue 3/3

7:18 am-3:10 pm

2 stops25h 52m

$695

LyonCharleston

LYS - CHS

LYSCHS

Lyon-Saint Exupéry

Wed 2/18

7:00 pm-6:22 pm

2 stops29h 22m

Charleston

Sun 2/22

2:42 pm-6:10 pm

2 stops21h 28m

$781

LyonCharlotte

LYS - CLT

LYSCLT

Lyon-Saint Exupéry

Wed 4/15

9:45 pm-3:50 pm

1 stop24h 05m

Charlotte Douglas

Sat 5/2

6:02 pm-2:25 pm

2 stops14h 23m

$797

LyonCharlotte

LYS - CLT

LYSCLT

Lyon-Saint Exupéry

Sat 5/30

2:35 pm-11:56 pm

2 stops15h 21m

Charlotte Douglas

Sat 9/5

1:05 pm-12:20 pm

2 stops17h 15m

$800

LyonCharlotte

LYS - CLT

LYSCLT

Lyon-Saint Exupéry

Tue 6/16

7:10 pm-3:55 pm

1 stop26h 45m

Charlotte Douglas

Tue 8/4

4:15 pm-12:50 pm

2 stops14h 35m

$802

LyonCharlotte

LYS - CLT

LYSCLT

Lyon-Saint Exupéry

Wed 4/15

6:25 am-9:15 pm

2 stops20h 50m

Charlotte Douglas

Sat 5/2

6:00 am-11:40 am

2 stops23h 40m

$804

LyonCharleston

LYS - CHS

LYSCHS

Lyon-Saint Exupéry

Thu 3/5

6:20 am-7:00 pm

2 stops18h 40m

Charleston

Mon 3/9

6:30 am-10:05 am

2 stops22h 35m

$840

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/1

Showing 1-10 of 23 results
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Best time to book a flight from Lyon to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Lyon with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Lyon to South Carolina
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Lyon to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Lyon to South Carolina?

    Lyon-Saint Exupéry (LYS) is the airport you will fly out of if you book a flight from Lyon to South Carolina. It is only a 12.5 mi journey to Lyon-Saint Exupéry (LYS) from Lyon’s city center.

  • How long is the flight from Lyon to South Carolina?

    For as low as $800, American Airlines can have you in South Carolina from Lyon in 15h 21m. Airlines will cover a distance of 4357 mi. This flight may include one or multiple stops.

  • What are the most popular routes from Lyon to South Carolina?

    The most popular flight routes from Lyon to South Carolina are Lyon-Saint Exupéry - Charlotte Douglas, Lyon-Saint Exupéry - Charleston and Lyon-Saint Exupéry - Greenville.

  • Can I find deals for flights from Lyon to South Carolina that include hotel bookings?

    Yes. In addition to deals on Lyon to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Lyon to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Lyon to South Carolina.

  • Can I find deals for business class flights from Lyon to South Carolina?

    Yes. Cheapflights offers flight deals from Lyon to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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