What are the cheapest airlines flying from Santiago to Santo Domingo round-trip?

Flying on Copa Airlines is currently your cheapest option to Santo Domingo, with prices starting at $379. Another option worth looking into is Avianca, starting at $502 round trip. Copa Airlines is 32% cheaper than the average price of flights available within the next 90 days to this destination.

What is the cheapest day to fly from Santiago to Santo Domingo?

Travelers seeking maximum savings on their Santiago to Santo Domingo flight should consider departing on Sunday mornings when fares are most often at their lowest. Friday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in Santo Domingo ranges from 1.6 - 6.7 inches per month. May is typically the wettest month, when rainfall can reach 6.7 in. February is typically the driest time to visit Santo Domingo when rainfall is around 1.6 in.

If weather is an important factor for your trip to Santo Domingo, use this chart to help with planning. For those seeking warmer temperatures, June is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 75.2 F).

What are the cheapest flights from Santiago to Santo Domingo?

The cheapest flight price from Santiago to Santo Domingo is $220. On average you can expect to pay $261. The most popular route, (Santiago Arturo Merino Benitez - Santo Domingo Las Americas), can usually be booked for $536.

How far in advance should I book a flight from Santiago to Santo Domingo?

Travelers have found it’s best to book a flight 13 days in advance to save up to 8% compared to booking the same week of travel. As your travel date approaches, the cost of this flight route may potentially increase. While opting to book 13 days out may not be an option for all, there are still additional ways to secure a deal in the near future. You might find a flight from Santiago to Santo Domingo 1-2 weeks in advance for as low as $509, or $618 for flights within the next 24 hours.

What is the cheapest month to fly from Santiago to Santo Domingo?

October is one of the best times of the year to fly to Santo Domingo from Santiago. Prices for October average $564 per person but you can even find prices for as low as $241. The most expensive prices can be found in the month of January. Opting for a October flight can save you 17% on your journey compared to booking in January

What is the cheapest time of day to fly from SCL to SDQ?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Santiago to Santo Domingo as you normally would.

Can I find deals for flights from Santiago to Santo Domingo that include hotel bookings?

Yes. In addition to deals on Santiago to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Santiago to Santo Domingo?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santiago to Santo Domingo.

Can I find deals for business class flights from Santiago to Santo Domingo?

Yes. Cheapflights offers flight deals from Santiago to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$225+ Cheap Flights from Santiago to Santo Domingo

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Cheap flight deals from Santiago to Santo Domingo

Round-trip from	$533 (Priceline)
One-way from	$225 (Kiwi.com)
Popular in	January
Cheapest in	October
Average price	$532
Good one-way deal	$261 or less

From Santiago Arturo Merino Benitez to Santo Domingo Las Americas

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One-way flight from Santiago Arturo Merino Benitez to Santo Domingo Las Americas

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Highest demand for flights based on searches. 11% potential increase in price ($70 potential increase over avg. RT price).

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Cheapest flight prices on average. 1% potential price decrease ($9 potential savings vs. average RT price).

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Average for round-trip flights in August 2025

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Price to beat on a one-way flight from Santiago Arturo Merino Benitez to Santo Domingo Las Americas.

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Find flight deals from Santiago to Santo Domingo

Cheapest flights from Santiago to Santo Domingo
Explore the most affordable flight options available from Santiago to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.

Sat 9/2712:55 amSCL - SDQ

1 stop17h 20mAvianca

Sun 10/56:10 pmSDQ - SCL

1 stop10h 05mAvianca

Deal found 8/14

$533

Wed 9/2412:55 amSCL - SDQ

1 stop17h 20mAvianca

Sat 10/411:45 amSDQ - SCL

1 stop16h 30mAvianca

Deal found 8/13

$534

Wed 9/175:11 amSCL - SDQ

1 stop12h 06mCopa Airlines

Thu 9/252:09 pmSDQ - SCL

1 stop14h 49mCopa Airlines

Deal found 8/14

$536

Sun 10/263:35 amSCL - SDQ

1 stop10h 37mCopa Airlines

Sun 11/28:55 amSDQ - SCL

1 stop17h 48mCopa Airlines

Deal found 8/14

$537

Thu 11/205:12 amSCL - SDQ

1 stop18h 13mCopa Airlines

Fri 11/288:55 amSDQ - SCL

1 stop17h 29mCopa Airlines

Deal found 8/12

$539

Wed 8/2012:24 amSCL - SDQ

1 stop17h 48mCopa Airlines

Sat 8/307:07 pmSDQ - SCL

1 stop9h 55mCopa Airlines

Deal found 8/13

$556

Mon 10/64:35 amSCL - SDQ

1 stop12h 35mMultiple Airlines

Tue 10/217:40 amSDQ - SCL

3 stops21h 20mMultiple Airlines

Deal found 8/13

$590

Sat 9/2712:55 amSCL - SDQ

1 stop17h 20mMultiple Airlines

Sun 10/51:55 pmSDQ - SCL

2 stops21h 05mMultiple Airlines

Deal found 8/14

$593

Thu 9/113:26 amSCL - SDQ

1 stop13h 51mCopa Airlines

Fri 9/198:59 amSDQ - SCL

1 stop10h 21mCopa Airlines

Deal found 8/13

$600

Fri 10/2412:29 pmSCL - SDQ

1 stop10h 56mCopa Airlines

Wed 11/52:15 pmSDQ - SCL

1 stop12h 28mCopa Airlines

Deal found 8/14

$601

Best flights from Santiago to Santo Domingo
Discover carefully curated flight deals from Santiago to Santo Domingo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 14, 2025.

Sat 9/277:10 amSCL - SDQ

1 stop11h 05mAvianca

Sat 10/46:10 pmSDQ - SCL

1 stop10h 05mAvianca

Deal found 8/12

$533

Tue 9/212:13 amSCL - SDQ

1 stop12h 56mCopa Airlines

Mon 9/82:09 pmSDQ - SCL

1 stop12h 33mCopa Airlines

Deal found 8/13

$536

Sun 9/283:30 pmSCL - SDQ

1 stop20h 20mAvianca

Sun 10/56:10 pmSDQ - SCL

1 stop19h 15mAvianca

Deal found 8/14

$533

Thu 9/185:11 amSCL - SDQ

1 stop12h 06mCopa Airlines

Tue 9/2311:56 amSDQ - SCL

1 stop10h 44mCopa Airlines

Deal found 8/12

$536

Sun 9/77:10 amSCL - SDQ

1 stop11h 05mAvianca

Mon 9/811:45 amSDQ - SCL

1 stop16h 30mAvianca

Deal found 8/13

$533

Wed 9/171:13 amSCL - SDQ

1 stop10h 45mCopa Airlines

Mon 9/2911:56 amSDQ - SCL

1 stop14h 46mCopa Airlines

Deal found 8/13

$536

Sun 10/512:55 amSCL - SDQ

1 stop10h 55mAvianca

Tue 10/2111:45 amSDQ - SCL

1 stop10h 45mAvianca

Deal found 8/13

$533

Thu 9/257:10 amSCL - SDQ

1 stop11h 05mAvianca

Sat 10/411:45 amSDQ - SCL

1 stop16h 30mAvianca

Deal found 8/13

$534

Last-minute flights from Santiago to Santo Domingo
Discover last-minute flight deals from Santiago to Santo Domingo. Data last updated August 14, 2025 and is based on user searches.

Wed 8/2011:55 pmSCL - SDQ

1 stop17h 20mAvianca

Wed 8/276:10 pmSDQ - SCL

1 stop10h 05mAvianca

Deal found 8/13

$533

Wed 8/202:26 amSCL - SDQ

1 stop15h 46mCopa Airlines

Sat 8/307:07 pmSDQ - SCL

1 stop9h 55mCopa Airlines

Deal found 8/13

$556

Wed 8/204:11 amSCL - SDQ

2 stops21h 44mMultiple Airlines

Wed 8/276:10 pmSDQ - SCL

1 stop10h 05mMultiple Airlines

Deal found 8/13

$686

Thu 8/214:11 amSCL - SDQ

1 stop18h 15mCopa Airlines

Mon 8/258:57 amSDQ - SCL

1 stop13h 47mCopa Airlines

Deal found 8/14

$536

Thu 8/2112:24 amSCL - SDQ

1 stop10h 34mCopa Airlines

Fri 8/2911:54 amSDQ - SCL

1 stop10h 50mCopa Airlines

Deal found 8/13

$664

Fri 8/292:26 amSCL - SDQ

1 stop15h 46mCopa Airlines

Mon 3/98:48 amSDQ - SCL

1 stop17h 56mCopa Airlines

Deal found 8/13

$624

Sun 8/312:26 amSCL - SDQ

1 stop20h 00mCopa Airlines

Sun 9/75:25 amSDQ - SCL

1 stop17h 15mCopa Airlines

Deal found 8/14

$623

Sun 9/79:15 pmSCL - SDQ

1 stop13h 00mMultiple Airlines

Mon 9/86:40 pmSDQ - SCL

3 stops33h 21mMultiple Airlines

Deal found 8/13

$625

Thu 9/113:26 amSCL - SDQ

1 stop13h 51mCopa Airlines

Fri 9/198:59 amSDQ - SCL

1 stop10h 21mCopa Airlines

Deal found 8/13

$600

Sun 9/141:13 amSCL - SDQ

1 stop16h 04mCopa Airlines

Wed 10/158:58 amSDQ - SCL

1 stop20h 02mCopa Airlines

Deal found 8/13

$643

Wed 9/175:11 amSCL - SDQ

1 stop12h 06mCopa Airlines

Thu 9/252:09 pmSDQ - SCL

1 stop14h 49mCopa Airlines

Deal found 8/14

$536

Wed 9/2412:55 amSCL - SDQ

1 stop17h 20mAvianca

Sat 10/411:45 amSDQ - SCL

1 stop16h 30mAvianca

Deal found 8/13

$534

One-way flights from Santiago to Santo Domingo
Search for one-way flight options from Santiago to Santo Domingo. Find affordable one-way fares based on user searches. Data last updated August 14, 2025.

Tue 9/95:55 amSCL - SDQ

1 stop28h 20mMultiple Airlines

Deal found 8/12

$225

Wed 10/224:35 amSCL - SDQ

1 stop11h 50mMultiple Airlines

Deal found 8/13

$248

Sat 8/236:10 amSCL - SDQ

1 stop11h 05mAvianca

Deal found 8/14

$274

Sun 8/313:35 amSCL - SDQ

1 stop12h 35mMultiple Airlines

Deal found 8/14

$302

Thu 9/42:26 amSCL - SDQ

1 stop20h 00mCopa Airlines

Deal found 8/14

$340

Tue 12/235:44 amSCL - SDQ

1 stop11h 31mCopa Airlines

Deal found 8/14

$361

Sat 8/239:40 pmSCL - SDQ

2 stops22h 35mMultiple Airlines

Deal found 8/14

$370

Tue 12/305:44 amSCL - SDQ

1 stop18h 12mCopa Airlines

Deal found 8/14

$384

Cheapflights Fare Finder

Use the filters below to find and compare flights from Santiago to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

SantiagoSanto Domingo

SCL - SDQ

SCLSDQ

Santiago Arturo Merino Benitez

Sat 9/27

7:10 am-5:15 pm

1 stop11h 05m

Santo Domingo Las Americas

Sat 10/4

6:10 pm-5:15 am

1 stop10h 05m

$533

SantiagoSanto Domingo

SCL - SDQ

SCLSDQ

Santiago Arturo Merino Benitez

Sun 9/28

3:30 pm-10:50 am

1 stop20h 20m

Santo Domingo Las Americas

Sun 10/5

6:10 pm-2:25 pm

1 stop19h 15m

$533

SantiagoSanto Domingo

SCL - SDQ

SCLSDQ

Santiago Arturo Merino Benitez

Sun 9/7

7:10 am-5:15 pm

1 stop11h 05m

Santo Domingo Las Americas

Mon 9/8

11:45 am-5:15 am

1 stop16h 30m

$533

SantiagoSanto Domingo

SCL - SDQ

SCLSDQ

Santiago Arturo Merino Benitez

Sun 10/5

12:55 am-10:50 am

1 stop10h 55m

Santo Domingo Las Americas

Tue 10/21

11:45 am-11:30 pm

1 stop10h 45m

$533

SantiagoSanto Domingo

SCL - SDQ

SCLSDQ

Santiago Arturo Merino Benitez

Thu 9/25

7:10 am-5:15 pm

1 stop11h 05m

Santo Domingo Las Americas

Sat 10/4

11:45 am-5:15 am

1 stop16h 30m

$534

SantiagoSanto Domingo

SCL - SDQ

SCLSDQ

Santiago Arturo Merino Benitez

Tue 9/2

12:13 am-1:09 pm

1 stop12h 56m

Santo Domingo Las Americas

Mon 9/8

2:09 pm-3:42 am

1 stop12h 33m

$536

SantiagoSanto Domingo

SCL - SDQ

SCLSDQ

Santiago Arturo Merino Benitez

Thu 9/18

5:11 am-4:17 pm

1 stop12h 06m

Santo Domingo Las Americas

Tue 9/23

11:56 am-11:40 pm

1 stop10h 44m

$536

SantiagoSanto Domingo

SCL - SDQ

SCLSDQ

Santiago Arturo Merino Benitez

Wed 9/17

1:13 am-10:58 am

1 stop10h 45m

Santo Domingo Las Americas

Mon 9/29

11:56 am-3:42 am

1 stop14h 46m

$536

SantiagoSanto Domingo

SCL - SDQ

SCLSDQ

Santiago Arturo Merino Benitez

Tue 9/9

5:55 am-9:15 am

1 stop28h 20m

$225

SantiagoSanto Domingo

SCL - SDQ

SCLSDQ

Santiago Arturo Merino Benitez

Wed 10/22

4:35 am-3:25 pm

1 stop11h 50m

$248

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/12

Showing 1-10 of 15 results

Best time to book a flight from Santiago to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Santiago with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santiago to Santo Domingo

How far ahead should I book a flight from Santiago to Santo Domingo?

Booking 12 days in advance of your planned departure date is, on average, the best time to get cheap flights from Santiago to Santo Domingo. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Santiago to Santo Domingo?

Currently, January is the cheapest month in which you can book a flight from Santiago to Santo Domingo (average of $362). Flying from Santiago to Santo Domingo in December is currently the most expensive (average of $583). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Santo Domingo

Peruse reviews from past customers who have flown with Copa Airlines and Avianca from Santiago to Santo Domingo to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Copa Airlines

7.5

Good

1,509 reviews

Reviews

1 / 20

4.0

Okay

Paul,Jun 2025

PTY - MIA

The boarding process was terrible. No one followed the group numbers. Everyone got up and stood in the tiles upon landing. People kept getting up during the meal and beverage service to go the bathrooms, the crew had to go back and forth in the isles, the service took forever.

Copa Airlines

7.5

Good

1,509 reviews

Copa Airlines

7.5

Good

1,509 reviews

Reviews

1 / 20

4.0

Okay

Paul,Jun 2025

PTY - MIA

Avianca

6.7

Okay

2,401 reviews

Copa Airlines

7.5

Good

1,509 reviews

Reviews

1 / 20

4.0

Okay

Paul,Jun 2025

PTY - MIA

Related info for your journey

What are the cheapest airlines flying from Santiago to Santo Domingo round-trip?
Flying on Copa Airlines is currently your cheapest option to Santo Domingo, with prices starting at $379. Another option worth looking into is Avianca, starting at $502 round trip. Copa Airlines is 32% cheaper than the average price of flights available within the next 90 days to this destination.
What are the cheapest flights from Santiago to Santo Domingo?
The cheapest flight price from Santiago to Santo Domingo is $220. On average you can expect to pay $261. The most popular route, (Santiago Arturo Merino Benitez - Santo Domingo Las Americas), can usually be booked for $536.
Can I find deals for flights from Santiago to Santo Domingo that include hotel bookings?
Yes. In addition to deals on Santiago to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Santiago to Santo Domingo?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santiago to Santo Domingo.
Can I find deals for business class flights from Santiago to Santo Domingo?
Yes. Cheapflights offers flight deals from Santiago to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Santiago to Santo Domingo?
Currently, January is the cheapest month in which you can book a flight from Santiago to Santo Domingo (average of $362). Flying from Santiago to Santo Domingo in December is currently the most expensive (average of $583). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Juan Dolio

Browse thousands of different options on Cheapflights for your next trip

Top 2 airlines flying from Santiago to Santo Domingo

Airline	Cheapest	Average	Flexibility	On-time
Copa Airlines	Cheapest$379	Average$615	FlexibilityNo cancel fee	On-time70%
Avianca	Cheapest$502	Average$513	FlexibilityNo cancel fee	On-time71%

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$225+ Cheap flights from Santiago (SCL) to Santo Domingo (SDQ)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/9. Fares are subject to change and may not be available on all flights or dates of travel.

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Cheap flight deals from Santiago to Santo Domingo

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Find flight deals from Santiago to Santo Domingo

Cheapest flights from Santiago to Santo DomingoExplore the most affordable flight options available from Santiago to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.

Explore the most affordable flight options available from Santiago to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Santiago to Santo Domingo that are best for you.

Best time to book a flight from Santiago to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Santiago with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Santiago to Santo Domingo

How far ahead should I book a flight from Santiago to Santo Domingo?

Use this chart to determine the optimal time to book a round-trip flight from Santiago to Santo Domingo. Price data was last updated on August 8, 2025.

What is the cheapest month to book a flight from Santiago to Santo Domingo?

Reviews of airlines servicing Santo Domingo

Peruse reviews from past customers who have flown with Copa Airlines and Avianca from Santiago to Santo Domingo to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Santiago to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Santiago to Santo Domingo round-trip?

What are the cheapest flights from Santiago to Santo Domingo?

Can I find deals for flights from Santiago to Santo Domingo that include hotel bookings?

How can I find direct flights from Santiago to Santo Domingo?

Can I find deals for business class flights from Santiago to Santo Domingo?

What is the cheapest month to book a flight from Santiago to Santo Domingo?

Traveling to a place near Santo Domingo?

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Alternative routes for Santiago to Santo Domingo

See prices for flight routes from nearby airports that may be better suited for you.

Top 2 airlines flying from Santiago to Santo Domingo

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Cheapest flights from Santiago to Santo Domingo
Explore the most affordable flight options available from Santiago to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.