$346+ Cheap flights from Detroit (DTT) to Santiago de los Caballeros (STI)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/7. Fares are subject to change and may not be available on all flights or dates of travel.
DTT — STI
Oct 29 — Nov 51
Round-trip
1 adult, Economy
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Find cheap flights from Detroit to Santiago de los Caballeros with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Detroit to Santiago de los Caballeros
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Cheapest flights from Detroit to Santiago de los CaballerosExplore the most affordable flight options available from Detroit to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 29, 2026.
Explore the most affordable flight options available from Detroit to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 29, 2026.
This Cheapflightsfares deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/136:10 am -
1 stop7h 45m
Fri 11/205:01 am -
1 stop11h 18m
Deal found 9/28![JetBlue logo]()
$731
This American Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/106:10 am -
1 stop8h 06m
Tue 11/174:16 pm -
1 stop8h 00m
Deal found 9/26![American Airlines logo]()
$750
This Cheapflightsfares deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/226:00 am -
1 stop8h 47m
Tue 10/276:01 am -
1 stop12h 07m
Deal found 9/28![JetBlue logo]()
$767
This American Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/137:42 pm -
2 stops16h 44m
Fri 11/202:22 pm -
2 stops11h 15m
Deal found 9/28![American Airlines logo]()
$780
This JetBlue deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/146:10 am -
1 stop7h 45m
Wed 11/184:20 pm -
1 stop8h 36m
Deal found 9/27![JetBlue logo]()
$812
This Cheapflightsfares deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/196:00 am -
1 stop7h 50m
Fri 10/238:15 am -
1 stop7h 08m
Deal found 9/27![JetBlue logo]()
$830
This American Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/227:55 pm -
2 stops18h 17m
Tue 10/273:12 pm -
1 stop7h 47m
Deal found 9/28![American Airlines logo]()
$847
This American Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/306:00 am -
2 stops15h 02m
Wed 1/67:20 am -
2 stops16h 47m
Deal found 9/28![American Airlines logo]()
$870
This American Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:00 am -
1 stop8h 12m
Sun 10/253:12 pm -
1 stop7h 47m
Deal found 9/28![American Airlines logo]()
$875
This American Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/216:33 pm -
1 stop20h 42m
Sun 1/172:12 pm -
1 stop10h 31m
Deal found 9/24![American Airlines logo]()
$893
Best flights from Detroit to Santiago de los CaballerosDiscover carefully curated flight deals from Detroit to Santiago de los Caballeros that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 29, 2026.
Discover carefully curated flight deals from Detroit to Santiago de los Caballeros that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 29, 2026.
This American Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/157:54 pm -
2 stops16h 36m
Fri 3/197:00 am -
2 stops15h 37m
Deal found 9/27![American Airlines logo]()
$727
This Cheapflightsfares deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/136:10 am -
1 stop7h 45m
Fri 11/205:01 am -
1 stop11h 18m
Deal found 9/28![JetBlue logo]()
$731
This American Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:10 am -
1 stop8h 06m
Thu 11/195:08 pm -
1 stop7h 51m
Deal found 9/28![American Airlines logo]()
$750
This JetBlue deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/146:10 am -
1 stop7h 45m
Wed 11/184:20 pm -
1 stop8h 36m
Deal found 9/26![JetBlue logo]()
$812
This American Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/104:46 pm -
2 stops22h 22m
Tue 11/175:08 pm -
2 stops19h 38m
Deal found 9/26![American Airlines logo]()
$755
This American Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/137:42 pm -
2 stops16h 44m
Fri 11/202:22 pm -
2 stops11h 15m
Deal found 9/28![American Airlines logo]()
$780
This American Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/216:33 pm -
1 stop20h 42m
Sun 1/172:12 pm -
1 stop10h 31m
Deal found 9/24![American Airlines logo]()
$893
This American Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/306:00 am -
1 stop15h 02m
Wed 1/67:20 am -
2 stops16h 47m
Deal found 9/27![American Airlines logo]()
$899
Last-minute flights from Detroit to Santiago de los CaballerosDiscover last-minute flight deals from Detroit to Santiago de los Caballeros. Data last updated September 29, 2026 and is based on user searches.
Discover last-minute flight deals from Detroit to Santiago de los Caballeros. Data last updated September 29, 2026 and is based on user searches.
This Cheapflightsfares deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/196:00 am -
1 stop7h 50m
Fri 10/238:15 am -
1 stop7h 08m
Deal found 9/27![JetBlue logo]()
$830
This American Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/198:54 pm -
2 stops17h 18m
Fri 10/233:12 pm -
2 stops17h 49m
Deal found 9/27![American Airlines logo]()
$935
This American Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:00 am -
1 stop8h 12m
Sun 10/253:12 pm -
1 stop7h 47m
Deal found 9/28![American Airlines logo]()
$875
This Cheapflightsfares deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/226:00 am -
1 stop8h 47m
Tue 10/276:01 am -
1 stop12h 07m
Deal found 9/28![JetBlue logo]()
$767
This American Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/227:55 pm -
2 stops18h 17m
Tue 10/273:12 pm -
1 stop7h 47m
Deal found 9/28![American Airlines logo]()
$847
One-way flights from Detroit to Santiago de los CaballerosSearch for one-way flight options from Detroit to Santiago de los Caballeros. Find affordable one-way fares based on user searches. Data last updated September 29, 2026.
Search for one-way flight options from Detroit to Santiago de los Caballeros. Find affordable one-way fares based on user searches. Data last updated September 29, 2026.
This Expedia deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/76:00 am -
1 stop8h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/24![JetBlue logo]()
$346
This Cheapflightsfares deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/54:20 pm -
1 stop7h 37m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/24![JetBlue logo]()
$347
This American Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/76:25 pm -
2 stops20h 43m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/24![American Airlines logo]()
$370
This Cheapflightsfares deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:10 am -
1 stop7h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/24![JetBlue logo]()
$372
This American Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/56:25 pm -
2 stops18h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/24![American Airlines logo]()
$387
This Cheapflightsfares deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1012:10 pm -
1 stop10h 44m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/24![JetBlue logo]()
$395
This Kiwi.com deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:46 pm -
3 stops20h 12m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/28![Multiple Airlines logo]()
$446
This United Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1010:48 am -
2 stops12h 03m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/24![United Airlines logo]()
$468
This American Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:00 am -
1 stop8h 12m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/28![American Airlines logo]()
$498
This Cheapflightsfares deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:00 am -
1 stop8h 47m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/25![JetBlue logo]()
$502
This American Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:10 am -
2 stops8h 02m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/25![American Airlines logo]()
$503
This United Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/146:00 am -
1 stop16h 51m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/26![United Airlines logo]()
$533
Find flight deals from Detroit to Santiago de los Caballeros
Discover tips and strategies to find the most affordable flight options for your journey from Detroit (DTT) to Santiago de los Caballeros (STI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 29, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $727 (American Airlines) |
One-way from | $346 (Expedia) |
Cheapflights Fare Finder
Customize your flight search to find flights from Detroit to Santiago de los Caballeros that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 29, 2026.
Use the filters below to find and compare flights from Detroit to Santiago de los Caballeros that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
DetroitSantiago de los Caballeros
DTW Detroit Metropolitan Wayne County - STI Santiago de los Caballeros
DTWSTI
Detroit Metropolitan Wayne County
Sat 12/5
4:20 pm-12:57 am
1 stop7h 37m
Santiago de los Caballeros
Wed 12/31
12:00 am-11:30 pm
Nonstop0h 00m
$347
DetroitSantiago de los Caballeros
DTW Detroit Metropolitan Wayne County - STI Santiago de los Caballeros
DTWSTI
Detroit Metropolitan Wayne County
Mon 12/7
6:25 pm-4:08 pm
2 stops20h 43m
Santiago de los Caballeros
Wed 12/31
12:00 am-11:30 pm
Nonstop0h 00m
$370
DetroitSantiago de los Caballeros
DTW Detroit Metropolitan Wayne County - STI Santiago de los Caballeros
DTWSTI
Detroit Metropolitan Wayne County
Wed 10/14
6:46 pm-2:58 pm
3 stops20h 12m
Santiago de los Caballeros
Wed 12/31
12:00 am-11:30 pm
Nonstop0h 00m
$446
DetroitSantiago de los Caballeros
DTW Detroit Metropolitan Wayne County - STI Santiago de los Caballeros
DTWSTI
Detroit Metropolitan Wayne County
Wed 11/11
7:26 am-11:51 pm
2 stops15h 25m
Santiago de los Caballeros
Wed 12/31
12:00 am-11:30 pm
Nonstop0h 00m
$468
DetroitSantiago de los Caballeros
DTW Detroit Metropolitan Wayne County - STI Santiago de los Caballeros
DTWSTI
Detroit Metropolitan Wayne County
Tue 11/10
10:48 am-11:51 pm
2 stops12h 03m
Santiago de los Caballeros
Wed 12/31
12:00 am-11:30 pm
Nonstop0h 00m
$468
DetroitSantiago de los Caballeros
DTW Detroit Metropolitan Wayne County - STI Santiago de los Caballeros
DTWSTI
Detroit Metropolitan Wayne County
Wed 10/14
6:00 am-2:12 pm
1 stop8h 12m
Santiago de los Caballeros
Wed 12/31
12:00 am-11:30 pm
Nonstop0h 00m
$498
DetroitSantiago de los Caballeros
DTW Detroit Metropolitan Wayne County - STI Santiago de los Caballeros
DTWSTI
Detroit Metropolitan Wayne County
Tue 10/13
6:00 am-2:47 pm
1 stop8h 47m
Santiago de los Caballeros
Wed 12/31
12:00 am-11:30 pm
Nonstop0h 00m
$502
DetroitSantiago de los Caballeros
DTW Detroit Metropolitan Wayne County - STI Santiago de los Caballeros
DTWSTI
Detroit Metropolitan Wayne County
Tue 10/13
6:10 am-2:12 pm
2 stops8h 02m
Santiago de los Caballeros
Wed 12/31
12:00 am-11:30 pm
Nonstop0h 00m
$503
DetroitSantiago de los Caballeros
DTW Detroit Metropolitan Wayne County - STI Santiago de los Caballeros
DTWSTI
Detroit Metropolitan Wayne County
Mon 12/14
8:41 am-11:51 pm
2 stops14h 10m
Santiago de los Caballeros
Wed 12/31
12:00 am-11:30 pm
Nonstop0h 00m
$578
DetroitSantiago de los Caballeros
DTW Detroit Metropolitan Wayne County - STI Santiago de los Caballeros
DTWSTI
Detroit Metropolitan Wayne County
Tue 11/10
3:02 pm-12:55 pm
3 stops44h 53m
Santiago de los Caballeros
Wed 12/31
12:00 am-11:30 pm
Nonstop0h 00m
$599
Showing 1-10 of 20 resultsSorted by cheapest first
Compare providers for flights from Detroit to Santiago de los Caballeros
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Detroit to Santiago de los Caballeros in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Detroit-Santiago de los Caballeros flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Detroit-Santiago de los Caballeros flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Detroit-Santiago de los Caballeros flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Detroit-Santiago de los Caballeros flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Detroit-Santiago de los Caballeros flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Detroit to Santiago de los Caballeros
Have a flexible travel schedule? Discover the best time to fly to Santiago de los Caballeros from Detroit with our price prediction graph.
DTT-STI
DTW-STI
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Detroit to Santiago de los Caballeros
DTT-STI
DTW-STI
No data available for this route at this time. Please check back soon.
Related info for your journey
Find useful and relevant information for your journey from Detroit to Santiago de los Caballeros. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Santiago de los Caballeros flight routes
Alternative routes for Detroit to Santiago de los Caballeros
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Complete your trip
Complete your trip to Santiago de los Caballeros by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Detroit to Santiago de los Caballeros by cabin class
Find flights from Detroit to Santiago de los Caballeros, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Detroit and Santiago de los Caballeros flights
Browse other Detroit and Santiago de los Caballeros flight options. Last updated on September 29, 2026.
Other flights from Detroit
Browse through other flights departing from Detroit. Flights are based on user searches made on Cheapflights and were last updated on September 29, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago de los Caballeros
Explore flights to Santiago de los Caballeros departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 29, 2026.
Top airline flying from Detroit to Santiago de los Caballeros
Discover the top airline that operate flights from Detroit to Santiago de los Caballeros. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 29, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$446 | Average$669 | FlexibilityNo cancel fee | On-time62% |