HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Santiago

$593+ Cheap flights from Santa Fe (SAF) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/2. Fares are subject to change and may not be available on all flights or dates of travel.
SAF — SCL
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Santa Fe to Santiago with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Santa Fe to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Santa Fe (SAF) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$828
(United Airlines)

One-way from

$593
(American Airlines)
From Santa Fe to Santiago Arturo Merino Benitez
Search Deals
One-way flight from Santa Fe to Santiago Arturo Merino Benitez
Search Deals

Find flight deals from Santa Fe to Santiago

Cheapest flights from Santa Fe to Santiago
Explore the most affordable flight options available from Santa Fe to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/61:20 pmSAF - SCL
2 stops15h 30mUnited Airlines
Wed 12/1010:45 pmSCL - SAF
2 stops17h 52mUnited Airlines
Deal found 9/10$828
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/69:58 amSAF - SCL
1 stop17h 52mAmerican Airlines
Wed 12/1011:15 pmSCL - SAF
1 stop17h 31mAmerican Airlines
Deal found 9/10$979

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santa Fe to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Santa Fe to Santiago that are best for you.

Fly from

Santa Fe

Fly to

Santiago

Route

Depart

Return

Price

Santa FeSantiago

SAF - SCL

SAFSCL

Santa Fe

Sat 12/6

7:00 am-8:50 am

2 stops21h 50m

Santiago Arturo Merino Benitez

Wed 12/10

10:45 pm-2:39 pm

2 stops19h 54m

$828

Santa FeSantiago

SAF - SCL

SAFSCL

Santa Fe

Sat 1/31

6:05 pm-8:50 am

2 stops58h 45m

Santiago Arturo Merino Benitez

Sat 2/14

10:45 pm-9:32 am

2 stops38h 47m

$880

Santa FeSantiago

SAF - SCL

SAFSCL

Santa Fe

Sat 1/31

8:11 am-9:05 am

2 stops20h 54m

Santiago Arturo Merino Benitez

Sat 2/14

11:15 pm-9:26 am

1 stop14h 11m

$884

Santa FeSantiago

SAF - SCL

SAFSCL

Santa Fe

Sat 12/6

9:58 am-7:50 am

1 stop17h 52m

Santiago Arturo Merino Benitez

Wed 12/10

11:15 pm-9:28 am

1 stop14h 13m

$979

Santa FeSantiago

SAF - SCL

SAFSCL

Santa Fe

Thu 10/2

2:05 pm-7:55 am

2 stops14h 50m

$593

Santa FeSantiago

SAF - SCL

SAFSCL

Santa Fe

Fri 10/3

11:47 am-7:55 am

2 stops17h 08m

$633

Santa FeSantiago

SAF - SCL

SAFSCL

Santa Fe

Fri 12/26

12:48 pm-8:30 pm

2 stops27h 42m

$1,863

Santa FeSantiago

SAF - SCL

SAFSCL

Santa Fe

Thu 10/2

4:58 pm-3:05 pm

3 stops43h 07m

$3,057

Santa FeSantiago

SAF - SCL

SAFSCL

Santa Fe

Fri 10/3

5:18 pm-3:05 pm

3 stops42h 47m

$3,570

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/9

Best time to book a flight from Santa Fe to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Santa Fe with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santa Fe to Santiago

What is the cheapest month to book a flight from Santa Fe to Santiago?

Currently, April is the cheapest month in which you can book a flight from Santa Fe to Santiago (average of $752). Flying from Santa Fe to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Santa Fe to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santa Fe to Santiago?

    Departing from Santa Fe to Santiago will take you 20h 54m. Santa Fe and Santiago are separated by a distance of 5282 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Santa Fe to Santiago one-way?

    To fly one-way, consider booking your trip with American Airlines, which is currently one of the cheapest options available, starting at $593. Iberia flights start at $1,863 while deals on Qantas Airways start at $3,057 one-way.

  • Can I find deals for flights from Santa Fe to Santiago that include hotel bookings?

    Yes. In addition to deals on Santa Fe to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santa Fe to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santa Fe to Santiago.

  • Can I find deals for business class flights from Santa Fe to Santiago?

    Yes. Cheapflights offers flight deals from Santa Fe to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santa Fe to Santiago?

    Currently, April is the cheapest month in which you can book a flight from Santa Fe to Santiago (average of $752). Flying from Santa Fe to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Santa Fe to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
Albuquerque to Santiago flights
El Paso to Santiago flights

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.