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$515+ Cheap flights from Roanoke (ROA) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/15. Fares are subject to change and may not be available on all flights or dates of travel.
ROA — SCL
Aug 6 — Aug 131
Wed 8/6
Wed 8/13
1 adult, Economy
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Cheap flight deals from Roanoke to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Roanoke (ROA) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 1, 2025.

Round-trip from

$785
(American Airlines)

One-way from

$515
(Avianca)
From Roanoke to Santiago Arturo Merino Benitez
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One-way flight from Roanoke to Santiago Arturo Merino Benitez
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Find flight deals from Roanoke to Santiago

Cheapest flights from Roanoke to Santiago
Explore the most affordable flight options available from Roanoke to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 1, 2025.

This American Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/158:21 amROA - SCL
2 stops22h 34mAmerican Airlines
Mon 9/229:55 pmSCL - ROA
2 stops15h 16mAmerican Airlines
Deal found 7/31$785
This United Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/17:50 pmROA - SCL
2 stops36h 00mUnited Airlines
Sat 11/1510:45 pmSCL - ROA
2 stops26h 45mUnited Airlines
Deal found 7/31$818
This LATAM Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/53:32 pmROA - SCL
1 stop15h 28mLATAM Airlines
Thu 9/116:35 amSCL - ROA
2 stops18h 50mLATAM Airlines
Deal found 7/30$834
This Delta deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/53:32 pmROA - SCL
1 stop15h 28mDelta
Thu 9/119:40 pmSCL - ROA
1 stop27h 45mDelta
Deal found 7/30$939

Cheapflights Fare Finder

 
Customize your flight search to find flights from Roanoke to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 1, 2025.
Use the filters below to find and compare flights from Roanoke to Santiago that are best for you.

Fly from

Roanoke

Fly to

Santiago

Route

Depart

Return

Price

RoanokeSantiago

ROA - SCL

ROASCL

Roanoke

Mon 9/15

8:21 am-7:55 am

2 stops22h 34m

Santiago Arturo Merino Benitez

Mon 9/22

9:55 pm-12:11 pm

2 stops15h 16m

$785

RoanokeSantiago

ROA - SCL

ROASCL

Roanoke

Sat 11/1

7:50 pm-8:50 am

2 stops36h 00m

Santiago Arturo Merino Benitez

Sat 11/15

10:45 pm-11:30 pm

2 stops26h 45m

$818

RoanokeSantiago

ROA - SCL

ROASCL

Roanoke

Fri 9/5

3:32 pm-7:00 am

1 stop15h 28m

Santiago Arturo Merino Benitez

Thu 9/11

6:35 am-12:25 am

2 stops18h 50m

$834

RoanokeSantiago

ROA - SCL

ROASCL

Roanoke

Fri 9/5

3:32 pm-7:00 am

1 stop15h 28m

Santiago Arturo Merino Benitez

Thu 9/11

9:40 pm-12:25 am

1 stop27h 45m

$939

RoanokeSantiago

ROA - SCL

ROASCL

Roanoke

Mon 9/15

7:35 pm-5:15 am

2 stops32h 40m

$515

RoanokeSantiago

ROA - SCL

ROASCL

Roanoke

Mon 9/15

3:31 pm-7:00 am

1 stop14h 29m

$538

RoanokeSantiago

ROA - SCL

ROASCL

Roanoke

Fri 8/8

6:00 am-7:00 am

1 stop25h 00m

$679

RoanokeSantiago

ROA - SCL

ROASCL

Roanoke

Mon 9/15

3:31 pm-11:40 pm

3 stops31h 09m

$805

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/30

Best time to book a flight from Roanoke to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Roanoke with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Roanoke to Santiago

What is the cheapest time of day to fly from ROA to SCL?

Find hourly flight availability from Roanoke to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 1, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Roanoke to Santiago as you normally would.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated August 1, 2025.
Read reviews from past customers who have flown Delta, LATAM Airlines, and United Airlines from Roanoke to Santiago. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,981 reviews

Comfort

7.9

Boarding

8.2

Crew

8.5

Entertainment

7.9

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,981 reviews
Delta
8.0
Very good
7,981 reviews

Comfort

7.9

Boarding

8.2

Crew

8.5

Entertainment

7.9

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
LATAM Airlines
7.5
Good
1,822 reviews
Delta
8.0
Very good
7,981 reviews

Comfort

7.9

Boarding

8.2

Crew

8.5

Entertainment

7.9

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,900 reviews
Delta
8.0
Very good
7,981 reviews

Comfort

7.9

Boarding

8.2

Crew

8.5

Entertainment

7.9

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,981 reviews

Comfort

7.9

Boarding

8.2

Crew

8.5

Entertainment

7.9

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Avianca
6.7
Okay
2,388 reviews
Delta
8.0
Very good
7,981 reviews

Comfort

7.9

Boarding

8.2

Crew

8.5

Entertainment

7.9

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Roanoke to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines to fly from Roanoke to Santiago one-way?

    To fly one-way, consider booking your trip with Avianca, which is currently one of the cheapest options available, starting at $515. LATAM Airlines flights start at $538 while deals on Delta start at $679 one-way.

  • Can I find deals for flights from Roanoke to Santiago that include hotel bookings?

    Yes. In addition to deals on Roanoke to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Roanoke to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Roanoke to Santiago.

  • Can I find deals for business class flights from Roanoke to Santiago?

    Yes. Cheapflights offers flight deals from Roanoke to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Roanoke to Santiago?

    Currently, April is the cheapest month in which you can book a flight from Roanoke to Santiago (average of $752). Flying from Roanoke to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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