$316+ Cheap flights from Houston to Santiago (SCL)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/21. Fares are subject to change and may not be available on all flights or dates of travel.
HOU — SCL
Dec 4 — Dec 111
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Houston to Santiago with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Houston to Santiago
Cheapest
Best
Last-minute
One-way
Cheapest flights from Houston to SantiagoExplore the most affordable flight options available from Houston to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 4, 2026.
Explore the most affordable flight options available from Houston to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 4, 2026.
This Mytrip deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/18:40 pm -
3 stops30h 05m
Thu 12/104:15 pm -
3 stops31h 24m
Deal found 11/1![Multiple Airlines logo]()
$715
This Air Canada deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/111:50 am -
1 stop16h 00m
Tue 12/158:25 am -
2 stops29h 28m
Deal found 10/31![Air Canada logo]()
$840
This Mytrip deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/410:47 am -
2 stops16h 51m
Mon 12/74:15 pm -
3 stops28h 14m
Deal found 10/31![Multiple Airlines logo]()
$844
This Mytrip deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/309:39 am -
2 stops26h 06m
Mon 12/74:15 pm -
3 stops28h 14m
Deal found 11/2![Multiple Airlines logo]()
$865
This Trip.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/111:50 am -
1 stop16h 00m
Thu 12/109:55 pm -
1 stop22h 23m
Deal found 11/1![Air Canada logo]()
$881
Best flights from Houston to SantiagoDiscover carefully curated flight deals from Houston to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 4, 2026.
Discover carefully curated flight deals from Houston to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 4, 2026.
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/118:30 pm -
Nonstop9h 20m
Thu 1/2110:45 pm -
Nonstop9h 40m
Deal found 10/30![United Airlines logo]()
$1,291
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/183:56 pm -
1 stop12h 44m
Tue 4/138:40 pm -
1 stop15h 26m
Deal found 11/2![Delta logo]()
$1,306
This Delta deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/272:40 pm -
2 stops21h 20m
Tue 1/128:25 pm -
2 stops24h 29m
Deal found 11/1![Delta logo]()
$1,346
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/78:30 pm -
Nonstop9h 20m
Mon 12/2110:45 pm -
Nonstop9h 40m
Deal found 10/30![United Airlines logo]()
$1,413
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/233:24 pm -
1 stop12h 16m
Fri 4/168:40 pm -
1 stop15h 26m
Deal found 11/2![Delta logo]()
$1,386
This United Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/18:30 pm -
Nonstop9h 20m
Tue 12/1510:45 pm -
Nonstop9h 40m
Deal found 10/31![United Airlines logo]()
$1,540
This United Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/48:30 pm -
Nonstop9h 20m
Mon 12/710:45 pm -
Nonstop9h 40m
Deal found 10/31![United Airlines logo]()
$1,831
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/318:30 pm -
Nonstop9h 20m
Sat 1/910:45 pm -
Nonstop9h 40m
Deal found 11/1![United Airlines logo]()
$1,916
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/208:30 pm -
Nonstop9h 20m
Sun 11/2910:45 pm -
Nonstop9h 40m
Deal found 10/30![United Airlines logo]()
$2,081
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/278:30 pm -
Nonstop9h 20m
Tue 12/110:45 pm -
Nonstop9h 40m
Deal found 11/2![United Airlines logo]()
$2,091
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/268:30 pm -
Nonstop9h 20m
Thu 1/710:45 pm -
Nonstop9h 40m
Deal found 10/30![United Airlines logo]()
$2,166
Last-minute flights from Houston to SantiagoDiscover last-minute flight deals from Houston to Santiago. Data last updated November 4, 2026 and is based on user searches.
Discover last-minute flight deals from Houston to Santiago. Data last updated November 4, 2026 and is based on user searches.
This Mytrip deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/309:39 am -
2 stops26h 06m
Mon 12/74:15 pm -
3 stops28h 14m
Deal found 11/2![Multiple Airlines logo]()
$865
This Mytrip deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/18:40 pm -
3 stops30h 05m
Thu 12/104:15 pm -
3 stops31h 24m
Deal found 11/1![Multiple Airlines logo]()
$715
This Air Canada deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/111:50 am -
1 stop16h 00m
Tue 12/158:25 am -
2 stops29h 28m
Deal found 10/31![Air Canada logo]()
$840
This Trip.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/111:50 am -
1 stop16h 00m
Thu 12/109:55 pm -
1 stop22h 23m
Deal found 11/1![Air Canada logo]()
$881
This Mytrip deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/410:47 am -
2 stops16h 51m
Mon 12/74:15 pm -
3 stops28h 14m
Deal found 10/31![Multiple Airlines logo]()
$844
One-way flights from Houston to SantiagoSearch for one-way flight options from Houston to Santiago. Find affordable one-way fares based on user searches. Data last updated November 4, 2026.
Search for one-way flight options from Houston to Santiago. Find affordable one-way fares based on user searches. Data last updated November 4, 2026.
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/2112:03 pm -
2 stops45h 42m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/3![Multiple Airlines logo]()
$316
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/249:39 am -
3 stops40h 21m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/1![Multiple Airlines logo]()
$336
This Kiwi.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/1712:03 pm -
2 stops45h 42m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![Multiple Airlines logo]()
$345
This Kiwi.com deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/239:14 pm -
3 stops51h 24m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/31![Multiple Airlines logo]()
$362
This Kiwi.com deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/309:39 am -
2 stops33h 56m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/31![Multiple Airlines logo]()
$366
This Kiwi.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/112:03 pm -
3 stops47h 57m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/4![Multiple Airlines logo]()
$375
This Kiwi.com deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/29:24 pm -
3 stops46h 11m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/31![Multiple Airlines logo]()
$378
This Kiwi.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/3112:03 pm -
3 stops50h 07m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/4![Multiple Airlines logo]()
$380
This Kiwi.com deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/710:57 am -
3 stops57h 53m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/31![Multiple Airlines logo]()
$387
This Kiwi.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/25:44 pm -
3 stops49h 06m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/4![Multiple Airlines logo]()
$388
Find flight deals from Houston to Santiago
Discover tips and strategies to find the most affordable flight options for your journey from Houston (HO1) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 4, 2026.
Round-trip from | $715 (Mytrip) |
|---|---|
One-way from | $316 (Kiwi.com) |
Popular in | May |
Cheapest in | February |
Average price | $1,375 |
Cheapflights Fare Finder
Customize your flight search to find flights from Houston to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 4, 2026.
Use the filters below to find and compare flights from Houston to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
HoustonSantiago
IAH Houston George Bush Intcntl - SCL Santiago Arturo Merino Benitez
IAHSCL
Houston George Bush Intcntl
Wed 11/11
9:43 pm-12:24 am
3 stops47h 41m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$503
HoustonSantiago
IAH Houston George Bush Intcntl - SCL Santiago Arturo Merino Benitez
IAHSCL
Houston George Bush Intcntl
Thu 1/21
8:32 pm-9:15 pm
1 stop21h 43m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$506
HoustonSantiago
IAH Houston George Bush Intcntl - SCL Santiago Arturo Merino Benitez
IAHSCL
Houston George Bush Intcntl
Mon 11/30
3:30 pm-12:15 pm
1 stop17h 45m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$562
HoustonSantiago
IAH Houston George Bush Intcntl - SCL Santiago Arturo Merino Benitez
IAHSCL
Houston George Bush Intcntl
Wed 11/11
11:55 am-12:15 pm
1 stop21h 20m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$582
HoustonSantiago
IAH Houston George Bush Intcntl - SCL Santiago Arturo Merino Benitez
IAHSCL
Houston George Bush Intcntl
Fri 11/13
7:01 pm-9:15 pm
1 stop23h 14m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$672
Quickest round-trip
HoustonSantiago
IAH Houston George Bush Intcntl - SCL Santiago Arturo Merino Benitez
IAHSCL
Houston George Bush Intcntl
Wed 1/13
8:30 pm-8:50 am
Nonstop9h 20m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$1,214
HoustonSantiago
IAH Houston George Bush Intcntl - SCL Santiago Arturo Merino Benitez
IAHSCL
Houston George Bush Intcntl
Tue 2/2
8:30 pm-8:50 am
Nonstop9h 20m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$1,264
HoustonSantiago
IAH Houston George Bush Intcntl - SCL Santiago Arturo Merino Benitez
IAHSCL
Houston George Bush Intcntl
Mon 1/11
8:30 pm-8:50 am
Nonstop9h 20m
Santiago Arturo Merino Benitez
Thu 1/21
10:45 pm-5:25 am
Nonstop9h 40m
$1,291
HoustonSantiago
IAH Houston George Bush Intcntl - SCL Santiago Arturo Merino Benitez
IAHSCL
Houston George Bush Intcntl
Sat 1/16
8:30 pm-8:50 am
Nonstop9h 20m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$1,294
HoustonSantiago
IAH Houston George Bush Intcntl - SCL Santiago Arturo Merino Benitez
IAHSCL
Houston George Bush Intcntl
Sun 1/17
8:30 pm-8:50 am
Nonstop9h 20m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$1,294
Showing 1-10 of 20 resultsSorted by cheapest first
Best time to book a flight from Houston to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from Houston with our price prediction graph.
HO1-SCL
IAH-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Houston to Santiago
HO1-SCL
IAH-SCL
What is the cheapest month to book a flight from Houston to Santiago?
Currently, October is the cheapest month in which you can book a flight from Houston to Santiago (average of $1,135). Flying from Houston to Santiago in May is currently the most expensive (average of $2,231). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from HOU to SCL?
Find hourly flight availability from Houston to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 4, 2026.
When flying from Houston to Santiago, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
How much does it cost to fly round-trip from Houston to Santiago?
Airfare is below average for this route at the moment.
Houston to Santiago flights typically cost between $1,096 and $1,417 in December.The cheapest round-trip price found within the last 5 days was $715 on Multiple Airlines (Dec 1-Dec 10).
Reviews of airlines servicing Santiago
Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated November 4, 2026.
See what other customers who have flown with United Airlines and American Airlines from Houston to Santiago have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.3
Comfort
7.3
Boarding
7.7
Entertainment
7.1
Food
6.7
Crew
8.1
Reviews
1 / 20
2.0
MediocreSebrena,Oct 2025
IAH - RSW
Overall
7.3
Comfort
7.3
Boarding
7.7
Entertainment
7.1
Food
6.7
Crew
8.1
Reviews
1 / 20
2.0
MediocreSebrena,Oct 2025
IAH - RSW
Overall
7.3
Comfort
7.3
Boarding
7.7
Entertainment
7.1
Food
6.7
Crew
8.1
Reviews
1 / 20
2.0
MediocreSebrena,Oct 2025
IAH - RSW
Related info for your journey
Find useful and relevant information for your journey from Houston to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
Santiago flight routes
Alternative routes for Houston to Santiago
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Houston to Santiago by cabin class
Find flights from Houston to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Houston and Santiago flights
Browse other Houston and Santiago flight options. Last updated on November 4, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on November 4, 2026.
Top 2 airlines flying from Houston to Santiago
Discover the top 2 airlines that operate flights from Houston to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 4, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$989 | Average$1,343 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$1,005 | Average$1,460 | FlexibilityNo cancel fee | On-time71% |