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$431+ Cheap flights from Houston to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/6. Fares are subject to change and may not be available on all flights or dates of travel.
HOU — SCL
Mar 5 — Mar 121
Thu 3/5
Thu 3/12
1 adult, Economy
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Cheap flight deals from Houston to Santiago

Cheapest flights from Houston to Santiago
Explore the most affordable flight options available from Houston to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 3, 2026.

This Mytrip deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/95:15 am
IAH
-
SCL
3 stops21h 56m
Multiple Airlines
Wed 4/225:00 am
SCL
-
IAH
2 stops19h 51m
Multiple Airlines
Deal found 2/1$572
This Mytrip deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/195:15 am
IAH
-
SCL
3 stops27h 24m
Multiple Airlines
Thu 3/269:05 pm
SCL
-
IAH
2 stops28h 44m
Multiple Airlines
Deal found 2/2$576
This Mytrip deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/115:15 am
IAH
-
SCL
3 stops21h 56m
Multiple Airlines
Mon 5/188:20 pm
SCL
-
IAH
2 stops28h 31m
Multiple Airlines
Deal found 2/2$581
This Mytrip deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/179:24 am
IAH
-
SCL
3 stops24h 41m
Multiple Airlines
Tue 5/193:35 am
SCL
-
IAH
2 stops21h 16m
Multiple Airlines
Deal found 2/2$583
This Mytrip deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/16:14 am
IAH
-
SCL
3 stops30h 16m
Multiple Airlines
Wed 4/228:20 pm
SCL
-
IAH
2 stops28h 31m
Multiple Airlines
Deal found 2/3$591
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/125:24 pm
IAH
-
SCL
3 stops40h 36m
Multiple Airlines
Tue 3/177:15 am
SCL
-
IAH
2 stops18h 34m
Multiple Airlines
Deal found 2/2$592
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/189:24 am
IAH
-
SCL
2 stops19h 06m
Multiple Airlines
Wed 5/278:30 am
SCL
-
IAH
2 stops24h 49m
Multiple Airlines
Deal found 2/2$595
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/127:35 am
IAH
-
SCL
2 stops19h 21m
Multiple Airlines
Fri 5/1510:30 am
SCL
-
IAH
1 stop22h 49m
Multiple Airlines
Deal found 2/2$600
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1810:12 am
HOU
-
SCL
2 stops18h 48m
Delta
Mon 5/258:40 pm
SCL
-
HOU
1 stop13h 37m
Delta
Deal found 2/2$985
This KAYAK deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/155:10 pm
HOU
-
SCL
1 stop13h 05m
LATAM Airlines
Tue 5/268:40 pm
SCL
-
HOU
1 stop13h 37m
LATAM Airlines
Deal found 2/2$1,017
This KAYAK deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/11:31 pm
HOU
-
SCL
2 stops16h 24m
LATAM Airlines
Wed 5/137:45 pm
SCL
-
HOU
2 stops17h 26m
LATAM Airlines
Deal found 2/3$1,022
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/1510:12 am
HOU
-
SCL
2 stops18h 48m
Delta
Mon 6/18:40 pm
SCL
-
HOU
1 stop13h 37m
Delta
Deal found 2/2$1,025

Find flight deals from Houston to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Houston (HO1) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 3, 2026.

Round-trip from

$572
(Mytrip)

One-way from

$431
(Kiwi.com)

Popular in

June

Cheapest in

April

Average price

$1,129
From Houston to Santiago Arturo Merino Benitez
Search Deals
One-way flight from Houston to Santiago Arturo Merino Benitez
Search Deals
Highest demand for flights based on searches. 5% potential increase in price ($74 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($37 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Houston to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
Use the filters below to find and compare flights from Houston to Santiago that are best for you.

Fly from

Houston

Fly to

Santiago

Route

Depart

Return

Price

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Fri 3/27

9:26 am-10:39 am

2 stops23h 13m

Santiago Arturo Merino Benitez

Sat 4/4

11:00 pm-11:49 pm

1 stop26h 49m

$658

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Thu 3/12

9:36 am-2:40 pm

2 stops27h 04m

Santiago Arturo Merino Benitez

Wed 3/18

11:25 pm-1:54 pm

1 stop16h 29m

$676

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Mon 3/9

5:24 pm-12:00 pm

3 stops40h 36m

Santiago Arturo Merino Benitez

Mon 3/23

8:15 am-11:49 pm

2 stops17h 34m

$690

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Tue 3/3

5:24 pm-7:00 am

1 stop34h 36m

Santiago Arturo Merino Benitez

Tue 3/10

5:59 am-8:23 pm

2 stops40h 24m

$719

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Mon 3/16

5:24 pm-10:15 pm

2 stops26h 51m

Santiago Arturo Merino Benitez

Sun 3/22

10:35 am-11:49 pm

1 stop15h 14m

$726

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Sun 3/15

11:00 am-7:30 am

1 stop18h 30m

Santiago Arturo Merino Benitez

Thu 3/19

10:35 am-11:49 pm

1 stop15h 14m

$782

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Tue 4/7

5:24 pm-6:55 am

1 stop12h 31m

Santiago Arturo Merino Benitez

Sat 4/11

11:00 pm-11:49 pm

1 stop25h 49m

$786

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Tue 3/10

5:24 pm-2:10 pm

1 stop18h 46m

Santiago Arturo Merino Benitez

Mon 3/16

8:15 am-11:49 pm

2 stops17h 34m

$802

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Mon 3/9

10:48 am-7:30 am

3 stops42h 42m

Santiago Arturo Merino Benitez

Wed 3/25

11:24 am-10:18 am

3 stops24h 54m

$804

HoustonSantiago

HOU - SCL

HOUSCL

Houston Hobby

Wed 4/1

5:27 pm-8:15 am

1 stop12h 48m

Santiago Arturo Merino Benitez

Wed 4/22

8:40 pm-9:51 am

1 stop14h 11m

$985

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/2

Showing 1-10 of 29 results
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Best time to book a flight from Houston to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Houston with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Houston to Santiago

What is the cheapest month to book a flight from Houston to Santiago?

Currently, November is the cheapest month in which you can book a flight from Houston to Santiago (average of $325). Flying from Houston to Santiago in February is currently the most expensive (average of $949). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from HOU to SCL?

Find hourly flight availability from Houston to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 3, 2026.

When flying from Houston to Santiago, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

How much does it cost to fly round-trip from Houston to Santiago?

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated February 3, 2026.
See what other customers who have flown with LATAM Airlines, United Airlines, and American Airlines from Houston to Santiago have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
LATAM Airlines
7.5
Good
1,918 reviews

Entertainment

7.0

Food

6.7

Boarding

7.5

Comfort

7.3

Crew

8.0

Overall

7.5

Reviews

1 / 20
2.0
Mediocre

Jess,Jan 2026

GRU - MIA

sat on the tarmac for 4.5 hours with no explanation, climate control, honesty about the timeline or the situation, or even letting anyone off. The crew was passive-aggressive and sneaky, trying to skirt legal time limits requiring financial restitution for passengers, pretending the "flight had started" even though they didn't budge for another 40 minutes. One of the worst flights I've ever taken
LATAM Airlines
7.5
Good
1,918 reviews
LATAM Airlines
7.5
Good
1,918 reviews

Entertainment

7.0

Food

6.7

Boarding

7.5

Comfort

7.3

Crew

8.0

Overall

7.5

Reviews

1 / 20
2.0
Mediocre

Jess,Jan 2026

GRU - MIA

sat on the tarmac for 4.5 hours with no explanation, climate control, honesty about the timeline or the situation, or even letting anyone off. The crew was passive-aggressive and sneaky, trying to skirt legal time limits requiring financial restitution for passengers, pretending the "flight had started" even though they didn't budge for another 40 minutes. One of the worst flights I've ever taken
United Airlines
7.4
Good
9,234 reviews
LATAM Airlines
7.5
Good
1,918 reviews

Entertainment

7.0

Food

6.7

Boarding

7.5

Comfort

7.3

Crew

8.0

Overall

7.5

Reviews

1 / 20
2.0
Mediocre

Jess,Jan 2026

GRU - MIA

sat on the tarmac for 4.5 hours with no explanation, climate control, honesty about the timeline or the situation, or even letting anyone off. The crew was passive-aggressive and sneaky, trying to skirt legal time limits requiring financial restitution for passengers, pretending the "flight had started" even though they didn't budge for another 40 minutes. One of the worst flights I've ever taken
American Airlines
7.2
Good
11,216 reviews
LATAM Airlines
7.5
Good
1,918 reviews

Entertainment

7.0

Food

6.7

Boarding

7.5

Comfort

7.3

Crew

8.0

Overall

7.5

Reviews

1 / 20
2.0
Mediocre

Jess,Jan 2026

GRU - MIA

sat on the tarmac for 4.5 hours with no explanation, climate control, honesty about the timeline or the situation, or even letting anyone off. The crew was passive-aggressive and sneaky, trying to skirt legal time limits requiring financial restitution for passengers, pretending the "flight had started" even though they didn't budge for another 40 minutes. One of the worst flights I've ever taken
Avianca
6.5
Okay
2,497 reviews
LATAM Airlines
7.5
Good
1,918 reviews

Entertainment

7.0

Food

6.7

Boarding

7.5

Comfort

7.3

Crew

8.0

Overall

7.5

Reviews

1 / 20
2.0
Mediocre

Jess,Jan 2026

GRU - MIA

sat on the tarmac for 4.5 hours with no explanation, climate control, honesty about the timeline or the situation, or even letting anyone off. The crew was passive-aggressive and sneaky, trying to skirt legal time limits requiring financial restitution for passengers, pretending the "flight had started" even though they didn't budge for another 40 minutes. One of the worst flights I've ever taken

Related info for your journey

Find useful and relevant information for your journey from Houston to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santiago from Houston?

    Located just 8.4 mi from the city center, Santiago Arturo Merino Benitez is the airport most travelers will use when flying to Santiago from Houston. Booking flights from Houston to Arturo Merino Benitez (SCL) should be relatively easy as there are 0 daily inbound flights from Houston from 4 different airlines.

  • How long is the flight from Houston to Santiago?

    Departing from Houston to Santiago will take you 12h 48m. Houston and Santiago are separated by a distance of 4637 mi.

  • What are the cheapest airlines flying from Houston to Santiago round-trip?

    Cheapflights users have booked flights from Houston to Santiago round-trip from $548. Other airlines that can offer you cheap pricing are LATAM Airlines, from $949, and United Airlines, from $949. Users have found that Avianca is 54% cheaper than the other options available to this destination.

  • Can I find deals for flights from Houston to Santiago that include hotel bookings?

    Yes. In addition to deals on Houston to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Houston to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Houston to Santiago.

  • Can I find deals for business class flights from Houston to Santiago?

    Yes. Cheapflights offers flight deals from Houston to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Houston to Santiago?

    Currently, November is the cheapest month in which you can book a flight from Houston to Santiago (average of $325). Flying from Houston to Santiago in February is currently the most expensive (average of $949). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 4 airlines flying from Houston to Santiago

Discover the top 4 airlines that operate flights from Houston to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$548Average$742FlexibilityNo cancel feeOn-time71%
LATAM AirlinesCheapest$949Average$1,318FlexibilityNo cancel feeOn-time81%
United AirlinesCheapest$949Average$1,301FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$964Average$1,523FlexibilityNo cancel feeOn-time71%

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