Santiago

$288+ Cheap flights from Houston to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/19. Fares are subject to change and may not be available on all flights or dates of travel.
HOU — SCL
Apr 22 — Apr 291
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Houston to Santiago with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Houston to Santiago

Cheapest flights from Houston to Santiago
Explore the most affordable flight options available from Houston to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 23, 2026.

This Mytrip deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2011:39 am
IAH
-
SCL
2 stops24h 51m
Multiple Airlines
Mon 4/278:20 pm
SCL
-
IAH
2 stops24h 05m
Multiple Airlines
Deal found 3/23$635
This Trip.com deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/85:24 pm
IAH
-
SCL
2 stops19h 51m
Multiple Airlines
Sun 4/196:40 am
SCL
-
IAH
2 stops26h 43m
Multiple Airlines
Deal found 3/20$686
This Mytrip deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2711:39 am
IAH
-
SCL
2 stops24h 51m
Multiple Airlines
Sat 5/212:30 am
SCL
-
IAH
2 stops16h 40m
Multiple Airlines
Deal found 3/23$692
This Mytrip deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/156:00 am
IAH
-
SCL
3 stops41h 11m
Multiple Airlines
Sun 4/193:20 pm
SCL
-
IAH
2 stops18h 03m
Multiple Airlines
Deal found 3/20$734
This Mytrip deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/1611:39 am
IAH
-
SCL
2 stops24h 51m
Multiple Airlines
Thu 4/233:20 pm
SCL
-
IAH
3 stops32h 27m
Multiple Airlines
Deal found 3/19$741
This Mytrip deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/196:00 am
IAH
-
SCL
3 stops31h 15m
Multiple Airlines
Sun 4/266:40 am
SCL
-
IAH
2 stops26h 43m
Multiple Airlines
Deal found 3/21$744
This Mytrip deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/115:24 pm
IAH
-
SCL
2 stops28h 56m
Multiple Airlines
Wed 4/153:20 pm
SCL
-
IAH
2 stops18h 03m
Multiple Airlines
Deal found 3/22$748
This KAYAK deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/2610:27 am
HOU
-
SCL
2 stops18h 33m
LATAM Airlines
Tue 6/98:40 pm
SCL
-
HOU
1 stop13h 40m
LATAM Airlines
Deal found 3/21$1,111
This KAYAK deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/210:05 am
HOU
-
SCL
2 stops18h 40m
LATAM Airlines
Wed 9/98:40 pm
SCL
-
HOU
1 stop17h 24m
LATAM Airlines
Deal found 3/22$1,119
This KAYAK deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/51:00 pm
HOU
-
SCL
1 stop17h 15m
LATAM Airlines
Thu 8/208:40 pm
SCL
-
HOU
1 stop16h 24m
LATAM Airlines
Deal found 3/21$1,127
This KAYAK deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/25:35 pm
HOU
-
SCL
2 stops25h 10m
LATAM Airlines
Wed 8/198:40 pm
SCL
-
HOU
1 stop13h 35m
LATAM Airlines
Deal found 3/21$1,132
This Cheapflightsfares deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/211:06 pm
HOU
-
SCL
1 stop17h 09m
LATAM Airlines
Mon 6/18:40 pm
SCL
-
HOU
1 stop16h 31m
LATAM Airlines
Deal found 3/22$1,133

Find flight deals from Houston to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Houston (HO1) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 23, 2026.

Round-trip from

$635
(Mytrip)

One-way from

$288
(Kiwi.com)

Popular in

June

Cheapest in

November

Average price

$1,029
From Houston to Santiago Arturo Merino Benitez
One-way flight from Houston to Santiago Arturo Merino Benitez
High demand for flights, 5% potential price rise
Cheapest flight prices on average. 3% potential price decrease ($39 potential savings vs. average RT price).
Average for round-trip flights in March 2026

Cheapflights Fare Finder

 
Customize your flight search to find flights from Houston to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 23, 2026.
Use the filters below to find and compare flights from Houston to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Fri 5/15

7:44 pm-6:55 am

3 stops34h 11m

Santiago Arturo Merino Benitez

Sun 5/31

12:01 am-1:17 pm

2 stops38h 16m

$753

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Thu 4/9

11:15 am-2:15 pm

2 stops26h 00m

Santiago Arturo Merino Benitez

Wed 7/1

8:20 pm-7:25 pm

2 stops24h 05m

$879

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Fri 5/1

5:45 pm-2:15 pm

2 stops19h 30m

Santiago Arturo Merino Benitez

Tue 5/12

12:30 am-4:10 pm

2 stops16h 40m

$1,054

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Tue 4/7

5:45 pm-2:15 pm

2 stops19h 30m

Santiago Arturo Merino Benitez

Sat 4/18

12:30 am-4:10 pm

2 stops16h 40m

$1,054

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Wed 9/2

8:55 pm-5:45 am

3 stops31h 50m

Santiago Arturo Merino Benitez

Wed 9/9

7:40 am-4:10 pm

2 stops34h 30m

$1,067

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Sat 5/2

10:15 pm-5:35 am

1 stop30h 20m

Santiago Arturo Merino Benitez

Sat 5/9

11:00 pm-8:18 am

1 stop34h 18m

$1,071

HoustonSantiago

HOU - SCL

HOUSCL

Houston Hobby

Wed 9/2

10:05 am-6:00 am

2 stops18h 55m

Santiago Arturo Merino Benitez

Wed 9/9

7:45 pm-12:04 pm

2 stops18h 19m

$1,119

HoustonSantiago

HOU - SCL

HOUSCL

Houston Hobby

Wed 9/2

10:05 am-7:15 am

1 stop20h 10m

Santiago Arturo Merino Benitez

Wed 9/9

8:40 pm-9:15 am

1 stop14h 35m

$1,135

HoustonSantiago

HOU - SCL

HOUSCL

Houston Hobby

Wed 5/13

1:06 pm-2:05 pm

2 stops23h 59m

Santiago Arturo Merino Benitez

Thu 5/21

7:55 pm-12:11 pm

2 stops17h 16m

$1,135
Quickest round-trip

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Wed 9/2

3:40 pm-7:15 am

1 stop14h 35m

Santiago Arturo Merino Benitez

Wed 9/9

8:40 pm-8:32 am

1 stop13h 52m

$1,135

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/18

Showing 1-10 of 34 resultsSorted by cheapest first
1
2
3
4

Best time to book a flight from Houston to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Houston with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Houston to Santiago

What is the cheapest month to book a flight from Houston to Santiago?

Currently, November is the cheapest month in which you can book a flight from Houston to Santiago (average of $325). Flying from Houston to Santiago in February is currently the most expensive (average of $949). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from HOU to SCL?

Find hourly flight availability from Houston to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 23, 2026.

When flying from Houston to Santiago, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated March 23, 2026.
See what other customers who have flown with LATAM Airlines,United Airlines, andAmerican Airlines from Houston to Santiago have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Crew

8.0

Boarding

7.5

Comfort

7.3

Food

6.7

Entertainment

7.0

Overall

7.4

Reviews

1 / 20
2.0
Mediocre

Jess,Jan 2026

GRU - MIA

sat on the tarmac for 4.5 hours with no explanation, climate control, honesty about the timeline or the situation, or even letting anyone off. The crew was passive-aggressive and sneaky, trying to skirt legal time limits requiring financial restitution for passengers, pretending the "flight had started" even though they didn't budge for another 40 minutes. One of the worst flights I've ever taken

Crew

8.0

Boarding

7.5

Comfort

7.3

Food

6.7

Entertainment

7.0

Overall

7.4

Reviews

1 / 20
2.0
Mediocre

Jess,Jan 2026

GRU - MIA

sat on the tarmac for 4.5 hours with no explanation, climate control, honesty about the timeline or the situation, or even letting anyone off. The crew was passive-aggressive and sneaky, trying to skirt legal time limits requiring financial restitution for passengers, pretending the "flight had started" even though they didn't budge for another 40 minutes. One of the worst flights I've ever taken

Crew

8.0

Boarding

7.5

Comfort

7.3

Food

6.7

Entertainment

7.0

Overall

7.4

Reviews

1 / 20
2.0
Mediocre

Jess,Jan 2026

GRU - MIA

sat on the tarmac for 4.5 hours with no explanation, climate control, honesty about the timeline or the situation, or even letting anyone off. The crew was passive-aggressive and sneaky, trying to skirt legal time limits requiring financial restitution for passengers, pretending the "flight had started" even though they didn't budge for another 40 minutes. One of the worst flights I've ever taken

Crew

8.0

Boarding

7.5

Comfort

7.3

Food

6.7

Entertainment

7.0

Overall

7.4

Reviews

1 / 20
2.0
Mediocre

Jess,Jan 2026

GRU - MIA

sat on the tarmac for 4.5 hours with no explanation, climate control, honesty about the timeline or the situation, or even letting anyone off. The crew was passive-aggressive and sneaky, trying to skirt legal time limits requiring financial restitution for passengers, pretending the "flight had started" even though they didn't budge for another 40 minutes. One of the worst flights I've ever taken

Crew

8.0

Boarding

7.5

Comfort

7.3

Food

6.7

Entertainment

7.0

Overall

7.4

Reviews

1 / 20
2.0
Mediocre

Jess,Jan 2026

GRU - MIA

sat on the tarmac for 4.5 hours with no explanation, climate control, honesty about the timeline or the situation, or even letting anyone off. The crew was passive-aggressive and sneaky, trying to skirt legal time limits requiring financial restitution for passengers, pretending the "flight had started" even though they didn't budge for another 40 minutes. One of the worst flights I've ever taken

Related info for your journey

Find useful and relevant information for your journey from Houston to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What airport do you fly into for flights to Santiago from Houston?

    Located just 8.4 mi from the city center, Santiago Arturo Merino Benitez is the airport most travelers will use when flying to Santiago from Houston. Booking flights from Houston to Arturo Merino Benitez (SCL) should be relatively easy as there are 0 daily inbound flights from Houston from 4 different airlines.

  • How long is the flight from Houston to Santiago?

    Departing from Houston to Santiago will take you 18h 55m. Houston and Santiago are separated by a distance of 4637 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Houston to Santiago round-trip?

    Cheapflights users have booked flights from Houston to Santiago round-trip from $548. Other airlines that can offer you cheap pricing are LATAM Airlines, from $949, and United Airlines, from $949. Users have found that Avianca is 55% cheaper than the other options available to this destination.

  • Can I find deals for flights from Houston to Santiago that include hotel bookings?

    Yes. In addition to deals on Houston to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Houston to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Houston to Santiago.

  • Can I find deals for business class flights from Houston to Santiago?

    Yes. Cheapflights offers flight deals from Houston to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Houston to Santiago?

    Currently, November is the cheapest month in which you can book a flight from Houston to Santiago (average of $325). Flying from Houston to Santiago in February is currently the most expensive (average of $949). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Houston to Santiago

See prices for flight routes from nearby airports that may be better suited for you.

Top 4 airlines flying from Houston to Santiago

Discover the top 4 airlines that operate flights from Houston to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 23, 2026.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$548Average$708FlexibilityNo cancel feeOn-time71%
LATAM AirlinesCheapest$949Average$1,319FlexibilityNo cancel feeOn-time81%
United AirlinesCheapest$949Average$1,176FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$964Average$1,588FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.