$288+ Cheap flights from Houston to Santiago (SCL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/19. Fares are subject to change and may not be available on all flights or dates of travel.
HOU — SCL
Apr 22 — Apr 291
Round-trip
1 adult, Economy
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Find cheap flights from Houston to Santiago with Cheapflights
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Cheapest flights from Houston to SantiagoExplore the most affordable flight options available from Houston to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 23, 2026.
Explore the most affordable flight options available from Houston to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 23, 2026.
This Mytrip deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2011:39 am
IAH
- SCL
2 stops24h 51m
Multiple Airlines
Mon 4/278:20 pm
SCL
- IAH
2 stops24h 05m
Multiple Airlines
Deal found 3/23![Multiple Airlines logo]()
$635
This Trip.com deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/85:24 pm
IAH
- SCL
2 stops19h 51m
Multiple Airlines
Sun 4/196:40 am
SCL
- IAH
2 stops26h 43m
Multiple Airlines
Deal found 3/20![Multiple Airlines logo]()
$686
This Mytrip deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2711:39 am
IAH
- SCL
2 stops24h 51m
Multiple Airlines
Sat 5/212:30 am
SCL
- IAH
2 stops16h 40m
Multiple Airlines
Deal found 3/23![Multiple Airlines logo]()
$692
This Mytrip deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/156:00 am
IAH
- SCL
3 stops41h 11m
Multiple Airlines
Sun 4/193:20 pm
SCL
- IAH
2 stops18h 03m
Multiple Airlines
Deal found 3/20![Multiple Airlines logo]()
$734
This Mytrip deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/1611:39 am
IAH
- SCL
2 stops24h 51m
Multiple Airlines
Thu 4/233:20 pm
SCL
- IAH
3 stops32h 27m
Multiple Airlines
Deal found 3/19![Multiple Airlines logo]()
$741
This Mytrip deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/196:00 am
IAH
- SCL
3 stops31h 15m
Multiple Airlines
Sun 4/266:40 am
SCL
- IAH
2 stops26h 43m
Multiple Airlines
Deal found 3/21![Multiple Airlines logo]()
$744
This Mytrip deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/115:24 pm
IAH
- SCL
2 stops28h 56m
Multiple Airlines
Wed 4/153:20 pm
SCL
- IAH
2 stops18h 03m
Multiple Airlines
Deal found 3/22![Multiple Airlines logo]()
$748
This KAYAK deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/2610:27 am
HOU
- SCL
2 stops18h 33m
LATAM Airlines
Tue 6/98:40 pm
SCL
- HOU
1 stop13h 40m
LATAM Airlines
Deal found 3/21![LATAM Airlines logo]()
$1,111
This KAYAK deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/210:05 am
HOU
- SCL
2 stops18h 40m
LATAM Airlines
Wed 9/98:40 pm
SCL
- HOU
1 stop17h 24m
LATAM Airlines
Deal found 3/22![LATAM Airlines logo]()
$1,119
This KAYAK deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/51:00 pm
HOU
- SCL
1 stop17h 15m
LATAM Airlines
Thu 8/208:40 pm
SCL
- HOU
1 stop16h 24m
LATAM Airlines
Deal found 3/21![LATAM Airlines logo]()
$1,127
This KAYAK deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/25:35 pm
HOU
- SCL
2 stops25h 10m
LATAM Airlines
Wed 8/198:40 pm
SCL
- HOU
1 stop13h 35m
LATAM Airlines
Deal found 3/21![LATAM Airlines logo]()
$1,132
This Cheapflightsfares deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/211:06 pm
HOU
- SCL
1 stop17h 09m
LATAM Airlines
Mon 6/18:40 pm
SCL
- HOU
1 stop16h 31m
LATAM Airlines
Deal found 3/22![LATAM Airlines logo]()
$1,133
Best flights from Houston to SantiagoDiscover carefully curated flight deals from Houston to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 23, 2026.
Discover carefully curated flight deals from Houston to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 23, 2026.
This eDestinos deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/157:44 pm
IAH
- SCL
3 stops34h 11m
Multiple Airlines
Sun 5/3112:01 am
SCL
- IAH
2 stops38h 16m
Multiple Airlines
Deal found 3/18![Multiple Airlines logo]()
$753
This Avianca deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/15:45 pm
IAH
- SCL
2 stops19h 30m
Avianca
Tue 5/1212:30 am
SCL
- IAH
2 stops16h 40m
Avianca
Deal found 3/20![Avianca logo]()
$1,054
This KAYAK deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/210:05 am
HOU
- SCL
2 stops18h 55m
LATAM Airlines
Wed 9/97:45 pm
SCL
- HOU
2 stops18h 19m
LATAM Airlines
Deal found 3/22![LATAM Airlines logo]()
$1,119
This Delta deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/210:05 am
HOU
- SCL
1 stop20h 10m
Delta
Wed 9/98:40 pm
SCL
- HOU
1 stop14h 35m
Delta
Deal found 3/22![Delta logo]()
$1,135
This Mytrip deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/911:15 am
IAH
- SCL
2 stops26h 00m
Multiple Airlines
Wed 7/18:20 pm
SCL
- IAH
2 stops24h 05m
Multiple Airlines
Deal found 3/18![Multiple Airlines logo]()
$879
This Avianca deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/75:45 pm
IAH
- SCL
2 stops19h 30m
Avianca
Sat 4/1812:30 am
SCL
- IAH
2 stops16h 40m
Avianca
Deal found 3/19![Avianca logo]()
$1,054
This Delta deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/131:06 pm
HOU
- SCL
2 stops23h 59m
Delta
Thu 5/217:55 pm
SCL
- HOU
2 stops17h 16m
Delta
Deal found 3/23![Delta logo]()
$1,135
This Gurufare deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gurufare is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/23:40 pm
IAH
- SCL
1 stop14h 35m
LATAM Airlines
Wed 9/98:40 pm
SCL
- IAH
1 stop13h 52m
LATAM Airlines
Deal found 3/22![LATAM Airlines logo]()
$1,135
This Mytrip deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/28:55 pm
IAH
- SCL
3 stops31h 50m
Multiple Airlines
Wed 9/97:40 am
SCL
- IAH
2 stops34h 30m
Multiple Airlines
Deal found 3/22![Multiple Airlines logo]()
$1,067
This Delta deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2110:27 am
HOU
- SCL
2 stops18h 33m
Delta
Mon 6/18:40 pm
SCL
- HOU
1 stop16h 31m
Delta
Deal found 3/22![Delta logo]()
$1,135
This eDestinos deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/211:15 pm
IAH
- SCL
2 stops16h 40m
LATAM Airlines
Sun 10/47:45 pm
SCL
- IAH
2 stops18h 22m
LATAM Airlines
Deal found 3/22![LATAM Airlines logo]()
$1,139
This Kiwi.com deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/210:15 pm
IAH
- SCL
1 stop30h 20m
Multiple Airlines
Sat 5/911:00 pm
SCL
- IAH
1 stop34h 18m
Multiple Airlines
Deal found 3/18![Multiple Airlines logo]()
$1,071
This Cheapflightsfares deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/154:28 pm
IAH
- SCL
1 stop13h 47m
LATAM Airlines
Mon 6/18:40 pm
SCL
- IAH
1 stop17h 34m
LATAM Airlines
Deal found 3/21![LATAM Airlines logo]()
$1,171
This Delta deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/1510:27 am
HOU
- SCL
1 stop19h 48m
Delta
Mon 6/18:40 pm
SCL
- HOU
1 stop13h 52m
Delta
Deal found 3/18![Delta logo]()
$1,175
This Kiwi.com deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2011:39 am
IAH
- SCL
1 stop18h 16m
Multiple Airlines
Fri 4/2411:25 pm
SCL
- IAH
1 stop19h 37m
Multiple Airlines
Deal found 3/18![Multiple Airlines logo]()
$1,159
This Delta deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/810:05 am
HOU
- SCL
1 stop20h 10m
Delta
Tue 8/188:40 pm
SCL
- HOU
1 stop16h 24m
Delta
Deal found 3/21![Delta logo]()
$1,175
This Delta deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/612:05 pm
IAH
- SCL
1 stop18h 10m
Delta
Sun 8/168:40 pm
SCL
- IAH
1 stop15h 14m
Delta
Deal found 3/21![Delta logo]()
$1,175
Last-minute flights from Houston to SantiagoDiscover last-minute flight deals from Houston to Santiago. Data last updated March 23, 2026 and is based on user searches.
Discover last-minute flight deals from Houston to Santiago. Data last updated March 23, 2026 and is based on user searches.
This Trip.com deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/85:24 pm
IAH
- SCL
2 stops19h 51m
Multiple Airlines
Sun 4/196:40 am
SCL
- IAH
2 stops26h 43m
Multiple Airlines
Deal found 3/20![Multiple Airlines logo]()
$686
This Mytrip deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/115:24 pm
IAH
- SCL
2 stops28h 56m
Multiple Airlines
Wed 4/153:20 pm
SCL
- IAH
2 stops18h 03m
Multiple Airlines
Deal found 3/22![Multiple Airlines logo]()
$748
This Mytrip deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/156:00 am
IAH
- SCL
3 stops41h 11m
Multiple Airlines
Sun 4/193:20 pm
SCL
- IAH
2 stops18h 03m
Multiple Airlines
Deal found 3/20![Multiple Airlines logo]()
$734
This Mytrip deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/1611:39 am
IAH
- SCL
2 stops24h 51m
Multiple Airlines
Thu 4/233:20 pm
SCL
- IAH
3 stops32h 27m
Multiple Airlines
Deal found 3/19![Multiple Airlines logo]()
$741
This American Airlines deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/1612:42 pm
HOU
- SCL
2 stops17h 23m
American Airlines
Thu 4/238:35 pm
SCL
- HOU
2 stops16h 37m
American Airlines
Deal found 3/19![American Airlines logo]()
$1,376
This Mytrip deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/196:00 am
IAH
- SCL
3 stops31h 15m
Multiple Airlines
Sun 4/266:40 am
SCL
- IAH
2 stops26h 43m
Multiple Airlines
Deal found 3/21![Multiple Airlines logo]()
$744
This eDestinos deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/195:23 pm
HOU
- SCL
2 stops18h 42m
LATAM Airlines
Sun 4/266:45 pm
SCL
- HOU
2 stops18h 55m
LATAM Airlines
Deal found 3/21![LATAM Airlines logo]()
$1,420
This Mytrip deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2011:39 am
IAH
- SCL
2 stops24h 51m
Multiple Airlines
Mon 4/278:20 pm
SCL
- IAH
2 stops24h 05m
Multiple Airlines
Deal found 3/23![Multiple Airlines logo]()
$635
This Gurufare deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gurufare is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/201:31 pm
HOU
- SCL
1 stop16h 44m
LATAM Airlines
Mon 4/278:40 pm
SCL
- HOU
1 stop14h 18m
LATAM Airlines
Deal found 3/23![LATAM Airlines logo]()
$1,365
This American Airlines deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2112:42 pm
HOU
- SCL
2 stops17h 23m
American Airlines
Mon 5/259:00 pm
SCL
- HOU
2 stops19h 45m
American Airlines
Deal found 3/21![American Airlines logo]()
$1,253
This Delta deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2110:53 am
HOU
- SCL
2 stops16h 57m
Delta
Tue 5/198:40 pm
SCL
- HOU
1 stop13h 52m
Delta
Deal found 3/21![Delta logo]()
$1,385
This Mytrip deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2711:39 am
IAH
- SCL
2 stops24h 51m
Multiple Airlines
Sat 5/212:30 am
SCL
- IAH
2 stops16h 40m
Multiple Airlines
Deal found 3/23![Multiple Airlines logo]()
$692
One-way flights from Houston to SantiagoSearch for one-way flight options from Houston to Santiago. Find affordable one-way fares based on user searches. Data last updated March 23, 2026.
Search for one-way flight options from Houston to Santiago. Find affordable one-way fares based on user searches. Data last updated March 23, 2026.
This Kiwi.com deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/197:00 am
IAH
- SCL
2 stops19h 55m
Multiple Airlines
Deal found 3/18![Multiple Airlines logo]()
$288
This Kiwi.com deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/69:25 pm
IAH
- SCL
2 stops27h 55m
Multiple Airlines
Deal found 3/19![Multiple Airlines logo]()
$305
This Kiwi.com deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/84:20 pm
IAH
- SCL
2 stops20h 55m
Multiple Airlines
Deal found 3/20![Multiple Airlines logo]()
$309
This Kiwi.com deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/286:57 pm
IAH
- SCL
2 stops30h 23m
Multiple Airlines
Deal found 3/18![Multiple Airlines logo]()
$313
This Kiwi.com deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/125:45 am
IAH
- SCL
3 stops22h 40m
Multiple Airlines
Deal found 3/21![Multiple Airlines logo]()
$321
This Kiwi.com deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/197:27 pm
IAH
- SCL
2 stops30h 08m
Multiple Airlines
Deal found 3/22![Multiple Airlines logo]()
$327
This Kiwi.com deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/259:17 pm
IAH
- SCL
3 stops53h 59m
Multiple Airlines
Deal found 3/22![Multiple Airlines logo]()
$339
This Kiwi.com deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:17 pm
IAH
- SCL
3 stops32h 59m
Multiple Airlines
Deal found 3/22![Multiple Airlines logo]()
$344
This eDestinos deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/236:12 pm
HOU
- SCL
3 stops34h 48m
Multiple Airlines
Deal found 3/22![Multiple Airlines logo]()
$624
This Cheapflightsfares deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2810:53 am
HOU
- SCL
2 stops25h 42m
LATAM Airlines
Deal found 3/18![LATAM Airlines logo]()
$947
This Cheapflightsfares deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/65:27 pm
HOU
- SCL
1 stop12h 48m
LATAM Airlines
Deal found 3/19![LATAM Airlines logo]()
$957
This KAYAK deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/72:13 pm
HOU
- SCL
1 stop16h 02m
LATAM Airlines
Deal found 3/20![LATAM Airlines logo]()
$978
Find flight deals from Houston to Santiago
Discover tips and strategies to find the most affordable flight options for your journey from Houston (HO1) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 23, 2026.
Round-trip from | $635 (Mytrip) |
|---|---|
One-way from | $288 (Kiwi.com) |
Popular in | June |
Cheapest in | November |
Average price | $1,029 |
Cheapflights Fare Finder
Customize your flight search to find flights from Houston to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 23, 2026.
Use the filters below to find and compare flights from Houston to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
HoustonSantiago
IAH - SCL
IAHSCL
Houston George Bush Intcntl
Fri 5/15
7:44 pm-6:55 am
3 stops34h 11m
Santiago Arturo Merino Benitez
Sun 5/31
12:01 am-1:17 pm
2 stops38h 16m
$753
HoustonSantiago
IAH - SCL
IAHSCL
Houston George Bush Intcntl
Thu 4/9
11:15 am-2:15 pm
2 stops26h 00m
Santiago Arturo Merino Benitez
Wed 7/1
8:20 pm-7:25 pm
2 stops24h 05m
$879
HoustonSantiago
IAH - SCL
IAHSCL
Houston George Bush Intcntl
Fri 5/1
5:45 pm-2:15 pm
2 stops19h 30m
Santiago Arturo Merino Benitez
Tue 5/12
12:30 am-4:10 pm
2 stops16h 40m
$1,054
HoustonSantiago
IAH - SCL
IAHSCL
Houston George Bush Intcntl
Tue 4/7
5:45 pm-2:15 pm
2 stops19h 30m
Santiago Arturo Merino Benitez
Sat 4/18
12:30 am-4:10 pm
2 stops16h 40m
$1,054
HoustonSantiago
IAH - SCL
IAHSCL
Houston George Bush Intcntl
Wed 9/2
8:55 pm-5:45 am
3 stops31h 50m
Santiago Arturo Merino Benitez
Wed 9/9
7:40 am-4:10 pm
2 stops34h 30m
$1,067
HoustonSantiago
IAH - SCL
IAHSCL
Houston George Bush Intcntl
Sat 5/2
10:15 pm-5:35 am
1 stop30h 20m
Santiago Arturo Merino Benitez
Sat 5/9
11:00 pm-8:18 am
1 stop34h 18m
$1,071
HoustonSantiago
HOU - SCL
HOUSCL
Houston Hobby
Wed 9/2
10:05 am-6:00 am
2 stops18h 55m
Santiago Arturo Merino Benitez
Wed 9/9
7:45 pm-12:04 pm
2 stops18h 19m
$1,119
HoustonSantiago
HOU - SCL
HOUSCL
Houston Hobby
Wed 9/2
10:05 am-7:15 am
1 stop20h 10m
Santiago Arturo Merino Benitez
Wed 9/9
8:40 pm-9:15 am
1 stop14h 35m
$1,135
HoustonSantiago
HOU - SCL
HOUSCL
Houston Hobby
Wed 5/13
1:06 pm-2:05 pm
2 stops23h 59m
Santiago Arturo Merino Benitez
Thu 5/21
7:55 pm-12:11 pm
2 stops17h 16m
$1,135
Quickest round-trip
HoustonSantiago
IAH - SCL
IAHSCL
Houston George Bush Intcntl
Wed 9/2
3:40 pm-7:15 am
1 stop14h 35m
Santiago Arturo Merino Benitez
Wed 9/9
8:40 pm-8:32 am
1 stop13h 52m
$1,135
Showing 1-10 of 34 resultsSorted by cheapest first
Best time to book a flight from Houston to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from Houston with our price prediction graph.
HO1-SCL
IAH-SCL
HOU-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Houston to Santiago
HO1-SCL
IAH-SCL
HOU-SCL
What is the cheapest month to book a flight from Houston to Santiago?
Currently, November is the cheapest month in which you can book a flight from Houston to Santiago (average of $325). Flying from Houston to Santiago in February is currently the most expensive (average of $949). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from HOU to SCL?
Find hourly flight availability from Houston to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 23, 2026.
When flying from Houston to Santiago, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
Reviews of airlines servicing Santiago
Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated March 23, 2026.
See what other customers who have flown with LATAM Airlines,United Airlines, andAmerican Airlines from Houston to Santiago have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.0
Boarding
7.5
Comfort
7.3
Food
6.7
Entertainment
7.0
Overall
7.4
Reviews
1 / 20
2.0
MediocreJess,Jan 2026
GRU - MIA
Crew
8.0
Boarding
7.5
Comfort
7.3
Food
6.7
Entertainment
7.0
Overall
7.4
Reviews
1 / 20
2.0
MediocreJess,Jan 2026
GRU - MIA
Crew
8.0
Boarding
7.5
Comfort
7.3
Food
6.7
Entertainment
7.0
Overall
7.4
Reviews
1 / 20
2.0
MediocreJess,Jan 2026
GRU - MIA
Crew
8.0
Boarding
7.5
Comfort
7.3
Food
6.7
Entertainment
7.0
Overall
7.4
Reviews
1 / 20
2.0
MediocreJess,Jan 2026
GRU - MIA
Crew
8.0
Boarding
7.5
Comfort
7.3
Food
6.7
Entertainment
7.0
Overall
7.4
Reviews
1 / 20
2.0
MediocreJess,Jan 2026
GRU - MIA
Related info for your journey
Find useful and relevant information for your journey from Houston to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Santiago flight routes
Alternative routes for Houston to Santiago
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Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Houston to Santiago by cabin class
Find flights from Houston to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Houston and Santiago flights
Browse other Houston and Santiago flight options. Last updated on March 23, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on March 23, 2026.
Top 4 airlines flying from Houston to Santiago
Discover the top 4 airlines that operate flights from Houston to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 23, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$548 | Average$708 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$949 | Average$1,319 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$949 | Average$1,176 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$964 | Average$1,588 | FlexibilityNo cancel fee | On-time71% |