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$241+ Cheap flights from Houston to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/24. Fares are subject to change and may not be available on all flights or dates of travel.
HOU — SCL
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheap flight deals from Houston to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Houston (HO1) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 17, 2025.

Round-trip from

$546
(Mytrip)

One-way from

$241
(Trip.com)

Popular in

December

Cheapest in

May

Average price

$1,368
From Houston to Santiago Arturo Merino Benitez
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One-way flight from Houston to Santiago Arturo Merino Benitez
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Highest demand for flights based on searches. 7% potential increase in price ($102 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($25 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Houston to Santiago

Cheapest flights from Houston to Santiago
Explore the most affordable flight options available from Houston to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This Mytrip deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/138:35 amIAH - SCL
3 stops25h 45mMultiple Airlines
Mon 10/2012:30 pmSCL - IAH
2 stops34h 47mMultiple Airlines
Deal found 9/15$546
This Mytrip deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/166:43 pmIAH - SCL
2 stops33h 17mMultiple Airlines
Tue 11/45:50 amSCL - IAH
2 stops34h 49mMultiple Airlines
Deal found 9/17$555
This Mytrip deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/126:43 pmIAH - SCL
2 stops33h 17mMultiple Airlines
Fri 10/175:55 amSCL - IAH
2 stops17h 22mMultiple Airlines
Deal found 9/15$556
This Mytrip deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/176:18 pmIAH - SCL
2 stops24h 57mMultiple Airlines
Wed 12/34:25 pmSCL - IAH
2 stops19h 07mMultiple Airlines
Deal found 9/17$561
This Mytrip deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/66:18 pmIAH - SCL
2 stops24h 57mMultiple Airlines
Wed 11/199:05 pmSCL - IAH
2 stops19h 34mMultiple Airlines
Deal found 9/15$568
This Mytrip deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/167:00 amIAH - SCL
3 stops26h 15mMultiple Airlines
Wed 11/199:05 pmSCL - IAH
2 stops19h 34mMultiple Airlines
Deal found 9/15$569
This Mytrip deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/36:59 pmIAH - SCL
2 stops25h 16mMultiple Airlines
Fri 10/249:15 pmSCL - IAH
2 stops26h 02mMultiple Airlines
Deal found 9/17$570
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/2010:55 amIAH - SCL
3 stops23h 25mMultiple Airlines
Thu 10/3010:50 amSCL - IAH
1 stop25h 10mMultiple Airlines
Deal found 9/15$579
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/72:48 pmIAH - SCL
2 stops29h 27mMultiple Airlines
Tue 10/1411:00 amSCL - IAH
1 stop36h 17mMultiple Airlines
Deal found 9/15$580
This FlightHub deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/32:22 pmHOU - SCL
1 stop14h 18mLATAM Airlines
Mon 11/2412:55 amSCL - HOU
2 stops20h 03mLATAM Airlines
Deal found 9/14$964
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/310:13 amHOU - SCL
2 stops16h 47mDelta
Tue 11/256:30 pmSCL - HOU
2 stops18h 15mDelta
Deal found 9/14$968
This SmartFares deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1710:40 amHOU - SCL
1 stop18h 00mLATAM Airlines
Wed 12/311:10 pmSCL - HOU
1 stop21h 42mLATAM Airlines
Deal found 9/17$976

Cheapflights Fare Finder

 
Customize your flight search to find flights from Houston to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Houston to Santiago that are best for you.

Fly from

Houston

Fly to

Santiago

Route

Depart

Return

Price

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Sun 11/16

7:00 am-12:15 pm

3 stops26h 15m

Santiago Arturo Merino Benitez

Wed 11/19

9:05 pm-1:39 pm

2 stops19h 34m

$569

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Fri 10/31

12:42 pm-10:15 pm

3 stops31h 33m

Santiago Arturo Merino Benitez

Fri 11/7

12:30 pm-1:39 pm

2 stops28h 09m

$583

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Tue 10/14

1:08 pm-10:15 pm

3 stops31h 07m

Santiago Arturo Merino Benitez

Thu 10/23

9:15 pm-10:40 pm

3 stops27h 25m

$599

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Thu 11/6

6:18 pm-5:50 am

2 stops32h 32m

Santiago Arturo Merino Benitez

Wed 11/19

11:25 pm-1:39 pm

1 stop17h 14m

$608

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Mon 11/3

10:55 am-2:40 pm

2 stops24h 45m

Santiago Arturo Merino Benitez

Tue 11/25

11:25 pm-8:32 am

1 stop36h 07m

$647

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Wed 9/24

4:36 pm-2:51 pm

2 stops44h 15m

Santiago Arturo Merino Benitez

Wed 10/1

11:00 am-5:54 pm

1 stop32h 54m

$655

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Sat 11/1

8:10 pm-5:20 pm

3 stops43h 10m

Santiago Arturo Merino Benitez

Sat 11/8

12:30 pm-1:39 pm

2 stops28h 09m

$662

HoustonSantiago

HOU - SCL

HOUSCL

Houston Hobby

Mon 11/3

2:22 pm-7:40 am

1 stop14h 18m

Santiago Arturo Merino Benitez

Tue 11/25

11:10 pm-9:45 am

1 stop13h 35m

$964

HoustonSantiago

HOU - SCL

HOUSCL

Houston Hobby

Mon 11/3

10:13 am-6:00 am

2 stops16h 47m

Santiago Arturo Merino Benitez

Tue 11/25

6:30 pm-9:45 am

2 stops18h 15m

$968

HoustonSantiago

HOU - SCL

HOUSCL

Houston Hobby

Mon 11/17

10:40 am-7:40 am

1 stop18h 00m

Santiago Arturo Merino Benitez

Wed 12/3

11:10 pm-5:52 pm

1 stop21h 42m

$976

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/16

Showing 1-10 of 33 results
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Best time to book a flight from Houston to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Houston with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Houston to Santiago

What is the cheapest month to book a flight from Houston to Santiago?

Currently, April is the cheapest month in which you can book a flight from Houston to Santiago (average of $752). Flying from Houston to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from HOU to SCL?

Find hourly flight availability from Houston to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 17, 2025.

A simple way to save on the total cost of your ticket is to fly from Houston to Santiago at noon. If you’re flexible enough to do this you can expect to save up to 57% on your trip compared to booking a flight in the evening.

What is the cheapest day to fly from Houston to Santiago?

Use this chart to determine the cheapest time to fly round-trip from Houston to Santiago. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Houston to Santiago flight should consider departing on Friday at noon when fares are most often at their lowest. Sunday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated September 17, 2025.
See what other customers who have flown with Delta, LATAM Airlines, and United Airlines from Houston to Santiago have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,961 reviews

Overall

8.0

Boarding

8.2

Food

7.3

Comfort

7.9

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,961 reviews
Delta
8.0
Very good
7,961 reviews

Overall

8.0

Boarding

8.2

Food

7.3

Comfort

7.9

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
LATAM Airlines
7.5
Good
1,849 reviews
Delta
8.0
Very good
7,961 reviews

Overall

8.0

Boarding

8.2

Food

7.3

Comfort

7.9

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,926 reviews
Delta
8.0
Very good
7,961 reviews

Overall

8.0

Boarding

8.2

Food

7.3

Comfort

7.9

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,961 reviews

Overall

8.0

Boarding

8.2

Food

7.3

Comfort

7.9

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Avianca
6.7
Okay
2,436 reviews
Delta
8.0
Very good
7,961 reviews

Overall

8.0

Boarding

8.2

Food

7.3

Comfort

7.9

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Houston to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santiago from Houston?

    Located just 8.4 mi from the city center, Santiago Arturo Merino Benitez is the airport most travelers will use when flying to Santiago from Houston. Booking flights from Houston to Arturo Merino Benitez (SCL) should be relatively easy as there are 0 daily inbound flights from Houston from 5 different airlines.

  • How long is the flight from Houston to Santiago?

    Departing from Houston to Santiago will take you 14h 18m. Houston and Santiago are separated by a distance of 4637 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Houston to Santiago round-trip?

    Cheapflights users have booked flights from Houston to Santiago round-trip from $499. Other airlines that can offer you cheap pricing are Delta, from $963, and LATAM Airlines, from $963. Users have found that Avianca is 62% cheaper than the other options available to this destination.

  • Can I find deals for flights from Houston to Santiago that include hotel bookings?

    Yes. In addition to deals on Houston to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Houston to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Houston to Santiago.

  • Can I find deals for business class flights from Houston to Santiago?

    Yes. Cheapflights offers flight deals from Houston to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Houston to Santiago?

    Currently, April is the cheapest month in which you can book a flight from Houston to Santiago (average of $752). Flying from Houston to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 5 airlines flying from Houston to Santiago

Discover the top 5 airlines that operate flights from Houston to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$499Average$674FlexibilityNo cancel feeOn-time71%
DeltaCheapest$963Average$1,362FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$963Average$1,392FlexibilityNo cancel feeOn-time81%
United AirlinesCheapest$1,129Average$1,543FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$1,242Average$1,581FlexibilityNo cancel feeOn-time71%

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